Article
Biochemistry & Molecular Biology
Simona Mattioli, Elisa Angelucci, Alessandro Dal Bosco, Cinzia Signorini, Lakamy Sylla, Luigia Bosa, Giulia Collodel, Thierry Durand, Jean-Marie Galano, Camille Oger, Cesare Castellini
Summary: Dietary factors can affect sperm traits, and diets rich in pro-oxidant and pro-atherogenic substances may lead to a decline in sperm kinetics and viability.
Article
Marine & Freshwater Biology
Gilles Tinant, Melusine Van Larebekea, Benjamin Lemaire, Marine Courteille, Cecile Gardin, Ineke Neefs, Krishna Das, Melissa M. Page, Jean-Francois Rees, Yvan Larondelle, Cathy Debier
Summary: This study investigated the impacts of dietary MeHg and fatty acids on lipid metabolism in rainbow trout. The results showed that a diet enriched in linoleic acid (LA) increased the overall lipid content, while the addition of MeHg significantly reduced the lipid content. The size of adipocytes was influenced by both LA and MeHg. The fatty acid composition of adipose tissue and liver was significantly altered by the dietary fatty acids. Exposure to MeHg led to a release of n-6 PUFA from the hepatic membranes. This study highlights the important impact of MeHg exposure and dietary fatty acids on lipid metabolism in fish.
AQUATIC TOXICOLOGY
(2023)
Article
Nutrition & Dietetics
Masayuki Okuda, Aya Fujiwara, Satoshi Sasaki
Summary: The study found that in Japanese youths, high intake of omega-6 polyunsaturated fatty acids was associated with low levels of low-density-lipoprotein cholesterol, while high intake of saturated fatty acids was associated with high levels of gamma-glutamyl transpeptidase, indicating a close relationship between dietary fatty acid composition and cardiometabolic risk.
Article
Nutrition & Dietetics
Mohsen Mazidi, Andre P. Kengne, Mario Siervo, Richard Kirwan
Summary: The study suggests that higher dietary intake of polyunsaturated fatty acids (PUFAs) is associated with improved renal function and lower risk of chronic kidney disease (CKD), while there is no significant association between monounsaturated fatty acids (MUFAs) intake and renal function or CKD risk. Genetically determined serum levels of PUFAs and MUFAs also do not show significant association with renal function and CKD risk.
Article
Biochemistry & Molecular Biology
Zhiming Hu, Liangcheng Jiao, Xiaoman Xie, Li Xu, Jinyong Yan, Min Yang, Yunjun Yan
Summary: The search and characterization of new lipases with excellent properties are urgently needed to meet industrial needs. In this study, a new lipase, lipB, from Pseudomonas fluorescens SBW25, was cloned and expressed in Bacillus subtilis WB800N. The recombinant LipB exhibited high activity towards p-nitrophenyl caprylate, showed stability at high temperature and pH, and had noticeable tolerance to organic solvents. Moreover, LipB was able to enrich polyunsaturated fatty acids from fish oil, making it a potential candidate for industrial applications, especially in health food production.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Nutrition & Dietetics
Aowen Tian, Zewen Sun, Miaoran Zhang, Jiuling Li, Xingchen Pan, Peng Chen
Summary: This study aimed to investigate the relationship between dietary fatty acid composition and non-alcoholic fatty liver disease (NAFLD) in populations with typical diets. It found that a PUFA enriched vegetarian dietary pattern was negatively associated with NAFLD risk, while a PUFA enriched carnivore dietary pattern was not associated with NAFLD risk. The mediation analysis indicated that specific fatty acids had a significant indirect effect on the association between dietary patterns and NAFLD.
FRONTIERS IN NUTRITION
(2023)
Article
Oncology
Iman Moussa, Rena S. Day, Ruosha Li, Ahmed Kaseb, Prasun K. Jalal, Carrie Daniel-MacDougall, Rikita I. Hatia, Ahmed Abdelhakeem, Asif Rashid, Yun Shin Chun, Donghui Li, Manal M. Hassan
Summary: This study found an inverse association between monounsaturated fatty acid intake and hepatocellular carcinoma (HCC) risk, and a direct association between total polyunsaturated fatty acid intake and HCC risk. Omega-6 PUFA intake was directly associated with HCC risk, while long-chain omega-3 PUFA intake was inversely associated with HCC risk. No significant association was observed for saturated fat and HCC risk.
Article
Food Science & Technology
Ligang Yang, Chao Yang, Zhixiu Song, Min Wan, Hui Xia, Xian Yang, Dengfeng Xu, Da Pan, Hechun Liu, Shaokang Wang, Guiju Sun
Summary: Postprandial metabolism plays significant roles in various pathological conditions, and the n-6/n-3 polyunsaturated fatty acid ratio is closely associated with physiological disorders. This study investigated the effects of high fat meals with different n-6/n-3 PUFA ratios on postprandial metabolism in normal control and hypertriglyceridemia rats. The results showed that the n-6/n-3 PUFA ratio influenced the postprandial response of triglyceride, total cholesterol, tumor necrosis factor alpha, malondialdehyde, and reactive oxygen species in both normal control and hypertriglyceridemia rats.
FOOD SCIENCE AND HUMAN WELLNESS
(2023)
Review
Nutrition & Dietetics
Karla MacDonald-Ramos, Alejandra Martinez-Ibarra, Adriana Monroy, Juan Miranda-Rios, Marco Cerbon
Summary: Dietary fatty acids play crucial roles in metabolic diseases and inflammation, with diverse effects on miRNA expression. Recent studies have shown that high fat ketogenic diets do not increase saturated fat content in the serum and are not associated with increased inflammation. Further research is needed to explore the complex interactions and potential therapeutic applications of DFAs.
Article
Ecology
Francine Mathieu, Fen Guo, Martin J. Kainz
Summary: This study in a lake found that the variation of fatty acids (FA) in zooplankton's membrane (phospholipids; PL) and storage (triacylglycerols; TAG) lipids is mainly influenced by dietary FA, temperature, and physico-chemical variables. Dietary FA is a major predictor of FA in TAG, while the taxonomic composition of zooplankton is a major predictor of FA in PL. Temperature and physico-chemical variables have little impact on the variations in zooplankton FA.
FRESHWATER BIOLOGY
(2022)
Article
Microbiology
Kitty Reemst, Sebastian Tims, Kit-Yi Yam, Mona Mischke, Jan Knol, Stanley Brul, Lidewij Schipper, Aniko Korosi
Summary: Early-life stress and dietary polyunsaturated fatty acids have an impact on the gut microbiota, which is related to cognitive, metabolic, and fatty acid profiles.
Article
Nutrition & Dietetics
Domenico Sergi, Juana Maria Sanz, Stefano Lazzer, Gloria Brombo, Giovanni Zuliani, Gianni Biolo, Bostjan Simunic, Rado Pisot, Edoardo Dalla Nora, Angelina Passaro
Summary: Dietary lipids play a crucial role in modulating metabolic inflammation, and interleukin 18 (IL-18) has been consistently linked to obesity and insulin resistance. This study aimed to assess if the quality of lipid intake affects IL-18 plasma levels and its implications on insulin resistance. The study confirmed that IL-18 is positively correlated with insulin resistance, and individuals with higher HOMA-IR levels displayed elevated IL-18 levels. The quality of dietary lipids, particularly the ratio between different fatty acids and the intake of omega-3, showed a negative correlation with IL-18 levels.
Review
Nutrition & Dietetics
Camila Farias, Camila Cisternas, Juan Cristobal Gana, Gigliola Alberti, Francisca Echeverria, Luis A. Videla, Lorena Mercado, Yasna Munoz, Rodrigo Valenzuela
Summary: Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in pediatrics, and children and adolescents with obesity are at increased risk of the disease. Currently, there is no effective drug therapy in pediatrics, making lifestyle interventions the primary treatment option.
Article
Multidisciplinary Sciences
Li Li, Zuxian Xu, Ruipin Cao, Jiaxin Li, Chang-Jer Wu, Yinglu Wang, Hu Zhu
Summary: We investigated the influence of hydroxyl groups on the anti-quorum-sensing (anti-QS) and anti-biofilm activity of cyclic dipeptides against Pseudomonas aeruginosa PAO1. The presence of hydroxyl groups improved the inhibition of virulence factors and cytotoxicity, but reduced the ability to inhibit biofilm formation. These cyclic dipeptides interacted with the QS-related protein LasR, and the introduction of hydroxyl groups enhanced their self-assembly ability.
Article
Nutrition & Dietetics
Walter Currenti, Justyna Godos, Amer M. Alanazi, Giuseppe Lanza, Raffaele Ferri, Filippo Caraci, Giuseppe Grosso, Fabio Galvano, Sabrina Castellano
Summary: The increase in life expectancy has led to a higher prevalence of age-related neurological diseases, such as cognitive impairment, dementia, and Alzheimer's disease. This study aimed to examine the association between specific categories and subcategories of dietary fats and cognitive status in older Italian adults. The results showed that moderate consumption of certain types of saturated fatty acids and monounsaturated fatty acids was associated with a lower risk of cognitive impairment, while moderate intake of linoleic acid was associated with a higher risk of cognitive impairment.
Article
Nutrition & Dietetics
Jules Morcel, Laurent Beghin, Nathalie Michels, Jeremy Vanhelst, Julien Labreuche, Elodie Drumez, Angela Polito, Marika Ferrari, Laura Censi, Dominique Deplanque, Maria Luisa Miguel-Berges, Thais De Ruyter, Stefaan De Henauw, Luis A. Moreno, Frederic Gottrand
Summary: Cardiovascular diseases are the leading cause of death worldwide. The BELINDA study aims to evaluate cardiovascular risk and its association with risk factors during adolescence. By following up on the HELENA study, this research collects comprehensive clinical and biological data, and identifies differences in BMI and maternal education level among the participating population.
Article
Pediatrics
Agate Bourg, Frederic Gottrand, Benoit Parmentier, Julie Thomas, Anne Lehn, Christian Piolat, Arnaud Bonnard, Rony Sfeir, Julie Lienard, Veronique Rousseau, Myriam Pouzac, Agnes Liard, Philippe Buisson, Aurore Haffreingue, Louis David, Sophie Branchereau, Veronique Carcauzon, Nicolas Kalfa, Marc -David Leclair, Hubert Lardy, Sabine Irtan, Francois Varlet, Thomas Gelas, Diana Potop, Marie Auger-Hunault
Summary: This study evaluated the outcomes of long gap esophageal atresia (EA) compared to non-long gap EA/tracheo-esophageal fistula (TEF) at the ages of 1 and 6 years. The study also assessed whether the initial treatment (delayed primary anastomosis of native esophagus vs. esophageal replacement) influenced mortality and morbidity at these ages. The results showed that the long gap EA group had more complications and longer hospital stay at age 1 year, and digestive complications were more frequent in the long gap group at age 6 years. The study concluded that long gap strongly influenced digestive morbidity at age 6 years.
JOURNAL OF PEDIATRIC SURGERY
(2023)
Article
Infectious Diseases
Matthaios Papadimitriou-Olivgeris, Damien Jacot, Laurence Senn, Benoit Guery
Summary: This retrospective study compared patients with Staphylococcus aureus bacteraemia (SABA) with or without concomitant bacteriuria (SABU) at Lausanne University Hospital from 2015 to 2021. Out of 448 included bacteraemic patients, 62 (13.8%) had concurrent S. aureus isolated from urine. The study found significant differences in community-onset bacteraemia, malignancy, > 1 pair of positive blood cultures, and persistent bacteraemia for at least 48 h in patients with concurrent SABU. However, there was no difference in mortality. SABU was associated with higher rates of SABA recurrence after antibiotic cessation.
EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES
(2023)
Article
Infectious Diseases
Matthaios Papadimitriou-Olivgeris, Giorgia Caruana, Laurence Senn, Benoit Guery
Summary: This study aimed to identify predictors of mortality among patients with S. aureus bacteremia and evaluate the role of early source control. The results showed that high mortality was associated with factors such as Charlson comorbidity index > 5, nosocomial bacteremia, time to blood culture positivity <= 13 h, persistent bacteremia for >= 48 h, sepsis, bacteremia of unknown origin, and lower respiratory tract infection. Infectious diseases consultation within 48 h was associated with better survival. Early source control was also found to be associated with better survival.
EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES
(2023)
Article
Immunology
Matthaios Papadimitriou-Olivgeris, Benoit Guery, Nicoleta Ianculescu, Vincent Dunet, Yosra Messaoudi, Silvia Pistocchi, Piergiorgio Tozzi, Matthias Kirsch, Pierre Monney
Summary: Cerebral imaging did not significantly change patient classification according to Duke criteria among those suspected of infective endocarditis. However, it did lead to the establishment of a new surgical indication for preventing embolic events in 20% of patients.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Infectious Diseases
Elisavet Stavropoulou, Benoit Guery, Nicoleta Ianculescu, Piergiorgio Tozzi, Matthias Kirsch, Pierre Monney, Matthaios Papadimitriou-Olivgeris
Summary: This study evaluated the role of defervescence within 4 days from antibiotic treatment initiation in ruling out suspected infective endocarditis (IE). The results showed that defervescence within 4 days cannot rule out the diagnosis of IE.
CLINICAL MICROBIOLOGY AND INFECTION
(2023)
Article
Pharmacology & Pharmacy
Adele Rakotonirina, Tatiana Galperine, Maxime Audry, Marie Kroemer, Aurelie Baliff, Laurent Carrez, Farshid Sadeghipour, Jacques Schrenzel, Benoit Guery, Eric Allemann
Summary: Clostridioides difficile infection (CDI) is a severe nosocomial infection with a high mortality rate. Although antibiotic treatment is the standard of care, the relapse rate is high and less effective against recurrent infection. Fecal microbiota transplantation (FMT) is a recommended treatment with a high efficacy. The formulation of diluted donor stool needs innovation, and the administration routes should be optimized.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Nutrition & Dietetics
Lucie Marousez, Lea Chantal Tran, Edwina Micours, Matthieu Antoine, Frederic Gottrand, Jean Lesage, Delphine Ley
Summary: Inadequate perinatal nutrition can affect the maturity of the intestinal barrier and the development of the intestinal microbiota in mice. Supplementing with prebiotic fiber appears to improve gut microbiota establishment in postnatal-growth-restricted mice and can lead to changes in intestinal morphology and microbial composition.
Review
Gastroenterology & Hepatology
Paolo Lionetti, Eytan Wine, Rinat Ran Ressler, Gerard J. Minor, Giles Major, Boutaina Zemrani, Frederic Gottrand, Claudio Romano
Summary: Children who require enteral nutrition often experience gastrointestinal symptoms. Fiber-containing enteral formulas can improve bowel function, promote healthy gut microbiota growth, and improve immune homeostasis. However, there is a lack of guidance in clinical practice.
EXPERT REVIEW OF GASTROENTEROLOGY & HEPATOLOGY
(2023)
Article
Medicine, General & Internal
Laurence Bamps, Jean-Philippe Armenti, Mirela Bojan, Bruno Grandbastien, Christophe von Garnier, Renaud Du Pasquier, Florian Desgranges, Matthaios Papadimitriou-Olivgeris, Lorenzo Alberio, Martin Preisig, Jurg Schwitter, Benoit Guery
Summary: This study collected health complaints from 474 patients one year after COVID-19 diagnosis and found that age, comorbidity index, and smoking habits were associated with hospital admission. Patients with a history of thromboembolism before SARS-CoV-2 infection had a higher risk of recurrence of thromboembolism at 1 year. Fatigue was the most common neurologic symptom, followed by feeling slowed down, headache, and smell disturbance. COVID-19 patients scored higher in anxiety, depression, fatigue, and sleep measures compared to the healthy population.
JOURNAL OF CLINICAL MEDICINE
(2023)
Editorial Material
Infectious Diseases
Judith Strawbridge, John Heritage, Marcela Krutova, Benoit Guery, Kerrie Davies, Fidelma Fitzpatrick, Jane Freeman
CLINICAL MICROBIOLOGY AND INFECTION
(2023)
Article
Medicine, General & Internal
Miguel Seral-Cortes, Sergio Sabroso-Lasa, Marcela Gonzalez-Gross, Carlos Quesada-Gonzalez, Peter Stehle, Frederic Gottrand, Ascension Marcos, Ligia Esperanza-Diaz, Yannis Manios, Odysseas Androutsos, Kurt Widhalm, Denes Molnar, Inge Huybrechts, Manon Muntaner, Aline Meirhaeghe, Diego R. Salazar-Tortosa, Jonatan Ruiz, Luis Mariano Esteban, Idoia A. Labayen, Luis Moreno, HELENA Study Grp
Summary: The study aimed to develop an ALT-specific genetic risk score to evaluate hepatic damage risk in European adolescents. The unweighted and weighted genetic risk scores were found to be significantly associated with ALT levels, and the predictive ability was further improved by integrating BMI as a clinical factor.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2023)
Article
Infectious Diseases
Matthaios Papadimitriou-Olivgeris, Benoit Guery, Nicoleta Ianculescu, Denise Auberson, Piergiorgio Tozzi, Matthias Kirsch, Pierre Monney
Summary: The purpose of this study was to identify risk factors for the occurrence of embolic events (EEs) before or after antibiotic treatment among patients with infective endocarditis (IE). The results showed that vegetation size, intracardiac abscess, S. aureus, and sepsis were independently associated with the occurrence of EEs in patients with left-side IE. In addition, early surgery led to a further decrease in EEs incidence.
Letter
Gastroenterology & Hepatology
Marcela Krutova, Kerrie Davis, Benoit Guery, Frederic Barbut
LANCET GASTROENTEROLOGY & HEPATOLOGY
(2023)
Article
Multidisciplinary Sciences
Florine Ruthmann, Nadia Guerouaou, Francis Vasseur, Maria-Claire Migaud, Dominique Deplanque, Frederic Gottrand, Laurent Beghin, Odile Viltart
Summary: Recent studies have found associations between emotional disorders, cognitive impairments, and cardiovascular disorders at the subclinical level. This exploratory study aimed to investigate these relationships in the general population. The results suggest that anxiety and depression are differentially related to cognitive and endothelial functions, but the relationship between cognitive performance and endothelial function was not significant.