Review
Nutrition & Dietetics
Giulio Verna, Annamaria Sila, Marina Liso, Mauro Mastronardi, Marcello Chieppa, Hellas Cena, Pietro Campiglia
Summary: Iron deficiency affects people of all ages globally, particularly IBD patients, women, and children. Current therapies can restore normal levels but may have side effects, leading to a growing interest in innovative nutritional supplements and iron-rich superfoods.
Article
Plant Sciences
Maria Bernal, Ute Kraemer
Summary: The text discusses the interaction between iron and copper in biological systems and their importance in biological processes. Studies have found an inter-dependence of iron and copper in certain eukaryotes, including green algae, yeast, and mammals. In Arabidopsis, copper deficiency can lead to secondary iron deficiency, affecting root-to-shoot iron translocation and ferroxidase activity.
FRONTIERS IN PLANT SCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Kaja Gutowska, Dorota Formanowicz, Piotr Formanowicz
Summary: A deficiency of vitamin A and iron is a common nutritional problem worldwide, and their interactions have been extensively studied. However, the exact mechanism of how vitamin A regulates iron metabolism remains unclear. This study used a mathematical model and a systems approach to analyze the system and identify the key mechanisms involved in the positive and negative regulation of hepcidin expression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
D. Gashu, P. C. Nalivata, T. Amede, E. L. Ander, E. H. Bailey, L. Botoman, C. Chagumaira, S. Gameda, S. M. Haefele, K. Hailu, E. J. M. Joy, A. A. Kalimbira, D. B. Kumssa, R. M. Lark, I. S. Ligowe, S. P. McGrath, A. E. Milne, A. W. Mossa, M. Munthali, E. K. Towett, M. G. Walsh, L. Wilson, S. D. Young, M. R. Broadley
Summary: Micronutrient deficiencies are widespread among people in sub-Saharan Africa due to limited access to micronutrient-rich food sources. Research in Ethiopia and Malawi shows geographical variation in the micronutrient composition of staple cereal grains, influenced by soil and environmental factors. Understanding these geographical effects is crucial for designing interventions to alleviate micronutrient deficiencies.
Article
Nutrition & Dietetics
Anna Dera-Szymanowska, Dorota Filipowicz, Natalia Misan, Krzysztof Szymanowski, Thilo Samson Chillon, Sabrina Asaad, Qian Sun, Ewelina Szczepanek-Parulska, Lutz Schomburg, Marek Ruchala
Summary: This study aims to compare iron and calcium levels in singleton and twin pregnancies, and found no significant differences between the two. Prenatal iron supplementation was shown to effectively increase iron levels.
Review
Nutrition & Dietetics
Edouard Charlebois, Kostas Pantopoulos
Summary: Dietary iron is crucial for health, but its absorption and metabolism are tightly regulated to prevent toxicity. Hepcidin deficiency causes hereditary hemochromatosis, an iron overload disorder. High intake of heme iron, found in meat products, is associated with metabolic syndrome, cardiovascular diseases, and cancers. Cohort studies provide epidemiological data, but further research is needed to establish causality and understand molecular mechanisms.
Review
Biochemistry & Molecular Biology
Christina A. Porras, Tracey A. Rouault
Summary: This review provides an overview of the role of iron homeostasis disruption in various neurological disorders, discussing the consequences of both iron accumulation and deficiency. It also examines the history of animal models and presents a comparison of patients with a newly discovered neurodegenerative disorder caused by mutations in iron regulatory protein 2.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Nutrition & Dietetics
Shashi Bhushan Kumar, Shanvanth R. Arnipalli, Priyanka Mehta, Silvia Carrau, Ouliana Ziouzenkova
Summary: Iron deficiency anemia has become an epidemic in developing countries, particularly affecting young children and women of childbearing age. The condition can lead to a range of health issues, including weakness, impaired growth, and cognitive performance. Despite efforts to increase iron intake, other factors such as cultural diets, infections, genetics, and socioeconomic factors also play a role in IDA. This review discusses IDA mitigation programs in India and the need for a multifactorial approach to address the problem.
Article
Public, Environmental & Occupational Health
Jean-Pierre Chouraqui, Dominique Turck, Andre Briend, Dominique Darmaun, Alain Bocquet, Francois Feillet, Marie-Laure Frelut, Jean-Philippe Girardet, Dominique Guimber, Regis Hankard, Alexandre Lapillonne, Noel Peretti, Jean-Christophe Roze, Umberto Simeoni, Christophe Dupont
Summary: Most religious dietary rules, when followed according to traditions, are not harmful to health. However, strict adherence to some rules may result in nutritional deficiencies, particularly in populations facing unfavorable socio-economic or environmental conditions.
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
(2021)
Article
Nutrition & Dietetics
Frederick K. Grant, Rose Wanjala, Jan Low, Carol Levin, Donald C. Cole, Haile S. Okuku, Robert Ackatia-Armah, Amy W. Girard
Summary: Infection has an impact on the nutritional status of infants, and acute phase proteins are a better indicator for defining infection.
FRONTIERS IN NUTRITION
(2022)
Review
Plant Sciences
Nabila Riaz, Mary Lou Guerinot
Summary: Iron is an essential micronutrient for plants and animals, with deficiency leading to anemia in humans. Plants heavily rely on plant-based foods as their primary source of iron, but these foods are often poor sources of dietary iron. Understanding how plants adapt to iron deficiency is crucial for optimizing iron uptake and ensuring optimal plant growth.
JOURNAL OF EXPERIMENTAL BOTANY
(2021)
Review
Cell Biology
Marceau Quatredeniers, Pedro Mendes-Ferreira, Diana Santos-Ribeiro, Morad K. Nakhleh, Maria-Rosa Ghigna, Sylvia Cohen-Kaminsky, Frederic Perros
Summary: The article mainly discusses the relationship between pulmonary arterial hypertension (PAH) and iron deficiency, reviews the mechanisms regulating iron homeostasis and the clinical data available, and discusses the potential implications of iron deficiency on the development and management of PAH.
Article
Plant Sciences
Bouthayna El Amine, Fatema Mosseddaq, Rachida Naciri, Abdallah Oukarroum
Summary: Iron (Fe) deficiency and manganese (Mn) deficiency have negative effects on the growth and physiological parameters of soybean cultivars. The deficiencies affect photosynthetic efficiency, nutrient uptake, and antioxidant activity. Simultaneous Fe and Mn deficiency had a more pronounced impact compared to individual deficiencies. However, rational fertilization of Fe and Mn can improve these parameters in hydroponic conditions.
PLANT PHYSIOLOGY AND BIOCHEMISTRY
(2023)
Article
Multidisciplinary Sciences
Lamia M. Hafez, Hebatallah Mohammed Aboudeya, Noura A. Matar, Ashraf S. El-Sebeay, Azhar Mohamed Nomair, Shaymaa Ali El-hamshary, Hanan Mohamed Nomeir, Fawziya A. R. Ibrahim
Summary: Obesity is associated with cognitive impairments and increases the risk of developing dementia. Zinc supplementation has shown potential as a therapeutic agent for cognitive disorders. The study investigated the effects of low and high doses of zinc supplementation on cognitive biomarkers and leptin signaling pathway in rats fed with a high-fat diet. Results showed that obesity in rats led to increased body weight, glucose levels, and lipid levels, as well as reduced BDNF levels and increased acetylcholinesterase (AChE) activity. Zinc supplementation improved these metabolic abnormalities and cognitive deficits in both male and female obese rats. Furthermore, the study found that males were more vulnerable to weight gain and metabolic alterations, while females were more responsive to zinc treatment. Overall, this study suggests that zinc treatment may be effective in improving obesity-related metabolic dysfunction, central leptin resistance, and cognitive deficits, and that males and females may differ in their response to zinc treatment.
SCIENTIFIC REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Nuo Shen, Sifan Hou, Guoqing Tu, Wenzhi Lan, Yanping Jing
Summary: This study identified a previously unrecognized signaling crosstalk between WRKY33 and the ALMT1-mediated malate transport system to regulate plant responses to phosphate deficiency.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)