Article
Radiology, Nuclear Medicine & Medical Imaging
Xiaomei Gao, Yongxiang Tang, Minfeng Chen, Jian Li, Hongling Yin, Yu Gan, Xiongbin Zu, Yi Cai, Shuo Hu
Summary: This study compared [Ga-68]Ga-RM26 PET/CT and [Ga-68]Ga-PSMA-617 PET/CT for diagnosing prostate cancer, and found that [Ga-68]Ga-PSMA-617 PET/CT had superior accuracy in detecting clinically significant PCa, while [Ga-68]Ga-RM26 PET/CT showed an advantage for imaging low-risk PCa.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Halil Komek, Canan Can, Ihsan Kaplan, Cihan Gundogan, Ferat Kepenek, Huseyin Karaoglan, Aykut Demirkiran, Senar Ebinc, Yunus Guzel, Ebubekir Gundes
Summary: [(68) Ga]Ga-DOTA-FAPI-04 PET/CT demonstrates higher sensitivity and specificity in the evaluation of primary lesions and metastases in patients with colorectal cancer.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yining Wang, Zijun Chen, Yinjie Zhu, Haitao Zhao, Lianghua Li, Gang Huang, Wei Xue, Ruohua Chen, Jianjun Liu
Summary: The purpose of this study was to assess whether total-body [(68) Ga]Ga-PSMA-11 PET/CT could improve the detection rate compared with conventional [(68) Ga]Ga-PSMA-11 PET/CT in patients with biochemical recurrent prostate cancer. The results showed that total-body [(68) Ga]Ga-PSMA-11 PET/CT had better objective evaluation in terms of background noise, lesion prominence, liver SD, SNR, and lesion SUVmax compared with conventional [(68) Ga]Ga-PSMA-11 PET/CT. Overall, total-body [(68) Ga]Ga-PSMA-11 PET/CT had a significantly higher detection rate for biochemical recurrent prostate cancer compared to conventional [(68) Ga]Ga-PSMA-11 PET/CT. Rating: 9/10.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yuheng Liu, Lianghua Li, Yanyu Qin, Zijun Chen, Haitao Zhao, Xinlu Wang, Ruohua Chen
Summary: The objective of this study was to compare the diagnostic performance and image quality of total-body PET/CT imaging using half-dose of [(68) Ga]Ga-PSMA radiotracer to conventional PET/CT imaging using full dose of [(68) Ga]Ga-PSMA. The results showed that total-body PET/CT with half-dose of [(68) Ga]Ga-PSMA yielded comparable image quality and diagnostic performance to conventional PET/CT, while reducing radiation exposure for the subjects.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Jolanta Kunikowska, Beata E. Chrapko
Summary: This article reports two cases of recurrent grade III hemangiopericytoma with high expression of Ga-68-PSMA-11 in PET/CT. Based on the examination, one of them received targeted α-therapy with IV injection of Ac-225-PSMA-617.
CLINICAL NUCLEAR MEDICINE
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Ruohua Chen, Yee Ling Ng, Xinlan Yang, Yinjie Zhu, Lianghua Li, Haitao Zhao, Yun Zhou, Gang Huang, Jianjun Liu
Summary: Total-body parametric imaging of [(68) Ga]Ga-PSMA-11 improved lesion contrast and detectability compared to SUV images, which may serve as an imaging biomarker and theranostic tool for precise diagnosis and treatment evaluation in prostate cancer patients.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Piyush Aggarwal, Harmandeep Singh, Rajender Kumar, Ritambhra Nada, Girdhar S. Bora, Rama Walia
Summary: Adrenal schwannoma is a rare benign tumor arising from the Schwann cells, and differentiating it from malignant adrenal lesions requires a combination of clinical, biochemical, imaging, and histopathological findings. Ga-68-DOTANOC PET/CT is a sensitive imaging modality for detecting adrenal lesions like pheochromocytoma. However, false-positive findings on somatostatin receptor imaging are common due to the expression of somatostatin receptors in both benign and malignant lesions. Here, we present a case of adrenal incidentaloma that showed positive findings on Ga-68-DOTANOC PET, but was confirmed as a benign adrenal spindle cell tumor on histopathology.
CLINICAL NUCLEAR MEDICINE
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yael Eshet, Noam Tau, Keren Levanon, Rinat Bernstein-Molho, Ofer Globus, Amit Itay, Tal Shapira, Cecilie Oedegaard, Michal Eifer, Tima Davidson, Meital Nidam, Einav Gal-Yam, Liran Domachevsky
Summary: This study investigated the use of 68Ga-fibroblast activation protein inhibitor (FAPI) PET/CT for response assessment and follow-up in patients with invasive lobular breast cancer (ILC). The results showed a strong correlation between 68Ga-FAPI tumor volume and blood tumor biomarkers, suggesting the potential of 68Ga-FAPI PET/CT for disease evaluation and monitoring.
CLINICAL NUCLEAR MEDICINE
(2023)
Article
Oncology
Wenxiao Yu, Ming Zhao, Yingjun Deng, Shengjing Liu, Guanchao Du, Bin Yan, Ziwei Zhao, Ning Sun, Jun Guo
Summary: This study compared the diagnostic value of (18) F-PSMA-1007 PET/CT, (18) F-FDG PET/CT, and Ga-68-PSMA PET/CT in prostate cancer. The results showed that both (18) F-PSMA-1007 PET/CT and Ga-68 PSMA PET/CT demonstrated higher diagnostic efficacy compared to (18) F-FDG PET/CT.
Article
Radiology, Nuclear Medicine & Medical Imaging
Jun Wen, Yinjie Zhu, Lianghua Li, Jianjun Liu, Yumei Chen, Ruohua Chen
Summary: Dynamic total-body PET imaging in patients with prostate cancer showed that 6 minutes post-injection was the optimal time for imaging, avoiding interference from bladder activity and detecting lesions with relatively low PSMA uptake. Additionally, imaging at 35-59 minutes post-injection could also yield similar results to imaging at 60 minutes post-injection.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2022)
Article
Biotechnology & Applied Microbiology
Andras Polyak, Heidi Harting, Nina Angrisani, Timo Herrmann, Nina Ehlert, Jessica Meissner, Michael Willmann, Silav Al-Bazaz, Tobias L. Ross, Jens P. Bankstahl, Janin Reifenrath
Summary: This study aimed to determine the temporal in vivo resolution of magnetic nanoporous silica nanoparticle (MNPSNP) distribution and the effect of PEGylation and clodronate application using PET/CT imaging and gamma counting in an implant mouse model. The pharmacokinetics and biodistribution of all radiolabeled nanoparticles were visualized and followed by dynamic PET/CT imaging. Although PEGylation increases circulation time, nanoparticle accumulation at the implantation site was still insufficient for infection treatment and additional efforts are needed to increase local accumulation.
JOURNAL OF NANOBIOTECHNOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Guokun Wang, Qinqin Yang, Shengyong Wu, Xudong Xu, Xiao Li, Siyu Liang, Guixia Pan, Changjing Zuo, Xianxian Zhao, Chao Cheng, Suxuan Liu
Summary: [(68) Ga]Ga-FAPI-04 PET/CT can monitor early cardiac fibrosis in pressure overload heart failure and predict the deterioration of cardiac function.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Venkata Subramanian Krishnaraju, Rajender Kumar, Bhagwant Rai Mittal, Vishal Sharma, Harjeet Singh, Ritambhra Nada, Amanjit Bal, Manish Rohilla, Harmandeep Singh, Surinder S. Rana
Summary: The study aimed to differentiate malignant and benign pancreatic lesions by evaluating PSMA expression and comparing Ga-68 PSMA-PET/CT and F-18 FDG-PET/CT. Ga-68 PSMA-PET/CT showed higher specificity and accuracy in pre-operatively diagnosing primary pancreatic malignancy compared to FDG-PET/CT.
EUROPEAN RADIOLOGY
(2021)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Ihsan Kaplan, Canan Can, Yunus Guzel, Ulas Alabalik, Halil Komek
Summary: F-18-FDG PET/CT and Ga-68-FAPI 04 PET/CT were used for restaging in a 16-year-old boy with malignant mixed germ cell tumor. Results showed that Ga-68-FAPI-04 PET/CT was superior to F-18-FDG PET/CT in the evaluation of metastases in the testicular tumor.
CLINICAL NUCLEAR MEDICINE
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
David A. Pattison, Maciej Debowski, Brook Gulhane, Evyn G. Arnfield, Anita M. Pelecanos, Peter L. Garcia, Melissa J. Latter, Charles Y. Lin, Matthew J. Roberts, Stuart C. Ramsay, Paul A. Thomas
Summary: This study aimed to compare the concordance of [F-18]PSMA-1007 and [(68)Ga]Ga-PSMA-11 in TNM diagnosis and tracer uptake. The results showed differences in tracer uptake in most physiological sites, but high consistency in overall AJCC prognostic stage.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Maryam Oroujeni, Hanna Tano, Anzhelika Vorobyeva, Yongsheng Liu, Olga Vorontsova, Tianqi Xu, Kristina Westerlund, Anna Orlova, Vladimir Tolmachev, Amelie Eriksson Karlstrom
Summary: Combination therapy with trastuzumab and Affibody-mediated PNA-based radionuclide pretargeting significantly increased survival in mice bearing HER2-expressing xenografts, without toxicity to normal tissues.
JOURNAL OF NUCLEAR MEDICINE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Kambiz Rahbar, Markus Essler, Kim M. Pabst, Matthias Eiber, Christian la Fouge, Vikas Prasad, Philipp Rassek, Ergela Hasa, Helmut Dittmann, Ralph A. Bundschuh, Wolfgang P. Fendler, Milena Kurtinecz, Anja Schmall, Frank Verholen, Oliver Sartor
Summary: The RALU study evaluated the feasibility of using sequential a and b emitters in patients with bone-predominant metastatic castration-resistant prostate cancer. The study found that treatment with 177Lu-PSMA after 223Ra was feasible and led to a prolongation of overall survival. Few adverse events, mainly anemia and thrombocytopenia, were observed during treatment.
JOURNAL OF NUCLEAR MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Mei Li, Roman Zelchan, Anna Orlova
Summary: In this review, the clinical performance of FDA-approved imaging agents for prostate cancer diagnosis was evaluated, and PSMA-targeted imaging agents were found to have superior diagnostic performance in both primary and recurrent PCa.
Article
Biochemistry & Molecular Biology
Vladimir Tolmachev, Vitalina Bodenko, Maryam Oroujeni, Sergey Deyev, Elena Konovalova, Alexey Schulga, Sarah Lindbo, Sophia Hober, Olga Bragina, Anna Orlova, Anzhelika Vorobyeva
Summary: Non-invasive radionuclide molecular visualization of human epidermal growth factor receptor type 2 (HER2) provides stratification and response monitoring for HER2-targeting therapy. Two imaging probes, [Tc-99m]Tc-ADAPT6 and [Tc-99m]Tc-(HE)(3)-G3, demonstrate high contrast imaging and clear discrimination of high and low HER2 expression. However, [Tc-99m]Tc-ADAPT6 has better conditions for stratification sensitivity and specificity, while [Tc-99m]Tc-(HE)(3)-G3 is more suitable for monitoring early treatment response.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Tianqi Xu, Alexey Schulga, Elena Konovalova, Sara S. Rinne, Hongchao Zhang, Olga Vorontsova, Anna Orlova, Sergey M. Deyev, Vladimir Tolmachev, Anzhelika Vorobyeva
Summary: Pancreatic cancer (PC) is an aggressive malignancy, and targeted therapies could improve its treatment. Overexpression of HER3 and EpCAM in PC is associated with poor prognosis. The study investigated whether co-targeting HER3 with MM-121 and EpCAM with Ec1-LoPE could enhance therapeutic efficacy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Fanny Lundmark, Ayman Abouzayed, Sara S. S. Rinne, Vasiliy Timofeev, Nadezhda Sipkina, Maria Naan, Anastasia Kirichenko, Maria Vasyutina, Daria Ryzhkova, Vladimir Tolmachev, Ulrika Rosenstrom, Anna Orlova
Summary: Prostate cancer is the most diagnosed cancer and leading cause of cancer-related deaths in men. This study presents the preclinical characterization and evaluation of a radiotracer that targets both PSMA and GRPR for PET imaging of prostate cancer. The findings support the clinical translation of the radiotracer and represent a step towards its first clinical trial.
Article
Pharmacology & Pharmacy
Yongsheng Liu, Rezan Gueler, Yunqi Liao, Anzhelika Vorobyeva, Olof Widmark, Theodorus J. J. Meuleman, Anna Koijen, Leendert J. J. van den Bos, Robert Naasz, Vitalina Bodenko, Anna Orlova, Caroline Ekblad, Vladimir Tolmachev, Fredrik Y. Y. Frejd
Summary: This study explores the use of Chemo-Enzymatic Peptide Synthesis (CEPS) to produce a therapeutic HER2 targeted Affibody molecule. The resulting molecule shows thermodynamic stability, binding specificity to HER2, and extended time in circulation. CEPS proves to be a viable method for producing functional Affibody-fusion molecules.
Article
Oncology
Yongsheng Liu, Tianqi Xu, Anzhelika Vorobyeva, Annika Loftenius, Vitalina Bodenko, Anna Orlova, Fredrik Y. Frejd, Vladimir Tolmachev
Summary: Affibody molecules are artificial proteins that can target cancer-related molecular abnormalities. Clinical studies have shown that they can be used for radionuclide diagnostics and therapy. This study demonstrated that re-engineered Affibody molecules can increase the survival of mice with human tumors, and the combination of Affibody molecules and a monoclonal antibody was the most effective treatment.
Article
Oncology
Olga Bragina, Vladimir Chernov, Alexey Schulga, Elena Konovalova, Sophia Hober, Sergey Deyev, Jens Sorensen, Vladimir Tolmachev
Summary: The overexpression of HER2 receptor in certain breast cancers can be successfully treated with trastuzumab and pertuzumab antibodies. Radionuclide imaging can assist in selecting patients for antibody treatment. The small-sized radiolabelled scaffold proteins ADAPT6 and DARPin have shown excellent imaging properties and promising results in the imaging of HER2 in preclinical and Phase I clinical trials.
Article
Medicine, General & Internal
Ayman Abouzayed, Jesper Borin, Fanny Lundmark, Anastasiya Rybina, Sophia Hober, Roman Zelchan, Vladimir Tolmachev, Vladimir Chernov, Anna Orlova
Summary: A kit was successfully prepared for prospective use in an early-phase clinical study, allowing for one-pot single-step radiolabeling with technetium-99m. The radiolabeled peptide maintained its binding properties and showed good safety in animal models after 18 months of storage. Therefore, the prepared kit can be further evaluated for clinical application.
Article
Biochemistry & Molecular Biology
Ayman Abouzayed, Panagiotis Kanellopoulos, Alisa Gorislav, Vladimir Tolmachev, Theodosia Maina, Berthold A. Nock, Anna Orlova
Summary: This study presents a new GRPR antagonist with improved stability and specificity for the theranostics of prostate cancer. In vitro and in vivo experiments showed that the new compound demonstrated higher stability and selective targeting, indicating its potential therapeutic value.
Article
Medicine, General & Internal
O. D. Bragina, S. M. Deyev, E. Yu Garbukov, V. E. Goldberg, V. I. Chernov, V. M. Tolmachev
Summary: This study compared the diagnostic efficacy of two diagnostic agents, [(99)mTc]Tc-ADAPT6 and [(99)mTc]Tc-(HE)3-G3, in HER2-positive breast cancer patients. The results showed that [(99)mTc]Tc-ADAPT6 had higher accumulation values, making it a more promising diagnostic agent.
BYULLETEN SIBIRSKOY MEDITSINY
(2023)