Article
Oncology
Li Li, Ning Liu, Hui Zhang, Rongjie Tao, Shuqiang Zhao, Zhaoqiu Chen, Zheng Fu, Wanhu Li, Liang Xu, Yuhui Liu, Jinming Yu, Shuanghu Yuan
Summary: This study investigates the ability of F-18-AlF-NOTA-PRGD2 positron emission tomography/computed tomography (F-18-RGD PET/CT) and dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) to predict the response to bevacizumab combined with conventional therapy in newly diagnosed glioblastoma patients. The results show that a greater decrease in SUVmean predicts better progression-free survival (PFS), while a small decrease in K-trans predicts improved overall survival (OS).
FRONTIERS IN ONCOLOGY
(2022)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Jin Qi, Elizabeth Kurian, Orhan K. oez
Summary: Hibernomas are rare benign tumors originating from fetal brown adipose tissue. They can occur in various parts of the body, with thigh, shoulder, back, and neck being the most common locations, and are rarely found in the abdominal cavity, retroperitoneum, breast, bones, scrotum, and perirectum. We present a case of a 58-year-old woman with a mediastinal mass, who was incidentally found to have an FDG-avid fat-containing lesion in the omentum abutting the stomach.
CLINICAL NUCLEAR MEDICINE
(2023)
Article
Neurosciences
Yanxiao Li, Yee Ling Ng, Manish D. Paranjpe, Qi Ge, Fengyun Gu, Panlong Li, Shaozhen Yan, Jie Lu, Xiuying Wang, Yun Zhou
Summary: This study aimed to improve the statistical power in detecting changes in brain glucose metabolism, amyloid, and tau deposition in Alzheimer's disease studies by using a reference tissue-based quantification approach. The results showed that the tracer-specific reference tissue improved the detection of PET SUVR changes, which is beneficial for early diagnosis, disease progression monitoring, and therapeutic response in Alzheimer's disease.
HUMAN BRAIN MAPPING
(2022)
Article
Oncology
Fei Wang, Rui Guo, Yan Zhang, Boqi Yu, Xiangxi Meng, Hanjing Kong, Yang Yang, Zhi Yang, Nan Li
Summary: This study investigated the value of F-18-FDG PET/MRI in the preoperative assessment of ESCC and compared it with other imaging methods. The results showed that F-18-FDG PET/MRI had higher accuracy and area under the curve in diagnosing primary tumors and regional lymph node metastases. Therefore, F-18-FDG PET/MRI may be a potential supplement or alternative imaging method for preoperative staging of ESCC.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Janna Morawitz, Nils-Martin Bruckmann, Kai Jannusch, Frederic Dietzel, Aleksandar Milosevic, Ann-Kathrin Bittner, Oliver Hoffmann, Svjetlana Mohrmann, Eugen Ruckhaeberle, Lena Haeberle, Wolfgang Peter Fendler, Ken Herrmann, Frederik Lars Giesel, Gerald Antoch, Lale Umutlu, Bernd Kowall, Andreas Stang, Julian Kirchner
Summary: F-18-FDG PET/MRI is superior to conventional imaging and MRI in nodal staging in patients with newly diagnosed breast cancer. It accurately detects nodal positive status and classifies it into the correct clinical lymph node stage more often. F-18-FDG PET/MRI has the potential to be an alternative to invasive staging procedures for assessing the N stage.
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Sophia Huntley Antippa, Leanne Du, Nathan Price, Charlie Chia-Tsong Hsu
Summary: Recognition of the imaging pattern of hyoid ORN is crucial for avoiding misdiagnosis and enabling prompt treatment. Hyoid ORN is a rare complication following radiation treatment for head and neck malignancy, with limited cases described in the literature.
CLINICAL NUCLEAR MEDICINE
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Sung Ryul Shim, Seong-Jang Kim
Summary: This study evaluated the diagnostic accuracies of F-18-FDG PET or PET/CT for Merkel cell carcinoma (MCC) through a systematic review and meta-analysis. The results showed that F-18-FDG PET/CT had excellent performance in diagnosing MCC and could be useful for exclusion and confirmation of the disease. Further large multicenter studies are needed to validate its diagnostic accuracy.
CLINICAL NUCLEAR MEDICINE
(2022)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Ursula Thome, Helio Rubens Machado, Marcelo Volpon Santos, Antonio Carlos Santos, Lauro Wichert-Ana
Summary: A 15-year-old boy presented with left body epilepsia partialis continua, hemiparesis, and right hemisphere dominant electroencephalogram abnormalities. MRI revealed a small hyperintense signal in the left putamen. F-18-FDG PET showed focal glucose hypermetabolism in the right paracentral lobule and hypometabolism in the inferior right frontal and precentral gyri. A subsequent MRI showed a hyperintense signal over the paracentral lobule, which was confirmed as Rasmussen encephalitis by biopsy. The patient underwent right hemispherotomy and achieved seizure freedom. This case highlights the importance of PET in the early diagnosis of Rasmussen encephalitis.
CLINICAL NUCLEAR MEDICINE
(2023)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Evyn Arnfield, David A. Pattison
Summary: A 69-year-old woman presented with symptomatic hypercalcemia and deranged liver function. Imaging studies showed intense activity in the liver parenchyma, which was later confirmed to be hepatic sarcoidosis through MRI and liver biopsy.
CLINICAL NUCLEAR MEDICINE
(2021)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Yun Chen, Shan Zheng, Zenan Wu, Yanmin Lin, Weibing Miao
Summary: A 76-year-old man with yellowish discoloration of sclera and skin for 2 months was referred for F-18-FDG PET/CT to characterize a mass in the pancreas. PET/CT images showed intense FDG uptake in the head of the pancreas, with a lymph nodal mass in the hepatic hilar region, consistent with pancreatic malignancy. Histopathologic findings confirmed diffuse large B-cell lymphoma with no evidence of adenocarcinoma.
CLINICAL NUCLEAR MEDICINE
(2023)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Sayak Choudhury, Nilendu Purandare, Sneha Shah, Archi Agrawal, Venkatesh Rangarajan
Summary: Delayed-onset radiation-induced myelitis is a rare but serious complication of radiation exposure to the spinal cord. In this report, we describe the F-18-FDG PET/CT findings of radiation-induced myelitis in a patient with carcinoma of buccal mucosa treated with external beam radiotherapy.
CLINICAL NUCLEAR MEDICINE
(2022)
Article
Medicine, Research & Experimental
Jiang Wu, Xiaoyi Zhang, Zhijun Jia, Xiaodie Zhou, Rongxin Qi, Hengshan Ji, Jingjing Sun, Chuanjin Sun, Zhaogang Teng, Guangming Lu, Xiaoyuan Chen
Summary: This study explored the combination of F-18-FDG and F-18-Alfatide II in predicting molecular subtypes of invasive breast cancer using noninvasive PET molecular imaging. The results suggest that the combination of F-18-FDG and F-18-Alfatide II, as represented by FAR, can be used to predict molecular subtypes of invasive breast cancer, particularly the luminal B (HER2 negative) subtype and the nonluminal subtype.
MOLECULAR PHARMACEUTICS
(2022)
Article
Oncology
Longjie Xia, Jianqin Lai, Di Huang, Shenghui Qiu, Huiqiong Hu, Yunxiang Luo, Jie Cao
Summary: This meta-analysis compared the diagnostic efficacy of [F-18]FDG PET/CT and [F-18]FDG PET/MRI in detecting bone metastases in breast cancer patients. The results showed that [F-18]FDG PET/MRI has higher sensitivity but similar specificity compared to [F-18]FDG PET/CT. Further prospective research is needed to confirm these findings and evaluate the clinical application of these techniques.
RADIOLOGY AND ONCOLOGY
(2023)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Birgit Pernthaler, Luka Brcic, Reingard Maria Aigner, Michael Fuchsjaeger, Emina Talakic
Summary: This article presents a rare case of primary malignant mesothelioma in the liver, with the patient being a 48-year-old woman who experienced increasing upper abdominal discomfort and inappetence, accompanied by a weight loss of approximately 10 kg. CT and MRI revealed a highly suspicious mass lesion in the liver. F-18-FDG PET/CT performed for staging showed a pathological F-18-FDG uptake of the known liver tumor. Histology and immunohistochemistry indicated mesothelioma of the liver.
CLINICAL NUCLEAR MEDICINE
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Abarnaa Sivapathasundaram, Nicolas Golse, Alina Pascale, Emmanuel Durand, Mylene Sebagh, Florent L. Besson
Summary: Contrary to common belief, F-18-FDG/F-18-choline dual-tracer PET behavior is not a relevant surrogate of tumor differentiation in hepatocellular carcinoma (HCC). Future multitracer PET studies are necessary to improve our understanding of their biological significance in this field.
CLINICAL NUCLEAR MEDICINE
(2023)
Article
Oncology
Nouran R. R. Zaid, Peter Kletting, Ambros J. Beer, Tania A. Rozgaja Stallons, Julien J. Torgue, Gerhard Glatting
Summary: A mathematical model was developed to describe the kinetics of Pb-212-labeled pharmaceuticals and its radioactive daughters. The simulation revealed that alpha emissions contributed significantly to the total released energy, and the Bi-212-DOTAM complexes had a certain dissociation during retention. The contributions of different chelators to the energy released by free radionuclides were varied.
CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS
(2023)
Article
Cardiac & Cardiovascular Systems
Susan Notohamiprodjo, Stephan G. Nekolla, Stephanie Robu, Alberto Villagran Asiares, Christian Kupatt, Tareq Ibrahim, Karl-Ludwig Laugwitz, Marcus R. Makowski, Markus Schwaiger, Wolfgang A. Weber, Zohreh Varasteh
Summary: This study demonstrated the feasibility of noninvasive imaging of fibroblast activation protein (FAP) expression after myocardial infarction (MI) using Ga-68-FAPI-04-PET, and showed that Ga-68-FAPI-04 uptake extends beyond the actual infarcted area in the infarct territory. Follow-up CMR confirmed the overestimation of the infarct size by Ga-68-FAPI-04 uptake.
JOURNAL OF NUCLEAR CARDIOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Nicolo Capobianco, Ludovic Sibille, Maythinee Chantadisai, Andrei Gafita, Thomas Langbein, Guenther Platsch, Esteban Lucas Solari, Vijay Shah, Bruce Spottiswoode, Matthias Eiber, Wolfgang A. Weber, Nassir Navab, Stephan G. Nekolla
Summary: This study developed a deep learning method that improved the accuracy and efficiency of prostate cancer staging by using training data from different radiotracers.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Esteban Lucas Solari, Andrei Gafita, Sylvia Schachoff, Borjana Bogdanovi, Alberto Villagran Asiares, Thomas Amiel, Wang Hui, Isabel Rauscher, Dimitris Visvikis, Tobias Maurer, Kristina Schwamborn, Mona Mustafa, Wolfgang Weber, Nassir Navab, Matthias Eiber, Mathieu Hatt, Stephan G. Nekolla
Summary: The study evaluated the performance of combined PET and mpMRI radiomics for predicting postsurgical Gleason scores in primary prostate cancer patients. The results showed that the PET + ADC double-modality model performed the best, significantly outperforming other models, and had better predictive ability for psGS compared to biopsy GS.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Jana Kupusovic, Lukas Kessler, Stephan G. Nekolla, Lisa Riesinger, Manuel M. Weber, Justin Ferdinandus, Simon Kochhaeuser, Tienush Rassaf, Reza Wakili, Christoph Rischpler, Johannes Siebermair
Summary: The purpose of the study was to assess (68) Ga-fibroblast-activation protein inhibitor (FAPI) uptake in the pulmonary vein region after pulmonary vein isolation (PVI) with cryoballoon ablation (CBA) and radiofrequency (RFA). The results showed higher FAPI uptake in PVs in PVI patients compared to controls, and CBA seemed to cause more pronounced fibroblast activation following tissue injury than RFA. Future studies are needed to further understand the mechanisms of AF recurrence after PVI.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2022)
Correction
Oncology
Constantin Lapa, Ursula Nestle, Nathalie L. Albert, Christian Baues, Ambros Beer, Andreas Buck, Volker Budach, Rebecca Buetof, Stephanie E. Combs, Thorsten Derlin, Matthias Eiber, Wolfgang P. Fendler, Christian Furth, Cihan Gani, Eleni Gkika, Anca-L. Grosu, Christoph Henkenberens, Harun Ilhan, Steffen Loeck, Simone Marnitz-Schulze, Matthias Miederer, Michael Mix, Nils H. Nicolay, Maximilian Niyazi, Christoph Poettgen, Claus M. Roedel, Imke Schatka, Sarah M. Schwarzenboeck, Andrei S. Todica, Wolfgang Weber, Simone Wegen, Thomas Wiegel, Constantinos Zamboglou, Daniel Zips, Klaus Zoephel, Sebastian Zschaeck, Daniela Thorwarth, Esther G. C. Troost
STRAHLENTHERAPIE UND ONKOLOGIE
(2022)
Article
Oncology
Catharina Silvia Lisson, Christoph Gerhard Lisson, Marc Fabian Mezger, Daniel Wolf, Stefan Andreas Schmidt, Wolfgang M. Thaiss, Eugen Tausch, Ambros J. Beer, Stephan Stilgenbauer, Meinrad Beer, Michael Goetz
Summary: The study compares the performance of deep learning algorithms and radiomics-based machine learning models in predicting relapse of mantle cell lymphoma (MCL) based on baseline CT scans. The optimized 3D CNN model shows the best accuracy of 70% in predicting MCL relapse, offering potential for precision imaging in clinical management.
Article
Cardiac & Cardiovascular Systems
Nabeel Mansour, Stephan G. Nekolla, Eliana Reyes, George Angelidis, Panagiotis Georgoulias, Constantinos Anagnostopoulos, Paco Bravo, Isabella Bruno, Albert Flotats, Francisco Fuentes-Ocampo, Roberto Sciagra, Felix Keng, Lukas Kessler, Maria Papathanasiou, Prem Soman, Christoph Rischpler
Summary: CZT-MPI has higher diagnostic sensitivity in detecting coronary artery disease compared to conventional Anger-MPI, but it has reduced specificity and diagnostic accuracy. Experienced readers show higher inter-rater agreement and special training is required for non-experienced readers.
JOURNAL OF NUCLEAR CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Alberto Villagran Asiares, Teresa Vitadello, Borjana Bogdanovic, Esteban Lucas Solari, Lachlan McIntosh, Sylvia Schachoff, Tareq Ibrahim, Stephan G. Nekolla
Summary: This study investigated the impact of different cardiac gating methods on the assessment of cardiac function using FDG-PET. The results showed that the PET and MR-based cardiac function parameters were highly correlated, but the selected PET ECG gating method introduced variabilities and led to substantial disagreement in the assessment.
JOURNAL OF NUCLEAR CARDIOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Carl Ganter
Summary: It is shown that the steady state of rapid TR-periodic SSFP sequences at small to moderate flip angles follows a universal scaling law with respect to variations of B-1(+). The accuracy and precision of relaxometry experiments are discussed through analytical solutions, Cramer-Rao bound, and Monte Carlo simulations. Simultaneous estimation of R-1 and B-1(+) from SSFP steady states alone is not recommended, and additional transient state information is needed to address the issue.
MAGNETIC RESONANCE IN MEDICINE
(2023)
Article
Medicine, General & Internal
Korbinian Westphal, Matthias Eiber, Martin Henninger, Klemens Scheidhauer, Ambros J. Beer, Wolfgang Thaiss, Christoph Rischpler
Summary: In this retrospective study, MRI and CT were compared in patients with recurrent DTC. The results showed that MRI performed better in evaluating cervical recurrence, while CT performed better in evaluating lung lesions. Therefore, PET/MRI combined with low-dose CT may be the ideal staging tool for patients with recurrent DTC.
Review
Radiology, Nuclear Medicine & Medical Imaging
Stephan G. Nekolla, Christoph Rischpler, Takahiro Higuchi
Summary: Noninvasive imaging techniques, such as SPECT, PET, CT, echocardiography, or MRI, have become essential in cardiovascular research and offer numerous advantages, such as high sensitivity and reliable quantification. Incorporating SPECT and PET imaging into a well-defined workflow similar to clinical imaging can effectively implement the concept of bench to bedside in cardiology translational research.
SEMINARS IN NUCLEAR MEDICINE
(2023)
Article
Oncology
Colmar Hilbrig, Jessica Loeffler, Gabriel Fischer, Ellen Scheidhauer, Christoph Solbach, Markus Huber-Lang, Ambros J. J. Beer, Volker Rasche, Gordon Winter
Summary: The CAM model shows promise as an alternative to mouse models in terms of the 3Rs principles. However, further evaluation is needed to determine its value in noninvasive assessment of radiolabeled macromolecules using PET and MRI. This study analyzed the biodistribution and tumor accumulation of Zr-89-labeled albumin in both CAM and mouse models, and found no significant differences in albumin influx kinetics between the two models. These findings suggest that the CAM model could be a potential alternative for initial PET studies on the characteristics of EPR-dependent target accumulation of radiolabeled macromolecules.
Meeting Abstract
Cardiac & Cardiovascular Systems
Remigiusz Kazimierczyk, Piotr Szumowski, Stephan Nekolla, Lukasz Malek, Piotr Blaszczak, Marcin Hladunski, Bozena Sobkowicz, Janusz Mysliwiec, Karol Kaminski
Meeting Abstract
Radiology, Nuclear Medicine & Medical Imaging
A. Krizsan, K. Kukuts, W. Al-Muhanna, Z. Szoboszlai, L. Balazs, J. Kiss, S. Nekolla, S. Barna, I. Garai, T. Bukki, A. Forgacs
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2022)
