Article
Clinical Neurology
Eun Hye Jeong, Mun Kyung Sunwoo, Jae Yong Lee, Sun-Ku Han, Sung Wook Hyung, Yoo Sung Song
Summary: This study estimated the asymmetry of specific binding ratio (SBR) of I-123 FP-CIT SPECT images during 4-years of follow up in Parkinson's disease (PD) patients. The results showed that the second method of calculating the asymmetry index revealed a more significant decrease over the 4-year follow up period. Furthermore, the baseline asymmetry index was significantly correlated with the non-dominant putamen SBRs and could be used to predict and evaluate the natural course of PD.
FRONTIERS IN NEUROLOGY
(2022)
Article
Neurosciences
Lars Frings, Franziska Henninger, Martin Treppner, Goran Koeber, Martin Boeker, Philipp T. Meyer
Summary: DAT SPECT, commonly used in dementia diagnostics, has been found to provide valuable prognostic information. Patients with nigrostriatal degeneration (NSD) detected by DAT SPECT have a significantly higher mortality risk compared to those without NSD, with lower striatal DAT binding associated with increased mortality risk.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Article
Computer Science, Artificial Intelligence
Diego Castillo-Barnes, Carmen Jimenez-Mesa, Francisco J. Martinez-Murcia, Diego Salas-Gonzalez, Javier Ramirez, Juan M. Gorriz
Summary: Spatial normalization allows quantitative comparison of brain scans and the quantification of bias introduced by nonlinear transformations is important for studying neurological disorders. Nonlinear transformations can alter diagnosis outcomes and introduce artificial information.
INTERNATIONAL JOURNAL OF NEURAL SYSTEMS
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yuliya Piatkova, Pierre Payoux, Caroline Boursier, Manon Bordonne, Veronique Roch, Pierre-Yves Marie, Gabriela Hossu, Laetitia Imbert, Antoine Verger
Summary: This study compared I-123-FP-CIT SPECT imaging obtained from a 360 degrees CZT camera with different focus configurations to that from a conventional Anger camera. The results showed that the 360 degrees CZT camera provided higher image quality, shorter acquisition times, and fewer discordant cases compared to the conventional camera, possibly due to its higher spatial resolution.
CLINICAL NUCLEAR MEDICINE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
M. Dotinga, J. D. van Dijk, B. N. Vendel, C. H. Slump, A. T. Portman, J. A. van Dalen
Summary: The study aimed to develop and validate a machine learning-based approach for interpreting I-123 FP-CIT SPECT scans to discriminate Parkinson's disease. The results showed that the method was generalizable in two centers and accurately differentiated PD from non-PD, with performance comparable to that of nuclear medicine physicians.
ANNALS OF NUCLEAR MEDICINE
(2021)
Article
Medicine, General & Internal
KyungAh Chun, EunJung Kong, IhnHo Cho
Summary: This study demonstrates a strong correlation between regional brain uptake ratios (URs) in perfusion FP-CIT PET and ECD SPECT images in patients with Parkinson's symptoms, especially in dopamine poor regions. The findings suggest that a single tracer dual phase N-3-fluoropropyl-2-beta-carboxymethoxy-3-beta-(4-iodophenyl) nortropane test may aid in the differential diagnosis of parkinsonian disorders. Further large-scale, longitudinal studies are needed to investigate the changes in correlations between perfusion F-18-FP-CIT PET/CT and Tc-99m-ECD SPECT over time in diseases with parkinsonian patterns.
Review
Clinical Neurology
Balestrino Roberta, Barone Paolo, Filippi Massimo, Erro Roberto
Summary: Although the diagnosis of Parkinson's disease relies on clinical presentation, the use of imaging techniques, particularly DAT imaging, can aid in differential diagnosis. Structural lesions and certain medications may alter the results of DAT imaging, and unexpected findings such as SWEDD or SWIDD should be considered.
JOURNAL OF NEUROLOGY
(2022)
Article
Multidisciplinary Sciences
Mahmood Nazari, Andreas Kluge, Ivayla Apostolova, Susanne Klutmann, Sharok Kimiaei, Michael Schroeder, Ralph Buchert
Summary: This study utilized explainable artificial intelligence to identify extrastriatal brain regions that could assist in the interpretation of dopamine transporter SPECT in parkinsonian syndromes. The study found that besides the striatum, other brain regions like insula, amygdala, and prefrontal cortex also played a significant role in differentiating neurodegenerative and non-neurodegenerative parkinsonian syndromes.
SCIENTIFIC REPORTS
(2021)
Article
Engineering, Biomedical
Yuan Chen, Marlies C. Goorden, Freek J. Beekman
Summary: The study investigated the feasibility of CNN methods for axially focused I-123-FP-CIT scans, showing that CNN-AC can significantly improve the quantitative accuracy of localized regions.
PHYSICS IN MEDICINE AND BIOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Felix Thiele, Franziska Schau, Julian M. M. Rogasch, Christoph Wetz, Stephanie Bluemel, Winfried Brenner, Holger Amthauer, Catharina Lange, Imke Schatka
Summary: The study aimed to establish a normal database for semiquantification of DAT SPECT using [I-123]FP-CIT on a CZT camera, compare it with the preexisting NaI-derived database, and evaluate its diagnostic findings. The results showed that semiquantification based on the CZT NDB led to fewer discordant ratings compared to the GE NDB in CZT scans, improving agreement between semiquantification and visual assessment.
Article
Radiology, Nuclear Medicine & Medical Imaging
Susanna Jakobson Mo, Jan Axelsson, Lars J. Stiernman, Anne Larsson, Sara Af Bjerken, David Backstrom, Therese Gabrielsson Kellgren, Andrea Varrone, Katrine Riklund
Summary: This study investigated the potential impact of polymorphism in the SLC6A3 gene on dopamine transporter (DAT) imaging. The results showed no significant effect of genotype on imaging, instead age had a significant effect on DAT levels.
NUCLEAR MEDICINE COMMUNICATIONS
(2022)
Article
Neurosciences
Cecilia Boccalini, Giulia Carli, Andrea Pilotto, Alessandro Padovani, Daniela Perani
Summary: This study investigated the impact of gender differences on clinical features, dopaminergic dysfunction, and connectivity in patients with Parkinson's disease across different clinical subtypes. Results showed that males and females with idiopathic PD exhibit distinct vulnerabilities and disease expressions, particularly in cognitive function, anxiety symptoms, and dopaminergic binding patterns in different brain regions.
NEUROBIOLOGY OF DISEASE
(2022)
Article
Clinical Neurology
Hiroo Terashi, Takeshi Taguchi, Yuki Ueta, Hiroshi Mitoma, Hitoshi Aizawa
Summary: The results of this study showed that I-123-FP-CIT-SPECT findings were significantly associated with motor severity and gait severity in drug-naive patients with Parkinson's disease (PD), particularly the mean specific binding ratios of the striatum and anterior putamen.
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2021)
Article
Clinical Neurology
Claudia Del Gamba, Antonino Bruno, Daniela Frosini, Duccio Volterrani, Gianmichele Migaleddu, Nicola Benedetto, Paolo Perrini, Claudio Pacchetti, Mirco Cosottini, Ubaldo Bonuccelli, Roberto Ceravolo
Summary: iNPH is a debated condition with controversial pathogenesis and diagnostic criteria. Parkinsonian signs are frequently reported, which may or may not be related to an underlying neurodegenerative parkinsonism, and distinguishing between the two is crucial for predicting long-term response to cerebrospinal fluid drainage.
NEUROLOGICAL SCIENCES
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yoshinori Ito, Naotoshi Fujita, Kazuhiro Hara, Tomohiro Tada, Shinji Abe, Masahisa Katsuno, Shinji Naganawa, Katsuhiko Kato
Summary: This study proposed a novel semi-quantitative approach to accurately evaluate the accumulation of tracers in the caudate and putamen. By examining the approximate image, the proposed method could calculate accurate accumulation amounts. Compared to conventional methods, the correlation of the proposed method was higher.
JOURNAL OF APPLIED CLINICAL MEDICAL PHYSICS
(2022)
Article
Clinical Neurology
Drummond E-Wen McCulloch, Martin Korsbak Madsen, Dea Siggaard Stenbaek, Sara Kristiansen, Brice Ozenne, Peter Steen Jensen, Gitte Moos Knudsen, Patrick MacDonald Fisher
Summary: This study evaluated the long-term effects of psilocybin on resting-state functional connectivity in healthy psychedelic-naive volunteers. The results showed that psilocybin decreased executive control network connectivity at 1 week, which predicted increased mindfulness at 3 months. This suggests that psilocybin may have lasting effects on brain connectivity and mindfulness.
JOURNAL OF PSYCHOPHARMACOLOGY
(2022)
Article
Infectious Diseases
Lars Haukali Omland, Jacob Bodilsen, Jannik Helweg-Larsen, Jens Otto Jarlov, Morten Ziebell, Svend Ellermann-Eriksen, Ulrik Stenz Justesen, Niels Frimodt-Moller, Niels Obel
Summary: This population-based cohort study reveals that long-term functional outcomes are poor for patients with brain abscess, often leading to increased healthcare visits and higher rates of sick leave. However, these differences diminish over time, suggesting potential improvement in patients' conditions. Nonetheless, these individuals still experience permanently decreased employment rates and a higher risk of disability retirement.
JOURNAL OF INFECTION
(2022)
Article
Clinical Neurology
Christian Mirian, Kathrine Grell, Tareq A. Juratli, Felix Sahm, Sabine Spiegl-Kreinecker, Matthieu Peyre, Annamaria Biczok, Joerg-Christian Tonn, Stephane Goutagny, Luca Bertero, Andrea Daniela Maier, Lasse Rehne Jensen, Gabriele Schackert, Helle Broholm, David Scheie, Daniel P. Cahill, Priscilla K. Brastianos, Jane Skjoth-Rasmussen, Kare Fugleholm, Morten Ziebell, Tina Norgaard Munch, Bjarne Winther Kristensen, Tiit Mathiesen
NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY
(2022)
Review
Clinical Neurology
Jeppe Haslund-Vinding, Jens Riis Moller, Morten Ziebell, Frederik Vilhardt, Tiit Mathiesen
Summary: Inflammatory cell infiltration is common in meningiomas and influences tumor behavior and peritumoral edema. Macrophage polarization and T-helper cell differentiation have prognostic value. The expression of programmed cell death protein 1 is a well-documented immunosuppressive and tumor-promoting mechanism found in meningiomas.
NEUROSURGICAL REVIEW
(2022)
Article
Clinical Neurology
Patrick M. Fisher, Brice Ozenne, Melanie Ganz, Vibe G. Frokjaer, Vibeke Nh Dam, Brenda Wjh Penninx, Anajli Sankar, Kamilla Miskowiak, Peter S. Jensen, Gitte M. Knudsen, Martin B. Jorgensen
Summary: This study aimed to investigate the brain responses to emotional faces in individuals with major depressive disorder (MDD) and determine whether these responses could predict the response to antidepressant treatment. The results showed that the brain responses did not differ between MDD patients and healthy controls, and they were not predictive of antidepressant treatment response.
JOURNAL OF PSYCHOPHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Drummond E-Wen McCulloch, Maria Zofia Grzywacz, Martin Korsbak Madsen, Peter Steen Jensen, Brice Ozenne, Sophia Armand, Gitte Moos Knudsen, Patrick MacDonald Fisher, Dea Siggaard Stenbaek
Summary: Psychedelic drugs like psilocybin have shown promise in treating psychiatric conditions and producing long-lasting positive psychological changes. This study found that a strong mystical experience induced by psilocybin is associated with positive effects, while transcendence of time and space and ineffability are not.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Clinical Neurology
Hannah Spitzer, Mathilde Ripart, Kirstie Whitaker, Felice D'Arco, Kshitij Mankad, Andrew A. Chen, Antonio Napolitano, Luca De Palma, Alessandro De Benedictis, Stephen Foldes, Zachary Humphreys, Kai Zhang, Wenhan Hu, Jiajie Mo, Marcus Likeman, Shirin Davies, Christopher Guttler, Matteo Lenge, Nathan T. Cohen, Yingying Tang, Shan Wang, Aswin Chari, Martin Tisdall, Nuria Bargallo, Estefania Conde-Blanco, Jose Carlos Pariente, Saul Pascual-Diaz, Ignacio Delgado-Martinez, Carmen Perez-Enriquez, Ilaria Lagorio, Eugenio Abela, Nandini Mullatti, Jonathan O'Muircheartaigh, Katy Vecchiato, Yawu Liu, Maria Eugenia Caligiuri, Ben Sinclair, Lucy Vivash, Anna Willard, Jothy Kandasamy, Ailsa McLellan, Drahoslav Sokol, Mira Semmelroch, Ane G. Kloster, Giske Opheim, Leticia Ribeiro, Clarissa Yasuda, Camilla Rossi-Espagnet, Khalid Hamandi, Anna Tietze, Carmen Barba, Renzo Guerrini, William Davis Gaillard, Xiaozhen You, Irene Wang, Sofia Gonzalez-Ortiz, Mariasavina Severino, Pasquale Striano, Domenico Tortora, Reetta Kalviainen, Antonio Gambardella, Angelo Labate, Patricia Desmond, Elaine Lui, Terence O'Brien, Jay Shetty, Graeme Jackson, John S. Duncan, Gavin P. Winston, Lars H. Pinborg, Fernando Cendes, Fabian J. Theis, Russell T. Shinohara, J. Helen Cross, Torsten Baldeweg, Sophie Adler, Konrad Wagstyl
Summary: One of the challenges in applying machine learning to diagnostic biomedical imaging is the interpretability of algorithms. This study developed an open-source and interpretable machine-learning algorithm to automatically identify FCDs from structural MRI data, improving the confidence of physicians in identifying subtle MRI lesions in individuals with epilepsy.
Article
Immunology
Lars Haukali Omland, Jacob Bodilsen, Malte Mose Tetens, Jannik Helweg-Larsen, Jens Otto Jarlov, Morten Ziebell, Svend Ellermann-Eriksen, Ulrik Stenz Justesen, Niels Frimodt-Moller, Preben Bo Mortensen, Niels Obel
Summary: Patients with brain abscess are not at increased risk of psychiatric disorders, but have an increased receipt of psychiatric medication.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Biochemistry & Molecular Biology
Apostolos Mikroulis, Eliska Waloschkova, Johan Bengzon, David Woldbye, Lars H. Pinborg, Bo Jespersen, Anna Sanchez Avila, Zsofia Laszlo, Christopher Henstridge, Marco Ledri, Merab Kokaia
Summary: GDNF enhances GABAergic inhibitory transmission to counteract seizures, and may be a potential treatment for epileptic patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Neurosciences
Emil W. Westi, Emil Jakobsen, Caroline M. Voss, Lasse K. Bak, Lars H. Pinborg, Blanca Aldana, Jens Andersen
Summary: Differences in cellular composition and structure may influence the metabolism of rodent and human brain. Human cerebral slices have lower metabolic rates but higher coupled respiration and more efficient mitochondrial coupling compared to mouse slices.
MOLECULAR NEUROBIOLOGY
(2022)
Article
Infectious Diseases
Lars Haukali Omland, Jacob Bodilsen, Jannik Helweg-Larsen, Jens Otto Jarlov, Kristian Andreasen, Morten Ziebell, Svend Ellermann-Eriksen, Ulrik S. Justesen, Niels Frimodt-Moller, Niels Obel
Summary: The research suggests that there is an association between invasive procedures and brain abscess, especially more pronounced in the hospital-based setting.
INFECTIOUS DISEASES
(2023)
Article
Biochemistry & Molecular Biology
Jens D. Mikkelsen, Sanjay S. Aripaka, Sif Kaad, Burcu A. Pazarlar, Lars Pinborg, Bente Finsen, Andrea Varrone, Benny Bang-Andersen, Jesper F. Bastlund
Summary: A newly developed radioligand [JNJ-64413739] that selectively binds to the purinergic receptor P2X7R has been found to detect neuroinflammation in the brain. The binding properties of JNJ-64413739 in human brain tissue were investigated, and it was found to have different binding abilities in gray and white matter. These findings demonstrate that JNJ-64413739 is suitable for evaluating the distribution and expression of P2X7R in the human brain.
ACS CHEMICAL NEUROSCIENCE
(2023)
Article
Medicine, General & Internal
Martin Prener, Giske Opheim, Zahra Shams, Christian Baastrup Sondergaard, Ulrich Lindberg, Henrik B. W. Larsson, Morten Ziebell, Vibeke Andree Larsen, Mark Bitsch Vestergaard, Olaf B. Paulson
Summary: In this exploratory study, the potential clinical implication of using single-voxel MRS at 7T to assess metabolic information on lesions in patients with grade II and III gliomas was evaluated. The findings showed significant changes in various metabolic ratios in glioma patients compared to healthy controls, as well as the presence of 2-HG. Evaluating metabolic information of gliomas is of significant importance in clinical practice.
Article
Medicine, General & Internal
Martin Prener, Giske Opheim, Helle Juhl Simonsen, Christina Malling Engelmann, Morten Ziebell, Jonathan Carlsen, Olaf B. Paulson
Summary: This study aimed to compare the gross tumor volume (GTV) in 7T and 3T MRI scans of diffuse low-grade gliomas (DLGGs). The results showed that GTVs delineated from 7T images were smaller, and increasing the field strength improved inter-observer agreement only on the FLAIR sequence.
Article
Clinical Neurology
Siri A. Vulpius, Sebastian Werge, Isabella Friis Jorgensen, Troels Siggaard, Jorge Hernansanz Biel, Gitte M. Knudsen, Soren Brunak, Lars H. Pinborg
Summary: This study demonstrates that text mining of clinical notes can improve the accuracy of epilepsy diagnosis and classification of different epilepsy types for patients. It suggests that combining population-based health registries with electronic health records can be crucial for future precision medicine development for epilepsy patients.