Article
Cell Biology
Nery Jara, Eder Ramirez, Luciano Ferrada, Katterine Salazar, Francisca Espinoza, Ivan Gonzalez-Chavarria, Francisco Nualart
Summary: Vitamin C deficiency has shown inhibitory effects on the progression of GBM, especially in a GBM cell line with stem cell features, indicating potential antitumor effects in certain GBM models.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Mathieu Garand, Mohammed Toufiq, Parul Singh, Susie Shih Yin Huang, Sara Tomei, Rebecca Mathew, Valentina Mattei, Mariam Al Wakeel, Elham Sharif, Souhaila Al Khodor
Summary: The study investigated the impact of vitamin D3 supplementation on the blood transcriptome in vitamin D-deficient women. Significant changes were observed in immune-related pathways and gene expression, suggesting a strong effect of vitamin D3 on the immune system. The findings provide insights into the molecular mechanisms underlying vitamin D3 supplementation and its potential implications for individuals in the Middle East and beyond.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Nutrition & Dietetics
Yali Ling, Feng Xu, Xuedi Xia, Dexing Dai, An Xiong, Ruoman Sun, Lei Qiu, Zhongjian Xie
Summary: The combination of vitamin D and calcium has a beneficial effect in preventing falls among elderly individuals, particularly those with 25(OH)D levels lower than 50 nmol/L. Vitamin D supplementation alone does not reduce the risk of falls in elderly individuals with 25(OH)D levels higher than 50 nmol/L.
CLINICAL NUTRITION
(2021)
Article
Nutrition & Dietetics
Hadeil M. Alsufiani, Shareefa A. AlGhamdi, Huda F. AlShaibi, Sawsan O. Khoja, Safa F. Saif, Carsten Carlberg
Summary: The study aimed to investigate the safety and effectiveness of a single high dose of vitamin D-3 on vitamin D status and proinflammatory cytokines in healthy Saudi females. The results showed that the high dose was able to rapidly and effectively improve serum vitamin D levels and reduce the concentration of proinflammatory cytokines in healthy females.
Article
Nutrition & Dietetics
Souzana E. Xyda, Kalliopi Kotsa, Argyrios Doumas, Emmanouil Papanastasiou, Alexandros A. Garyfallos, George Samoutis
Summary: The prevalence of vitamin D deficiency is paradoxically high in both Mediterranean countries, Greece and Cyprus, despite ample sunlight in the region. Only the month and gender were significantly associated with vitamin D levels.
Article
Oncology
Laura A. Sena, Julia Fountain, Pedro Isaacsson Velho, Su Jin Lim, Hao Wang, Emily Nizialek, Nityam Rathi, Roberto Nussenzveig, Benjamin L. Maughan, Miguel Gonzalez Velez, Ryan Ashkar, Amanda C. Larson, Colin C. Pritchard, Nabil Adra, Alan H. Bryce, Neeraj Agarwal, Drew M. Pardoll, James R. Eshleman, Tamara L. Lotan, Emmanuel S. Antonarakis
Summary: In patients with DNA mismatch repair-deficient prostate cancer, tumor frameshift mutation proportion (FSP) is correlated with response to anti-PD1 therapy.
Article
Endocrinology & Metabolism
Johanna Oberg, Rolf Jorde, Bjorg Almas, Christopher Sivert Nielsen, Thomas Alexander Gerds, Kevin D. Cashman, Guri Grimnes
Summary: This study presents population-based data from an Arctic adolescent population, investigating the changes in vitamin D status during adolescence and the potential impact of lifestyle changes on vitamin D levels.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Medicine, General & Internal
Andjelka Stojkovic, Katerina Dajic, Jasmina Milovanovic, Slobodan M. Jankovic, Nenad V. Markovic, Andrijana Kostic
Summary: This study investigated the supplementation of vitamin D3 in children with allergic diseases and concomitant hypovitaminosis D. Results showed a significant increase in serum levels of 25-(OH)D after supplementation, with patients using corticosteroids having a more intense effect of vitamin D3 supplementation.
MEDICINA-LITHUANIA
(2021)
Article
Nutrition & Dietetics
Carla A. Lopes, Susana Prazeres, Jose Martinez-de-Oliveira, Edward Limbert, Manuel C. Lemos
Summary: Iodine deficiency is a common issue in pregnant women, and supplementation can improve iodine status, although it may not reach the recommended levels in iodine-deficient regions.
Review
Immunology
Yanrui Wu, Chuan Liu, Weiguo Dong
Summary: Growing evidence suggests that micronutrient status may affect the course of inflammatory bowel disease (IBD), but deficiencies are often overlooked during treatment. Studies have focused on vitamin D and iron supplementation, but research on other vitamins and minerals is still limited. This review provides an overview of the therapeutic effects of micronutrient supplementation in IBD, aiming to draw attention to monitoring and supplementation in IBD patients and provide perspectives for future research.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Angela Feiner Solis, Ana Avedillo Salas, Maria Jose Luesma Bartolome, Sonia Santander Ballestin
Summary: This systematic review examines the impact of vitamin D supplementation on the disease course of COVID-19. The results suggest that regardless of initial vitamin D serum levels, patients benefit from vitamin D supplementation, although the outcomes are inconsistent and larger clinical trials are needed for confirmation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Nutrition & Dietetics
Manuel Rupprecht, Stefan Wagenpfeil, Jakob Schoepe, Reinhold Vieth, Thomas Vogt, Joerg Reichrath
Summary: A meta-analysis was conducted to investigate the impact of oral vitamin D supplementation on serum 25-hydroxyvitamin D levels in healthy adults in Europe. The findings suggest that vitamin D supplementation can significantly increase serum 25(OH)D levels, with the effect influenced by dosage and baseline serum levels.
Article
Nutrition & Dietetics
Chih-Wei Tsao, Yuan-Ru Liao, Ting-Chia Chang, Yih-Fong Liew, Chin-Yu Liu
Summary: This study aimed to investigate the effects of iron supplementation on spermatogenesis and testicular functions in iron-deficient rats. The results showed that iron deficiency resulted in poorer spermatogenesis and testis dysfunction, while iron supplementation reversed the impairment and improved antioxidant levels.
Article
Nutrition & Dietetics
Myeongseob Lee, Hae In Lee, Kyungchul Song, Han Saem Choi, Junghwan Suh, Se Hee Kim, Hyun Wook Chae, Hoon-Chul Kang, Joon Soo Lee, Heung Dong Kim, Ho-Seong Kim, Ahreum Kwon
Summary: This study aimed to evaluate the dose-dependent association between vitamin D-3 and hypercalciuria/urolithiasis in patients undergoing KDT and dose optimization for renal complications.
FRONTIERS IN NUTRITION
(2022)
Article
Nutrition & Dietetics
Christian Mingiano, Tommaso Picchioni, Guido Cavati, Filippo Pirrotta, Marco Calabrese, Ranuccio Nuti, Stefano Gonnelli, Alberto Fortini, Bruno Frediani, Luigi Gennari, Daniela Merlotti
Summary: This study aimed to evaluate the relationship between 25-OH vitamin D (25OHD) levels and prognosis, mortality, mechanical ventilation, and orotracheal intubation in hospitalized COVID-19 patients. The study found a positive correlation between 25OHD levels and oxygenation levels, and significantly lower levels in patients requiring mechanical ventilation and intubation. Patients with severe 25OHD deficiency had longer hospital stays and higher mortality rates. Additionally, supplementation with calcifediol reduced hospitalization duration and mortality rates.
Article
Gastroenterology & Hepatology
Yuhao Sun, Shuai Yuan, Xuejie Chen, Jing Sun, Rahul Kalla, Lili Yu, Lijuan Wang, Xuan Zhou, Xiangxing Kong, Therese Hesketh, Gwo-tzer Ho, Kefeng Ding, Malcolm Dunlop, Susanna C. Larsson, Jack Satsangi, Jie Chen, Xiaoyan Wang, Xue Li, Evropi Theodoratou, Edward L. Giovannucci
Summary: This study investigated the associations between genetic risk, modifiable lifestyle factors, and inflammatory bowel disease (IBD). The results showed that high genetic risk and unhealthy lifestyle were associated with increased risk of developing Crohn's disease (CD) and ulcerative colitis (UC). However, for individuals with high genetic risk, adhering to a healthy lifestyle can reduce the risk by nearly 50%.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2023)
Letter
Oncology
Rachel H. Horton, Malcolm G. Dunlop, Richard S. Houlston, Anneke Lucassen, Margaret McCartney, Alan McNeill, Amit Sud
BRITISH JOURNAL OF CANCER
(2023)
Article
Gastroenterology & Hepatology
Jie Chen, Yajing Zhou, Yuhao Sun, Shuai Yuan, Rahul Kalla, Jing Sun, Jianhui Zhao, Lijuan Wang, Xuejie Chen, Xuan Zhou, Siqi Dai, Yu Zhang, Gwo-tzer Ho, Dajing Xia, Qian Cao, Zhanju Liu, Susanna C. Larsson, Xiaoyan Wang, Kefeng Ding, Jonas Halfvarson, Xue Li, Evropi Theodoratou, Jack Satsangi
Summary: This study identified 14 proteins associated with the risk of ulcerative colitis (UC) through the analysis of serum proteomic profiling data. Further analysis using Mendelian randomisation confirmed the causal relationship between two chemokines and the increased risk of UC. Additionally, a new protein associated with UC risk was identified. Reverse Mendelian randomisation analysis did not find any influence of genetic predisposition to UC on these three inflammation proteins.
JOURNAL OF CROHNS & COLITIS
(2023)
Article
Genetics & Heredity
Ceres Fernandez-Rozadilla, Maria Timofeeva, Zhishan Chen, Philip Law, Minta Thomas, Stephanie Bien, Virginia Diez-Obrero, Li Li, Juan Fernandez-Tajes, Claire Palles, Kitty Sherwood, Sarah Harris, Victoria Svinti, Kevin McDonnell, Susan Farrington, James Studd, Peter Vaughan-Shaw, Xiao-ou Shu, Jirong Long, Qiuyin Cai, Xingyi Guo, Yingchang Lu, Peter Scacheri, James Studd, Jeroen Huyghe, Tabitha Harrison, David Shibata, Christopher Haiman, Mathew Devall, Fredrick Schumacher, Marilena Melas, Gad Rennert, Mireia Obon-Santacana, Vicente Martin-Sanchez, Ferran Moratalla-Navarro, Jae Hwan Oh, Jeongseon Kim, Sun Ha Jee, Keum Ji Jung, Sun-Seog Kweon, Min-Ho Shin, Aesun Shin, Yoon-Ok Ahn, Dong-Hyun Kim, Isao Oze, Wanqing Wen, Keitaro Matsuo, Koichi Matsuda, Chizu Tanikawa, Zefang Ren, Yu-Tang Gao, Wei-Hua Jia, John Potter, Mark Jenkins, Aung Ko Win, Rish Pai, Jane Figueiredo, Robert Haile, Steven Gallinger, Michael Woods, Polly Newcomb, David Shibata, Jeremy Cheadle, Richard Kaplan, Timothy Maughan, Rachel Kerr, David Kerr, Iva Kirac, Jan Boehm, Lukka-Pekka Mecklin, Pekka Jousilahti, Paul Knekt, Lauri Aaltonen, Harri Rissanen, Eero Pukkala, Johan Eriksson, Tatiana Cajuso, Ulrika Hanninen, Johanna Kondelin, Kimmo Palin, Tomas Tanskanen, Laura Renkonen-Sinisalo, Brent Zanke, Satu Mannisto, Demetrius Albanes, Stephanie Weinstein, Edward Ruiz-Narvaez, Julie Palmer, Daniel Buchanan, Elizabeth Platz, Kala Visvanathan, Cornelia Ulrich, Erin Siegel, Stefanie Brezina, Andrea Gsur, Peter Campbell, Jenny Chang-Claude, Michael Hoffmeister, Hermann Brenner, Martha Slattery, John Potter, Konstantinos Tsilidis, Matthias Schulze, Marc Gunter, Neil Murphy, Antoni Castells, Sergi Castellvi-Bel, Leticia Moreira, Volker Arndt, Anna Shcherbina, Mariana Stern, Bens Pardamean, Timothy Bishop, Graham Giles, Melissa Southey, Gregory Idos, Kevin McDonnell, Zomoroda Abu-Ful, Joel Greenson, Katerina Shulman, Flavio Lejbkowicz, Kenneth Offit, Yu-Ru Su, Robert Steinfelder, Temitope Keku, Bethany van Guelpen, Thomas Hudson, Heather Hampel, Rachel Pearlman, Sonja Berndt, Richard Hayes, Marie Elena Martinez, Sushma Thomas, Douglas Corley, Paul Pharoah, Susanna Larsson, Yun Yen, Heinz-Josef Lenz, Emily White, Li Li, Kimberly Doheny, Elizabeth Pugh, Tameka Shelford, Andrew Chan, Marcia Cruz-Correa, Annika Lindblom, David Shibata, Amit Joshi, Clemens Schafmayer, Peter Scacheri, Anshul Kundaje, Deborah Nickerson, Robert Schoen, Jochen Hampe, Zsofia Stadler, Pavel Vodicka, Ludmila Vodickova, Veronika Vymetalkova, Nickolas Papadopoulos, Chistopher Edlund, William Gauderman, Duncan Thomas, David Shibata, Amanda Toland, Sanford Markowitz, Andre Kim, Stephen Gruber, Franzel van Duijnhoven, Edith Feskens, Lori Sakoda, Manuela Gago-Dominguez, Alicja Wolk, Alessio Naccarati, Barbara Pardini, Liesel FitzGerald, Soo Chin Lee, Shuji Ogino, Stephanie Bien, Charles Kooperberg, Christopher Li, Yi Lin, Ross Prentice, Conghui Qu, Stephane Bezieau, Catherine Tangen, Elaine Mardis, Taiki Yamaji, Norie Sawada, Motoki Iwasaki, Christopher Haiman, Loic Le Marchand, Anna Wu, Chenxu Qu, Caroline McNeil, Gerhard Coetzee, Caroline Hayward, Ian Deary, Sarah Harris, Evropi Theodoratou, Stuart Reid, Marion Walker, Li Yin Ooi, Victor Moreno, Graham Casey, Stephen Gruber, Ian Tomlinson, Wei Zheng, Malcolm Dunlop, Richard Houlston, Ulrike Peters
Summary: This study identified 205 independent risk associations for colorectal cancer through a genome-wide association study meta-analysis. Transcriptome and methylome analysis further revealed 53 risk associations. These findings provide insights into the genetic and molecular mechanisms of colorectal oncogenesis and suggest potential targets for new treatment and prevention strategies.
Article
Nutrition & Dietetics
Ying Lu, Doudou Li, Lijuan Wang, Han Zhang, Fangyuan Jiang, Rongqi Zhang, Liying Xu, Nan Yang, Shuhui Dai, Xiaolin Xu, Evropi Theodoratou, Xue Li
Summary: This study summarized the most updated evidence from 54 observational and four Mendelian Randomization studies, and found that high dietary intake of EPA, DHA, and DPA was associated with a decreased risk of CRC, while the n-6/n-3 PUFA ratio and trans-FA were associated with an increased risk of CRC. SFA and DHA intake were protective factors for CRC, while a high intake of the n-6/n-3 PUFA ratio was a risk factor. In terms of cancer subsites, LA and trans-FA intake were risk factors for colon cancer, while DPA was a protective factor. High dietary DHA intake was associated with a lower risk of rectal cancer, while the dietary n-6/n-3 PUFA ratio was associated with a higher risk. Meta-analysis of blood FA levels showed a reverse association between blood pentadecanoic acid and CRC risk, but no significant association for other blood Fas. All included MR studies showed that high plasma AA was associated with increased CRC risk. The current evidence on the relationship between dietary intake and blood levels of Fas and CRC risk is inconsistent, and further studies are needed to investigate the role of Fas metabolism in CRC development.
Article
Oncology
Rongqi Zhang, Daniel Boakye, Nan Yang, Xuan Zhou, Yajing Zhou, Fangyuan Jiang, Lili Yu, Lijuan Wang, Jing Sun, Shuai Yuan, Jie Chen, Ashleigh C. Hamilton, Helen G. Coleman, Susanna C. Larsson, Julian Little, Malcolm G. Dunlop, Edward L. Giovannucci, Evropi Theodoratou, Xue Li
Summary: This study systematically evaluated the associations between environmental and genetic factors and the risk of EOCRC and EOCRA. It identified 12 risk factors and 3 protective factors for EOCRC. No significant associations were found between the examined genetic variants and EOCRC risk.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2023)
Article
Oncology
Wanxin Li, Xuan Zhou, Shuai Yuan, Lijuan Wang, Lili Yu, Jing Sun, Jie Chen, Qian Xiao, Zhongxiao Wan, Ju-Sheng Zheng, Cai-Xia Zhang, Susanna C. Larsson, Susan M. Farrington, Philip Law, Richard S. Houlston, Ian Tomlinson, Ke-Feng Ding, Malcolm G. Dunlop, Evropi Theodoratou, Xue Li
Summary: This study uses forward and reverse Mendelian randomization analysis to discover a causal relationship between genetic susceptibility and two microbiota taxa related to colorectal adenoma, highlighting the importance of further studies exploring the causal mechanisms linking host genetic variation with the gut microbiome and susceptibility to colorectal cancer.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2023)
Letter
Gastroenterology & Hepatology
Jianhui Zhao, Jie Chen, Yuhao Sun, Shuai Yuan, Judith Wellens, Rahul Kalla, Evropi Theodoratou, Xue Li, Jack Satsangi
Article
Biochemistry & Molecular Biology
Jing Sun, Lijuan Wang, Xuan Zhou, Lidan Hu, Shuai Yuan, Zilong Bian, Jie Chen, Yingshuang Zhu, Susan M. Farrington, Harry Campbell, Kefeng Ding, Dongfeng Zhang, Malcolm G. Dunlop, Evropi Theodoratou, Xue Li
Summary: This study identified three novel genetic variants and three genes associated with colorectal cancer (CRC) through a systematic genome-wide analysis. These genetic variants significantly influenced the expression of their respective genes in colon tissue and interacted with environmental factors such as smoking and alcohol drinking. The findings provide important insights into the genetic architecture of CRC.
HUMAN MOLECULAR GENETICS
(2023)
Correction
Genetics & Heredity
Ceres Fernandez-Rozadilla, Maria Timofeeva, Zhishan Chen, Philip Law, Minta Thomas, Stephanie Schmit, Virginia Diez-Obrero, Li Hsu, Juan Fernandez-Tajes, Claire Palles, Kitty Sherwood, Sarah Briggs, Victoria Svinti, Kevin Donnelly, Susan Farrington, James Blackmur, Peter Vaughan-Shaw, Xiao-ou Shu, Jirong Long, Qiuyin Cai, Xingyi Guo, Yingchang Lu, Peter Broderick, James Studd, Jeroen Huyghe, Tabitha Harrison, David Conti, Christopher Dampier, Mathew Devall, Fredrick Schumacher, Marilena Melas, Gad Rennert, Mireia Obon-Santacana, Vicente Martin-Sanchez, Ferran Moratalla-Navarro, Jae Hwan Oh, Jeongseon Kim, Sun Ha Jee, Keum Ji Jung, Sun-Seog Kweon, Min-Ho Shin, Aesun Shin, Yoon-Ok Ahn, Dong-Hyun Kim, Isao Oze, Wanqing Wen, Keitaro Matsuo, Koichi Matsuda, Chizu Tanikawa, Zefang Ren, Yu-Tang Gao, Wei-Hua Jia, John Hopper, Mark Jenkins, Aung Ko Win, Rish Pai, Jane Figueiredo, Robert Haile, Steven Gallinger, Michael Woods, Polly Newcomb, David Duggan, Jeremy Cheadle, Richard Kaplan, Timothy Maughan, Rachel Kerr, David Kerr, Iva Kirac, Jan Bohm, Lukka-Pekka Mecklin, Pekka Jousilahti, Paul Knekt, Lauri Aaltonen, Harri Rissanen, Eero Pukkala, Johan Eriksson, Tatiana Cajuso, Ulrika Hanninen, Johanna Kondelin, Kimmo Palin, Tomas Tanskanen, Laura Renkonen-Sinisalo, Brent Zanke, Satu Mannisto, Demetrius Albanes, Stephanie Weinstein, Edward Ruiz-Narvaez, Julie Palmer, Daniel Buchanan, Elizabeth Platz, Kala Visvanathan, Cornelia Ulrich, Erin Siegel, Stefanie Brezina, Andrea Gsur, Peter Campbell, Jenny Chang-Claude, Michael Hoffmeister, Hermann Brenner, Martha Slattery, John Potter, Konstantinos Tsilidis, Matthias Schulze, Marc Gunter, Neil Murphy, Antoni Castells, Sergi Castellvi-Bel, Leticia Moreira, Volker Arndt, Anna Shcherbina, Mariana Stern, Bens Pardamean, Timothy Bishop, Graham Giles, Melissa Southey, Gregory Idos, Kevin McDonnell, Zomoroda Abu-Ful, Joel Greenson, Katerina Shulman, Flavio Lejbkowicz, Kenneth Offit, Yu-Ru Su, Robert Steinfelder, Temitope Keku, Bethany van Guelpen, Thomas Hudson, Heather Hampel, Rachel Pearlman, Sonja Berndt, Richard Hayes, Marie Elena Martinez, Sushma Thomas, Douglas Corley, Paul Pharoah, Susanna Larsson, Yun Yen, Heinz-Josef Lenz, Emily White, Li Li, Kimberly Doheny, Elizabeth Pugh, Tameka Shelford, Andrew Chan, Marcia Cruz-Correa, Annika Lindblom, David Hunter, Amit Joshi, Clemens Schafmayer, Peter Scacheri, Anshul Kundaje, Deborah Nickerson, Robert Schoen, Jochen Hampe, Zsofia Stadler, Pavel Vodicka, Ludmila Vodickova, Veronika Vymetalkova, Nickolas Papadopoulos, Chistopher Edlund, William Gauderman, Duncan Thomas, David Shibata, Amanda Toland, Sanford Markowitz, Andre Kim, Stephen Chanock, Franzel van Duijnhoven, Edith Feskens, Lori Sakoda, Manuela Gago-Dominguez, Alicja Wolk, Alessio Naccarati, Barbara Pardini, Liesel FitzGerald, Soo Chin Lee, Shuji Ogino, Stephanie Bien, Charles Kooperberg, Christopher Li, Yi Lin, Ross Prentice, Conghui Qu, Stephane Bezieau, Catherine Tangen, Elaine Mardis, Taiki Yamaji, Norie Sawada, Motoki Iwasaki, Christopher Haiman, Loic Le Marchand, Anna Wu, Chenxu Qu, Caroline McNeil, Gerhard Coetzee, Caroline Hayward, Ian Deary, Sarah Harris, Evropi Theodoratou, Stuart Reid, Marion Walker, Li Yin Ooi, Victor Moreno, Graham Casey, Stephen Gruber, Ian Tomlinson, Wei Zheng, Malcolm Dunlop, Richard Houlston, Ulrike Peters
Article
Genetics & Heredity
Lili Yu, Lijuan Wang, Jing Sun, Xuan Zhou, Yeting Hu, Lidan Hu, Yazhou He, Chunqing Lin, Jie Chen, Xiaolin Xu, Malcolm G. Dunlop, Evropi Theodoratou, Kefeng Ding, Xue Li
Summary: This study developed a risk score based on m6A-related gene expression signatures for predicting the overall survival of colorectal cancer (CRC) patients. The risk score was significantly associated with CRC survival and had predictive value in different age, sex, and tumor stage groups. Furthermore, high-risk patients showed distinct patterns of immune cell composition and tumor microenvironment compared to low-risk patients.
FRONTIERS IN GENETICS
(2023)
Article
Medicine, General & Internal
Shuai Yuan, Lijuan Wang, Han Zhang, Fengzhe Xu, Xuan Zhou, Lili Yu, Jing Sun, Jie Chen, Haochao Ying, Xiaolin Xu, Yongfu Yu, Athina Spiliopoulou, Xia Shen, Jim Wilson, Dipender Gill, Evropi Theodoratou, Susanna C. Larsson, Xue Li
Summary: A genetic study showed that the TYK2 gene mutation is associated with a reduced risk of autoimmune diseases, especially in the treatment of psoriasis, but is also associated with an increased risk of prostate and breast cancer. Clinical trial results confirmed the effectiveness of TYK2 inhibitors for psoriasis, but also reported some adverse reactions.
Letter
Surgery
Adam D. Gerrard, Malcolm G. Dunlop, Farhat V. N. Din
BRITISH JOURNAL OF SURGERY
(2023)
Article
Surgery
A. D. Gerrard, Y. Maeda, J. Miller, F. Gunn, E. Theodoratou, C. Noble, L. Porteous, S. Glancy, P. MacLean, R. Pattenden, M. G. Dunlop, F. V. N. Din
Summary: Single- and double-faecal immunochemical test (FIT) strategies were tested in high-risk symptomatic patients. A double-FIT strategy reduced missed colorectal cancers by 50.0 per cent and all significant bowel pathology by 30.0 per cent, while improving prioritization to investigation.
BRITISH JOURNAL OF SURGERY
(2023)