Article
Endocrinology & Metabolism
Frank Qian, Andres V. Ardisson Korat, Fumiaki Imamura, Matti Marklund, Nathan Tintle, Jyrki K. Virtanen, Xia Zhou, Julie K. Bassett, Heidi Lai, Yoichiro Hirakawa, Kuo-Liong Chien, Alexis C. Wood, Maria Lankinen, Rachel A. Murphy, Cecilia Samieri, Kamalita Pertiwi, Vanessa D. de Mello, Weihua Guan, Nita G. Forouhi, Nick Wareham, Frank B. Hu, Ulf Riserus, Lars Lind, William S. Harris, Aladdin H. Shadyab, Jennifer G. Robinson, Lyn M. Steffen, Allison Hodge, Graham G. Giles, Toshiharu Ninomiya, Matti Uusitupa, Jaakko Tuomilehto, Jaana Lindstrom, Markku Laakso, David S. Siscovick, Catherine Helmer, Johanna M. Geleijnse, Jason H. Y. Wu, Amanda Fretts, Rozenn N. Lemaitre, Renata Micha, Dariush Mozaffarian, Qi Sun
Summary: A global consortium of 20 prospective studies involving 65,147 participants found that higher circulating biomarkers of seafood-derived n-3 fatty acids were associated with lower risk of type 2 diabetes, while biomarkers of plant-derived ALA were not significantly linked with diabetes risk.
Article
Clinical Neurology
Ting Liu, Lu Wang, Jimin Guo, Tingyu Zhao, Hui Tang, Fang Dong, Chuanyue Wang, Jindong Chen, Mimi Tang
Summary: The levels of erythrocyte membrane fatty acids were found to be elevated in patients with severe depression and anxiety. These findings suggest that erythrocyte membrane fatty acid levels could serve as biological indicators for the severity of depressive symptoms and anxiety.
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
(2023)
Article
Nutrition & Dietetics
Jingyi Shen, Jinchen Li, Yinan Hua, Bingjie Ding, Cui Zhou, Huiyan Yu, Rong Xiao, Weiwei Ma
Summary: Dietary fatty acid intake is closely associated with the cognitive function of overweight and obese individuals, with different effects depending on body mass index (BMI) groups. The fatty acid profile in erythrocyte membranes can reflect cognitive function, and n-3 PUFAs have a protective effect on the overweight group.
Article
Nutrition & Dietetics
Bert B. Boyer, Scarlett E. Hopkins, Howard W. Wiener, Jonathan Q. Purnell, Diane M. O'Brien, Cindy X. Zhang, Joseph E. Aslan, Theresa Aliwarga, Jeremy J. Pomeroy, Kenneth E. Thummel, Hemant K. Tiwari
Summary: This study found that habitual intake of marine mammals and fish rich in n-3 PUFAs is associated with reduced systemic inflammation in Yup'ik Alaska Native adults.
JOURNAL OF NUTRITION
(2022)
Review
Nutrition & Dietetics
Franklin Chamorro, Paz Otero, Maria Carpena, Maria Fraga-Corral, Javier Echave, Sepidar Seyyedi-Mansour, Lucia Cassani, Miguel A. Prieto
Summary: Oily fish is a rich source of nutrients, including energy, proteins, lipids, vitamins, and minerals. Long-chain omega-3 polyunsaturated fatty acids (DHA and EPA) in oily fish play a beneficial role in promoting health and preventing various diseases. Oily fish consumption is important throughout the human lifespan. However, the presence of chemical pollutants in oily fish can pose health risks, especially for vulnerable groups like pregnant women and young children.
Article
Nutrition & Dietetics
Xuan Wang, Tiantian Li, Huini Ding, Yuru Liu, Xiaoqiang Liu, Kang Yu, Rong Xiao, Yuandi Xi
Summary: This study found that specific dietary patterns and fatty acid patterns are associated with the development of cognitive function, which may be important for preventing mild cognitive impairment.
FRONTIERS IN NUTRITION
(2022)
Article
Nutrition & Dietetics
Zhi Huang, Xing Liu, Ziming Li, Luwei Cui, Candi Liu, Weifeng Wang, Yuming Hu, Bo Chen
Summary: This study found direct correlations between mineral elements (Cu, Zn, and Mg) in whole blood and fatty acid levels in erythrocytes of Chinese children. The interactions between Mg, Cu, and Zn with fatty acids may affect fatty acid metabolism.
Article
Nutrition & Dietetics
Mengyang Su, Xuanrui Zhang, Wei Hu, Zhenxiao Yang, Danyu Chen, Yingdi Yang, Keliang Xie, Yuming Chen, Zheqing Zhang
Summary: This study investigated the longitudinal relationship between erythrocyte membrane PUFAs concentrations and age-related changes in skeletal muscle mass in a Chinese middle-aged and older adult population. The study found that the associations between different individual PUFAs and age-related muscle loss may differ, with high concentrations of n-6 PUFAs being correlated with less muscle mass loss, while extremely high concentrations of n-3 PUFAs being correlated with more muscle loss.
CLINICAL NUTRITION
(2023)
Article
Oncology
Pei Liang, Susanne M. Henning, Tristan Grogan, David Elashoff, Jonathan Said, Pinchas Cohen, William J. Aronson
Summary: Preclinical and clinical translational research supports the role of an omega-3 fatty acid diet for prostate cancer prevention and treatment, but the underlying mechanisms are not fully understood. This study found that the anticancer effects of an omega-3 diet are mediated through GPR120 functional M2-like macrophages.
PROSTATE CANCER AND PROSTATIC DISEASES
(2023)
Article
Medicine, General & Internal
Olivia Okereke, Chirag M. Vyas, David Mischoulon, Grace Chang, Nancy R. Cook, Alison Weinberg, Vadim Bubes, Trisha Copeland, Georgina Friedenberg, I-Min Lee, Julie E. Buring, Charles F. Reynolds, JoAnn E. Manson
Summary: The study found that long-term supplementation with marine omega-3 fatty acids led to a small but statistically significant increase in the risk of depression or clinically relevant depressive symptoms. However, it did not show any significant difference in mood scores.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2021)
Article
Nutrition & Dietetics
Hongmei Wu, Qing Zhang, Li Liu, Ge Meng, Yeqing Gu, Zhanxin Yao, Shunming Zhang, Yawen Wang, Tingjing Zhang, Xuena Wang, Xing Wang, Shaomei Sun, Qiyu Jia, Kun Song, Kaijun Niu
Summary: This study found a positive relationship between saltwater fish consumption and handgrip strength in men, but not in women. Additionally, there was a correlation between dietary intake of n-3 PUFA and handgrip strength.
NUTRITION RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Carla Ferreri, Alessandra Ferocino, Gessica Batani, Chryssostomos Chatgilialoglu, Vanda Randi, Maria Vittoria Riontino, Fabrizio Vetica, Anna Sansone
Summary: Plasmalogens are membrane phospholipids that play a role in peroxidation and have the potential for cis-trans double bond isomerization. Through experiments using representative molecules and liposomes under specific conditions, the reactivity and outcomes of these processes were studied. The results provide important insights for lipidomic applications and understanding radical stress in living organisms.
Article
Nutrition & Dietetics
Olivier Goulet, Antonin Lamaziere, Elie Abi Nader, Cecile Talbotec, Claude Wolf, Cecile Lambe
Summary: This study evaluated the tolerance and erythrocyte fatty acid profile of children on long-term home parenteral nutrition (HPN) receiving a composite fish oil-based emulsion (FOLE). The results showed that the FOLE was well tolerated in HPN-dependent children and the alterations in erythrocyte fatty acid profile were consistent with the composition of the emulsion, indicating no evidence of essential fatty acid deficiency.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2022)
Article
Cell Biology
Florina Zakany, Mate Szabo, Gyula Batta, Levente Karpati, Istvan M. Mandity, Peter Fulop, Zoltan Varga, Gyorgy Panyi, Peter Nagy, Tamas Kovacs
Summary: The article introduces a novel method for measuring the intramembrane dipole potential (DP) and identifies several substances that affect DP. ALA is suggested as a compound that lowers DP and facilitates the entry of penetratin into the cytoplasm.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Medicine, General & Internal
Christine M. Albert, Nancy R. Cook, Julie Pester, M. Vinayaga Moorthy, Claire Ridge, Jacqueline S. Danik, Baris Gencer, Hasan K. Siddiqi, Chee Ng, Heike Gibson, Samia Mora, Julie E. Buring, JoAnn E. Manson
Summary: The study showed that marine omega-3 fatty acids and vitamin D-3 supplementation did not have a significant effect on preventing atrial fibrillation. The findings do not support the use of these supplements for primary prevention of incident AF.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2021)
Article
Cardiac & Cardiovascular Systems
Jing Pang, David R. Sullivan, David L. Hare, David M. Colquhoun, Timothy R. Bates, Jacqueline D. M. Ryan, Warrick Bishop, John R. Burnett, Damon A. Bell, Leon A. Simons, Sam Mirzaee, Karam M. Kostner, Paul J. Nestel, Andrew M. Wilson, Richard C. O'Brien, Edward D. Janus, Peter M. Clifton, Justin J. Ardill, Dick C. Chan, Frank van Bockxmeer, Gerald F. Watts
Summary: Analysis of the FH Australasia Network registry revealed that patients are typically identified later in life, have a high burden of coronary artery disease, and do not achieve guideline-recommended LDL-cholesterol targets. Genetic and cascade testing are under-utilised, highlighting the need for improved care strategies as a public health priority.
HEART LUNG AND CIRCULATION
(2021)
Article
Instruments & Instrumentation
Tahlia R. Meola, Ahmad Y. Abuhelwa, Paul Joyce, Peter Clifton, Clive A. Prestidge
Summary: The study demonstrated that SLH formulations significantly enhanced the bioavailability of SIM, particularly SIMA, compared to a commercial formulation. SLH formulations have the potential for dose reduction and improving the bioavailability of poorly water-soluble drugs.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2021)
Article
Nutrition & Dietetics
Peter M. Clifton, Jennifer B. Keogh
Summary: The chronic consumption of moderate doses of fructose in solid foods had effects on triglycerides, glucose, and uric acid levels. The increase in fasting TAG levels in participants with IFG/IGT suggests caution for those at increased risk of type 2 diabetes. Other lipid profiles and glucose levels did not significantly differ between fructose and sucrose consumption over a 1-month period.
BRITISH JOURNAL OF NUTRITION
(2021)
Article
Environmental Sciences
Kristy L. Gray, Mayya Grebenshchikova, Sharleen L. O'Reilly, Lois McKellar, Peter M. Clifton, Jennifer B. Keogh
Summary: This study outlines the development and validation process of a survey investigating barriers to weight loss, perception of diabetes risk, and diet strategies following gestational diabetes. The survey underwent three stages of development: item generation, expert evaluation, and pilot testing. Through expert evaluation and pilot testing, a final survey tool with 30 items was established, achieving content validation.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Article
Oncology
Holly El Evans, Cynthia C. Forbes, Daniel A. Galvao, Corneel Vandelanotte, Robert U. Newton, Gary Wittert, Suzanne Chambers, Andrew D. Vincent, Ganessan Kichenadasse, Danielle Girard, Nicholas Brook, Camille E. Short
Summary: This study focused on investigating the acceptability and usability of a web-based exercise intervention for men with metastatic prostate cancer. The overall results showed that the intervention was deemed satisfactory and improvements were made based on participant feedback. The personalized multimodal exercise prescription and computer-tailored education were seen as valuable by the participants.
Article
Nutrition & Dietetics
Deepti K. Sharma, Paul H. Anderson, Howard A. Morris, Peter M. Clifton
Summary: The study finds that intake of 1000 mg calcium from milk or calcium carbonate is effective in acutely suppressing bone resorption in postmenopausal women, regardless of visceral fat levels.
JOURNAL OF NUTRITION
(2022)
Article
Endocrinology & Metabolism
Gary Wittert, Mathis Grossmann
Summary: In the absence of obesity and adverse lifestyle behaviors, the decrease in serum testosterone concentrations is minimal. Obesity contributes to functional hypogonadism, leading to low testosterone levels and increased risk of type 2 diabetes. Weight loss can increase testosterone levels and prevent or reverse diabetes, while testosterone treatment can improve outcomes in lifestyle interventions.
REVIEWS IN ENDOCRINE & METABOLIC DISORDERS
(2022)
Article
Nutrition & Dietetics
Kristina S. Petersen, Jess Murphy, Jane Whitbread, Peter M. Clifton, Jennifer B. Keogh
Summary: This study found that consuming 35 g of peanuts prior to two main meals per day in the context of an energy-restricted diet can achieve weight loss comparable to a traditional low-fat weight loss diet and can significantly lower blood pressure.
Article
Cardiac & Cardiovascular Systems
Francisco Lopez-Jimenez, Wael Almahmeed, Harold Bays, Ada Cuevas, Emanuele Di Angelantonio, Carel W. le Roux, Naveed Sattar, Marie Chan Sun, Gary Wittert, Fausto J. Pinto, John P. H. Wilding
Summary: Obesity is a global public health crisis that leads to poor health outcomes and millions of deaths each year. It is associated with an increased risk of cardiovascular morbidity and mortality, mainly due to the accumulation of body fat, particularly abdominal fat. The complex mechanisms underlying obesity-related cardiovascular disease pose challenges for clinical practice. Intentional weight loss can reduce cardiovascular risk, but long-term maintenance requires ongoing commitment. This position paper aims to improve understanding of the links between obesity and cardiovascular disease, address controversies, and provide recommendations for clinicians.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2022)
Review
Endocrinology & Metabolism
Gary A. Wittert, Mathis Grossmann, Bu B. Yeap, David J. Handelsman
Summary: Testosterone, acting as both androgen receptor and as aromatization to oestradiol, plays important roles in adipose tissue, bone, and skeletal muscle biology. Epidemiological studies have linked lower testosterone levels with obesity, disordered glucose metabolism, and an increased risk of type 2 diabetes in men. The Testosterone for the Prevention of Type 2 Diabetes (T4DM) study found that a 2-year treatment with testosterone undecanoate reduced the likelihood of T2D diagnosis by 40% and led to favorable changes in body composition, bone mineral density, and skeletal microarchitecture, but not in glycaemic control.
JOURNAL OF ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
David J. Handelsman, Mathis Grossmann, Bu B. Yeap, Bronwyn G. A. Stuckey, Nandini Shankara-Narayana, Ann J. Conway, Warrick J. Inder, Robert Mclachlan, Carolyn Allan, Alicia J. Jenkins, David Jesudason, Karen Bracken, Gary A. Wittert
Summary: The T4DM study shows that testosterone treatment for men with impaired glucose tolerance or newly diagnosed diabetes reduces the risk of diabetes and improves sleep apnea diagnosis during the study period, but these effects disappear after the study. There is also evidence of androgen dependence in some men receiving prolonged injectable testosterone treatment.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Emily Jane Meyer, Gary Allen Wittert
Summary: Obstructive sleep apnea (OSA) and obesity are closely associated; OSA is often unrecognized in women; OSA increases the risk of developing comorbid chronic disorders and impairs quality of life; appropriate treatment can improve symptoms and related diseases.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Review
Clinical Neurology
Cricket Fauska, Tarun Bastiampillai, Robert J. Adams, Gary Wittert, Danny J. Eckert, Kelly A. Loffler
Summary: This article discusses the effects of quetiapine on sleep and breathing, emphasizing the importance of understanding its impact on obstructive sleep apnea and its mechanisms. It also proposes future research priorities to address the current knowledge gaps.
JOURNAL OF SLEEP RESEARCH
(2023)
Review
Psychology, Multidisciplinary
Melissa J. J. Opozda, Melissa Oxlad, Deborah Turnbull, Himanshu Gupta, Andrew D. D. Vincent, Samuel Ziesing, Murray Nankivell, Gary Wittert
Summary: This study aimed to evaluate the characteristics of psychotherapeutic e-mental health interventions for depression or anxiety in men and their effects on men's depression and anxiety symptoms. The findings indicate that e-mental health interventions are effective in improving men's depression symptoms. It is crucial to consider gender and sex in the development, evaluation, and dissemination of such interventions for men.
CURRENT PSYCHOLOGY
(2023)
Article
Psychology, Clinical
Holly E. L. Evans, Cynthia C. Forbes, Corneel Vandelanotte, Daniel A. Galvao, Robert U. Newton, Gary Wittert, Suzanne Chambers, Ganessan Kichenadasse, Nicholas Brook, Danielle Girard, Camille E. Short
Summary: This study examines the perspectives of individuals with metastatic prostate cancer towards exercise and exercise-based web-based eHealth interventions. The findings suggest a need for individualized, user-friendly and reliable information with support from a professional. Additionally, the clinical implications of some participants not accurately reporting metastasis locations were highlighted.
INTERNATIONAL JOURNAL OF BEHAVIORAL MEDICINE
(2021)