Review
Biochemistry & Molecular Biology
Poul F. Hoilund-Carlsen, Reza Piri, Per Lav Madsen, Mona-Elisabeth Revheim, Thomas J. Werner, Abass Alavi, Oke Gerke, Michael Sturek
Summary: Arteriosclerosis is a common cause of death in diabetic patients, and its frequency is higher in diabetic patients compared to non-diabetic individuals. Previous studies mainly relied on indirect methods to observe the disease, but PET/CT imaging using specific tracers now allow early insights into arterial inflammation and microcalcification processes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Simon A. Castro, Daniele Muser, Hwan Lee, Emily C. Hancin, Austin J. Borja, Oswaldo Acosta, Thomas J. Werner, Anders Thomassen, Caius Constantinescu, Poul Flemming Hoilund-Carlsen, Abass Alavi
Summary: The study investigated the relationship between arterial mineralization in the left common carotid artery assessed by [F-18]fluoride PET/CT and cardiovascular/thromboembolic risk. Results showed that arterial [F-18]fluoride uptake was significantly increased in patients with unfavorable cardiovascular and thromboembolic risk profiles. Age, body mass index, arterial hypertension, and level of physical activity were identified as independent associations of arterial [F-18]fluoride uptake.
EUROPEAN RADIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Patimat Murtazalieva, Darya Ryzhkova, Eduard Malev, Ekaterina Zhiduleva, Olga Moiseeva
Summary: The study aimed to assess the prognostic value of valvular inflammation and calcification measured by F-18-FDG and F-18-NaF PET/CT in patients with TAV and BAV. The results suggest that F-18-NaF PET/CT may be a valuable predictor for hemodynamic progression of calcific AS in TAV patients, while F-18-FDG PET/CT does not play a significant role in predicting AS progression.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Oncology
Francois Benard, Sara Harsini, Don Wilson, Katherine Zukotynski, Gad Abikhzer, Eric Turcotte, Marieve Cossette, Ur Metser, Jonathan Romsa, Montgomery Martin, Colin Mar, Fred Saad, Jean-Paul Soucy, Bernhard J. Eigl, Peter Black, Andra Krauze, Steven Burrell, Alan Nichol, Jean-Claude Tardif
Summary: This study compared the diagnostic performance of Tc-99m-MDP SPECT and F-18-NaF PET-CT for detecting bone metastases in high-risk prostate or breast cancer patients. The results showed that F-18-NaF PET-CT had a higher accuracy. This study is clinically significant.
Article
Radiology, Nuclear Medicine & Medical Imaging
Hee Jin Park, Sung Hae Chang, Jeong Won Lee, Sang Mi Lee
Summary: The study investigated the clinical implication of F-18 sodium fluoride PET/CT in assessing disease activity of rheumatoid arthritis. Results showed strong positive correlation between joint uptake on F-18 NaF PET/CT and DAS28ESR, with accurate predictions of high disease activity. F-18 NaF PET/CT parameters could be used as imaging biomarkers for disease activity in rheumatoid arthritis.
QUANTITATIVE IMAGING IN MEDICINE AND SURGERY
(2021)
Article
Medicine, General & Internal
William Y. Raynor, Peter Sang Uk Park, Austin J. Borja, Yusha Sun, Thomas J. Werner, Sze Jia Ng, Hui Chong Lau, Poul Flemming Hoilund-Carlsen, Abass Alavi, Mona-Elisabeth Revheim
Summary: PET imaging using FDG and NaF plays a crucial role in assessing atherosclerosis, with NaF potentially being more sensitive to detecting atherogenic changes. Global assessment is key in quantifying the burden of vascular disease.
Article
Radiology, Nuclear Medicine & Medical Imaging
Koosha Paydary, Mona-Elisabeth Revheim, Sahra Emamzadehfard, Saeid Gholami, Sara Pourhassan, Thomas J. Werner, Poul Flemming Hoilund-Carlsen, Abass Alavi
Summary: The study showed that active calcification in the thoracic aorta is correlated with age, with a higher correlation in individuals with cardiovascular risk factors. Global assessment (ACS) can predict unfavorable cardiovascular disease risk profile.
EUROPEAN RADIOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Nelisa Helena Rocha, Samara Riguete Zacchi, Heitor Naoki Sado, Carlos Alberto Buchpiguel, Paulo Schiavom Duarte, Marcelo Tatit Sapienza
Summary: This study aimed to compare the effectiveness of oral and IV administration of F-18-NaF PET/CT in detecting bone metastatic lesions of breast and prostate cancers. The results showed that there was no significant difference in TBR between the two administration routes, and there was a high consistency between the two routes. Therefore, oral administration can be considered in patients with difficult venous access.
CLINICAL NUCLEAR MEDICINE
(2023)
Editorial Material
Hematology
Zahi A. Fayad, Philip M. Robson
Summary: Calcification is an important component in the development of atherosclerotic plaque, with CT imaging being a well-established tool for noninvasive assessment in the coronary arteries. PET imaging with 18F-sodium fluoride is gaining popularity as a method for assessing atherosclerosis activity and providing insight into future clinical events. Molecular imaging can provide additional information, adding a color dimension to CT or MRI images.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Jerney de Jongh, Robert Hemke, Gerben J. C. Zwezerijnen, Maqsood Yaqub, Irene E. Van der Horst-Bruinsma, Marleen G. H. van de Sande, Arno W. R. van Kuijk, Alexandre E. Voskuyl, Conny J. van der Laken
Summary: This study demonstrates that F-18-sodium fluoride PET-CT scans can detect new bone formation in patients with psoriatic arthritis, with a majority of these findings being asymptomatic.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Article
Medicine, General & Internal
Kalevi Kairemo, S. Cheenu Kappadath, Timo Joensuu, Homer A. Macapinlac
Summary: In this study, the quantitative differences between Fluorocholine-18 (FCH) and sodium fluoride-18 (NaF) in assessing skeletal disease in prostate cancer patients were characterized. The results suggest that a combination of NaF and FCH provides complementary information about the activity of skeletal disease, improving diagnosis and disease staging in PCa.
Article
Multidisciplinary Sciences
T. Zadi, D. H. K. van Dam-Nolen, M. Aizaz, A. G. van der Kolk, P. J. Nederkoorn, J. Hendrikse, M. E. Kooi, A. van der Lugt, D. Bos
Summary: This study evaluated changes in carotid plaque calcification over a 2-year follow-up in patients with symptomatic carotid artery disease. The results showed both increases and decreases in the volume of extra- and intracranial carotid artery calcification, which were significantly correlated with baseline calcification volume. Factors such as diabetes and use of antihypertensive drugs were also associated with changes in calcification.
SCIENTIFIC REPORTS
(2023)
Article
Engineering, Biomedical
Abdelillah Douhi, Mamdouh S. Al-enezi, Nousra Berrahmoune, Abdelouahed Khalil, Tamas Fulop, Michel Nguyen, Eric Turcotte, Etienne Croteau, M'hamed Bentourkia
Summary: Arterial inflammation is a significant factor in plaque vulnerability, leading to heart attacks or strokes. This study used 18F-sodium fluoride and 18F-fluorodeoxyglucose imaging to analyze arterial plaques, finding metabolically active plaques associated with inflammation even without calcification. The study suggests that density on CT images may indicate active plaques.
PHYSICAL AND ENGINEERING SCIENCES IN MEDICINE
(2023)
Review
Radiology, Nuclear Medicine & Medical Imaging
Georgios Tzimas, David T. Ryan, David J. Murphy, Jonathon A. Leipsic, Jonathan D. Dodd
Summary: This review summarizes key publications in 2021 related to three key noninvasive cardiac imaging modalities: cardiac CT angiography (CTA), MRI, and PET/CT. The review focuses primarily on articles published in Radiology but also includes important studies from other major journals in the field of cardiovascular imaging. It highlights the value of cardiac CTA, the evolving role of artificial intelligence in cardiovascular disease, and the emphasis on nonischemic cardiomyopathies, valvular heart disease, and COVID-19 disease cardiac manifestations in cardiac MRI studies. The increasing role of cardiac PET/CT in the assessment of cardiac sarcoidosis and prosthetic valves is also discussed.
Article
Clinical Neurology
Nicola Giannotti, Jonathan McNulty, Shane Foley, John McCabe, Marey Barry, Morgan Crowe, Eamon Dolan, Joseph Harbison, Gillian Horgan, Eoin Kavanagh, Martin O'Connell, Michael Marnane, Sean Murphy, Ciaran Mc Donnell, Martin O'Donohoe, David Williams, Peter J. Kelly
Summary: This study identified novel correlations between non-invasive imaging biomarkers of inflammation-related plaque metabolism and morphological MRI markers of plaque instability. If replicated, these findings may support the use of combined MRI and PET to detect vulnerable plaque in future clinical practice and randomized trials.
FRONTIERS IN NEUROLOGY
(2021)
Article
Obstetrics & Gynecology
Manuela Tavares de Sousa, Kurt Hecher, Fabian Kording, Jin Yamamura, Alexander Lenz, Gerhard Adam, Peter Bannas, Bjoern P. Schoennagel
Summary: Dynamic MRI of the fetal aorta using Doppler ultrasound gating is feasible and provides high-quality imaging for assessing fetal cardiac structures. It can be a complementary tool to echocardiography in cases where echocardiography results are inconclusive.
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Gesine Knobloch, Scott Nagle, Timothy Colgan, Tilman Schubert, Kevin M. Johnson, Peter Bannas, Geng Li, Louis Hinshaw, James Holmes, Scott B. Reeder
Summary: The study aimed to evaluate the imaging characteristics of inferior vena cava filters. The results showed that using ultra-short echo time MRA for assessment was more feasible, especially in a free-breathing protocol. Compared to conventional Cartesian MRA, UTE-MRA performed better in depicting IVC filters and had fewer filter-related artifacts.
ABDOMINAL RADIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Johannes Petersen, Alexander Lenz, Gerhard Adam, Hermann Reichenspurner, Peter Bannas, Evaldas Girdauskas
Summary: Comparing asymmetric and symmetric bicuspid aortic valve repair, the study found that symmetric repair leads to more physiological flow patterns and significantly reduces wall shear stress. Asymmetric repair, on the other hand, increases wall shear stress in the aorta.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Hy Van Lam, Michael Groth, Thomas Mir, Peter Bannas, Gunnar K. Lund, Charlotte M. Jahnke, Malte Warncke, Kai-Jonathan Maas, Gerhard Adam, Jochen Herrmann, Enver Tahir
Summary: Chest wall deformity in paediatric MFS patients is associated with reduced RV volume, ejection fraction and GLS. Feature-tracking CMR also indicates impairment of systolic LV function in paediatric MFS patients.
EUROPEAN RADIOLOGY
(2021)
Article
Medicine, General & Internal
Fiona Ohlendorf, Rudolf A. Werner, Christoph Henkenberens, Tobias L. Ross, Hans Christiansen, Frank M. Bengel, Thorsten Derlin
Summary: The study evaluated the early predictive and prognostic significance of systemic inflammation markers in patients receiving PRRT for GEP-NETs. Inflammatory biomarkers and indexes showed significant differences in non-responders, with CRP, ANC, and PCM being notably higher. Changes in tumor burden were associated with CRP and NLR, indicating potential predictive value for treatment response and prognosis.
Article
Multidisciplinary Sciences
Ulf K. Radunski, Johannes Kluwe, Malte Klein, Antonio Galante, Gunnar K. Lund, Christoph Sinning, Sebastian Bohnen, Enver Tahir, Jitka Starekova, Peter Bannas, Christian Stehning, Gerhard Adam, Ansgar W. Lohse, Stefan Blankenberg, Kai Muellerleile, Daniel Benten
Summary: TIPS can reduce portal hypertension in patients with liver cirrhosis, but the effect on cardiac function is not fully understood. This study used CMR, echocardiography, and biomarkers to investigate the impact of TIPS on the heart, finding increased cardiac preload leading to changes in cardiac chamber volumes and eccentric left ventricular hypertrophy in the absence of cardiac impairment.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
Well Lennart, Careddu Anna, Stark Maria, Farschtschi Said, Bannas Peter, Adam Gerhard, Mautner Victor-Felix, Salamon Johannes
Summary: The prevalence of spinal abnormalities is higher in NF1 patients than in the control group, with specific abnormalities like scalloping, meningoceles, and neuroforaminal tumors being significantly associated with NF1. These abnormalities are linked to symptoms like back pain and loss of motor function.
SCIENTIFIC REPORTS
(2021)
Article
Immunology
Natalie Baum, Marie Eggers, Julia Koenigsdorf, Stephan Menzel, Julia Hambach, Tobias Staehler, Ralf Fliegert, Frederike Kulow, Gerhard Adam, Friedrich Haag, Peter Bannas, Friedrich Koch-Nolte
Summary: CD38 is a major NAD(+)-hydrolyzing ecto-enzyme in mammals and a potential target for immunotherapy in multiple myeloma. Mouse CD38-specific nanobodies isolated through phage display technology can induce cytotoxicity against CD38-expressing tumor cells, providing tools to assess cytotoxicity mechanisms.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Oncology
Inka Ristow, Frederic Madesta, Lennart Well, Farzad Y. Shenas, Felicia Wright, Isabel Molwitz, Said Farschtschi, Peter Bannas, Gerhard Adam, Victor F. Mautner, Rene Werner, Johannes Salamon
Summary: This study demonstrates that machine-learning classification using MRI-based radiomics features allows sensitive and specific differentiation of benign peripheral nerve sheath tumors (BPNST) and malignant peripheral nerve sheath tumors (MPNST) in patients with neurofibromatosis type 1 (NF1). The feature expression of premalignant atypical tumors (ANF) falls between that of benign and malignant tumors, suggesting the biological plausibility of these radiomics features.
Review
Medicine, General & Internal
Sebastian Weiss, Valentin Weisse, Alexander Korthaus, Peter Bannas, Karl-Heinz Frosch, Carsten Schlickewei, Alexej Barg, Matthias Priemel
Summary: Appendicular soft tissue lymphoma is a rare disease often misdiagnosed as soft tissue sarcoma. There is limited research on the MRI characteristics of ASTL, and the results are inconsistent. This study systematically reviewed the clinical presentations and MRI characteristics of ASTL described in the current literature.
Article
Medicine, General & Internal
Alonja Reiter, Katharina Trumm, Tobias M. Ballhause, Sebastian Weiss, Karl-Heinz Frosch, Alexander Korthaus, Ulrich Bechler, Anna Dupree, Andreas Luebke, Peter Bannas, Carsten W. Schlickewei, Matthias H. Priemel
Summary: Intramuscular myxomas (IMMs) are rare benign tumors with limited evidence and guidelines regarding diagnosis and treatment. This study analyzed 38 patients retrospectively and evaluated their diagnostic and therapeutic procedures. The findings showed that IMMs predominantly occurred in middle-aged women, mostly in the extremities, with the lower extremity being the most affected. The average size of IMMs was 5.0 cm and MRIs were commonly performed for imaging. Incision biopsies were effective in obtaining the right histopathological diagnosis. Surgical resection was successful in 89.5% of cases, and postoperative complications requiring revision were reported in 8.8% of cases. Recurrences and degenerations of IMMs were not observed.
Article
Oncology
Natalia Bogdanova, Hoda Radmanesh, Dhanya Ramachandran, Anne Caroline Knoechelmann, Hans Christiansen, Thorsten Derlin, Christoph Alexander Joachim von Klot, Roland Merten, Christoph Henkenberens
Summary: This study aims to evaluate the prognostic value of liquid biopsies in patients with oligometastatic prostate cancer relapse in order to determine the benefit of salvage radiotherapy. The study found significant correlations between the relative transcript levels of specific genes and clinicopathological parameters, as well as treatment outcomes. Therefore, liquid biopsies have the potential to serve as predictive examination methods prior to salvage radiotherapy.
Review
Radiology, Nuclear Medicine & Medical Imaging
Inka Ristow, Christoph Riedel, Alexander Lenz, Lennart Well, Gerhard Adam, Giuseppe Panuccio, Tilo Kolbel, Peter Bannas
Summary: Radiological imaging plays a vital role in the diagnosis and monitoring of AAA patients. Ultrasound is the main imaging modality for screening and surveillance. Contrast-enhanced CT angiography is considered the gold standard for preoperative imaging and treatment planning. Non-contrast MR angiography techniques provide accurate determination of aortic diameters, which is crucial for diameter-based surgical treatment guidelines. 3D imaging with multiplanar reformation and automatic centerline positioning enables more accurate assessment of the maximum aortic diameter. Modern imaging techniques like 4D flow MRI have the potential to improve individualized risk stratification in AAA patients.
ROFO-FORTSCHRITTE AUF DEM GEBIET DER RONTGENSTRAHLEN UND DER BILDGEBENDEN VERFAHREN
(2023)
Correction
Multidisciplinary Sciences
Lennart Well, Anna Careddu, Maria Stark, Said Farschtschi, Peter Bannas, Gerhard Adam, Victor-Felix Mautner, Johannes Salamon
SCIENTIFIC REPORTS
(2021)
Article
Oncology
Janna-Lisa Velthaus, Peter Iglauer, Ronald Simon, Carsten Bokemeyer, Peter Bannas, Niklas Beumer, Charles D. Imbusch, Eray Goekkurt, Sonja Loges
Summary: This case study highlights the clinical benefit of targeted treatment with ROS1 TKI in a pancreatic cancer patient with a previously undescribed ROS1 point mutation, showing a durable stable disease and significant decrease in tumor biomarkers. The findings suggest that ROS1 may be an oncogenic driver in pancreatic cancer and targeted treatments could potentially improve patient outcomes in this subgroup.
ONCOLOGY RESEARCH AND TREATMENT
(2021)
