Article
Nutrition & Dietetics
Yong Ma, Yanquan Fei, Xuebing Han, Gang Liu, Jun Fang
Summary: Lactobacillus plantarum can regulate lipid metabolism by modulating the structure of intestinal microbiota and increasing the production of short-chain fatty acids (SCFAs), thereby alleviating obesity and metabolic disorders.
FRONTIERS IN NUTRITION
(2022)
Article
Biochemistry & Molecular Biology
Young-Sil Lee, Daeyoung Lee, Gun-Seok Park, Seung-Hyun Ko, Juyi Park, You-Kyung Lee, Jihee Kang
Summary: The study suggests that Lactobacillus plantarum HAC01 can alleviate hyperglycemia and type 2 diabetes by regulating glucose metabolism in the liver, protecting insulin-secreting cells, and restoring gut microbiota and short-chain fatty acids.
Article
Pharmacology & Pharmacy
Shaoxiong Huang, Shiliang Dong, Lizhen Lin, Qiming Ma, Mengping Xu, Limei Ni, Qitong Fan
Summary: Inulin, a natural plant extract, improves metabolic syndrome by modulating the gut microbiota and inducing bile acid excretion.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Food Science & Technology
Hongying Cai, Zhiguo Wen, Lulu Zhao, Dali Yu, Kun Meng, Peilong Yang
Summary: This study found that Lactobacillus plantarum FRT4 has beneficial effects against obesity in high-fat diet-induced obese mice and can be used as a potential functional food for obesity prevention. FRT4 intervention can reduce body weight gain, liver weight, fat accumulation, and levels of cholesterol and triglycerides in the blood, while regulating gut microbiota composition and gut barrier function.
FOOD & NUTRITION RESEARCH
(2022)
Article
Food Science & Technology
Chao Tang, Weiwei Zhou, Mengyuan Shan, Zhaoxin Lu, Yingjian Lu
Summary: This study found that the probiotic Lactobacillus plantarum Q16 modulates lipid and energy metabolism, improves lipid profile, and regulates colonic microbiota composition to protect against high-fat diet-induced non-alcoholic fatty liver disease (NAFLD).
FOOD SCIENCE AND HUMAN WELLNESS
(2022)
Article
Food Science & Technology
Xiaomeng Wu, Yajuan Wang, Xinyu Du, Yujun Liu, Yuan Gao, Yanfeng Tuo, Guangqing Mu
Summary: This study found that Lacti-plantibacillus plantarum Y44 can regulate the health of high-fat diet fed mice by changing gut microbiota. Proteomics analysis showed that L. plantarum Y44 influences metabolic pathways in the hypothalamus, indicating its potential for improving high-fat diet related health issues.
Article
Microbiology
Xingjian Wen, Hejing Liu, Xiaoling Luo, Li Lui, Jiuyu Fan, Yajing Xing, Jia Wang, Xingfang Qiao, Na Li, Guixue Wang
Summary: Supplementation of L. plantarum ATCC 14917 can alleviate weight gain, improve hepatic steatosis and serum lipid metabolism, and ameliorate HFD-induced inflammation in rats fed with a high-fat diet.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Pharmacology & Pharmacy
Xubing Yuan, Junping Zheng, Lishi Ren, Siming Jiao, Cui Feng, Yuguang Du, Hongtao Liu
Summary: The study suggests that glucosamine can reverse the blood glucose levels of diabetic mice induced by high-fat diet and improve glucose tolerance. Additionally, glucosamine can regulate the imbalance of gut microbiota, inhibit inflammatory responses in the gut and white adipose tissues, and improve intestinal barrier damage.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Food Science & Technology
Hongying Cai, Daojie Li, Liye Song, Xin Xu, Yunsheng Han, Kun Meng, Zhiguo Wen, Peilong Yang
Summary: This study used liver and cecum contents metabonomics to analyze the metabolic profiles of obese mice and revealed the potential functions of Lactobacillus plantarum FRT10 in regulating liver and cecum contents metabolism. The results suggest that the anti-obesity effects of FRT10 may be related to alterations in glycerophospholipid metabolism, primary bile acid biosynthesis, amino metabolism, and purine and pyrimidine metabolism.
Article
Food Science & Technology
Yuhan Xu, Qiaoling Xie, Wei Zhang, Meizhen Zhu, Xiaoxuan Chen, Dongbei Guo, Lili Pan, Junru Li, Hui Lan, Hongwei Li
Summary: The effects of probiotics Lp662 and Lp299v on severe inflammatory bowel disease induced by dextran sodium sulfate were evaluated. The results showed that these probiotics can reduce weight loss caused by colitis, decrease tissue injury, and lower inflammatory factor levels. Additionally, probiotics can also increase bone density. Therefore, probiotics have the potential to be a treatment option for inflammatory bowel disease.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Article
Nutrition & Dietetics
Hao Zhong, Jian Wang, Abdullah, Muhammad Adnan Hafeez, Rongfa Guan, Fengqin Feng
Summary: Lactobacillus plantarum ZJUFB2 improves insulin resistance and hyperglycemia in high-fat diet-fed mice by regulating hepatic lipid metabolism, gut microbiota composition, and bile acid levels. It shows lower abundance of obesity-related and inflammation-associated microbes, while exhibiting higher abundance of short-chain fatty acids and bile salt hydrolase-producing bacteria. This novel probiotic is effective in preventing insulin resistance.
FRONTIERS IN NUTRITION
(2021)
Article
Biochemistry & Molecular Biology
Yajian Song, Huitao Shen, Tingting Liu, Bingju Pan, Sanduni De Alwis, Wanyi Zhang, Xuegang Luo, Zhongyuan Li, Nan Wang, Wenjian Ma, Tongcun Zhang
Summary: The study compared the effects of three mannans on obesity and obesity-related metabolic disorders in mice fed with a high-fat diet, showing that Konjac glucomannan (KGM), guar gum (GG), and locust bean gum (LBG) all had potential as alternative dietary supplements. However, the effects varied based on dosage and time, and the ability of mannans to regulate the gut microbiota played a crucial role in their functions. Analysis of gut microbiota sequencing revealed specific changes in abundance of certain OTUs, indicating a correlation with obesity and metabolic disorders.
Article
Biotechnology & Applied Microbiology
Amrita Bhanja, Nibedita Nayak, Sumit Mukherjee, Parag Prakash Sutar, Monalisa Mishra
Summary: This study demonstrates the effectiveness of probiotics and synbiotic in reducing diabetes-related symptoms in a fruit fly model. The findings show that probiotics and a combination of probiotics and prebiotics can decrease lipid deposition, improve insulin resistance, lower reactive oxygen species levels, and enhance the overall health of fruit flies.
PROBIOTICS AND ANTIMICROBIAL PROTEINS
(2022)
Article
Food Science & Technology
Negar Sabet-Sarvestani, Mohammad Hadi Eskandari, Seyed Mohammad Hashem Hosseini, Mehrdad Niakousari, Hadi Hashemi Gahruie, Mohammadreza Khalesi
Summary: The study produced synbiotic ice creams with fructooligosaccharides, fermented using Lactobacillus casei and Lactobacillus plantarum. The addition of fructooligosaccharides improved the growth and viability of probiotics, leading to higher antioxidant activity. However, the fermented ice creams had lower overall acceptability than the unfermented ice creams due to their higher acidity.
JOURNAL OF FOOD PROCESSING AND PRESERVATION
(2021)
Article
Food Science & Technology
Yue Teng, Yu Wang, Wu-yang Guan, Chao Wang, Han-song Yu, Xia Li, Yu-hua Wang
Summary: The beneficial effects of Lactobacillus plantarum LP104 on lipid level and disordered gut microbiota in mice fed a high-fat diet were investigated in this study. The results showed that LP104 supplementation could alleviate body weight gain, liver index increase, colon length reduction, as well as improve TC, TG, LDL, TNF alpha, and LPS levels. High-throughput sequencing analysis revealed that long-term high-fat diet negatively affected microbial abundance and composition in the gut, but LP104 supplementation reduced the ratio of Firmicutes to Bacteroides and positively regulated the gut microbiota community structure. Additionally, the intake of LP104 also increased the abundance of beneficial bacteria Bifidobacterium in the cecum, which improved the intestinal flora disorder induced by a high-fat diet. These findings suggest that LP104 supplementation can improve high-fat diet-induced hyperlipidemia by positively regulating intestinal microorganisms.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Article
Biochemistry & Molecular Biology
Dong Geun Lee, Shota Hori, Ohji Kohmoto, Shinri Kitta, Ryo Yoshida, Yasutake Tanaka, Hidehisa Shimizu, Keisuke Takahashi, Taizo Nagura, Hirokatsu Uchino, Satoru Fukiya, Atsushi Yokota, Satoshi Ishizuka
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
(2019)
Article
Urology & Nephrology
Nobuhiro Hashimoto, Isao Matsui, Satoshi Ishizuka, Kazunori Inoue, Ayumi Matsumoto, Karin Shimada, Shota Hori, Dong Geun Lee, Seiichi Yasuda, Yusuke Katsuma, Sachio Kajimoto, Yohei Dol, Satoshi Yamaguchi, Keiichi Kubota, Tatsufumi Oka, Yusuke Sakaguchi, Yoshitsugu Takabatake, Takayuki Hamano, Yoshitaka Lsaka
KIDNEY INTERNATIONAL
(2020)
Article
Biochemistry & Molecular Biology
Reika Yoshitsugu, Keidai Kikuchi, Shota Hori, Hitoshi Iwaya, Masahito Hagio, Hidehisa Shimizu, Tohru Hira, Satoshi Ishizuka
LIPIDS IN HEALTH AND DISEASE
(2020)
Article
Biochemistry & Molecular Biology
Shota Hori, Takayuki Abe, Dong Geun Lee, Satoru Fukiya, Atsushi Yokota, Nao Aso, Bungo Shirouchi, Masao Sato, Satoshi Ishizuka
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2020)
Article
Chemistry, Analytical
Siddabasave Gowda B. Gowda, Zi-Jun Gao, Zhen Chen, Takayuki Abe, Shota Hori, Satoru Fukiya, Satoshi Ishizuka, Atsushi Yokota, Hitoshi Chiba, Shu-Ping Hui
ANALYTICAL SCIENCES
(2020)
Article
Biochemistry & Molecular Biology
Ja-Young Lee, Hidehisa Shimizu, Masahito Hagio, Satoru Fukiya, Masamichi Watanabe, Yasutake Tanaka, Ga-Hyun Joe, Hitoshi Iwaya, Reika Yoshitsugu, Keidai Kikuchi, Misaki Tsuji, Nanako Baba, Takuma Nose, Koji Tada, Taketo Hanai, Shota Hori, Akari Takeuchi, Yumiko Furukawa, Bungo Shirouchi, Masao Sato, Tadasuke Ooka, Yoshitoshi Ogura, Tetsuya Hayashi, Atsushi Yokota, Satoshi Ishizuka
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
(2020)
Article
Nutrition & Dietetics
Kenta Maegawa, Haruka Koyama, Satoru Fukiya, Atsushi Yokota, Koichiro Ueda, Satoshi Ishizuka
Summary: The enterohepatic circulation of 12 alpha-hydroxylated bile acid is enhanced in rats fed a high-fat diet, and dietary supplementation of raffinose can normalize hepatic lipid accumulation by suppressing this circulation.
BRITISH JOURNAL OF NUTRITION
(2022)
Article
Multidisciplinary Sciences
Reika Yoshitsugu, Hongxia Liu, Yoshie Kamo, Akari Takeuchi, Ga-Hyun Joe, Koji Tada, Keidai Kikuchi, Nobuyuki Fujii, Shinri Kitta, Shota Hori, Manami Takatsuki, Hitoshi Iwaya, Yasutake Tanaka, Hidehisa Shimizu, Satoshi Ishizuka
Summary: Dietary supplementation with cholic acid reduces plasma adiponectin concentration and influences the distribution of adiponectin in the body, as well as the concentration of mucosal immunoglobulin A in the intestine of rats. This study suggests that 12 alpha OH BAs may modulate mucosal immune responses that are involved in the accumulation of adiponectin in the ileum.
SCIENTIFIC REPORTS
(2021)
Article
Food Science & Technology
Yeonmi Lee, Yasutake Tanaka, Wakana Iwasaki, Fumika Yokoyama, Ga-Hyun Joe, Misaki Tsuji, Takuma Nose, Koji Tada, Taketo Hanai, Shota Hori, Hidehisa Shimizu, Kimiko Minamida, Kazunori Miwa, Satoshi Ishizuka
Summary: Dietary supplementation with a synbiotic containing okara and Bacillus coagulans lilac-01 can improve hepatic lipid accumulation induced by cholic acid, by reducing de novo lipogenesis and enhancing fecal triglyceride excretion.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Article
Food Science & Technology
Hongxia Liu, Ohji Kohmoto, Ayana Sakaguchi, Shota Hori, Misuzu Tochigi, Koji Tada, Yeonmi Lee, Keidai Kikuchi, Satoshi Ishizuka
Summary: This study demonstrated the significance of taurocholic acid in proximal gut leakiness and ruled out the influence of secondary bile acids.
FOOD AND CHEMICAL TOXICOLOGY
(2022)
Article
Multidisciplinary Sciences
Wakana Iwasaki, Ryo Yoshida, Hongxia Liu, Shota Hori, Yuki Otsubo, Yasutake Tanaka, Masao Sato, Satoshi Ishizuka
Summary: This study found that the ratio of 12 alpha bile acid (BA)/non-12 BA in feces is closely associated with hepatic triacylglycerol accumulation in mice fed a high-fat diet.
SCIENTIFIC REPORTS
(2022)
Article
Agriculture, Multidisciplinary
Qingyun Huang, Nodoka Miyaki, Zongfei Li, Yutaroh Takahashi, Satoshi Ishizuka, Toru Hayakawa, Jun-ichi Wakamatsu, Haruto Kumura
Summary: This study investigated the potential of using whey and/or rice powder as substrates for monascin production in different Monascus strains. The results showed that Monascus ruber NBRC 32318 exhibited the highest growth and monascin production in a medium containing both whey and rice. Further investigation revealed that the mineral composition in whey had a significant impact on the monascin production of Monascus ruber NBRC 32318, but had minimal effects on M. pilosus NBRC 4520 and M. purpureus AHU 9085. Overall, the combination of whey and rice resulted in the highest monascin production.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2023)
Correction
Multidisciplinary Sciences
Wakana Iwasaki, Ryo Yoshida, Hongxia Liu, Shota Hori, Yuki Otsubo, Yasutake Tanaka, Masao Sato, Satoshi Ishizuka
SCIENTIFIC REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Tomoko Shimoda, Hidehisa Shimizu, Wakana Iwasaki, Hongxia Liu, Yoshie Kamo, Koji Tada, Taketo Hanai, Shota Hori, Ga-Hyun Joe, Yasutake Tanaka, Masao Sato, Hitoshi Miyazaki, Satoshi Ishizuka
Summary: The study found that a diet supplemented with CA (cholic acid) can lead to hepatic lipid accumulation and affect blood pressure in rats without obesity.
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
(2023)
Article
Nutrition & Dietetics
Shota Hori, Minako Satake, Ohji Kohmoto, Ryo Takagi, Kazufumi Okada, Satoru Fukiya, Atsushi Yokota, Satoshi Ishizuka
Summary: Primary 12 alpha OH BAs were found to decrease hepatic iron concentration in rats, with LCN2 potentially responsible for transporting iron out of the liver to achieve this effect.
JOURNAL OF NUTRITION
(2021)