Article
Oncology
Jonatan Dewulf, Christel Vangestel, Yannick Verhoeven, Jorrit De Waele, Karen Zwaenepoel, Peter A. van Dam, Filipe Elvas, Tim van den Wyngaert
Summary: RANKL has been recognized as an important target in the tumor microenvironment for promoting an immunosuppressive environment and resistance to immunotherapy. Assessment of RANKL expression is challenging due to its heterogeneous nature, but the development of anti-RANKL immuno-PET tracers shows promise in non-invasively monitoring RANKL expression.
Article
Multidisciplinary Sciences
Evelyne Lopez-Crapez, Luca Costa, Guillaume Tosato, Jeanne Ramos, Thibault Mazard, Janique Guiramand, Alain Thierry, Jacques Colinge, Pierre-Emmanuel Milhiet, Christine Benistant
Summary: In addition to standard parameters, new features are needed in CRC management to improve survival rates. By using a multidisciplinary approach, we characterized the stiffness of healthy and malignant colon specimens and found that tumor tissue rigidity is associated with clinical parameters.
SCIENTIFIC REPORTS
(2022)
Review
Medicine, General & Internal
Wenwen Liu, Charles A. Powell, Qi Wang
Summary: This review summarizes recent studies on the effects of tumor microenvironment (TME) on tumor cells in the process of brain metastasis (BM) derived from lung cancer. The crucial role of TME in assisting tumor cells to complete each step of BM is emphasized, and vulnerable targets in TME and their potential as novel therapeutic opportunities are discussed.
CHINESE MEDICAL JOURNAL
(2022)
Review
Oncology
Kun Liu, Xin Gao, Baoqiang Kang, Yunpeng Liu, Dingding Wang, Yi Wang
Summary: Exosomes are vesicles secreted by cells that play pivotal roles in intercellular communication. The exosomes secreted by tumor stem cells are important messengers involved in tumor recurrence and metastasis.
FRONTIERS IN ONCOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Xuerong Wang, Chao Wang, Jiaheng Guan, Baoan Chen, Lin Xu, Ceshi Chen
Summary: Breast cancer remains a serious issue among women in China and globally, with research focusing on cancer stem cells, cancer cell heterogeneity, metastasis, and drug resistance mechanisms. Chinese researchers have made new advances in breast cancer research, particularly in the areas of cancer stem cells and microenvironments.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Mayu Imamura, Tiantian Li, Chunning Li, Masayoshi Fujisawa, Naofumi Mukaida, Akihiro Matsukawa, Teizo Yoshimura
Summary: The interaction between breast cancer cells and fibroblasts plays a minor role in the production of monocyte chemoattractant protein-1 (MCP-1). While cancer cells can communicate with fibroblasts through platelet-derived growth factors (PDGFs), this communication does not significantly impact MCP-1 production or cancer progression in this model. Understanding the complex crosstalk between cancer cells and stromal cells may help identify new targets for treating breast cancer patients.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Anqi Lin, Wentao Xu, Peng Luo, Jian Zhang
Summary: Tumor immunotherapy has become an important treatment option, but the use of immune checkpoint inhibitors in colorectal cancer treatment still has limitations. This study found that mutations in the chemokine signaling pathway are closely associated with the prognosis of COAD patients receiving ICI treatment, with high mutation status potentially leading to a better prognosis. This discovery provides a possible direction for ICI therapy in COAD.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Daniela Gerovska, Patricia Garcia-Gallastegi, Olatz Crende, Joana Marquez, Gorka Larrinaga, Maite Unzurrunzaga, Marcos J. Arauzo-Bravo, Iker Badiola
Summary: Cancer is closely related to aging, with tumor cells being the main driver of cancer progression, but the cells and matrix of the tumor microenvironment (TME) also play crucial roles in disease advancement. Epigenetic changes, including miRNA dysregulation, are essential for phenotypic changes in the TME during cancer progression. Specific miRNAs related to the aging process, called geromiRs, are significantly downregulated in the liver TME during colon cancer colonization, suggesting a link between aging-related miRNA dysregulation and cancer progression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Yangyang Zhang, Lingxiu Zeng, Meng Wang, Zhenwei Yang, Hailin Zhang, Liping Gao, Ranran Zhang, Jialong Liu, Wenqing Shan, Ying Chang, Lan Liu, Qiu Zhao, Yong Li, Jing Liu
Summary: The study found that RIG-I plays an important role in the immunotherapy of colon cancer by maintaining the stability of PD-L1 to promote immune evasion. Silencing RIG-I increases the sensitivity of tumor cells to T cell killing and slows down the growth of colon tumors. High expression of RIG-I promotes tumor progression and enhances the sensitivity to PD-1 therapy.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Review
Oncology
Wei-Wei Chen, Timothy Shun Man Chu, LiangLiang Xu, Cai-Ning Zhao, Wai-Sang Poon, Gilberto Ka-Kit Leung, Feng-Ming (Spring) Kong
Summary: This article discusses immune-related biomarkers for cancer metastasis to the brain and the potential use of these markers in predicting disease progression and treatment outcomes. The authors hope to inspire further research and establish practical guidelines for developing and validating immune-related biomarkers to provide personalized treatment and improve outcomes for patients with metastatic brain cancers.
EXPERIMENTAL HEMATOLOGY & ONCOLOGY
(2022)
Review
Oncology
Shuangshuang Mei, Xing Chen, Kai Wang, Yuxin Chen
Summary: Ovarian cancer is a common gynecological malignancy with high morbidity and mortality. Peritoneal metastasis is common in ovarian cancer, involving large amounts of ascites. The mechanism behind this is still unclear.
CANCER CELL INTERNATIONAL
(2023)
Review
Biochemistry & Molecular Biology
Ethan J. Kilmister, Sabrina P. Koh, Freya R. Weth, Clint Gray, Swee T. Tan
Summary: Cancer metastasis and treatment resistance are major contributors to treatment failure and cancer-related deaths. Understanding the pathways that regulate cancer stem cells and the tumor microenvironment is crucial for developing effective cancer therapies.
Review
Oncology
Jie Deng, Rongqi Jiang, Enqing Meng, Hao Wu
Summary: CXCL5, a chemokine, plays a critical role in human malignant tumors, potentially associated with tumor metastasis and angiogenesis. Regulating CXCL5 may be a promising approach for tumor therapy.
FRONTIERS IN ONCOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Jicheng Zhang, Hanlin Yin, Qiangda Chen, Guochao Zhao, Wenhui Lou, Wenchuan Wu, Ning Pu
Summary: Basophils, previously overlooked, have been found to potentially play a role in cancer development, with their function as tumor-protecting or tumor-promoting components still being debated and possibly dependent on tumor biology and the microenvironment.
JOURNAL OF ZHEJIANG UNIVERSITY-SCIENCE B
(2021)
Review
Immunology
Saerok Shim, Siyoung Lee, Yasmin Hisham, Sinae Kim, Tam T. Nguyen, Afeisha S. Taitt, Jihyeong Hwang, Hyunjhung Jhun, Ho-Young Park, Youngmin Lee, Su Cheong Yeom, Sang-Yeob Kim, Yong-Gil Kim, Soohyun Kim
Summary: IL-32 plays a contradictory role in cancer development, with its high expression typically associated with tumor proliferation and progression. However, different isoforms of IL-32 may have different effects in cancer, such as IL-32 beta promoting cancer expansion and IL-32 theta inhibiting epithelial-mesenchymal transition. Further research is needed to understand the role of IL-32 in cancer therapy.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Chemistry, Medicinal
Xing Yang, Ronnie C. Mease, Mrudula Pullambhatla, Ala Lisok, Ying Chen, Catherine A. Foss, Yuchuan Wang, Hassan Shallal, Hannah Edelman, Adam T. Hoye, Giorgio Attardo, Sridhar Nimmagadda, Martin G. Pomper
JOURNAL OF MEDICINAL CHEMISTRY
(2016)
Article
Radiology, Nuclear Medicine & Medical Imaging
Sangeeta Ray Banerjee, Catherine A. Foss, Mrudula Pullambhatla, Yuchuan Wang, Senthamizhchelvan Srinivasan, Robert F. Hobbs, Kwamena E. Baidoo, Martin W. Brechbiel, Sridhar Nimmagadda, Ronnie C. Mease, George Sgouros, Martin G. Pomper
JOURNAL OF NUCLEAR MEDICINE
(2015)
Article
Biochemistry & Molecular Biology
Anju Singh, Sreedhar Venkannagari, Kyu H. Oh, Ya-Qin Zhang, Jason M. Rohde, Li Liu, Sridhar Nimmagadda, Kuladeep Sudini, Kyle R. Brimacombe, Sachin Gajghate, Jinfang Ma, Amy Wang, Xin Xu, Sampada A. Shahane, Menghang Xia, Juhyung Woo, Geore A. Mensah, Zhibin Wang, Marc Ferrer, Edward Gabrielson, Zhuyin Li, Fraydoon Rastinejad, Min Shen, Matthew B. Boxer, Shyam Biswal
ACS CHEMICAL BIOLOGY
(2016)
Article
Biochemical Research Methods
Wojciech G. Lesniak, Samit Chatterjee, Matthew Gabrielson, Ala Lisok, Bryan Wharram, Martin G. Pomper, Sridhar Nimmagadda
BIOCONJUGATE CHEMISTRY
(2016)
Article
Radiology, Nuclear Medicine & Medical Imaging
Babak Behnam Azad, Ala Lisok, Samit Chatterjee, John T. Poirier, Mrudula Pullambhatla, Gary D. Luker, Martin G. Pomper, Sridhar Nimmagadda
JOURNAL OF NUCLEAR MEDICINE
(2016)
Article
Radiology, Nuclear Medicine & Medical Imaging
Hiroto Kuwabara, Yongjun Gao, Michael Stabin, Jennifer Coughlin, Sridhar Nimmagadda, Robert F. Dannals, Martin G. Pomper, Andrew G. Horti
MOLECULAR IMAGING AND BIOLOGY
(2017)
Article
Chemistry, Multidisciplinary
Wojciech G. Lesniak, Nikita Oskolkov, Xiaolei Song, Bachchu Lal, Xing Yang, Martin Pornper, John Laterra, Sridhar Nimmagadda, Michael T. McMahon
Article
Oncology
Il Minn, Soo Min Koo, Hye Soo Lee, Mary Brummet, Steven P. Rowe, Michael A. Gorin, Polina Sysa-Shah, William D. Lewis, Hye-Hyun Ahn, Yuchuan Wang, Sangeeta Ray Banerjee, Ronnie C. Mease, Sridhar Nimmagadda, Mohamad E. Allaf, Martin G. Pomper, Xing Yang
Article
Oncology
Babak Behnam Azad, Samit Chatterjee, Wojciech G. Lesniak, Ala Lisok, Mrudula Pullambhatla, Zaver M. Bhujwalla, Martin G. Pomper, Sridhar Nimmagadda
Article
Oncology
Samit Chatterjee, Wojciech G. Lesniak, Matthew Gabrielson, Ala Lisok, Bryan Wharram, Polina Sysa-Shah, Babak Behnam Azad, Martin G. Pomper, Sridhar Nimmagadda
Article
Biochemistry & Molecular Biology
Ying Chen, Samit Chatterjee, Ala Lisok, Il Minn, Mrudula Pullambhatla, Bryan Wharram, Yuchuan Wang, Jiefu Jin, Zaver M. Bhujwalla, Sridhar Nimmagadda, Ronnie C. Mease, Martin G. Pomper
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY
(2017)
Article
Pathology
Thomas J. Gniadek, Qing Kay Li, Ellen Tully, Samit Chatterjee, Sridhar Nimmagadda, Edward Gabrielson
Article
Multidisciplinary Sciences
Aimen Zlitni, Melissa Yin, Nancy Janzen, Samit Chatterjee, Ala Lisok, Kathleen L. Gabrielson, Sridhar Nimmagadda, Martin G. Pomper, F. Stuart Foster, John F. Valliant
Article
Biochemistry & Molecular Biology
Samit Chatterjee, Wojciech G. Lesniak, Michelle S. Miller, Ala Lisok, Emilia Sikorska, Bryan Wharram, Dhiraj Kumar, Matthew Gabrielson, Martin G. Pomper, Sandra B. Gabelli, Sridhar Nimmagadda
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2017)
Review
Radiology, Nuclear Medicine & Medical Imaging
A. P. Kiess, S. R. Banerjee, R. C. Mease, S. P. Rowe, A. Rao, C. A. Foss, Y. Chen, X. Yang, S. Y. Cho, S. Nimmagadda, M. G. Pomper
QUARTERLY JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2015)