Article
Geriatrics & Gerontology
Andrea L. Rosso, Zachary A. Marcum, Xiaonan Zhu, Nicolaas Bohnen, Caterina Rosano
Summary: Anticholinergic medication use is associated with an increased risk of falls, while higher dopaminergic signaling may provide protection against this.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2022)
Article
Multidisciplinary Sciences
Yu Pei, Wenlu Li
Summary: This study aimed to identify predictive factors for malignant transformation (MT) in recurrent parotid pleomorphic adenomas (PAs) based on preoperative clinical parameters. Patients with a clinical diagnosis of recurrent parotid PA were included retrospectively. Univariate and multivariate analyses were used to assess the association between clinicopathologic variables and MT occurrence. MT occurred in 11.8% of the 467 patients. Univariate analysis showed that three or more previous recurrences, newly developed facial nerve paralysis, difficulty in mouth opening, tumors with a diameter >= 2.4 cm, and abnormal neck lymph node enlargement were associated with MT. Multivariate analysis revealed that three or more previous recurrences, newly developed facial nerve paralysis, difficulty in mouth opening, and abnormal neck lymph node enlargement independently predicted MT occurrence.
SCIENTIFIC REPORTS
(2023)
Review
Public, Environmental & Occupational Health
Daniel Joseph Warrington, Elizabeth Jane Shortis, Paula Jane Whittaker
Summary: This umbrella review of seven systematic reviews on wearable electronic devices for falls detection in adults found that these devices offer a low-cost and effective way to detect falls, with higher accuracy when sensors are placed on the trunk, foot, or leg. Multiple sensors can improve the accuracy, specificity, and sensitivity of these devices, highlighting the need for further research on their accuracy in real-world settings for frail older people.
Editorial Material
Medicine, General & Internal
Alvin S. Q. Ong, Lin Wang, Junjie Aw
Summary: This article presents a case study of an 84-year-old non-diabetic woman with recurrent falls and hypoglycemic episodes, who was subsequently diagnosed with a solitary insulinoma. The clinical and radiological findings of insulinoma are discussed.
Article
Geriatrics & Gerontology
Rebekah Harris, Elsa S. Strotmeyer, Leena Sharma, C. Kent Kwoh, Jennifer S. Brach, Robert Boudreau, Jane A. Cauley
Summary: This study examined how the severity of radiographic knee osteoarthritis (KOA) affects recurrent falls in middle-aged and older individuals. The results showed that older adults with radiographic evidence of KOA had a higher likelihood of experiencing recurrent falls compared to those without KOA, regardless of established risk factors. On the other hand, middle-aged adults with KOA did not have an increased odds of recurrent falls, except for those with possible KOA.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2023)
Article
Geriatrics & Gerontology
Hirotaka Iijima, Tomoki Aoyama
Summary: The coexistence of sarcopenia and knee OA in older adults increases the risk of falls, with individuals in the sarcopenia + knee OA group having higher odds of recurrent falls compared to controls. This study introduces the concept of sarcopenic knee OA as a subgroup associated with a higher risk of falls, which should be further validated in future large cohort studies.
Editorial Material
Medicine, General & Internal
Clement Lee, Diego Preciado, Alejandro Hoberman
Summary: This interactive feature discusses the treatment options for recurrent acute otitis media in young children, presenting a case vignette accompanied by two essays that support either the insertion of tympanostomy tubes or conservative medical management.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Medicine, General & Internal
Tao Chen, Fang Shao, Kangyu Chen, Yang Wang, Zhenqiang Wu, Yongjuan Wang, Yanpei Gao, Victoria Cornelius, Chao Li, Zhixin Jiang
Summary: This study aimed to estimate the time needed for older patients (60 years and above) with hypertension to potentially derive clinical benefit from intensive blood pressure (BP) treatment. Through a secondary analysis of individual patient data from published randomized clinical trials, it was found that intensive BP treatment may be appropriate for patients with a life expectancy of greater than 3 years, but may not be suitable for those with less than 1 year.
JAMA INTERNAL MEDICINE
(2022)
Article
Chemistry, Analytical
Hayslenne A. G. O. Araujo, Suhaila M. Smaili, Rosie Morris, Lisa Graham, Julia Das, Claire McDonald, Richard Walker, Samuel Stuart, Rodrigo Vitorio
Summary: Although the multifactorial nature of falls in Parkinson's disease (PD) is well described, optimal assessment for the identification of fallers remains unclear. Thus, we aimed to identify clinical and objective gait measures that best discriminate fallers from non-fallers in PD, with suggestions of optimal cutoff scores.
Article
Clinical Neurology
Hyo-Jung Kim, Ji-Soo Kim, Kwang-Dong Choi, Seo-Young Choi, Seung-Han Lee, Ileok Jung, Jae Han Park
Summary: This study aimed to evaluate the efficacy of a web-based diagnosis and treatment for recurrent benign paroxysmal positional vertigo (BPPV). The study found that using a web-based system for diagnosis and treatment can effectively alleviate the symptoms of recurrent BPPV, and it has significant implications for telemedicine in the field of vestibular disorders.
Article
Geriatrics & Gerontology
Mei-Ling Ge, Eleanor M. Simonsick, Bi-Rong Dong, Judith D. Kasper, Qian-Li Xue
Summary: This study found that physical frailty and cognitive impairment were separately associated with falls in older adults, and there was a lack of synergistic effect between frailty and cognitive impairment.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2021)
Article
Clinical Neurology
Hyo-Jung Kim, Ji-Soo Kim, Kwang-Dong Choi, Seo-Young Choi, Seung-Han Lee, Ileok Jung, Jae Han Park
Summary: This study aimed to determine the efficacy of a web-based diagnosis and treatment for recurrent BPPV. The randomized controlled trial found that the web-based system could effectively diagnose and treat recurrent BPPV, highlighting its potential role in telemedicine for vestibular disorders.
Article
Geriatrics & Gerontology
Theng Choon Ooi, Devinder Kaur Ajit Singh, Suzana Shahar, Nor Fadilah Rajab, Divya Vanoh, Razinah Sharif, Maw Pin Tan
Summary: The study found that the incidence rate of falls among community-dwelling older Malaysians was 17.53%, with 27.51% experiencing two or more falls. Factors such as being female, single, having a history of falls, higher depression scale scores, lower hemoglobin levels, and lower chair stand test scores were independent predictors of occasional falls. While factors such as history of falls, being a stroke survivor, higher body fat percentage, and lower chair stand test scores were predictors of recurrent falls.
Article
Multidisciplinary Sciences
Stacy A. Drake, Sadie H. Conway, Yijiong Yang, Latarsha S. Cheatham, Dwayne A. Wolf, Sasha D. Adams, Charles E. Wade, John B. Holcomb
Summary: This study revealed that readmissions and repeated falls are frequent occurrences in the clinical sequence of fall fatalities. Efforts to prevent fall-related readmissions should be a top priority for improving fall outcomes and increasing the quality of life among those at risk of falling.
Article
Medicine, General & Internal
Isla S. Mackenzie, Amy Rogers, Neil R. Poulter, Bryan Williams, Morris J. Brown, David J. Webb, Ian Ford, David A. Rorie, Greg Guthrie, J. W. Kerr Grieve, Filippo Pigazzani, Peter M. Rothwell, Robin Young, Alex McConnachie, Allan D. Struthers, Chim C. Lang, Thomas M. MacDonald
Summary: The TIME study aimed to investigate whether evening dosing of antihypertensive medication improves cardiovascular outcomes compared with morning dosing. The results showed that there was no difference in major cardiovascular outcomes between evening dosing and morning dosing, and patients can choose a convenient time to take their medications.
Review
Rehabilitation
Humberto Omana, Edward Madou, Manuel Montero-Odasso, Michael W. Payne, Ricardo Viana, Susan W. Hunter
Summary: This study systematically reviewed the literature on the effect of dual-task testing on the balance and gait of people with lower limb amputations, and found that individuals with lower limb amputations demonstrated greater instability and abnormal gait during dual-task testing. Further research is needed to understand how specific factors related to lower limb amputations influence dual-task performance.
Article
Multidisciplinary Sciences
Sophie Wist, Lena J. Carcreff, Sjoerd M. Bruijn, Gilles Allali, Christopher J. Newman, Joel Fluss, Stephane Armand
Summary: This study compared the gait stability of children with cerebral palsy and typically developing children under dual-task conditions. The results showed that the dual task had a significant effect on the children with cerebral palsy, and both groups demonstrated significant changes in gait stability during dual tasks.
Article
Clinical Neurology
Mahmoud Messerer, Marius Blanchard, Kyriakos Papadimitriou, Alberto Vandenbulcke, Dionys Rutz, Valerie Beaud, Ehab Shiban, Julien Bally, Gilles Allele, Roy T. Daniel, Giulia Cossu
Summary: This study evaluated surgical outcomes of patients with ventriculoperitoneal shunt for idiopathic normal pressure hydrocephalus, comparing patients showing objective improvement with patients improving only on subjective assessments. The results showed that there was no difference in surgical outcomes between the two groups, but in the group of subjective responders, a continuous improvement for incontinence and gait was more frequently observed.
WORLD NEUROSURGERY
(2022)
Editorial Material
Geriatrics & Gerontology
Manuel Montero-Odasso
Review
Geriatrics & Gerontology
Nolwenn Lapierre, Nathavy Um Din, Joel Belmin, Carmelo Lafuente-Lafuente
Summary: Exergame-assisted rehabilitation can reduce the incidence of falls and improve physical performance in older adults, but its effects on fall risk and fear of falling are inconclusive.
Article
Nutrition & Dietetics
Guillaume T. Duval, Anne-Marie Schott, Dolores Sanchez-Rodriguez, Francois R. Herrmann, Cedric Annweiler
Summary: The study suggests that older women born in the summer to early fall months have higher muscle mass and strength.
Article
Geriatrics & Gerontology
Frederico Pieruccini-Faria, Seyyed Mohammad Hassan, Nickolas W. Bray, Yanina Sarquis-Adamson, Robert Bartha, Manuel Montero-Odasso
Summary: Mild Cognitive Impairment (MCI) affects obstacle negotiation capabilities, potentially increasing the risk of falls in older adults. However, it is unclear whether smaller brain volumes typically observed in older individuals with MCI are related to the observed hazardous obstacle negotiation in this population.
Article
Clinical Neurology
Giulia Bommarito, Valentina Garibotto, Giovanni B. Frisoni, Frederic Assal, Patrice H. Lalive, Gilles Allali
Summary: Delirium disorder is a frequent neurological complication of SARS-CoV-2 infection and is associated with increased disease severity and mortality. Cognitive impairment is a major risk factor for developing delirium disorder during Covid-19, which then increases the risk of subsequent neurological complications and cognitive decline.
NEURODEGENERATIVE DISEASES
(2023)
Editorial Material
Clinical Neurology
Carmelo Lafuente-Lafuente, Celine Truong, Caryn Recto, Charlotte Lafont, Florence Canoui-Poitrine, Joel Belmin
Article
Multidisciplinary Sciences
Guillaume Duval, Anne-Marie Schott, Yves Rolland, Jennifer Gautier, Hubert Blain, Gustavo Duque, Cedric Annweiler
Summary: This study found that a decrease in systolic blood pressure while standing was associated with baseline cognitive impairment in older women, but orthostatic hypotension itself and a decrease in diastolic blood pressure while standing were not. Furthermore, none of these factors could predict incident cognitive decline after 7 years. This suggests that the relationship between orthostatic hypotension and cognitive impairment is more complex than previously thought.
Article
Clinical Neurology
Marine Thomasson, Philippe Voruz, Alexandre Cionca, Isabele Jacot de Alcantara, Anthony Nuber-Champier, Gilles Allali, Lamyae Benzakour, Patrice H. Lalive, Karl-Olof Loevblad, Olivia Braillard, Mayssam Nehme, Matteo Coen, Jacques Serratrice, Jean-Luc Reny, Jerome Pugin, Idris Guessous, Basile N. Landis, Alessandra Griffa, Dimitri Van de Ville, Frederic Assal, Julie A. Peron
Summary: A study on 105 patients with SARS-CoV-2 infection found that 6 to 9 months after infection, patients with severe respiratory symptoms had poorer recognition abilities for fear expressions, while patients with mild symptoms had poorer recognition abilities for disgust and irritation expressions. These findings suggest long-term consequences of SARS-Cov-2 infection on the limbic system.
BRAIN COMMUNICATIONS
(2023)
Article
Health Care Sciences & Services
Victoria Zolnowski-Kolp, Nathavy Um Din, Charlotte Havreng-Thery, Sylvie Pariel, Jacques -Henri Veyron, Carmelo Lafuente-Lafuente, Joel Belmin
Summary: This study aimed to design and validate an electronic version of the French Vulnerable Elders Survey-13 (eEVA-13) for use on a digital tablet. The results showed that eEVA-13 can effectively diagnose frailty and is highly correlated with the original version. Both older adults and family caregivers can easily use eEVA-13.
JOURNAL OF MEDICAL INTERNET RESEARCH
(2023)
Article
Nutrition & Dietetics
Dorien De Meester, Mathijs Goossens, Ester Marco, Marie Claessens, Jennifer Gautier, Cedric Annweiler, Siddhartha Lieten, Florence Benoit, Murielle Surquin, Dolores Sanchez-Rodriguez
Summary: The Geriatric Nutritional Risk Index (GNRI) on hospital admission was found to be associated with increased 14-day mortality risk in older inpatients with COVID-19. A GNRI score of <= 98 indicated a risk of malnutrition. However, no association was found between GNRI and 12-month mortality risk. Further studies are needed to validate the short-term predictive value of GNRI in this population.
CLINICAL NUTRITION ESPEN
(2023)
Article
Geriatrics & Gerontology
Manuel Montero-Odasso, Nathalie van der Velde, Finbarr C. Martin, Mirko Petrovic, Maw Pin Tan, Jesper Ryg, Sara Aguilar-Navarro, Neil B. Alexander, Clemens Becker, Hubert Blain, Robbie Bourke, Ian D. Cameron, Richard Camicioli, Lindy Clemson, Jacqueline Close, Kim Delbaere, Leilei Duan, Gustavo Duque, Suzanne M. Dyer, Ellen Freiberger, David A. Ganz, Fernando Gomez, Jeffrey M. Hausdorff, David B. Hogan, Susan M. W. Hunter, Jose R. Jauregui, Nellie Kamkar, Rose-Anne Kenny, Sarah E. Lamb, Nancy K. Latham, Lewis A. Lipsitz, Teresa Liu-Ambrose, Pip Logan, Stephen R. Lord, Louise Mallet, David Marsh, Koen Milisen, Rogelio Moctezuma-Gallegos, Meg E. Morris, Alice Nieuwboer, Monica R. Perracini, Frederico Pieruccini-Faria, Alison Pighills, Catherine Said, Ervin Sejdic, Catherine Sherrington, Dawn A. Skelton, Sabestina Dsouza, Mark Speechley, Susan Stark, Chris Todd, Bruce R. Troen, Tischa van der Cammen, Joe Verghese, Ellen Vlaeyen, Jennifer A. Watt, Tahir Masud
Summary: This article introduces the common occurrence and negative effects of falls and fall-related injuries in older adults, which impact their functional independence and quality of life, as well as increase morbidity, mortality, and health-related costs. Current guidelines are inconsistent and not globally applicable. Therefore, the objective of this study is to create evidence- and expert consensus-based falls prevention and management recommendations for older adults. These recommendations consider a person-centered approach, the perspectives of older adults, caregivers, and stakeholders, recent developments in e-health, and implementation in resource-limited locations.
Article
Geriatrics & Gerontology
Nathalie van der Velde, Lotta Seppala, Mirko Petrovic, Jesper Ryg, Maw Pin Tan, Manuel Montero-Odasso, Finbarr C. Martin, Tahir Masud
AGING CLINICAL AND EXPERIMENTAL RESEARCH
(2022)