Article
Biochemistry & Molecular Biology
Thomas M. Elliott, Louisa G. Gordon, Ann Webb, Richard Kift, Anna Foeglein, Rachel E. Neale
Summary: Our goal was to calculate the time required to maintain existing 25-hydroxyvitamin D (25(OH)D) concentration in different locations in Australia and New Zealand. Using a microsimulation model, we estimated monthly changes in 25(OH)D concentration based on data on standard erythemal dose, solar zenith angle, and climatological ozone. We found that 5-10 minutes of outdoor activity between 8 a.m. and 4 p.m., with 35% of the body surface area exposed, is sufficient to maintain existing 25(OH)D concentration in summer, while in winter, more time outdoors during the middle of the day is required, with 10% of the body surface area exposed.
PHOTOCHEMISTRY AND PHOTOBIOLOGY
(2023)
Article
Psychiatry
Jia-Hui Ma, Ning-Hao Huang, Tao Huang, Dong-Liang Mu
Summary: This study aimed to investigate the association between serum 25-hydroxyvitamin D levels and dementia, mild cognitive impairment (MCI), and delirium. The results showed that participants with higher 25(OH)D levels had a lower risk of dementia, MCI, and delirium compared to those with lower levels.
PSYCHIATRY RESEARCH
(2023)
Article
Anthropology
Caryn E. Oshiro, Teresa A. Hillier, Grant Edmonds, Missy Peterson, Patrick L. Hill, Sarah Hampson
Summary: The study aimed to examine the sources of vitamin D and their impact on deficiency among older adults. Analysis showed that despite living in a tropical climate with sun exposure, over one-third of participants were deficient in vitamin D. Factors like supplement use and sun exposure were associated with higher vitamin D levels and lower deficiency risks, while differences in sources varied by race/ethnicity.
AMERICAN JOURNAL OF HUMAN BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Shufei Zeng, Chang Chu, Cornelia Doebis, Volker von Baehr, Berthold Hocher
Summary: There is a strong positive linear correlation between free 25(OH)D (f25(OH)D) and total 25(OH)D, making them useful for assessing vitamin D levels. The recommended threshold level for f25(OH)D is 8.499 pg/mL, corresponding to a target concentration of at least 30 ng/mL for t25(OH)D. The upper limit for vitamin D is still unclear, with most experts favoring a upper limit of 100 ng/mL for t25(OH)D.
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2021)
Article
Nutrition & Dietetics
Jun-Hyuk Lee, Yu-Jin Kwon, Hye Sun Lee, Jee Hye Han, Boyoung Joung, Sung Jin Kim
Summary: This study confirms an inverse dose-dependent association between serum 25-hydroxyvitamin D levels and elevated intraocular pressure (EIOP) in a large sample of 15,338 individuals. Each unit increase in serum 25-hydroxyvitamin D is associated with a 3% decrease in the odds of having EIOP. Compared to individuals deficient in 25-hydroxyvitamin D, those with insufficiency and sufficiency have a 28% and 49% lower odds of EIOP, respectively. Therefore, clinical assessment of intraocular pressure may be helpful in the treatment and prevention of glaucoma in patients with insufficient 25-hydroxyvitamin D.
Article
Oncology
Beichen Cai, Qian Lin, Ruonan Ke, Xiuying Shan, Jiaqi Yu, Xuejun Ni, Xinjian Lin, Biao Wang
Summary: This study used Mendelian randomization to investigate the causal relationship between serum 25-Hydroxyvitamin D levels and melanoma incidence. The results indicated a potentially causal positive association, challenging traditional beliefs about vitamin D's role in melanoma. This highlights the importance of a balanced and personalized approach to vitamin D supplementation and sun exposure, particularly in high-risk populations.
FRONTIERS IN ONCOLOGY
(2023)
Article
Nutrition & Dietetics
RuTong Wang, Weijing Wang, Ping Hu, Ronghui Zhang, Xue Dong, Dongfeng Zhang
Summary: This study aimed to evaluate the association between dietary vitamin D intake and serum vitamin D concentrations with cognitive performance in older Americans. The results showed a positive association between dietary vitamin D intake, serum total 25-hydroxyvitamin D, and cognitive performance, with no significant gender differences in the associations. Further research is needed to clarify the effects of dietary vitamin D intake and specific serum D concentrations on cognitive performance.
Article
Medical Laboratory Technology
Francesco Vierucci, Lara Fusani, Alessandro Saba, Tania Minucciani, Maria Paola Belluomini, Raffaele Domenici, Gian Luca Bracco, Angelina Vaccaro, Giovanni Federico
Summary: This study assessed the relationship between assumed risk factors for maternal vitamin D deficiency and levels of cord blood 25(OH)D-3 and C-3-epimer. The results showed that vitamin D deficiency was common in newborns, especially those born to mothers who did not receive vitamin D supplementation and had poor sun exposure.
CLINICA CHIMICA ACTA
(2022)
Article
Nutrition & Dietetics
Chun Zhou, Ziliang Ye, Sisi Yang, Xiaoqin Gan, Yanjun Zhang, Mengyi Liu, Panpan He, Yuanyuan Zhang, Qimeng Wu, Jing Nie, Xianhui Qin
Summary: The study found that serum 25(OH)D concentrations, sun exposure time, and dietary vitamin D intake were all inversely associated with the risk of new-onset AKI. However, genetic susceptibility did not significantly modify these associations.
JOURNAL OF NUTRITION
(2023)
Article
Nutrition & Dietetics
Berenice Rivera-Paredez, Alberto Hidalgo-Bravo, Guadalupe Leon-Reyes, Leith S. Leon-Maldonado, Arnoldo Aquino-Galvez, Manuel Castillejos-Lopez, Edgar Denova-Gutierrez, Yvonne N. Flores, Jorge Salmeron, Rafael Velazquez-Cruz
Summary: This study evaluated the association between 25(OH)D (total, free, and bioavailable) with adiposity and metabolic traits. The findings suggest that free and bioavailable 25(OH)D do not offer additional advantages over total 25(OH)D regarding its association with adiposity and several metabolic traits in Mexican adults.
Article
Nutrition & Dietetics
Guowei Li, Likang Li, Jonathan D. Adachi, Ruoting Wang, Zebing Ye, Xintong Liu, Lehana Thabane, Gregory Y. H. Lip
Summary: This study found a quasi J-shaped relationship between serum circulating 25-hydroxyvitamin D (25(OH)D) level and risk of recurrent stroke in patients with a stroke history. The lowest risk of recurrent stroke was observed at a 25(OH)D level of approximately 60 nmol/L, which was associated with a 48% reduction in risk compared to a level of 10 nmol/L.
Article
Multidisciplinary Sciences
Jason Wyse, Rebecca Mangan, Lina Zgaga
Summary: Observational studies have linked vitamin D deficiency with various diseases, but randomised controlled trials often fail to show the benefits of supplementation. A flexible generative model was proposed to quantify power in RCTs, taking into account population characteristics and trial design which have a significant impact on power and required sample size in vitamin D RCTs.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
Hsin-Ya Tang, Wang-Sheng Ko, Yuan-Horng Yan, Su-Chen Yu, Ya-ling Chiou
Summary: Shift nurses in Taiwan often experience 25(OH)D deficiency, sleep disturbances, depression, and fatigue. However, no significant correlation was found between 25(OH)D levels and mental health.
SCIENTIFIC REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Frank Z. Stanczyk, Intira Sriprasert, Rachel Danis, Raj Pandian, Harpreet Matharu, Nicole Bender, Melissa Natavio
Summary: This study compared the effects of two combined oral contraceptive formulations on 25(OH)D levels and VDBP levels, revealing different impacts. LNG may have a suppressive effect on VDBP. Further research is needed to understand the influence of hormonal contraceptive formulations on vitamin D status and women's health.
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2021)
Article
Rheumatology
Bin Cai, Mengmeng Zhou, Qingqing Xiao, Hejian Zou, Xiaoxia Zhu
Summary: This study examined the relationship between serum 25-hydroxyvitamin D and all-cause, cause-specific mortality in patients with RA. It found a nonlinear, L-shaped association, with lower serum 25-hydroxyvitamin D levels being associated with increased risk of all-cause mortality.
Article
Oncology
Sandra Pavey, Alex Pinder, Winnie Fernando, Nicholas D'Arcy, Nicholas Matigian, Dubravka Skalamera, Kim-Anh Le Cao, Dorothy Loo-Oey, Michelle M. Hill, Mitchell Stark, Michael Kimlin, Andrew Burgess, Nicole Cloonan, Richard A. Sturm, Brian Gabrielli
MOLECULAR ONCOLOGY
(2020)
Article
Medicine, Research & Experimental
Serigne N. Lo, Amelia K. Smit, David Espinoza, Anne E. Cust
Article
Environmental Sciences
Ning Wang, Kerrie Mengersen, Shilu Tong, Michael Kimlin, Maigeng Zhou, Yang Liu, Wenbiao Hu
SCIENCE OF THE TOTAL ENVIRONMENT
(2020)
Article
Medicine, General & Internal
Visalini Nair-Shalliker, David P. Smith, Val Gebski, Manish Patel, Mark Frydenberg, John W. Yaxley, Robert Gardiner, David Espinoza, Michael G. Kimlin, Michael Fenech, David Gillatt, Henry Woo, Bruce K. Armstrong, Krishan Rasiah, Nader Awad, James Symons, Howard Gurney
Summary: The study aims to investigate if monthly oral high-dose vitamin D supplementation can prevent disease progression in low-to-intermediate risk prostate cancer patients managed by active surveillance. The trial will assess the feasibility, efficacy, and safety of supplementing with an initial loading dose followed by monthly doses over a 2-year period.
Article
Endocrinology & Metabolism
Hai Pham, Mary Waterhouse, Catherine Baxter, Briony Duarte Romero, Donald S. A. McLeod, Bruce K. Armstrong, Peter R. Ebeling, Dallas R. English, Gunter Hartel, Michael G. Kimlin, Adrian R. Martineau, Rachel O'Connell, Jolieke C. van der Pols, Alison J. Venn, Penelope M. Webb, David C. Whiteman, Rachel E. Neale
Summary: This study analyzed data from older Australian adults and found that monthly vitamin D supplementation did not reduce the overall risk of acute respiratory tract infection, but could slightly reduce the duration of symptoms in the general population.
LANCET DIABETES & ENDOCRINOLOGY
(2021)
Article
Medicine, Research & Experimental
Mary Waterhouse, Catherine Baxter, Briony Duarte Romero, Donald S. A. McLeod, Dallas R. English, Bruce K. Armstrong, Michael W. Clarke, Peter R. Ebeling, Gunter Hartel, Michael G. Kimlin, Rachel L. O'Connell, Hai Pham, Rachael M. Rodney Harris, Jolieke C. van der Pols, Alison J. Venn, Penelope M. Webb, David C. Whiteman, Rachel E. Neale
Summary: The D-Health Trial investigates the impact of high-dose vitamin D supplementation on mortality rate and cancer prevention. Predictive models were developed to estimate baseline serum 25(OH)D levels, with UV radiation and vitamin D intake identified as key predictors of low serum 25(OH)D concentrations.
CONTEMPORARY CLINICAL TRIALS
(2021)
Article
Oncology
Mark P. Little, Terrence Lee, Michael G. Kimlin, Cari M. Kitahara, Rui Zhang, Bruce H. Alexander, Martha S. Linet, Elizabeth K. Cahoon
Summary: The study found that the relative and absolute risk of basal cell carcinoma increased with cumulative ambient UVR exposure, with the highest absolute risk for the head/neck and to a lesser extent, the trunk. Additionally, individuals with Gaelic ancestry had lower relative risks but higher absolute risks.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2021)
Article
Geriatrics & Gerontology
Mary Waterhouse, Emma Sanguineti, Catherine Baxter, Briony Duarte Romero, Donald S. A. McLeod, Dallas R. English, Bruce K. Armstrong, Peter R. Ebeling, Gunter Hartel, Michael G. Kimlin, Rachel L. O'Connell, Hai Pham, Jolieke C. van der Pols, Alison J. Venn, Penelope M. Webb, David C. Whiteman, Rachel E. Neale
Summary: This study found that monthly high-dose vitamin D supplementation did not reduce the risk of falls, and may potentially increase the risk of falling in individuals with normal BMI. Further investigation is needed to better understand the impact of vitamin D supplementation on falls risk in different populations.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2021)
Article
Immunology
Hai Pham, Mary Waterhouse, Catherine Baxter, Briony Duarte Romero, Donald S. A. McLeod, Bruce K. Armstrong, Peter R. Ebeling, Dallas R. English, Gunter Hartel, Michael G. Kimlin, Rachel L. O'Connell, Jolieke C. van der Pols, Alison J. Venn, Penelope M. Webb, David C. Whiteman, Rachel E. Neale
Summary: This study analyzed the effect of vitamin D supplementation on infection risk and found that vitamin D may reduce the number of antibiotic prescriptions, especially in individuals with low vitamin D levels.
JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Environmental Sciences
Katharina M. D. Merollini, Louisa G. Gordon, Yiu M. Ho, Joanne F. Aitken, Michael G. Kimlin
Summary: The number of cancer survivors is increasing worldwide. This study aimed to quantify the long-term health service costs of cancer survivors in Queensland, Australia. The study found that the highest healthcare costs were incurred by patients with prostate, breast, and colorectal cancer. Costs were typically highest in the first year after diagnosis and decreased over time.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Letter
Public, Environmental & Occupational Health
Ran Zhang, Amelia K. Smit, David Espinoza, Martin Allen, Gillian Reyes-Marcelino, Michael G. Kimlin, Serigne N. Lo, Ashleigh R. Sharman, Matthew H. Law, Peter A. Kanetsky, Graham J. Mann, Anne E. Cust
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
(2022)
Article
Nutrition & Dietetics
Aninda Rahman, Mary Waterhouse, Catherine Baxter, Briony Duarte Romero, Donald S. A. McLeod, Bruce K. Armstrong, Peter R. Ebeling, Dallas R. English, Gunter Hartel, Michael G. Kimlin, Rachel O'Connell, Jolieke C. van der Pols, Alison J. Venn, Penelope M. Webb, David C. Whiteman, Rachel E. Neale
Summary: Observational studies suggest an inverse association between 25-hydroxy vitamin D (25(OH)D) concentration and pain, but intervention trials have inconsistent findings. In this large placebo-controlled trial, vitamin D supplementation with 60000 IU of vitamin D-3/month had negligible effect on bodily pain.
BRITISH JOURNAL OF NUTRITION
(2023)
Article
Environmental Sciences
Alan E. Stewart, Michael G. Kimlin
Summary: A total solar eclipse occurred over North America on 21 August 2017 and people spent around an hour observing it. The time spent outside differed according to individuals' self-reported skin response to the sun. The most common skin protective measures were seeking shade and wearing short-sleeve shirts.
Article
Genetics & Heredity
Chi Kin Law, Anne E. Cust, Amelia K. Smit, Lyndal Trevena, Pablo Fernandez-Penas, Omgo E. Nieweg, Alexander M. Menzies, Sarah Wordsworth, Managing Your Risk Study Grp
Summary: This study evaluates the long-term cost-effectiveness of a melanoma prevention program using personalized genomic risk provision and genetic counseling. The results show that targeting high-risk individuals with genomic risk provision is a cost-effective strategy for reducing sunburns.
GENETICS IN MEDICINE
(2023)
Article
Endocrinology & Metabolism
Rachel E. Neale, Catherine Baxter, Briony Duarte Romero, Donald S. A. McLeod, Dallas R. English, Bruce K. Armstrong, Peter R. Ebeling, Gunter Hartel, Michael G. Kimlin, Rachel O'Connell, Jolieke C. van der Pols, Alison J. Venn, Penelope M. Webb, David C. Whiteman, Mary Waterhouse
Summary: Supplementing older adults with monthly doses of vitamin D-3 does not reduce all-cause mortality and may even increase the risk of death from cancer in some cases.
LANCET DIABETES & ENDOCRINOLOGY
(2022)