Article
Multidisciplinary Sciences
D. T. S. Z. Miranda, A. L. Zanatta, E. A. Miles, P. C. Calder, A. Nishiyama
Summary: The study showed that supplementation of fish oil in asthmatic rats resulted in lower levels of certain lung eicosanoids produced by cyclooxygenase-2 and 15-lipoxygenase, but had limited effects on the metabolite LTB4 produced by 5-lipoxygenase.
Article
Multidisciplinary Sciences
Jennifer D. Helble, Michael J. Walsh, Julie E. Mccarthy, Neal P. Smith, Alice J. Tirard, Benjamin Y. Arnold, Alexandra-Chloe Villani, Linden T. Hu
Summary: Lyme disease is caused by Borrelia burgdorferi and can be modeled in laboratory mice. The study used single-cell RNA sequencing to analyze gene expression changes in infected mice and found significant differences in various cell types, as well as predicted cellular interactions.
Article
Multidisciplinary Sciences
Tae-Hwan Jung, Kyoung-Sik Han
Summary: The study showed that imbalanced dietary intake can lead to dysbiosis of colonic microbiota in growing rats, along with decreased concentrations of short chain fatty acids and serum immunoglobulins.
Article
Fisheries
Manuel Gesto, Lone Madsen, Nikolaj R. Andersen, Najlae El Kertaoui, Patrick Kestemont, Alfred Jokumsen, Ivar Lund
Summary: Different vegetable oils can be used as substitutes of fish oil in aquaculture feed, but they may cause deficiency in long chain polyunsaturated fatty acids in fish products. The welfare and health consequences of these alterations on fish are not well known.
Article
Fisheries
Bjorg Kristine Hundal, Nina Sylvia Liland, Grethe Rosenlund, Erik Hoglund, Pedro Araujo, Ingunn Stubhaug, Nini Hedberg Sissener
Summary: Increasing the dietary n-6/n-3 FA ratio in salmon feeds can potentially alter the way the fish respond to stressors, but growth and overall health of the fish are not affected by this dietary change.
Article
Genetics & Heredity
William B. Domingues, Tony L. R. Silveira, Leandro S. Nunes, Eduardo B. Blodorn, Augusto Schneider, Carine D. Corcine, Antonio S. Varela Junior, Izani B. Acosta, Mateus T. Kuetter, Gonzalo Greif, Carlos Robello, Danillo Pinhal, Luis F. Marins, Vinicius F. Campos
Summary: The overexpression of growth hormone in gh-transgenic zebrafish affects various aspects of their physiology, behavior, and reproductive performance. The dysregulation of miRNAs in sperm due to gh overexpression leads to a reduction in sperm quality and reproductive potential in these transgenic zebrafish.
FRONTIERS IN GENETICS
(2021)
Article
Fisheries
Zabih O. Pajand, Kourosh Haddadi Moghaddam, Fruzan Chubian, Esmaeil Farzaneh, Esmaeil Hosseinnia
Summary: This study investigated the effects of different oil sources on the growth, survival, and fatty acid profile of Hediste diversicolor. The results showed that mixed vegetable oil had significant impacts on the growth and survival rate of H. diversicolor, making it a potential economic alternative to fish oil in aquaculture.
AQUACULTURE RESEARCH
(2022)
Article
Agriculture, Dairy & Animal Science
Patricia G. Cardoso, Odete Goncalves, Thais Cavalheri, Vania E. Amorim, Weiwei Cao, Diogo A. M. Alexandrino, Zhongjun Jia, Maria F. F. Carvalho, Paulo Vaz-Pires, Rodrigo O. A. Ozorio
Summary: A fish trial was conducted to assess the effects of temperature and dietary lipid level on the body composition, growth performance, and freshness profile of the European seabass. The study showed that fish reared at 24 degrees C had lower lipid levels and higher daily growth index compared to fish reared at 20 degrees C. Sensory and microbiological analysis further revealed better freshness conditions in fish reared at 24 degrees C. However, dietary lipid level did not impact fish freshness. These findings suggest that increasing the temperature to 24 degrees C is beneficial for the growth and freshness profile of this particular species in aquaculture.
Article
Endocrinology & Metabolism
Lang Pan, Kexiang Shi, Jun Lv, Yuanjie Pang, Yu Guo, Pei Pei, Huaidong Du, Iona Millwood, Ling Yang, Yiping Chen, Ruqin Gao, Xiaoming Yang, Daniel Avery, Junshi Chen, Canqing Yu, Zhengming Chen, Liming Li
Summary: The aim of this study was to explore the associations between major dietary patterns and lipid profiles, as well as the associations between these profiles and the risks of general and central obesity. The study found that the newly affluent southern pattern was associated with 45 metabolites and with increased risks of obesity. The global lipid profile potentially explained a significant portion of the effects of this dietary pattern on obesity.
Article
Agriculture, Dairy & Animal Science
Grzegorz Skiba, Stanislawa Raj, Monika Sobol, Marian Czauderna, Pawel Kowalczyk, Eugeniusz R. Grela
Summary: The study found that supplementing growing lambs with diets containing bioactive components significantly improved the geometric, densitometric, and biomechanical properties of lamb femur.
Article
Environmental Sciences
Gulsun Ozyurt, Dilan Ekmen, Mustafa Durmus, Yilmaz Ucar
Summary: The fatty acid composition of popular fish oil dietary supplements on the market was compared with the labeled content, while their oxidative qualities and heavy metal contents were evaluated. Results showed that most capsule groups confirmed the label information, but some syrup groups had lower content. Capsules generally contained higher EPA and DHA levels compared to syrups in the samples analyzed.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Agriculture, Dairy & Animal Science
Irene Garcia-Meilan, Ramon Fontanillas, Joaquim Gutierrez, Encarnacion Capilla, Isabel Navarro, Angeles Gallardo
Summary: This study compared the effects of different dietary treatments containing soybean oil alone or in combination with other vegetable oils on the intestinal health of sea bream. The results showed that the blend of soybean and linseed oils negatively affected intestinal integrity due to high oxidative stress. However, the addition of palm oil to the mixture helped maintain low oxidative stress and preserve intestinal health.
Article
Fisheries
Min Su Ha, Sung Hwoan Cho, Taeho Kim
Summary: This study found that fish meal can be replaced with meat meal up to 400 g/kg in juvenile olive flounder without detrimental effects on growth, feed utilization, and disease resistance.
AQUACULTURE NUTRITION
(2021)
Article
Food Science & Technology
Kang Chen, Fangfei Zhou, Jian Zhang, Pin Li, Yumei Zhang, Baoru Yang
Summary: Sea buckthorn berry puree intervention can significantly alter the plasma metabolomics profile and gut microbiota in hypercholesterolemic patients, improving energy metabolism and modulating gut microbes linked to lipid metabolism.
Article
Food Science & Technology
Pengjia He, Yu Lei, Ke Zhang, Rui Zhang, Yunpeng Bai, Zeming Li, Li Jia, Jinping Shi, Qiang Cheng, Yannan Ma, Xiaoqiang Zhang, Lishan Liu, Zhaomin Lei
Summary: This study found that supplementation with oregano essential oil (OEO) can enhance the antioxidant capacity, water-holding capacity, and meat color of beef. It also helps to decrease pH levels and prevent lipid oxidation. Additionally, OEO supplementation increases the concentration of polyunsaturated fatty acids and conjugated linoleic acid, as well as essential amino acids, flavor amino acids, and total amino acids.
Article
Biochemistry & Molecular Biology
Daiki Hayashi, Varnavas D. Mouchlis, Edward A. Dennis
Summary: Glycerophospholipids are major components of cell membranes with diverse fatty acyl chain compositions and polar head groups. Phospholipase A(2) enzymes play a critical role in metabolism by hydrolyzing glycerophospholipids, and different human PLA(2) enzymes show distinct preferences for sn-1 acyl chain linkages.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
(2022)
Article
Multidisciplinary Sciences
Varnavas D. Mouchlis, Daiki Hayashi, Alexis M. Vasquez, Jian Cao, J. Andrew McCammon, Edward A. Dennis
Summary: Lipoprotein-associated phospholipase A(2) (Lp-PLA(2)) associates with lipoproteins in human plasma and hydrolyzes oxidized phospholipids. The mechanism of enzyme-membrane association and substrate specificity were studied using lipidomics and mass spectrometry techniques.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Biochemistry & Molecular Biology
Maria A. Theodoropoulou, Anastasia Psarra, Martin Erhardt, Aikaterini Nikolaou, Anna-Dimitra D. Gerogiannopoulou, Dimitra Hadjipavlou-Litina, Daiki Hayashi, Edward A. Dennis, Andrea Huwiler, George Kokotos
Summary: The search for new drugs that can regulate the production of prostaglandin E-2 (PGE(2)) is crucial in the treatment of inflammatory diseases. In this study, we synthesized and evaluated a series of compounds, and identified N-acylated and N-alkylated 2-aminobenzothiazoles as potential leads. These compounds showed significant inhibition of PGE(2) generation in rat mesangial cells and demonstrated better anti-inflammatory activity than indomethacin. The findings suggest that N-acylated or N-alkylated 2-aminobenzothiazoles could be promising candidates for regulating PGE(2) formation.
Article
Multidisciplinary Sciences
Loren M. DeVito, Edward A. Dennis, Barbara B. Kahn, Gerald Shulman, Joseph L. Witztum, Sudeshna Sadhu, Joseph Nickels, Matthew Spite, Susan Smyth, Sarah Spiegel
Summary: Recent research has revealed the cellular and molecular functions of bioactive lipids as signaling molecules in regulating inflammation and lipid metabolism, which can help identify mechanisms targeted to prevent or treat cardiometabolic conditions.
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Edward A. Dennis
Summary: Lipids play important roles in chronic diseases, but defining the substrate specificity of lipid metabolism enzymes is challenging. This research focuses on how membranes interact with enzymes to regulate cell signaling and metabolic pathways. By using substrate lipidomics and molecular dynamics simulations, the study reveals the link between enzyme specificity and hydrophobic binding subsites for membrane phospholipid substrates.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Daiki Hayashi, Varnavas D. Mouchlis, Seika Okamoto, Tomoka Namba, Liuqing Wang, Sheng Li, Shuji Ueda, Minoru Yamanoue, Hirofumi Tachibana, Hiroyuki Arai, Hitoshi Ashida, Edward A. Dennis, Yasuhito Shirai
Summary: Alpha-tocopherol (alpha Toc), the active form of vitamin E, has both antioxidant and non-antioxidant effects. It has been discovered that the membrane-bound 67 kDa laminin receptor (67LR) serves as a receptor for alpha Toc, mediating the non-antioxidant effects such as DGK alpha activation. This study provides the first evidence of a membrane receptor for alpha Toc and one of the underlying mechanisms of its non-antioxidant function.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2022)
Editorial Material
Biochemistry & Molecular Biology
Edward A. Dennis
Summary: The translation describes the author's laboratory research on lipids, focusing on phospholipases and lipidomics, and the evolution of the lipid field. The author also discusses the parallel side stories and activities that influenced their laboratory research and contributed to the development of the LIPID MAPS initiative.
Article
Agronomy
Khanh-Van Ho, Novianus Efrat, Kathy L. Schreiber, Phuc H. Vo, Marco N. De Canha, Analike Blom van Staden, Bianca D. Payne, Carel B. Oosthuizen, Danielle Twilley, Zhentian Lei, Lloyd W. Sumner, Charles R. Brown, Namrita Lall, Chung-Ho Lin
Summary: This study evaluated the anti-inflammatory properties of switchgrass and identified compounds in switchgrass extracts that inhibit the expression of inflammatory mediators. Different cultivars of switchgrass showed varying degrees of inhibition on the secretion of inflammatory mediators. Metabolomics and chromatography-mass spectrometry analyses were used to identify bioactive anti-inflammatory compounds in switchgrass. The Alamo and Kanlow cultivars of switchgrass showed potential as a natural source of anti-inflammatory compounds.
Review
Chemistry, Multidisciplinary
Varnavas D. Mouchlis, Edward A. Dennis
Summary: Water-soluble proteins and membrane-bound proteins interact with membrane surfaces and bind specific lipid molecules. Phospholipases are important enzymes in biological membranes that catalyze hydrolysis reactions by interacting with membranes and extracting phospholipid substrates. The association of phospholipases with membranes induces conformational changes and stabilizes the enzymes in an active state.
ACCOUNTS OF CHEMICAL RESEARCH
(2022)
Article
Immunology
Christa D. Jackson, Kinsey A. Hilliard, Charles R. Brown
Summary: The deficiency of 12/15-lipoxygenase (12/15-LO) exacerbates ankle swelling and arthritis severity in Lyme arthritis, suggesting that 12/15-LO lipid metabolites play a crucial role in resolving inflammatory arthritis. Therapeutic treatment with lipoxin A4 (LXA(4)) can alleviate joint edema and pain in Lyme arthritis patients.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Matthew J. Conroy, Robert M. Andrews, Simon Andrews, Lauren Cockayne, Edward A. Dennis, Eoin Fahy, Caroline Gaud, William J. Griffiths, Geoff Jukes, Maksim Kolchin, Karla Mendivelso, Andrea F. Lopez-Clavijo, Caroline Ready, Shankar Subramaniam, Valerie B. O'Donnell
Summary: LIPID MAPS is a systematic and standardized approach for organizing lipid structural and biochemical data, and it has become the accepted community standard. It provides databases, software tools, and educational resources. The recent expansion of LIPID MAPS includes richer metadata, improved interoperability, and programmatic access. In addition, LIPID MAPS collaborates with WikiPathways to curate pathway data and annotate lipids.
NUCLEIC ACIDS RESEARCH
(2023)
Article
Pathology
Christina M. Mckenzie, Matt Marinkovich, Anibal G. Armien, Judy St. Leger, Aaron M. Armando, Edward A. Dennis, Oswald Quehenberger, Alison Righton
Summary: This study presents the pedigree analysis, clinical manifestations, gross, microscopic, ultrastructural, and lipidomic findings of four female superb bird-of-paradise (SBOP) siblings, revealing a primary inherited glycerolipid storage disease. These birds, offspring of closely related parents, displayed characteristic lesions including tissue distortion due to the accumulation of lipid vacuoles in various organs. Lipidomic profiling confirmed the presence of triacylglycerols in the cytoplasmic lipid deposits. Further investigations, such as genome sequencing and genotyping, are necessary to determine the underlying genetic mechanism of this disease.
VETERINARY PATHOLOGY
(2023)
Review
Chemistry, Multidisciplinary
Varnavas D. Mouchlis, Edward A. Dennis
Summary: Water-soluble proteins and membrane-bound proteins bind specific lipid molecules on membrane surfaces. Phospholipases, especially PLA2, play an important role in hydrolyzing phospholipids. The interaction between PLA2 and membranes can induce conformational changes in PLA2 and activate it for catalysis. These studies provide insights into membrane-protein interactions and related biological functions.
ACCOUNTS OF CHEMICAL RESEARCH
(2022)
Meeting Abstract
Immunology
Christa D. Jackson, Charles R. Brown
JOURNAL OF IMMUNOLOGY
(2022)
Meeting Abstract
Biochemistry & Molecular Biology
E. A. Dennis