Article
Pharmacology & Pharmacy
Takeshi Suginohara, Megumi Kawaguchi, Seiwa Michihara, Nina Fujita, Li-Kun Han, Ryuji Takahashi
Summary: Ninjin'yoeito (NYT), a traditional Japanese medicine, may have therapeutic effects on symptoms, muscle atrophy, and increase in plasma IL-6 level caused by rheumatoid arthritis. It can inhibit the increases in arthritis scores, reduce pain threshold, and prevent muscle atrophy in the Collagen-induced arthritis (CIA) model.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Chemistry, Physical
Jing Zhong, Qin Zhang, Zheng Zhang, Kexin Shi, Yuanchen Sun, Teng Liu, Jun Lin, Kai Yang
Summary: The study introduces a drug-induced self-assembly strategy for treating rheumatoid arthritis, demonstrating the therapeutic efficacy of HSA-SOD-MTX nanoparticles in a mouse model through the synergistic action of SOD enzyme and MTX drug.
Article
Pharmacology & Pharmacy
Maroua Ferhat, Katia Mangano, Irina Mirkina, Julia Mayer, Gregor Rossmueller, Alexander Schinagl, Randolf Kerschbaumer, Ferdinando Nicoletti, Michael Thiele, Christine Landlinger
Summary: This study demonstrates the presence of circulating oxidized MIF (oxMIF) in rheumatoid arthritis (RA) patients and investigates the in vivo effects of an oxMIF-neutralizing antibody, ON104, in a murine model of RA. The results show that ON104 treatment profoundly modulates disease progression, improving clinical symptoms and reducing joint damage and macrophage infiltration. ON104 may represent a new and promising treatment option for RA and other autoimmune diseases.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Fathihah Basri, Sundo Jung, Se Hoon Park, Se-Ho Park
Summary: In the study of collagen-induced arthritis, it was discovered that the tolerogenicity of pM Phi is conferred by iNKT cells during pM Phi development, rather than by interactions of pM Phi with iNKT cells during antigen presentation to cognate T cells.
Article
Immunology
Hao Yuan, Si-Xian Wu, Yi-Feng Zhou, Fang Peng
Summary: The study demonstrates that SPD can protect CIA mice by inhibiting the polarization of M1 macrophages, reducing pro-inflammatory cytokines, and promoting the release of anti-inflammatory factors.
JOURNAL OF INFLAMMATION RESEARCH
(2021)
Article
Biotechnology & Applied Microbiology
Lyubomir Marinov, Iliya Mangarov, Irina Nikolova
Summary: In this pilot study, male mice were significantly more susceptible to developing collagen-induced arthritis compared to females. The severity of inflammation was assessed using visual scales and locomotor activity.
BIOTECHNOLOGY & BIOTECHNOLOGICAL EQUIPMENT
(2021)
Article
Pathology
G. Mendez-Frausto, E. E. Uresti-Rivera, S. Godina-Gonzalez, D. P. Portales-Perez, R. Gonzalez-Amaro, M. H. Garcia-Hernandez
Summary: This study aimed to analyze the expression of CRAMP, mBD-3, mBD-4, and MMP-3 in different phases of CIA in mice and their association with IL-10, IL-4, IFN-gamma, IL-17, RANK/RANKL/OPG. The results suggest that CRAMP plays a crucial role in CIA progression and may contribute to bone reconstruction in the late stage of the disease. The study also revealed complex interactions between various molecules and cytokines in the pathogenesis of CIA.
EXPERIMENTAL AND MOLECULAR PATHOLOGY
(2021)
Review
Immunology
Tomoya Agemura, Tetsuo Hasegawa, Shinya Yari, Junichi Kikuta, Masaru Ishii
Summary: Osteoclasts play a crucial role in maintaining bone homeostasis, and pathological osteoclasts under inflamed conditions differ from physiological osteoclasts under a steady-state. We have identified a novel osteoclast precursor that induces inflammatory bone destruction.
INFLAMMATION AND REGENERATION
(2022)
Article
Immunology
Bettina Sehnert, Veronica Valero-Esquitino, Georg Schett, Thomas Unger, Ulrike Muscha Steckelings, Reinhard Edmund Voll
Summary: The selective non-peptide AT(2)R agonist Compound 21 (C21) has therapeutic potential in collagen-induced arthritis by promoting the expansion of CD4(+) regulatory T cells and suppressing IL-17A production.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Computer Science, Information Systems
Maria Filomena Santarelli, Anna Mori, Michelangelo Bertasi, Vincenzo Positano, Alessia Gimelli, Michele Scipioni, Paolo Marzullo, Luigi Landini
Summary: A comparison was made between a dedicated cardiac SPECT system and a general-purpose SPECT system, evaluating their hardware differences and image quality through specific indices. The dedicated cardiac SPECT system showed superior performance in cardiac imaging, but was only suitable for patients with a low body mass index; whereas the general-purpose system could be used for various anatomical regions and patient types.
Article
Psychiatry
Daniel G. Amen, Theodore A. Henderson, Andrew Newberg
Summary: Brain perfusion SPECT imaging can distinguish between ADHD patients and healthy controls, with specific brain regions showing potential as biomarkers to reliably differentiate ADHD.
FRONTIERS IN PSYCHIATRY
(2021)
Article
Immunology
Lei Wang, Pengfei Li, Yu Zhou, Renjun Gu, Ge Lu, Chunbing Zhang
Summary: This study investigated the effects of Magnoflorine (Mag) on rheumatoid arthritis (RA) and the underlying mechanism using mouse models. The results showed that Mag could reduce arthritis severity, joint destruction, and macrophage infiltration. Further analysis revealed that Mag exerted its anti-arthritic and anti-inflammatory effects by inhibiting the activation of NF-kappa B and MAPK signaling pathways.
JOURNAL OF INFLAMMATION RESEARCH
(2023)
Article
Immunology
Yu Tai, Yue Zhu, Dan Mei, Han Wang, Qianqian Yu, Chongyang Hong, Xiaoyu Cai, Li Xu, Jinru Ge, Faqin Liang, Chunru Jiang, Ziyang Xue, Ling Hu, Ruijin Liu, Tianjing Zhang, Pan Wang, Xianzheng Zhang, Feng Zhang, Wei Wei, Lingling Zhang
Summary: RA is characterized by joint inflammation, erosion, and cytokine production. IgD-Fc-Ig fusion protein inhibits these processes by blocking the IgD/ IgDR pathway. Through suppressing the Wnt5A-Fzd5-CTHRC1-NF-kappa B signaling pathway, it reduces angiogenesis and joint inflammation.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Immunology
Wen-Wei Lin, Kai-Wen Ho, Hsiang-Han Su, Tien-Fang Fang, Shey-Cherng Tzou, I-Ju Chen, Yun-Chi Lu, Mu-Shen Chang, Yun-Chen Tsai, En-Shuo Liu, Yu-Cheng Su, Yen-Tseng Wang, Tian-Lu Cheng, Hsin-Kai Huang
Summary: The study found that FGL1 protein could potentially alleviate rheumatoid arthritis by reducing inflammation and inhibiting disease progression. There were no apparent adverse events associated with exogenous FGL1 treatment in mice, indicating its safety for potential therapeutic use in autoimmune diseases.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Chemistry, Multidisciplinary
Ya-Qiong Yan, Hao Wang, Yuliang Zhao
Summary: Radionuclide imaging is a premier imaging method in clinical practice, utilizing PET and SPECT to detect anatomical abnormalities. Peptides as targeting vectors for contrast agents offer high specificity and low toxicity. Radiolabeled peptide probes have become essential tools for clinical radionuclide diagnosis.
CHINESE CHEMICAL LETTERS
(2022)
Correction
Biochemistry & Molecular Biology
Kourosh Ahmadzadeh, Marie Pereira, Margot Vanoppen, Eline Bernaerts, Jeong-Hun Ko, Tania Mitera, Christy Maksoudian, Bella B. Manshian, Stefaan Soenen, Carlos D. Rose, Patrick Matthys, Carine Wouters, Jacques Behmoaras
Article
Allergy
Mathijs Willemsen, John S. Barber, Erika Van Nieuwenhove, Frederik Staels, Margaux Gerbaux, Julika Neumann, Teresa Prezzemolo, Emanuela Pasciuto, Vasiliki Lagou, Nancy Boeckx, Jessica Filtjens, Amber De Visscher, Patrick Matthys, Rik Schrijvers, Thomas Tousseyn, Mark O'Driscoll, Giorgia Bucciol, Susan Schlenner, Isabelle Meyts, Stephanie Humblet-Baron, Adrian Liston
Summary: This study reported a patient with severe congenital neutropenia and syndromic features, and a homozygous missense mutation in the DBF4 gene was identified using whole exome sequencing. This mutation caused defects in granulocyte differentiation and DNA replication, resulting in impaired immune system function.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Thomas Ertveldt, Ahmet Krasniqi, Hannelore Ceuppens, Janik Puttemans, Yana Dekempeneer, Kevin De Jonghe, Wout de Mey, Quentin Lecocq, Yannick De Vlaeminck, Robin Maximilian Awad, Cleo Goyvaerts, Kim De Veirman, Alfred Morgenstern, Frank Bruchertseifer, Marleen Keyaerts, Nick Devoogdt, Matthias D'Huyvetter, Karine Breckpot
Summary: Targeted radionuclide therapy (TRT) using targeting moieties labeled with α-particle-emitting radionuclides (a-TRT) is an intensely investigated treatment approach. However, there is a lack of profound assessment of the immunomodulatory effect of a-TRT in literature.
JOURNAL OF NUCLEAR MEDICINE
(2023)
Letter
Medicine, General & Internal
Ellen De Langhe, Sien Van Loo, Bert Malengier-Devlies, Mieke Metzemaekers, Frederik Staels, Jessica Vandenhaute, Nathalie Berghen, Raf Sciot, Anniek Corveleyn, Olga Tsuiko, Mieke Gouwy, Jan Lenaerts, Patrick Verschueren, Carine H. Wouters, Paul Proost, Patrick Matthys, Eric Legius, Rik Schrijvers
Summary: The article reports a case of adult-onset inflammatory disease. It is revealed that two somatic genetic events are responsible for the disease and its onset in adulthood.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Article
Multidisciplinary Sciences
Maxime Nachit, Christopher Montemagno, Romain Clerc, Mitra Ahmadi, Francois Briand, Sandrine Bacot, Nick Devoogdt, Cindy Serdjebi, Catherine Ghezzi, Thierry Sulpice, Alexis Broisat, Isabelle A. Leclercq, Pascale Perret
Summary: In this study, researchers found that molecular imaging of VCAM-1 could be a non-invasive alternative to biopsy for detecting liver inflammation in chronic liver disease. By using radiolabeled anti-VCAM-1 nanobody and SPECT, they were able to quantify liver uptake and correlate it with histological inflammatory scores and molecular markers. The diagnostic power of this imaging tool to detect liver inflammation was excellent, suggesting its potential for clinical use.
NATURE COMMUNICATIONS
(2023)
Article
Pharmacology & Pharmacy
Cyprine Neba Funeh, Jessica Bridoux, Thomas Ertveldt, Timo W. M. De Groof, Dora Mugoli Chigoho, Parinaz Asiabi, Peter Covens, Matthias D'Huyvetter, Nick Devoogdt
Summary: The combination of specific targeting vectors with radionuclides for targeted radionuclide therapy (TRT) efficiently delivers cytotoxic radiation to cancer cells, proving its value in cancer care. TRT is increasingly seen as a relevant treatment method for micro-metastases in relapsed and disseminated disease. Antibody fragments and peptides are gaining interest as superior alternatives to antibodies for TRT. Rigorous considerations in design, analysis, evaluation, and translation are crucial for the development of novel radiopharmaceuticals to ensure safety and effectiveness.
Review
Immunology
Neema Ahishakiye Jumapili, Maida Zivalj, Romina Mora Barthelmess, Geert Raes, Timo W. M. De Groof, Nick Devoogdt, Benoit Stijlemans, Cecile Vincke, Jo A. Van Ginderachter
Summary: mAbs have limitations in their distribution and penetration in tumor microenvironment, as well as their ability to reach the brain. Nanobodies, being smaller in size, possess superior abilities in tumor penetration and infiltration into brain tumors. However, the rapid clearance of nanobodies from circulation may affect their suitability for therapy, although their noncovalent binding to albumin can help increase their serum half-life.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2023)
Review
Pharmacology & Pharmacy
Tessa De Pauw, Lynn De Mey, Jens M. Debacker, Geert Raes, Jo A. Van Ginderachter, Timo W. M. De Groof, Nick Devoogdt
Summary: Monoclonal antibodies have played a significant role in personalized medicine for cancer, but their size and complexity may hinder certain cancer diagnosis and therapy applications. Nanobodies, with their unique structure and pharmacological features, have shown promising potential as complementary tools for cancer diagnostics and therapeutics. This overview provides insights into nanobody-based diagnostics and therapeutics that have been tested in clinical trials and highlights upcoming preclinical developments.
EXPERT OPINION ON INVESTIGATIONAL DRUGS
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Odrade Gondry, Catarina Xavier, Laurens Raes, Johannes Heemskerk, Nick Devoogdt, Hendrik Everaert, Karine Breckpot, Quentin Lecocq, Lore Decoster, Christel Fontaine, Denis Schallier, Sandrine Aspeslagh, Ilse Vaneycken, Geert Raes, Jo A. Van Ginderachter, Tony Lahoutte, Vicky Caveliers, Marleen Keyaerts
Summary: Macrophages play a vital role in the body, and anti-inflammatory macrophages targeting CD206 are involved in various diseases. This study evaluated the safety and biodistribution of a PET tracer targeting CD206 in human subjects, and found that the tracer was safe, rapidly cleared from the blood, and enabled high contrast imaging at 90 minutes after injection. Preliminary results showed higher tumor uptake in patients with disease progression.
JOURNAL OF NUCLEAR MEDICINE
(2023)
Article
Chemistry, Physical
Matthijs Bart C. Sevenois, Brian WM. Miller, Holger Jan Jensen, Matthias D'Huyvetter, Peter Covens
Summary: The yield of At-211 is currently limited by the incident He2+-beam energy of the Bi-209(alpha,2n)At-211 reaction, which needs to be approximately 28 MeV to avoid co-production of At-210 and its daughter Po-210 through Bi-209(alpha,3n)At-210. However, using higher energies could significantly increase the yield of At-211, but also raises concerns regarding the production and handling of Po-210 and its toxicity.
RADIATION PHYSICS AND CHEMISTRY
(2023)
Article
Immunology
Luna Dillemans, Youri Bekhuis, Albrecht Betrains, Karen Yu, Maarten van Hemelen, Noemie Portner, Lien De Somer, Patrick Matthys, Jeroen Breckpot, Thomas Tousseyn, Marijke Peetermans, Paul Proost, Carine Wouters, Steven Vanderschueren
Summary: We report a fatal case of a 20-year-old woman with refractory adult-onset Still's disease accompanied by fulminant macrophage activation syndrome and atypical hemolytic uremic syndrome. This case highlights the importance of prompt genetic assessment of complement-encoding alleles, in addition to HLH-related genes, in patients with severe adult-onset Still's disease with recurrent macrophage activation syndrome and features of thrombotic microangiopathy.
CLINICAL IMMUNOLOGY
(2023)
Meeting Abstract
Oncology
Hatice Satilmis, Niels Vandewalle, Emma Verheye, Rong Fan, Elke De Bruyne, Eline Menu, Nick Devoogdt, Karin Vanderkerken, Karine Breckpot, Kim De Veirman
CLINICAL LYMPHOMA MYELOMA & LEUKEMIA
(2023)