Article
Neurosciences
Raphael Sura Daveau, Ian Law, Otto Molby Henriksen, Steen Gregers Hasselbalch, Ulrik Bjorn Andersen, Lasse Anderberg, Liselotte Hojgaard, Flemming Littrup Andersen, Claes Nohr Ladefoged
Summary: The study demonstrates that using activity reduction and AI-assisted denoising in PET scans can successfully reduce image noise, improve visual quality, and maintain stability of clinical metrics.
Article
Radiology, Nuclear Medicine & Medical Imaging
Xinchong Shi, Yang Yang, Lulu Jiang, Jinhua Chen, Chang Yi, Ganhua Luo, Lei Wu, Jianmin Chu, Jian Wang, Ling Chen, Xiangsong Zhang
Summary: This study compared two imaging tracers, F-18-DOPA and F-18-DTBZ, for PET/CT imaging in idiopathic Parkinson disease (PD). The results showed that both tracers could reflect the same level of dopaminergic neuron degeneration in early stages of PD, and they had consistent visual analysis results.
CLINICAL NUCLEAR MEDICINE
(2022)
Article
Biology
Arturo Avendano-Estrada, Miguel Angel Olarte-Casas, Miguel Angel Avila-Rodriguez
Summary: The diagnosis of neurological diseases is complicated, but PET molecular imaging can help with early and accurate diagnosis and staging. This study proposed a novel method to combine PET data of two radiopharmaceuticals and obtain new quantitative metrics. The results showed that this method can effectively differentiate healthy controls from Parkinson's disease patients and detect slight changes in patients undergoing treatment.
COMPUTERS IN BIOLOGY AND MEDICINE
(2024)
Article
Geriatrics & Gerontology
Wen-biao Xian, Xin-chong Shi, Gan-hua Luo, Chang Yi, Xiang-song Zhang, Zhong Pei
Summary: The study demonstrated that co-registration analysis of F-18-flurodeoxyglucose and F-18-fluorodopa PET images can effectively differentiate between Parkinson's disease and multiple system atrophy parkinsonian subtype (MSA-P). Parkinson's disease patients showed hypermetabolism in the bilateral putamen, while MSA-P patients exhibited hypometabolism in this region.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Article
Chemistry, Physical
Sandip Porey, Yogesh Bairagi, Srimanta Guin, Xinglong Zhang, Debabrata Maiti
Summary: Fluorinated entities are highly valued in medicinal chemistry due to their enhanced bioactivity. This article presents a non-directed strategy for the regioselective synthesis of α-fluoro olefins using palladium-catalyzed C-H/C-F coupling. The method allows for late-stage derivatization of drugs and natural products, and provides a way to conjugate drugs with natural products through a fluoro-olefin bridge.
Review
Rheumatology
Manil Subesinghe, Shaheel Bhuva, Nikita Arumalla, Andrew Cope, David D'Cruz, Sujith Subesinghe
Summary: 2-deoxy-2[F-18]fluoro-D-glucose (FDG) PET-CT has revolutionized oncological imaging, and it is also widely used in the diagnosis and treatment of infectious and inflammatory diseases. Rheumatological diseases, which can affect multiple sites within the musculoskeletal system, can be accurately diagnosed and treated using FDG PET-CT.
Review
Neurosciences
Marcos Martinez-Banaclocha
Summary: Parkinson's disease is a prevalent age-related neurodegenerative disorder, with the majority of cases being sporadic, though a small percentage are associated with gene mutations. Environmental toxic substances and individual genetic susceptibility play a role in the onset of the disease. Despite efforts to treat and prevent Parkinson's disease, the pathophysiological mechanisms leading to its onset and progression are not fully understood.
Article
Chemistry, Medicinal
Benedikt Groener, Michael Willmann, Lisa Donnerstag, Elizaveta A. Urusova, Felix Neumaier, Swen Humpert, Heike Endepols, Bernd Neumaier, Boris D. Zlatopolskiy
Summary: In this study, a new type of F-18-labeled building blocks, 1-alkylamino-7-[F-18]fluoro-8-azaisatoic anhydrides ([F-18]AFAs), were introduced as versatile prosthetic groups. The [F-18]AFAs were efficiently prepared and conjugated with various amines or functionalized precursors using click chemistry. The practical utility and stability of the F-18-labeled prosthetic groups were demonstrated through the preparation and evaluation of F-18-labeled PSMA ligands.
JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Chemistry, Organic
Yuxiu Li, Xiangqian Li, Xiaowei Li, Dayong Shi
Summary: The direct synthesis of alpha-fluoro-beta-arylalkenyl sulfones without transition-metal and base conditions has been described, showing broad functional group compatibility and high stereoselectivity. This strategy is also applied to the late-stage modification of complex natural products and drugs.
JOURNAL OF ORGANIC CHEMISTRY
(2021)
Review
Clinical Neurology
Haim Golan, Olga Volkov, Eli Shalom
Summary: This review provides a comprehensive analysis of Parkinson's disease-related imaging techniques. While there is a wide range of imaging tools available for early diagnosis and treatment assessment of PD, there is still a need for further research in areas such as PD genetics, pathology, and early diagnosis.
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2022)
Article
Chemistry, Multidisciplinary
Shivashankar Khanapur, Kenneth Lye, Dipendu Mandal, Xin Jie Wee, Edward G. Robins, Rowan D. Young
Summary: We present a general method for labeling both CF3 and CF2H groups in various chemical settings. The method provides good radiochemical yields and molar activities, and is applicable to biologically relevant compounds. The use of target compounds as starting materials and the simplicity of the method make it attractive for drug and radiotracer development.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Chemistry, Physical
Itsuki Nohira, Naoto Chatani
Summary: In this study, a Ni-catalyzed cross-electrophile coupling between C(sp(2))-F bonds in ortho-fluoro-substituted aromatic amides and C(sp(2))-Cl bonds in aryl chlorides was reported. The reaction, using Zn as a reductant and (LiOBu)-Bu-t as a base, with LiCl and ZnCl2 as additives, displayed excellent functional group tolerance and a broad substrate scope. Furthermore, the reaction was also applicable to cross-electrophile coupling between C(sp(2))-F and C(sp(2))-O bonds in an aryl tosylate and a triflate derivative.
Article
Oncology
Suk-Hyun Lee, Jee-Soo Park, Hyunjeong Kim, Dongwoo Kim, Seung-Hwan Lee, Won-Sik Ham, Woong-Kyu Han, Young-Deuk Choi, Mijin Yun
Summary: The heterogeneous uptake of both F-18 FDG and C-11 methionine on PET/CT in renal cell carcinomas is associated with higher grades of cancer. The metabolic tumour volume on F-18 FDG PET/CT but not C-11 methionine PET/CT is significant in predicting advanced-stage renal cell carcinoma. These metabolic features derived from PET/CT imaging may aid in the development of new drugs targeting glucose and amino acid metabolic pathways.
Article
Veterinary Sciences
Su-Hyeon Kim, Sungin Lee
Summary: This case report describes the characteristics of 18F-FDG PET-CT imaging in a dog with an abdominal gossypiboma, which has not been reported in the veterinary literature before. A 13-year-old, spayed, female mixed breed dog underwent mastectomy and ovariohysterectomy and was referred for evaluation of metastasis after surgery. F-18-deoxy-2-D-glucose positron emission tomography/computed tomography (18F-FDG PET-CT) was performed and a soft-tissue mass was observed in the abdominal cavity.
FRONTIERS IN VETERINARY SCIENCE
(2023)
Review
Oncology
Luca Urso, Elena Bonatto, Alberto Nieri, Angelo Castello, Anna Margherita Maffione, Maria Cristina Marzola, Corrado Cittanti, Mirco Bartolomei, Stefano Panareo, Luigi Mansi, Egesta Lopci, Luigia Florimonte, Massimo Castellani
Summary: This review highlights the crucial role of molecular imaging, specifically using PET radiotracers, in the evaluation of patients with brain metastases. It outlines the current application and future prospects of PET radiotracers, including radiomics and theranostics approaches. The evidence confirms the significance of amino acid PET radiotracers in delineating tumor extension, assessing therapy response, and differentiating between tumor progression and radionecrosis.
Article
Cardiac & Cardiovascular Systems
Quentin Brana, Frederique Thibault, Maxime Courtehoux, Gilles Metrard, Maria Joao Ribeiro, Denis Angoulvant, Matthieu Bailly
Summary: This study compared the effects of dipyridamole and regadenoson on inducing hyperemia and found that they were equally effective in comparable patients.
JOURNAL OF NUCLEAR CARDIOLOGY
(2022)
Review
Neurosciences
Dominique Gouilly, Laure Saint-Aubert, Maria-Joao Ribeiro, Anne-Sophie Salabert, Clovis Tauber, Patrice Peran, Nicolas Arlicot, Jeremie Pariente, Pierre Payoux
Summary: This review provides an update on the results from 2018 and advances the characterization of TSPO imaging in Alzheimer's disease (AD) by re-examining TSPO function and expression. Although the biological basis of the TSPO PET signal is clearly related to microglia and astrocytes in AD, the exact process remains uncertain and may not be directly associated with neuroinflammation. Further studies are needed to explore the cellular significance underlying variations in the PET signal in AD.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2022)
Article
Ophthalmology
Munirah Alafaleq, Romain Freund, Marie-Aude Penet, Christine Fardeau, Corinne Isnard-Bagnis, Sophie Tezenas du Montcel, Gilbert Deray, Phuc L. E. Hoang, Bahram Bodaghi, Isabelle Tostivint
Summary: The study assessed CsA-induced nephrotoxicity and its reversibility after withdrawal in CPU patients. Monitoring renal tolerance early and long-term, as well as adjusting CsA doses in inflammatory stages of CPU were associated with reversible CsA nephrotoxicity.
Article
Neurosciences
Quentin Gallet, Vincent Bouteloup, Maxime Locatelli, Marie-Odile Habert, Marie Chupin, Julien Delrieu, Thibaud Lebouvier, Gabriel Robert, Renaud David, Samuel Bulteau, Anna-Chloe Balageas, Alexandre Surget, Catherine Belzung, Nicolas Arlicot, Maria-Joao Ribeiro, Laurent Barantin, Frederic Andersson, Jean-Philippe Cottier, Valerie Gissot, Wissam El-Hage, Vincent Camus, Benedicte Gohier, Thomas Desmidt
Summary: Recent evidence suggests a connection between BZDs use and lower brain amyloid load, with potential effects on hippocampal volume and symptoms of depression, anxiety, and apathy. Additional research is needed to confirm the causal relationship and explore potential therapeutic targets for Alzheimer's disease.
NEUROPSYCHOPHARMACOLOGY
(2022)
Article
Clinical Neurology
Heike Jacobi, Tamara Schaprian, Jan Beyersmann, Sophie Tezenas du Montcel, Matthias Schmid, Thomas Klockgether
Summary: The study investigated the evolution of disability in spinocerebellar ataxias (SCAs) type 1, 2, 3, and 6. The data showed that CAG repeat length was associated with faster progression in SCA1, SCA2, and SCA3, while female sex was associated with faster progression in SCA6. These findings are important for counseling patients, assessing outcome markers, and designing clinical trials.
ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY
(2022)
Article
Clinical Neurology
Giulia Coarelli, Anna Heinzmann, Claire Ewenczyk, Clara Fischer, Marie Chupin, Marie-Lorraine Monin, Hortense Hurmic, Fabienne Calvas, Patrick Calvas, Cyril Goizet, Stephane Thobois, Mathieu Anheim, Karine Nguyen, David Devos, Christophe Verny, Vito A. G. Ricigliano, Jean-Francois Mangin, Alexis Brice, Sophie Tezenas du Montcel, Alexandra Durr
Summary: A randomized, double-blind, placebo-controlled trial was conducted in France to assess the effectiveness of riluzole in patients with spinocerebellar ataxia type 2, involving 45 moderately affected patients. The study found that riluzole did not show improvement in clinical or radiological outcomes in these patients, but provided valuable data for the design of future clinical trials.
Article
Clinical Neurology
Sandrine Brice, Sonia Reyes, Aude Jabouley, Carla Machado, Christina Rogan, Nathalie Gastellier, Nassira Alili, Stephanie Guey, Eric Jouvent, Dominique Herve, Sophie Tezenas du Montcel, Hugues Chabriat
Summary: This study analyzed the trajectory pattern of cognitive decline in patients with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) from age 25 to 75. The results showed wide and heterogeneous variations in cognitive scores during the progression of the disease. Male gender, gait disorders, and certain disabilities at baseline were found to predict earlier or larger changes in specific cognitive scores.
Article
Genetics & Heredity
Lucie Pierron, Sophie Tezenas du Montcel, Anna Heinzmann, Giulia Coarelli, Delphine Heron, Solveig Heide, Ariane Herson, Juliette Hennessy, Elodie Petit, Marcela Gargiulo, Alexandra Durr
Summary: This study investigates how reproductive options are considered in families impacted by neurogenetic diseases and whether there is a relationship with the perceived severity of the disease. The findings suggest that the severity of the disease has some influence on reproductive options, but minimally impacts intrafamilial communication.
JOURNAL OF MEDICAL GENETICS
(2023)
Article
Clinical Neurology
Laurent Cleret de Langavant, Emmanuel Roze, Aimee Petit, Benoit Tressieres, Amin Gharbi-Meliani, Hugo Chaumont, Patrick Pierre Michel, Anne-Catherine Bachoud-Levi, Philippe Remy, Regine Edragas, Annie Lannuzel
Summary: The research found that in the Caribbean, the consumption of Annonaceae products is positively associated with the disease severity and cognitive deficits of patients with degenerative parkinsonism.
MOVEMENT DISORDERS
(2022)
Article
Clinical Neurology
Paul Moulaire, Pierre Emmanuel Poulet, Emilien Petit, Thomas Klockgether, Alexandra Durr, Tetsuo Ashisawa, Sophie Tezenas du Montcel
Summary: This study analyzed the temporal dynamics of SARA and f-SARA in assessing the severity of cerebellar ataxia. The global progression of SARA was found to be linear, while f-SARA showed slower progression, requiring a larger sample size for therapeutic trials.
MOVEMENT DISORDERS
(2023)
Article
Public, Environmental & Occupational Health
Joris Muller, Pierre Tran Ba Loc, Florence Binder Foucard, Aurelie Borde, Amelie Bruandet, Maggie Le Bourhis-Zaimi, Xavier Lenne, Eric Ouattara, Fabienne Seguret, Veronique Gilleron, Sophie Tezenas du Montcel
Summary: This study provides a detailed description of the geographic and temporal evolution of COVID-19 in France, revealing significant interregional differences. The findings can help understand the dynamics of future epidemic waves.
REVUE D EPIDEMIOLOGIE ET DE SANTE PUBLIQUE
(2022)
Article
Psychiatry
Hugues Lamothe, Christiane Schreiweis, Lizbeth Sirenia Mondragon-Gonzalez, Sana Rebbah, Oriana Lavielle, Luc Mallet, Eric Burguiere
Summary: Research has found that the behavior of Sapap3 knockout mice is more complex than previously described, including sudden and rapid twitching of the head and body, resembling tic-like movements. Aberrant hindpaw scratching may also be responsible for the skin lesions observed in this mouse model. Pharmacological treatment with aripiprazole significantly reduced the number of head/body twitches, scratching, and single-phase grooming, indicating a potential treatment for tic-like symptoms in Tourette syndrome and trichotillomania.
TRANSLATIONAL PSYCHIATRY
(2023)
Article
Genetics & Heredity
Sandra Martins, Ashraf Yahia, Ines P. D. Costa, Hassab E. Siddig, Rayan Abubaker, Mahmoud Koko, Marc Corral-Juan, Antoni Matilla-Duenas, Alexis Brice, Alexandra Durr, Eric Leguern, Laura P. W. Ranum, Antonio Amorim, Liena E. O. Elsayed, Giovanni Stevanin, Jorge Sequeiros
Summary: Machado-Joseph disease (MJD/SCA3) is the most common dominant ataxia worldwide, caused by a (CAG)n expansion. This study reports the first diagnosed MJD case in Sudan, with genetic analysis revealing shared ancestry with Portuguese, Spanish, and North American families. The STR-based haplotype of the Sudanese patients is distinct, indicating a unique genetic background.
Meeting Abstract
Clinical Neurology
Lucie Pierron, Sophie Tezenas Du Montcel, Anna Heinzmann, Giulia Coarelli, Delphine Heron, Solveig Heide, Ariane Herson, Juliette Hennessy, Elodie Petit, Marcela Gargiulo, Alexandra Dun
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2022)
Meeting Abstract
Radiology, Nuclear Medicine & Medical Imaging
Johnny Vercouillie, Anne-Claire Dupont, Nicolas Arlicot, Valerie Gissot, Gabrielle Chicheri, Laurent Barantin, Frederique Bonnet-Brilhault, Maria Joao Ribeiro
NUCLEAR MEDICINE AND BIOLOGY
(2022)