Article
Biochemistry & Molecular Biology
Morgane Placet, Caroline M. Molle, Guillaume Arguin, Sameh Geha, Fernand-Pierre Gendron
Summary: The P2Y(6) receptor plays an important role in the quality and stability of mucins in the intestine and has a protective effect against inflammatory bowel disease (IBD).
Article
Biochemistry & Molecular Biology
Ibrahim Y. Abdelgawad, Marianne K. O. Grant, Flavia E. Popescu, David A. Largaespada, Beshay N. Zordoky
Summary: DOX is widely used in pediatric oncology and induces inflammatory response; the study found that DOX treatment suppressed tumor growth but caused cardiac atrophy in both tumor-free and tumor-bearing mice; EL4 lymphoma cells elicited inflammatory response in heart, liver, and kidney.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Gastroenterology & Hepatology
Sung -E Choi, Yoonjung Hwang, Soo-Jin Lee, Hyunkyung Jung, Tae Hwan Shin, Youngho Son, Seokho Park, Seung Jin Han, Hae Jin Kim, Kwan Woo Lee, Gwang Lee, Jongsook Kim Kemper, Hyun Kyu Song, Yup Kang
Summary: The reduction of mitochondrial protease ClpP is associated with the development of non-alcoholic steatohepatitis (NASH). Supplementation of ClpP may improve diet-induced NASH.
JOURNAL OF HEPATOLOGY
(2022)
Article
Multidisciplinary Sciences
Rocco Latorre, Alan Hegron, Chloe J. Peach, Shavonne Teng, Raquel Tonello, Jeffri S. Retamal, Rafael Klein-Cloud, Diana Bok, Dane D. Jensen, Lena Gottesman-Katz, Jeanette Rientjes, Nicholas A. Veldhuis, Daniel P. Poole, Brian L. Schmidt, Charalabos H. Pothoulakis, Carl Rankin, Ying Xie, Hon Wai Koon, Nigel W. Bunnett
Summary: This study investigated the localization and signaling of protease-activated receptor 2 (PAR(2)) in colitis, revealing that PAR(2) endocytosis sustains protease-evoked inflammation and nociception. PAR(2) in endosomes is a potential therapeutic target for colitis.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Chemistry, Medicinal
Qian Wang, Dewei Peng, Bingyu Huang, Lintong Men, Tao Jiang, Shengqi Huo, Moran Wang, Junyi Guo, Jiagao Lv, Li Lin
Summary: It has been found that notopterol has a cardioprotective effect in hyperuricemic mice, improving exercise capacity and alleviating cardiac dysfunction. The mechanism involves the inhibition of the P2X7R/NLRP3 signaling pathway, suppressing inflammatory responses and pyroptosis. Notopterol could be a potential therapeutic strategy against hyperuricemia-induced cardiac damage.
Article
Environmental Sciences
Meng Yang, Dongming Wang, Shiming Gan, Bin Wang, Linling Yu, Yujia Xie, Lieyang Fan, Jixuan Ma, Weihong Chen
Summary: The administration of T3 can reduce lung damage, inflammation, and fibrosis caused by silica exposure. This protective effect may be partially mediated through thyroid hormone receptors and involve a reduction in glycolysis.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Food Science & Technology
Vasileios Paraskeuas, Eirini Griela, Dimitrios Bouziotis, Konstantinos Fegeros, Gunther Antonissen, Konstantinos C. Mountzouris
Summary: This study assessed the impact of two mycotoxins, DON and FUM, on a range of molecular intestinal biomarkers in broilers at the maximum allowable EU dietary levels. The results showed that these toxins had specific effects on different intestinal segments, affecting detoxification, antioxidant response, stress, inflammation, and integrity. The findings suggest that broiler molecular responses to DON and FUM are toxin and intestinal site specific.
Article
Medicine, Research & Experimental
Tingting Wu, Keye Xu, Chaobo Liu, Yan Li, Mingcai Li
Summary: This study aimed to investigate the effect of interleukin-37 (IL-37) on cigarette smoke-induced lung inflammation. By administering IL-37-expressing lentivirus to mice, it was found that IL-37 can alleviate weight loss and pulmonary inflammation induced by cigarette smoke. IL-37 also significantly inhibited inflammatory cell recruitment, reduced inflammatory cell increase, and suppressed the production of pro-inflammatory cytokines.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Pharmacology & Pharmacy
E. Wen, Guang Xin, Shiyi Li, Yuman Dong, Yuda Zhu, Chengyu Wan, Xiuxian Yu, Zeliang Wei, Yilan Wang, Fan Li, Kun Zhang, Hai Niu, Wen Huang
Summary: This study found that Tuftsin alleviates SAP-induced spleen injury by promoting NRP1 expression, mainly through alleviating mitochondrial dysfunction, oxidative stress, ATP depletion, and the expression of pro-inflammatory factors.
BIOCHEMICAL PHARMACOLOGY
(2022)
Article
Cell Biology
Yuting Zhang, Weijuan Xin, Xiaozhi Hu, Hanqi Wang, Xiaomiao Ye, Caili Xu, Yanyang Nan, Zhengyu Wu, Dianwen Ju, Jiajun Fan
Summary: This study revealed the critical role of hedgehog signaling in macrophage-derived foam cell formation and found that inhibiting the hedgehog signaling pathway can increase cholesterol efflux and improve foam cell formation. This finding provides a new target and treatment strategy for atherosclerosis.
CELL DEATH & DISEASE
(2023)
Article
Immunology
Yamini Chelpuri, Shivakumar Pabbathi, Gopala Reddy Alla, Ravi Kumar Yadala, Mounika Kamishetti, Anil Kumar Banothu, Ramya Boinepally, Kala Kumar Bharani, Amit Khurana
Summary: Hinokitiol has significant potential in preventing cerulein-induced acute pancreatitis by reducing pancreatic edema, lowering plasma enzyme levels, attenuating oxidative and nitrosative stress, improving antioxidant enzyme activity, and regulating inflammatory cytokine levels.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Lu Wang, Wu Lei, Shuijuan Zhang, Li Yao
Summary: MCC950 is a potent inhibitor of NLRP3 inflammasome with the ability to effectively suppress LPS-induced lung inflammation in mice by reducing inflammatory cell accumulation, pathological progression, and cytokine expression. These findings suggest potential clinical translation for the treatment of ARDS/COPD.
BIOORGANIC & MEDICINAL CHEMISTRY
(2021)
Article
Medicine, Research & Experimental
Ximiao Chen, Zhengli Li, Haofeng Hong, Ning Wang, Junyi Chen, Sisi Lu, Hongyuan Zhang, Xiaolei Zhang, Chaoyong Bei
Summary: The research found that Xanthohumol (XN) can inhibit the expression of nitric oxide synthase (INOS), IL-1 beta-promoted inducible nitric oxide (NO), tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), and cyclooxygenase-2 (COX-2) in vitro. Additionally, it down-regulates matrix metalloproteinase-13 and prothrombin, while up-regulating type II collagen and Aggrecan expression. XN also activates nuclear factor (Nrf2) and inhibits nuclear factor B (NF-kappaB) signal transduction to slow down the progression of osteoarthritis.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Biochemistry & Molecular Biology
Chen Zhang, Xiao Shi, Zhongping Su, Chao Hu, Xianmin Mu, Jinshun Pan, Mengjing Li, Fengmeng Teng, Tao Ling, Ting Zhao, Che Xu, Guozhong Ji, Qiang You
Summary: The study demonstrated that CD36 deficiency ameliorated APAP-induced acute liver injury and inflammatory responses by decreasing JNK activation. CD36 might serve as a new target to reduce acute liver injury.
MOLECULAR MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Kseniya M. Achasova, Elena N. Kozhevnikova, Mariya A. Borisova, Ekaterina A. Litvinova
Summary: This study found that Muc2(-/-) mice harboring a gut protozoan infection Tritrichomonas sp. are susceptible to antibiotic-induced depletion of bacterial microbiota. Effective suppression of the protozoan infection with metronidazole or L-fucose administration can ameliorate illnesses observed in antibiotic-treated Muc2(-/-) mice. Further investigation of the role of fucose in protozoan adhesion to host cells may be valuable.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)