期刊
JOURNAL OF NUCLEAR MEDICINE
卷 51, 期 -, 页码 51S-65S出版社
SOC NUCLEAR MEDICINE INC
DOI: 10.2967/jnumed.109.068163
关键词
clinical cardiology; molecular imaging; vascular; atherosclerosis; plaque; vascular remodeling
资金
- NCI NIH HHS [U54 CA119342, U54 CA119342-050001] Funding Source: Medline
- NHLBI NIH HHS [R01 HL085093-04, P01 HL070295-09, R01 HL092989, P01 HL070295, R01 HL073646, R01 HL092989-01A1, R01 HL071021-07, R01 HL073646-07, R01 HL085093-03, R01 HL085093, R01 HL071021] Funding Source: Medline
- NIBIB NIH HHS [R01 EB009638, R01 EB009638-07] Funding Source: Medline
- NINDS NIH HHS [R01 NS059302-05, R01 NS059302] Funding Source: Medline
Identifying patients at high risk for an acute cardiovascular event such as myocardial infarction or stroke and assessing the total atherosclerotic burden are clinically important. Currently available imaging modalities can delineate vascular wall anatomy and, with novel probes, target biologic processes important in plaque evolution and plaque stability. Expansion of the vessel wall involving remodeling of the extracellular matrix can be imaged, as can angiogenesis of the vasa vasorum, plaque inflammation, and fibrin deposits on early nonocclusive vascular thrombosis. Several imaging platforms are available for targeted vascular imaging to acquire information on both anatomy and pathobiology in the same imaging session using either hybrid technology (nuclear combined with CT) or MRI combined with novel probes targeting processes identified by molecular biology to be of importance. This article will discuss the current state of the art of these modalities and challenges to clinical translation.
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