Article
Biochemistry & Molecular Biology
Briana N. James, Cynthia Weigel, Christopher D. Green, Ryan D. R. Brown, Elisa N. D. Palladino, Anuj Tharakan, Sheldon Milstien, Richard L. Proia, Rebecca K. Martin, Sarah Spiegel
Summary: Genome-wide association studies have shown that ORMDL3 is associated with asthma severity. The effects of ORMDL3 overexpression on sphingolipid synthesis and neutrophil inflammation were examined in a preclinical mouse model of severe asthma. The findings suggest a novel connection between ORMDL3, sphingolipid levels, IL-17, and neutrophil recruitment into the lung.
Article
Oncology
Massimo Russo, Nicolo Panini, Paola Fabbrizio, Laura Formenti, Riccardo Becchetti, Cristina Matteo, Marina Meroni, Claudia Nastasi, Andrea Cappelleri, Roberta Frapolli, Giovanni Nardo, Eugenio Scanziani, Andrea Ponzetta, Maria Rosa Bani, Carmen Ghilardi, Raffaella Giavazzi
Summary: Chemotherapy is the standard treatment for most cancers and has a debulking effect on tumors. However, it can also paradoxically promote metastasis. Chemotherapy-induced neutropenia has been found to increase the burden of lung metastases in murine tumor models.
Article
Oncology
Mohammad Al Qadire, Cherry Ann C. Ballad, Ma'en Aljezawi, Omar Al Omari, Fawwaz Alaloul, Ahmad Musa, Sulaiman Al Sabei, Atika Khalaf
Summary: This study assesses nurses' knowledge of chemotherapy-induced neutropenia (CIN) and identifies factors associated with their level of knowledge. The results show that nurses have a moderate level of knowledge about CIN and its management. Those with post-graduate degrees, oncology education, and more oncology experience are more likely to have a higher level of knowledge. Further education and training are needed to improve nurses' understanding of CIN.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Multidisciplinary Sciences
Genta Ito, Kazuyoshi Kawakami, Takeshi Aoyama, Takashi Yokokawa, Masashi Nakamura, Masato Ozaka, Naoki Sasahira, Masayuki Hashiguchi, Hayato Kizaki, Toshihiro Hama, Satoko Hori
Summary: Combination therapy with gemcitabine and nanoparticle albumin-bound paclitaxel (GnP therapy) can significantly prolong the survival of pancreatic cancer patients but may also lead to severe neutropenia. This study identified low ANC, high T-Bil, and low CRP as risk factors for Grade 3/4 neutropenia during GnP therapy. Patients with these risk factors should be closely monitored for adverse events.
Article
Oncology
Mekonnen Dessalegn, Mengistu Fantahun, Abdu Adem Yesufe, Mintewab Hussein, Aster Tsegaye
Summary: A study was conducted at the Oncology unit of St. Paul Hospital Millennium Medical College in Addis Ababa, Ethiopia to assess the incidences of chemotherapy-induced neutropenia and febrile neutropenia in solid cancer patients. The study followed 101 patients diagnosed with any type of solid cancer and found that more than two thirds of the patients experienced chemotherapy-associated neutropenia, while half of the patients had febrile neutropenia. Close monitoring of these patients is necessary.
CANCER MANAGEMENT AND RESEARCH
(2023)
Article
Oncology
Ereny Samwel Poles Saad, Karima Oualla, Narmin Talibova, Snezhanna Gening, Shady Gayed YousefYousef
Summary: This study investigated the management of afebrile chemotherapy-induced neutropenia by oncologists and found that geographical and academic backgrounds influence their routine practices, highlighting the need to analyze and address related obstacles.
SUPPORTIVE CARE IN CANCER
(2022)
Article
Education, Scientific Disciplines
Mohammad Al Qadire, Cherry Ann C. Ballad, Omar Al Omari, Murad Alkhalaileh, Loai Abu Sharour, Atika Khalaf, Ma''en Aljezawi
Summary: The study reveals that student nurses have poor knowledge of neutropenia and its management, but those who have received previous education on neutropenia management scored significantly higher than those who did not.
NURSE EDUCATION TODAY
(2021)
Review
Medicine, Research & Experimental
David Dahlgren, Hans Lennernas
Summary: Chemotherapy damages the intestinal barrier by killing gut stem cells, leading to increased bacterial translocation and altered permeability. The mucus layer and epithelium are also affected by chemotherapy, making the barrier more permeable. However, the exact sequence of events and contributions of different barrier components are still unclear, and further research is needed to understand the development of chemotherapy-induced gut toxicity.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Microbiology
Sung-Yu Wu, Chu-Chyn Ou, Meng-Lin Lee, I-Lun Hsin, Yu-Ting Kang, Ming-Shiou Jan, Jiunn-Liang Ko
Summary: Cachexia is a multifactorial syndrome driven by metabolic dysregulation, anorexia, systemic inflammation, and insulin resistance. Approximately 80% of patients with advanced cancer have cachexia, and cachexia is the cause of death in 30% of cancer patients. This study investigates the potential protective effects of Liz-H on cachexia and gut microbiota dysbiosis induced by cisplatin + docetaxel treatment. The results show that Liz-H administration alleviates weight loss, muscle atrophy, and neutropenia, and restores gut microbial ecology. These findings suggest that Liz-H is an effective treatment for cisplatin + docetaxel-induced cachexia. It receives a score of 9 out of 10 for its importance.
MICROBIOLOGY SPECTRUM
(2023)
Article
Urology & Nephrology
Ernese. Gjafa, Kenrick Ng, Tami Grunewald, Myria Galazi, Erik Skyllberg, Peter Wilson, Constantine Alifrangis, Jonathan Shamash
Summary: The study showed that using a steroid-sparing antiemetic protocol (substituting dexamethasone with olanzapine) reduced hospital admissions related to febrile neutropenia in patients receiving BEP chemotherapy.
Article
Nutrition & Dietetics
E. Matthew Morris, Roberto D. Noland, Michael E. Ponte, Michelle L. Montonye, Julie A. Christianson, John A. Stanford, John M. Miles, Matthew R. Hayes, John P. Thyfault
Summary: The study suggests that reduced liver energy metabolism may contribute to diet-induced weight gain, with potential sex-specific effects, and indicates a role for vagal signaling in short-term diet-induced weight gain.
Article
Surgery
Sungjin Kim, Sung Il Kang, Sohyun Kim, Jae Hwang Kim
Summary: This study investigated the prognostic implications of severe chemotherapy-induced neutropenia (CIN) in patients with stage III colorectal cancer (CRC) who received adjuvant FOLFOX chemotherapy. Results showed that severe CIN did not significantly impact the survival outcomes of patients with stage III CRC.
JOURNAL OF SURGICAL RESEARCH
(2021)
Article
Oncology
Yantao Jiang, Ju Zhang, Jianxin Zhong, Hao Liao, Jiayang Zhang, Yaxin Liu, Yuehua Liang, Huiping Li
Summary: This study compared the clinical value of rhG-CSF and PEG-rhG-CSF in early-stage breast cancer patients receiving adjuvant chemotherapy. It also compared the efficacy of different doses of PEG-rhG-CSF and explored the timing of rhG-CSF rescue treatment.
Article
Environmental Sciences
Ai-Lian Wu, Xiao-Yan Jiao, Jin-Song Wang, Er-Wei Dong, Jun Guo, Li-Ge Wang, An-Qi Sun, Hang-Wei Hu
Summary: The study revealed that low-N stress significantly impacted the bacterial community composition in sorghum rhizosphere soils, with an increase in beneficial bacteria and a decrease in ammonia-oxidizing bacteria. Rhizosphere effects may reduce soil bacterial diversity by recruiting specific bacterial species under low-N stress.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Review
Medicine, General & Internal
Cindy Tofthagen, Mary Tanay, Adam Perlman, Jason Starr, Pooja Advani, Katharine Sheffield, Tara Brigham
Summary: This study evaluated the relationship between laboratory measures of nutrition and chemotherapy induced peripheral neuropathy (CIPN). It found that hemoglobin/hematocrit, vitamin D, albumin, and magnesium were associated with CIPN. Further research is needed to confirm these associations.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Allergy
Pantipa Chatchatee, Anna Nowak-Wegrzyn, Lars Lange, Suwat Benjaponpitak, Kok Wee Chong, Pasuree Sangsupawanich, Marleen T. J. van Ampting, Manon M. Oude Nijhuis, Lucien F. Harthoorn, Jane E. Langford, Jan Knol, Karen Knipping, Johan Garssen, Valerie Trendelenburg, Robert Pesek, Carla M. Davis, Antonella Muraro, Mich Erlewyn-Lajeunesse, Adam T. Fox, Louise J. Michaelis, Kirsten Beyer
Summary: This study evaluated tolerance development and safety of an amino acid-based formula including synbiotics in infants with cow's milk allergy. The results showed no difference in cow's milk tolerance between the two groups after 12 and 24 months, and fewer subjects receiving the formula with synbiotics required hospitalization due to infections during the intervention.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2022)
Article
Gastroenterology & Hepatology
Thomas Dierikx, Daniel Berkhout, Anat Eck, Sebastian Tims, Johan van Limbergen, Douwe Visser, Marjon de Boer, Nanne de Boer, Daan Touw, Marc Benninga, Nine Schierbeek, Laura Visser, Jan Knol, Guus Roeselers, Johanna de Vries, Tim de Meij
Summary: Cesarean section delivery has a strong impact on infant microbiome colonization, but maternal antibiotic administration before CS does not exacerbate the compromised microbiome. Long-term health effects need to be confirmed by larger studies.
Review
Clinical Neurology
Vivienne Huppertz, Sonia Guida, Anne Holdoway, Stefan Strilciuc, Laura Baijens, Jos M. G. A. Schols, Ardy van Helvoort, Mirian Lansink, Dafin F. Muresanu
Summary: This systematic review examines the prevalence of impaired nutritional condition (INC) across different phases after stroke. The study finds that INC and malnutrition are highly prevalent in all stages of stroke care. Since malnutrition has been shown to negatively affect clinical outcomes, mortality, and overall healthcare expenditure in stroke survivors, it is essential to examine and monitor the nutritional status of stroke patients throughout their care journey to guide and plan timely nutritional support and dietary modification.
FRONTIERS IN NEUROLOGY
(2022)
Article
Pediatrics
Emmy Van Daele, Kim Kamphorst, Arine M. Vlieger, Gerben Hermes, Christian Milani, Marco Ventura, Clara Belzer, Hauke Smidt, Ruurd M. van Elburg, Jan Knol
Summary: Study found that exposure to antibiotics in the first week of life can alter the development of the infant's fecal microbiota, with long-term deviations in relative abundance of certain taxa observed up to 1 year of age. The effects varied based on the mode of delivery.
ARCHIVES OF DISEASE IN CHILDHOOD-FETAL AND NEONATAL EDITION
(2022)
Article
Nutrition & Dietetics
Carla Morales-Ferre, Ignasi Azagra-Boronat, Malen Massot-Cladera, Sebastian Tims, Karen Knipping, Johan Garssen, Jan Knol, Angels Franch, Margarida Castell, Francisco J. Perez-Cano, Maria J. Rodriguez-Lagunas
Summary: In this study, the effects of a Lactofidus(TM), short-chain galacto-oligosaccharides (scGOS) and long-chain fructo-oligosaccharides (lcFOS) mixture, and their combination on RV infection in a rat model for early life diarrhea were analyzed. The supplementations significantly reduced the incidence and severity of diarrhea and showed various effects on immunoglobulin profiles, gut microbiota, and intestinal gene expression.
Article
Medicine, General & Internal
Rosanne J. H. C. G. Beijers, Lieke E. J. van Iersel, Lisanne T. Schuurman, Robert J. J. Hageman, Sami O. Simons, Ardy van Helvoort, Harry R. Gosker, Annemie M. W. J. Schols
Summary: This study aims to investigate the effectiveness of targeted nutrient supplementation on physical activity level and health-related quality of life in COPD patients. Cognitive function, psychological well-being, physical performance, and other outcomes will also be assessed. The study will provide valuable insights into the impact of nutrient supplementation on COPD patients and may have implications for treatment strategies.
Article
Pharmacology & Pharmacy
Charlotte E. Pelgrim, Ingrid van Ark, Thea Leusink-Muis, Maike A. D. Brans, Saskia Braber, Johan Garssen, Ardy van Helvoort, Aletta D. Kraneveld, Gert Folkerts
Summary: This study describes an optimized intratracheal administration technique and compares it with oropharyngeal aspiration. The results show that the intratracheal administration technique has higher efficacy, reproducibility, and accuracy compared to oropharyngeal aspiration, and can be used to improve the research design of respiratory disease mouse models.
JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS
(2022)
Article
Physiology
Charlotte E. Pelgrim, Lei Wang, Lucia N. Peralta Marzal, Stephanie Korver, Ingrid van Ark, Thea Leusink-Muis, Saskia Braber, Gert Folkerts, Johan Garssen, Ardy van Helvoort, Aletta D. Kraneveld
Summary: Brain-related comorbidities are commonly observed in chronic obstructive pulmonary disease (COPD) and are associated with disease progression and mortality. This study used a mouse model to investigate the impact of cigarette smoke and bacterial trigger exposure on brain and behavior. The findings suggest that cigarette smoke exposure leads to pulmonary inflammation and neuroinflammation, resulting in increased exploratory behavior and compromised blood-brain barrier integrity.
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
(2022)
Article
Physiology
Lei Wang, Charlotte E. Pelgrim, Lucia N. Peralta Marzal, Stephanie Korver, Ingrid van Ark, Thea Leusink-Muis, Ardy van Helvoort, Ali Keshavarzian, Aletta D. Kraneveld, Johan Garssen, Paul A. J. Henricks, Gert Folkerts, Saskia Braber
Summary: This study investigated the effects of cigarette smoke and lipopolysaccharide (LPS) on intestinal homeostasis and immunity in a COPD model. The findings suggest that cigarette smoke, with or without LPS, can impact intestinal health by altering histomorphology and the immune network for IgA production. Elevated systemic mediators may play a role in the lung-gut cross talk.
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
(2022)
Review
Nutrition & Dietetics
Annemarie J. F. Westheim, Lara M. Stoffels, Ludwig J. Dubois, Jeroen van Bergenhenegouwen, Ardy van Helvoort, Ramon C. J. Langen, Ronit Shiri-Sverdlov, Jan Theys
Summary: Nutritional status, especially the intake of fatty acids, plays a crucial role in the outcome of immunotherapy. Short-chain fatty acids and polyunsaturated fatty acids have significant effects on the immune system and immunogenicity of tumor cells, enhancing the efficacy of immunotherapy. Therefore, nutritional interventions focusing on these fatty acids have great potential to boost the therapeutic potential of immunotherapeutic approaches for cancer.
FRONTIERS IN NUTRITION
(2022)
Review
Biochemistry & Molecular Biology
Annemarie J. F. Westheim, Lara M. Stoffels, Ludwig J. Dubois, Jeroen van Bergenhenegouwen, Ardy van Helvoort, Ramon C. J. Langen, Ronit Shiri-Sverdlov, Jan Theys
Summary: Cancer burden is increasing rapidly globally, with lifestyle factors such as unhealthy diet being major contributors. The specific fatty acids that contribute to a healthy and balanced diet in terms of cancer risk and prognosis are still unclear. This review explores the associations between intake of different fatty acids and cancer risk, as well as the effects of specific fatty acids on tumor cells and inflammation-induced cancer progression, highlighting challenges and opportunities for fatty acid tailored nutritional interventions.
Review
Endocrinology & Metabolism
Shinjini Bhattacharya, Rohini Bhadra, Annemie M. W. J. Schols, Ardy van Helvoort, Sucharita Sambashivaiah
Summary: Sarcopenia, characterized by muscle mass and strength loss, is common in old age and can be accelerated by chronic disease, malnutrition, and physical inactivity. Early intervention to achieve and maintain higher muscle mass and strength may prevent or delay sarcopenia and promote independent living in old age. Malnutrition, a significant contributor to sarcopenia, is often overlooked in the Indian population. Maintaining an optimal energy and protein balance with adequate physical activity is crucial for preserving physical function in the aging population. However, research on the role of micronutrients in muscle maintenance is still in its early stages. This narrative review aims to explore the current status of international and Indian research on nutrition's role in mitigating sarcopenia and future directions.
OSTEOPOROSIS AND SARCOPENIA
(2022)
Article
Cell Biology
Hannah R. R. Wardill, Ana Rita Da Silva Ferreira, Himanshu Kumar, Emma H. H. Bateman, Courtney B. B. Cross, Joanne M. M. Bowen, Rick Havinga, Hermie J. M. Harmsen, Jan Knol, Bram Dorresteijn, Miriam van Dijk, Jeroen van Bergenhenegouwen, Wim J. E. Tissing
Summary: Cytotoxicity is the main mechanism of chemotherapy's anti-cancer effects, but it also causes damage to healthy tissues. The gastrointestinal tract is particularly affected, resulting in gastrointestinal mucositis and various side effects. This study found that a specific diet can protect the intestinal mucosa from chemotherapy toxicity without compromising its anti-tumor effects.
CELL DEATH & DISEASE
(2023)
Article
Geriatrics & Gerontology
Wouter R. P. H. van de Worp, Jan Theys, Alba Sanz Gonzalez, Brent van der Heyden, Frank Verhaegen, Duncan Hauser, Florian Caiment, Hubertus J. M. Smeets, Annemie M. W. J. Schols, Ardy van Helvoort, Ramon C. J. Langen
Summary: A syngeneic, orthotopic lung cancer mouse model was evaluated to see if it replicates the systemic and muscle-specific alterations associated with human lung cancer cachexia.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2023)
Meeting Abstract
Endocrinology & Metabolism
C. F. M. Marsaux, S. Tims, A. Pinto, A. Daly, D. Karall, M. Kuhn, S. Santra, J. Knol, A. MacDonald, S. Scholl-Buergi
MOLECULAR GENETICS AND METABOLISM
(2022)