Article
Cardiac & Cardiovascular Systems
Victoria Vaughan Dickson, Shayleigh Dickson Page
Summary: Mixed methods is an innovative research approach that combines quantitative and qualitative data to better understand complex cardiovascular phenomena. Careful planning and attention to methodological rigour are required in the data collection, analysis, and integration phases of conducting a mixed methods study.
EUROPEAN JOURNAL OF CARDIOVASCULAR NURSING
(2021)
Article
Cardiac & Cardiovascular Systems
Xavier Rossello, Maribel Gonzalez-Del-Hoyo
Summary: This article is the second part of an educational series on survival analysis. It introduces stratified Cox models and frailty models, as well as the issue of immortal time bias. The article also provides strategies to address the problem of multiple outcomes in time-to-event data analyses.
REVISTA ESPANOLA DE CARDIOLOGIA
(2022)
Review
Cell Biology
Haihuan Shan, Teng Fei
Summary: The recent advent and widespread application of CRISPR-based genome editing tools have revolutionized biomedical research and beyond. CRISPR screening, with its high perturbation efficiency and scalability, is regarded as one of the most powerful technologies in functional genomics. This mini-review discusses the implementation of CRISPR screening in cardiovascular research and related metabolic disorders, highlighting scientific progress and envisioning future applications in these fields.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Review
Urology & Nephrology
Pippa K. Bailey, Barnaby D. Hole, Lucy A. Plumb, Fergus J. Caskey
Summary: Mixed-methods research combines qualitative and quantitative methods to complement each other, providing a more comprehensive understanding of research problems. It can be used to explain initial results, generate instruments, evaluate services, optimize clinical trial design, and more.
KIDNEY INTERNATIONAL
(2022)
Review
Cell Biology
Yinan Chen, Yang Liu, Xiang Gao
Summary: Cardiovascular diseases are the leading cause of deaths worldwide, and single-cell omics technologies have been increasingly important in aiding our understanding of cardiovascular biology.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Chemistry, Analytical
Beibei Hu, Lanying Li, Danya Zhao, Yongshuai Jing, Zhongqiu Li, Shiguo Sun
Summary: Cardiovascular disease is a major cause of global deaths, and developing accurate and rapid detection methods is crucial. Electrochemical biosensors are considered ideal tools for monitoring the onset and progression of cardiovascular diseases.
MICROCHEMICAL JOURNAL
(2023)
Article
Hospitality, Leisure, Sport & Tourism
Babak Taheri, Fevzi Okumus
Summary: This paper offers a synopsis and guidelines on the application of mixed methods (MM) research design within the hospitality and tourism domain. It provides explanations, guidelines, and examples of MM research design in the field.
INTERNATIONAL JOURNAL OF CONTEMPORARY HOSPITALITY MANAGEMENT
(2023)
Article
Biochemical Research Methods
Yuanyuan Li
Summary: Epigenetics refers to molecular modifications on DNA that regulate gene activity independent of DNA sequence, with DNA methylation, histone modifications, and non-coding RNAs being the most recognized regulations. Recent advances in the field require thorough methodologies and advanced technologies to push epigenetics to the forefront of molecular biology.
Review
Clinical Neurology
Magda Bucholc, Charlotte James, Ahmad Al Khleifat, AmanPreet Badhwar, Natasha Clarke, Amir Dehsarvi, Christopher R. Madan, Sarah J. Marzi, Cameron Shand, Brian M. Schilder, Stefano Tamburin, Hanz M. Tantiangco, Ilianna Lourida, David J. Llewellyn, Janice M. Ranson
Summary: Artificial intelligence and machine learning face methodological challenges in dementia research, including analyzing high-dimensional data and translating research findings. To overcome these challenges, researchers should share code and data, develop models using interpretable methods, and prioritize reproducibility and generalizability.
ALZHEIMERS & DEMENTIA
(2023)
Review
Cardiac & Cardiovascular Systems
Laurel Y. Lee, Arvind K. Pandey, Bradley A. Maron, Joseph Loscalzo
Summary: Network medicine views diseases as consequences of perturbed interactions between multiple interconnected biological components, and plays a crucial role in studying complex disease mechanisms. It has the potential to accelerate cardiovascular disease research and advance precision medicine.
CARDIOVASCULAR RESEARCH
(2021)
Review
Cardiac & Cardiovascular Systems
Laurel Y. Lee, Arvind K. Pandey, Bradley A. Maron, Joseph Loscalzo
Summary: Network medicine views diseases as the consequences of perturbed interactions between multiple interconnected biological components, facilitating a deeper understanding of complex disease mechanisms. The limitations associated with traditional reductionist analytical methods are apparent, whereas the concept of network medicine provides a new approach to advancing cardiovascular disease research.
CARDIOVASCULAR RESEARCH
(2021)
Review
Chemistry, Inorganic & Nuclear
Anling Li, Guangfei Wang, Yong Zhang, Jiaqi Zhang, Wenjie He, Shuaiyang Ren, Zehua Xu, Jiwen Wang, Yongwei Ma
Summary: This paper presents the preparation methods and applications of superhydrophobic paper inspired by natural organisms, emphasizing the need for a green, efficient, and simple preparation method with excellent comprehensive properties. It also describes the properties and application fields of superhydrophobic paper prepared by various methods, and provides a prospect for future development.
COORDINATION CHEMISTRY REVIEWS
(2021)
Review
Biochemistry & Molecular Biology
Leena Patel, Joshua C. Worch, Andrew P. Dove, Katja Gehmlich
Summary: The behavior and morphology of cardiac fibroblasts (FBs) and cardiomyocytes (CMs) are influenced by their environment, highlighting the importance of biomaterial substrates in cell culture. Biomaterial hydrogels, such as hyaluronic acid, polydimethylsiloxane, and polyethylene glycol, have been used to culture induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) and provide a more physiological model of the cardiac extracellular matrix. Natural hydrogels show higher biocompatibility with iPSC-CMs but degrade quicker, while synthetic hydrogels can be modified to facilitate cell attachment and decrease degradation rates. Hydrogels have been extensively utilized in the cardiac field to recapitulate disease conditions, encourage alignment of iPSC-CMs, and facilitate further model development.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Nutrition & Dietetics
Ambria Crusan, Kerrie Roozen, Clara Godoy-Henderson, Kathy Zamarripa, Anayeli Remache
Summary: This research aims to understand the cultural dietary practices aligned with a DASH eating plan and the social determinants of health impacting fruit and vegetable consumption among immigrant Hispanic/Latine individuals. The study found that barriers to consuming fruits and vegetables among this population include financial constraints, limited time, and lack of transportation.
Article
Computer Science, Information Systems
Robert M. Davison, Maris G. Martinsons, Julien Malaurent
Summary: This article reviews the literature on action research within the information systems discipline, identifies 16 different methods, and proposes integrating their strengths to improve the canonical action research method. The principles and criteria for canonical action research are modified and expanded to enhance the consistency of undertaking action research, leading to a new method called integrated action research. The potential applications of integrated action research, particularly in investigating disruptive technologies such as artificial intelligence, are discussed.
JOURNAL OF THE ASSOCIATION FOR INFORMATION SYSTEMS
(2021)
Article
Nursing
Elizabeth Bichard, Jo Wray, Leanne M. Aitken
Summary: This study found that anxiety levels among teenagers discharged from PICU varied at 48-96 hours and 4 weeks post-discharge. Teenagers' experiences on PICU were mainly focused on memories of treatments, side effects, the environment, losing a sense of self, and feeling cared for.
NURSING IN CRITICAL CARE
(2022)
Review
Cardiac & Cardiovascular Systems
Julie Sanders, Nicole Makariou, Adam Tocock, Rosalie Magboo, Ashley Thomas, Leanne M. Aitken
Summary: This study aimed to identify and explore existing preoperative risk assessment tools for morbidity after cardiac surgery. 22 models were found, and despite methodological heterogeneity, all models demonstrated at least reasonable discriminatory power and could be implemented depending on local preferences. Future strategies should consider the aging population and patients with minor and/or multiple complex morbidities.
EUROPEAN JOURNAL OF CARDIOVASCULAR NURSING
(2022)
Review
Nursing
Sasithorn Mukpradab, Marion Mitchell, Andrea P. Marshall
Summary: This integrative review examines the literature on interprofessional team approaches to early mobilisation in critically ill adult patients. It synthesizes the findings and identifies strategies and clinical interventions to support the implementation of early mobilisation. Key factors that can affect the implementation process are also discussed.
INTERNATIONAL JOURNAL OF NURSING STUDIES
(2022)
Review
Nutrition & Dietetics
Gemma C. E. Lyons, Matthew J. Summers, Andrea P. Marshall, Lee-anne S. Chapple
Summary: Nutrition is crucial for critically ill patients, but delivery falls short of international recommendations. Clinicians' knowledge, attitudes, and beliefs may hinder nutrition delivery, highlighting the importance of improving understanding around nutrition support in critical care.
NUTRITION IN CLINICAL PRACTICE
(2022)
Article
Dermatology
Zhaoyu Li, Andrea P. Marshall, Frances Lin, Yanming Ding, Wendy Chaboyer
Summary: This study aimed to describe and compare pressure injury prevention strategies used by medical and surgical nurses in China. Observations and chart audits revealed that repositioning was the most frequently used prevention strategy, but other strategies such as skin care, nutritional risk screening, and support surface use were suboptimal. Improvement is needed in various prevention strategies such as nutrition, skin care, and support surfaces.
INTERNATIONAL WOUND JOURNAL
(2022)
Article
Critical Care Medicine
Elizabeth Wake, Kerin Walters, James Winearls, Andrea P. Marshall
Summary: The study evaluated the implementation data of a new practice, specifically the use of Point of Care ROTEM blood test for trauma patients. The findings showed an increase in the number of patients undergoing the test over time, with higher rates for major trauma patients admitted to the Intensive Care Unit. The presence of trauma services and sustainability phase of implementation were factors associated with increased test utilization. The study highlights the importance of careful planning, input from end-users, and continuous evaluation for effective implementation and sustainability.
AUSTRALIAN CRITICAL CARE
(2023)
Review
Nursing
Tracey Bowden, Catherine S. Hurt, Julie Sanders, Leanne M. Aitken
Summary: The study aimed to examine the effectiveness of cognitive interventions after general anesthesia to improve cognitive functioning. The results showed that cognitive interventions demonstrated some efficacy in improving cognitive function, particularly in memory. These findings suggest that implementing cognitive interventions in clinical practice could be promising for improving patient outcomes.
JOURNAL OF CLINICAL NURSING
(2023)
Review
Nursing
Georgia Tobiano, Shelley Roberts, Rachel Muir, Teresa Jerofke-Owen, Christine Ting, Sarah Thorning, Daren K. K. Heyland, Andrea P. P. Marshall
Summary: This study systematically describes hospital-based patient-mediated interventions and their impact on patient, clinician, and organization outcomes. The findings suggest that these interventions may influence patient communication and healthcare professional behavior. Further research is needed to explore the effectiveness and suitability of a wider range of hospital-based patient-mediated interventions.
JOURNAL OF ADVANCED NURSING
(2023)
Article
Nursing
Andrea P. Marshall, Lauren J. Van Scoy, Wendy Chaboyer, Mary Chew, Judy Davidson, Andrew G. Day, Angelly Martinez, Jayshil Patel, Shelley Roberts, Yoanna Skrobik, Beth Taylor, Georgia Tobiano, Daren K. Heyland
Summary: The aim of this study was to investigate the effect of family members partnering with health professionals on nutrition intakes and decision-making. However, the interventions did not demonstrate efficacy and further refinement of interventions and study protocol may be needed.
JOURNAL OF CLINICAL NURSING
(2023)
Article
Nursing
Sasithorn Mukpradab, Julie Cussen, Kristen Ranse, Praneed Songwathana, Andrea P. Marshall
Summary: The study aimed to explore healthcare professionals' perspectives on the feasibility and acceptability of family engagement in early mobilisation for adult critically ill patients.The results indicated that the healthcare professionals generally considered family engagement in early mobilisation to be feasible and acceptable. However, implementation is influenced by factors such as healthcare professionals' capability and capacity, and family members' willingness, availability, and readiness, as well as the healthcare context. Therefore, collaborative teamwork and preparation of family members and healthcare professionals are needed to support this practice.
JOURNAL OF CLINICAL NURSING
(2023)
Article
Critical Care Medicine
Marc R. Nickels, Robin Blythe, Nicole White, Azmat Ali, Leanne M. Aitken, Daren K. Heyland, Steven M. McPhail
Summary: The purpose of this study was to help clinicians identify critically ill patients at greater risk of acute muscle loss and analyze the associations between protein intake and exercise on acute muscle loss. The results showed that patients with higher mNUTRIC scores experienced greater muscle loss, but there was no significant relationship between in-bed cycling, protein intake, and muscle loss.
AUSTRALIAN CRITICAL CARE
(2023)
Editorial Material
Critical Care Medicine
Dunca Smith, Leanne M. Aitken
AUSTRALIAN CRITICAL CARE
(2023)
Review
Nursing
Julie Cussen, Sasithorn Mukpradab, Georgia Tobiano, Christopher Cooke, Joshua Pearcy, Andrea P. Marshall
Summary: This scoping review investigated early mobility interventions for critically ill patients and the extent to which family engagement in those interventions are reported in the literature. The findings suggest that while there are a range of early mobility interventions available, few involve families. There is a need to explore the feasibility and acceptability of family participation in early mobility interventions.
NURSING IN CRITICAL CARE
(2023)
Article
Critical Care Medicine
Zudin Puthucheary, Craig Brown, Evelyn Corner, Sarah Wallace, Julie Highfield, Danielle Bear, Nirandeep Rehill, Hugh Montgomery, Leanne Aitken, Lynne Turner-Stokes
Summary: The study demonstrated the feasibility of using the PICUPS tool as a screening mechanism for post-intensive care syndrome, with results showing no differences in rehabilitation needs between COVID-19 and non-COVID-19 patients. The RP could serve as a tool to drive professional interventions, emphasizing the personalized rehabilitation needs of critical illness survivors.
JOURNAL OF THE INTENSIVE CARE SOCIETY
(2022)
Article
Critical Care Medicine
Lynne Turner-Stokes, Evelyn J. Corner, Richard J. Siegert, Craig Brown, Sarah Wallace, Julie Highfield, Danielle Bear, Leanne M. Aitken, Hugh Montgomery, Zudin Puthucheary
Summary: This study describes the development of a tool for post-ICU rehabilitation and a person-centered rehabilitation prescription to guide therapy needs. The results of clinimetric analysis show that the tool has robust scaling properties and is useful for identifying patients' rehabilitation needs as they progress in their recovery journey.
JOURNAL OF THE INTENSIVE CARE SOCIETY
(2022)
