Article
Oncology
Fatma Nihan Akkoc Mustafayev, Mihir Amitabh Shukla, Amanda Lanier, Denai R. Milton, Angelica M. Gutierrez, Stephen K. Gruschkus, John E. Lewis, Rashmi K. Murthy, Banu K. Arun
Summary: BRCA1/2 mutations occurred in 6.6% of patients with human epidermal growth factor receptor 2 (HER2/neu)-positive breast cancer. However, BRCA mutation status did not affect survival outcomes in patients who had HER2/neu-positive breast cancer.
Article
Biochemistry & Molecular Biology
Sudath Hapuarachchige, Ge Si, Colin T. Huang, Wojciech G. Lesniak, Ronnie C. Mease, Xin Guo, Kathleen Gabrielson, Dmitri Artemov
Summary: Pretargeted drug delivery using a HER2 pretargeting component and a drug delivery component showed significant therapeutic efficacy in a HER2-positive breast cancer model, demonstrating a promising approach for cancer therapy.
Article
Oncology
Sinan Wang, Jun Li, Jun Hua, Yang Su, Denis R. Beckford-Vera, Walter Zhao, Mayuri Jayaraman, Tony L. Huynh, Ning Zhao, Yung-hua Wang, Yangjie Huang, Fujun Qin, Sui Shen, Daniel Gioeli, Robert Dreicer, Renuka Sriram, Emily A. Egusa, Jonathan Chou, Felix Y. Feng, Rahul Aggarwal, Michael J. Evans, Youngho Seo, Bin Liu, Robert R. Flavell, Jiang He
Summary: The novel CD46-targeted PET radiopharmaceutical [Zr-89]DFO-YS5 shows specific binding and uptake in human prostate cancer models, including PSMA-negative and AR-negative tumors, demonstrating potential for clinical translation as an imaging agent and biomarker in prostate cancer.
CLINICAL CANCER RESEARCH
(2021)
Review
Oncology
Martina Di Modica, Valeria Arlotta, Lucia Sfondrini, Elda Tagliabue, Tiziana Triulzi
Summary: Microbiota plays a key role in cancer by influencing various host physiological functions and affecting the efficacy of anticancer treatments. The involvement of the breast microbiota in breast cancer has been extensively studied. This review focuses on the impact of gut and breast microbiota on HER2+ breast cancer subtype and discusses the potential of defining microbial signatures associated with disease aggressiveness, treatment response, and therapy toxicity. The mechanisms of microorganism-host interactions and the possibility of microbiota editing in breast cancer prevention and treatment optimization are also explored.
FRONTIERS IN ONCOLOGY
(2022)
Article
Pharmacology & Pharmacy
Adhika Balgobind, Aliscia Daniels, Mario Ariatti, Moganavelli Singh
Summary: This study assessed the efficacy of cationic lipid-based systems for the delivery of HER2/neu siRNA in breast cancer. The results showed that cationic liposomes efficiently bound, compacted, and protected the therapeutic siRNA against degradation. The non-PEGylated Chol-T-siRNA lipoplexes exhibited the highest HER2/neu silencing.
Article
Oncology
Melody A. Cobleigh, Charles L. Vogel, Debu Tripathy, Nicholas J. Robert, Susy Scholl, Louis Fehrenbacher, Janet M. Wolter, Virginia Paton, Steven Shak, Gracie Lieberman, Dennis J. Slamon
Summary: Recombinant humanized anti-HER2 monoclonal antibody as a single agent shows durable objective responses and good tolerability in women with HER2-overexpressing metastatic breast cancer that has progressed after chemotherapy for metastatic disease.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Biochemical Research Methods
Cuicui Li, Lei Kang, Kevin Fan, Carolina A. Ferreira, Kaelyn Becker, Nan Huo, Hanxiao Liu, Yunan Yang, Jonathan W. Engle, Rongfu Wang, Xiaojie Xu, Dawei Jiang, Weibo Cai
Summary: The study investigated the use of Cu-64-NOTA-YY146 for imaging CD146 expressions in breast cancer, demonstrating its potential for diagnosis, prognosis prediction, and monitoring therapeutic response in orthotopic and metastatic tumor models.
BIOCONJUGATE CHEMISTRY
(2021)
Article
Oncology
Ziqi Li, Erika Belitzky, Ondrej Blaha, Alessandra Cavaliere, Samantha R. R. Katz, Mariam Aboian, Lindy Melegari, Khashayar Rajabimoghadam, Stephen Kurpiewski, Xiaohua Zhu, Bernadette Marquez-Nostra
Summary: This study aimed to evaluate the effects of a specific drug (Dasatinib) on triple-negative breast cancer (TNBC) cells, specifically the impact on gpNMB expression, and to explore the efficacy of combination therapy. The findings demonstrated that Dasatinib increased gpNMB expression and enhanced the effectiveness of antibody drug conjugates. Therefore, these findings are significant for combination therapy in TNBC.
Article
Medicine, General & Internal
Francisca Mulero, Marta Oteo, Guillermo Garaulet, Natalia Magro, Lluvia Rebollo, Guillermo Medrano, Clara Santiveri, Eduardo Romero, Ricela E. Sellek, Yago Margolles, Ramon Campos-Olivas, Alicia G. Arroyo, Luis Angel Fernandez, Miguel Angel Morcillo, Jorge L. Martinez-Torrecuadrada
Summary: In this study, a nanobody-based PET imaging strategy targeting MT1-MMP for TNBC detection was developed. ImmunoPET imaging with specific nanobodies showed precise tumor-targeting capacity in vivo with high signal-to-background ratios, and the imaging data correlated perfectly with the immunohistochemistry staining results. This research provides a promising candidate for nanobody-based PET imaging as a diagnostic tool in TNBC.
FRONTIERS IN MEDICINE
(2022)
Review
Medicine, General & Internal
Jeremy McGale, Sakshi Khurana, Alice Huang, Tina Roa, Randy Yeh, Dorsa Shirini, Parth Doshi, Abanoub Nakhla, Maria Bebawy, David Khalil, Andrew Lotfalla, Hayley Higgins, Amit Gulati, Antoine Girard, Francois-Clement Bidard, Laurence Champion, Phuong Duong, Laurent Dercle, Romain-David Seban
Summary: HER2-positive breast cancer, characterized by amplification of the HER2 gene, is associated with aggressive tumor growth, increased metastatic risk, and poorer prognosis compared to other subtypes. HER2 expression is a crucial tumor feature for breast cancer diagnosis and treatment. Advancements in HER2 in vivo imaging techniques like PET and SPECT may enhance the role of HER2 status in guiding breast cancer management, enabling determination of tumor size, location, and evaluation of treatment effectiveness. This review explores the current and future role of HER2 imaging in personalized care for breast cancer patients.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Pharmacology & Pharmacy
Kandasamy Saravanakumar, Anbazhagan Sathiyaseelan, Soyoung Park, Song-Rae Kim, Veeraraghavan Vishnu Priya, Myeong-Hyeon Wang
Summary: This study developed a dual stimuli responsive nanocarrier system for the treatment of HER2+ breast cancer. The nanocarrier demonstrated promising selectivity and cytotoxicity against HER2+ breast cancer cells. The biocompatibility of the nanocarrier was confirmed in mice, and it was shown to inhibit tumor growth through altering oxidative stress.
Article
Chemistry, Analytical
Merve Yilmaz, Monireh Bakhshpour, Ilgim Gokturk, Ayse Kevser Piskin, Adil Denizli
Summary: The heterogeneity and metastatic features of cancer cells lead to many casualties worldwide, making the development of a simple and effective diagnostic system to detect molecular markers of cancer crucial. Researchers have developed a specific and simple quartz crystal microbalance system to identify HER2/neu expressing breast cancer cells using a receptor-specific monoclonal antibody.
Article
Oncology
Carolina A. Ferreira, Lei Kang, Cuicui Li, Anyanee Kamkaew, Kendall E. Barrett, Eduardo Aluicio-Sarduy, Yunan Yang, Jonathan W. Engle, Dawei Jiang, Weibo Cai
Summary: This study developed a CD146-specific monoclonal antibody for targeting breast tumors, demonstrating its non-invasive imaging capabilities. The results showed that the antibody bound to CD146 and significantly improved the accuracy of PET imaging in vivo, providing new possibilities for cancer diagnosis.
AMERICAN JOURNAL OF CANCER RESEARCH
(2021)
Review
Chemistry, Medicinal
Alexandre Holzbach, Bernardo Perin Cima, Mari Dalva Staffen, Juliana Dal-Ri Lindenau, Yara Costa Netto Muniz
Summary: This study aims to identify the mechanisms of resistance to trastuzumab treatment in HER2+ breast cancer patients. Through comprehensive literature review and meta-analysis, a total of 102 resistance mechanisms were identified, mainly focused on the PI3K/Akt/mTOR pathway and low HER2 expression. Drug resistance poses a major challenge to trastuzumab-based treatment, and it is crucial to understand the mechanisms of cancer drug resistance, identify new therapeutic approaches, and develop predictive gene panels.
MINI-REVIEWS IN MEDICINAL CHEMISTRY
(2023)
Article
Oncology
Ioannis A. Vathiotis, Myrto K. Moutafi, Prajan Divakar, Thazin Nwe Aung, Tao Qing, Aileen Fernandez, Vesal Yaghoobi, Sarra El-Abed, Yingbo Wang, Sebastien Guillaume, Paolo Nuciforo, Jens Huober, Serena Di Cosimo, Sung-Bae Kim, Nadia Harbeck, Henry Gomez, Saba Shafi, Konstantinos N. Syrigos, George Fountzilas, Christos Sotiriou, Lajos Pusztai, Sarah Warren, David L. Rimm
Summary: Companion diagnostic test for trastuzumab has remained largely unchanged over the last 25 years. High-plex digital spatial profiling identified alpha-smooth muscle actin (alpha-SMA) as a potential biomarker of resistance to trastuzumab in HER2-positive breast cancer. Orthogonal validation confirmed the association of high alpha-SMA expression with shorter disease-free survival, suggesting its potential role in predicting response to trastuzumab in combination therapy settings.
CLINICAL CANCER RESEARCH
(2021)
Article
Oncology
Lalitha K. Shankar, Erich Huang, Saskia Litiere, Otto S. Hoekstra, Larry Schwartz, Sandra Collette, Ronald Boellaard, Jan Bogaerts, Lesley Seymour, Elisabeth G. E. deVries
Summary: Currently, guidelines for PET with FDG-PET interpretation for therapy response in oncology involve visual evaluation of FDG-PET/CT scans. However, quantitative measurements of metabolic activity in tumors may be more useful. Guidelines based on such measurements have been proposed, but more analysis is needed for regular use.
CLINICAL CANCER RESEARCH
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Joyce van Sluis, Walter Noordzij, Elisabeth G. E. de Vries, Iris C. Kok, Derk Jan A. de Groot, Mathilde Jalving, Marjolijn N. Lub-de Hooge, Adrienne H. Brouwers, Ronald Boellaard
Summary: This study explores the influence of using manual segmentations versus an AI-based automated segmentation tool on calculating whole-body effective doses. The results show that using AI-based segmentations can save time and achieve higher similarity coefficients compared to manual segmentations. The whole-body effective doses show minimal differences for the six patients.
MOLECULAR IMAGING AND BIOLOGY
(2023)
Article
Obstetrics & Gynecology
Koen De Decker, Hans H. B. Wenzel, Joost Bart, Maaike A. van der Aa, Roy F. P. M. Kruitwagen, Hans W. W. Nijman, Arnold-Jan Kruse
Summary: This study aimed to report trends in stage, primary treatment, and relative survival of low-grade serous carcinoma (LGSC) of the ovary in a large cohort of patients. The results showed that LGSC was increasingly diagnosed as advanced stage and interval debulking surgery was preferred more often. Relative survival did not change significantly, and worse survival outcomes were observed after interval debulking surgery.
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
(2023)
Article
Oncology
Ramsha Iqbal, Maqsood Yaqub, Huseyyin O. Bektas, Daniela E. Oprea-Lager, Elisabeth G. E. de Vries, Andor W. J. M. Glaudemans, Philippe Aftimos, Geraldine Gebhart, Andrew P. Beelen, Robert C. Schuit, Albert D. Windhorst, Ronald Boellaard, C. Willemien Menke-van der Houven van Oordt
Summary: The purpose of this study was to investigate the use of [18F]-fluorodeoxyglucose ([18F]FDG) and [18F]-fluoro-17(3-estradiol ([18F]FES) PET/CT imaging in patients with metastatic ER-positive breast cancer undergoing treatment with rintodestrant. The study found that absence of ER expression on [18F]FES PET is a predictor for no response to rintodestrant. [18F]FES uptake during treatment and at time of progression is useful to monitor the effect of therapy and continued mode of action of SERDs.
CLINICAL CANCER RESEARCH
(2023)
Article
Oncology
Miranda P. Steenbeek, Majke H. D. van Bommel, Joanna intHout, Christine B. Peterson, Michiel Simons, Kit C. B. Roes, Marleen Kets, Barbara M. Norquist, Elizabeth M. Swisher, Rosella P. M. G. Hermens, Karen H. Lu, Joanne A. de Hullu
Summary: This study aims to investigate whether delayed oophorectomy is non-inferior to standard salpingo-oophorectomy for the prevention of tubo-ovarian cancer among individuals at high inherited risk. It is an international prospective preference trial, where participants can choose between delayed oophorectomy and standard salpingo-oophorectomy. Recruitment is expected to be completed by the end of 2026, and the primary outcome will be available in 2036.
INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
(2023)
Article
Oncology
Lieke Lanjouw, Marian J. E. Mourits, Joost Bart, Arja ter Elst, Lieke P. Berger, Annemieke H. van der Hout, Naufil Alam, Geertruida H. de Bock
Summary: This study aimed to evaluate the BRCA1/2 testing rates in patients with epithelial ovarian cancer and compare the rates between germline testing and tumor-first testing. The results showed suboptimal testing rates and indicated that patients with non-high-grade serous carcinoma were less likely to receive BRCA1/2 testing. This suggests that clinicians may not be adhering to the guidelines recommending testing for all patients with epithelial ovarian cancer.
INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
(2023)
Article
Oncology
Iris A. S. Stroot, Jan Brouwer, Joost Bart, Harry J. Hollema, Denise M. Stommel-Jenner, Marise C. Wagner, Helena A. van Doorn, Joanne N. de Hullu, Katja Gaarenstroom, Marc Beurden, Luc R. C. W. van Lonkhuijzen, Brigitte F. M. P. Slangen, Ronald B. Zweemer, Encarna B. Gomez Garcia, Margreet G. E. M. A. Ausems, Ingrid Boere, Klaartje J. van Engelen, Christi K. van Asperen, Marjanka R. Schmidt, Marijke H. Wevers, Geertruida de Bock, Marian J. E. Mourits, HEBON Investigators
Summary: This study aimed to investigate the prevalence of and clinical factors associated with high-grade serous carcinoma (HGSC) at risk-reducing salpingo-oophorectomy (RRSO) in asymptomatic BRCA1/2-pathogenic variant (PV) carriers. The study found a prevalence of 1.5% (BRCA1-PV) and 0.6% (BRCA2-PV) of HGSC in RRSO specimens, with long-term oral contraceptive use being protective against cancer.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Oncology
Marianne Luyendijk, Otto Visser, Hedwig M. Blommestein, Ignace H. J. T. de Hingh, Frank J. P. Hoebers, Agnes Jager, Gabe S. Sonke, Elisabeth G. E. de Vries, Carin A. Uyl-de Groot, Sabine Siesling
Summary: This study evaluated the changes in survival of patients with de novo metastatic solid cancers over the past 30 years. The proportion of M1 disease and net survival rates varied among different cancer types. Better preventive measures and early detection are needed to reduce the incidence of metastatic disease.
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE
(2023)
Editorial Material
Multidisciplinary Sciences
Elena Garralda, Scott A. Laurie, Lesley Seymour, Elisabeth G. E. de Vries
Summary: Early detection of immunotherapy-induced tumor response is crucial, but therapy-induced pseudoprogression can make it complicated. A consensus guideline called iRECIST, a modification of RECIST version 1.1, was developed. This article explores the next steps required to test its validity and proposes novel approaches for response criteria.
NATURE COMMUNICATIONS
(2023)
Article
Oncology
Elisabeth G. E. de Vries, Josef Rueschoff, Martijn Lolkema, Josep Tabernero, Luca Gianni, Emile Voest, Derk Jan A. de Groot, Daniel Castellano, Gilles Erb, Julia Naab, Margarita Donica, Regula Deurloo, Michiel S. van Der Heijden, Giuseppe Viale
Summary: This study aimed to investigate tumor HER2 expression and its effects on T-DM1 treatment in patients with HER2-positive urothelial bladder cancer or pancreatic cancer/cholangiocarcinoma. The results showed that some HER2-positive bladder cancer and pancreatic cancer patients responded well to T-DM1, and it also provided insight into the prevalence of HER2 positivity and expression patterns in these three non-breast tumor types.
Article
Oncology
Eline J. Oymans, Cor D. de Kroon, Joost Bart, Hans W. Nijman, Maaike A. van der Aa
Summary: This study found that the number of diagnoses of gynaecological malignancies in the Netherlands did not significantly change during the COVID-19 pandemic and lockdown. However, there was a clear decrease in diagnoses during the first wave of the pandemic, followed by an increase in the second half of 2020 and in 2021. The study also found no differences in diagnoses between different socioeconomic groups. Rating: 8/10
CANCER EPIDEMIOLOGY
(2023)
Article
Oncology
C. J. H. Kramer, L. Lanjouw, D. Ruano, A. ter Elst, G. Santandrea, N. Solleveld-Westerink, N. Werner, A. H. van Der Hout, C. D. de Kroon, T. van Wezel, L. P. Berger, M. Jalving, J. Wesseling, V. T. H. B. M. Smit, G. H. de Bock, C. J. van Asperen, M. J. E. Mourits, M. P. G. Vreeswijk, J. Bart, T. Bosse
Summary: This study analyzed the causal BRCA1/2 gene variants in different types of ovarian cancer tissues. The results showed that except for high-grade serous ovarian carcinoma, there were minimal BRCA1/2 PVs in other types of ovarian cancer. The study also identified some potentially misdiagnosed cases and conducted in-depth analysis of the pathogenic mechanism of BRCA1/2 variants. These findings suggest that histotype-directed sequencing may be more informative than universal sequencing.
JOURNAL OF PATHOLOGY
(2023)
Article
Obstetrics & Gynecology
Hein S. Zelisse, Mignon van Gent, Sander de Ridder, Maaike A. van der Aa, Anne M. van Altena, Joost Bart, Jeroen A. M. Belien, Ingrid A. Boere, Steven L. Bosch, Annegien Broeks, Johan Bulten, Margriet Collee, Floris H. Groenendijk, Hugo Horlings, Maurice P. H. M. Jansen, G. N. Jonges, Loes Kooreman, Cornelis D. de Kroon, Sandrina Lambrechts, Christianne Lok, Jurgen M. Piek, Anna K. L. Reyners, Eva-Maria Roes, Michiel Simons, Gba Wisman, Refika Yigit, Ronald Zweemers, Constantijne H. Mom, Marc J. van de Vijver, Frederike Dijk
Summary: The Archipelago of Ovarian Cancer Research (AOCR) is a Dutch nationwide interdisciplinary infrastructure and biobank that aims to improve fundamental and translational research on ovarian cancer. It collects and stores biomaterials for future genetic research and encourages researchers to contribute their own data and materials. The ultimate goal is to enhance diagnostics, treatment, and survival rates for ovarian cancer patients.
GYNECOLOGIC AND OBSTETRIC INVESTIGATION
(2023)
Meeting Abstract
Medicine, Research & Experimental
Maaike Bleeker, Tjalling Bosse, Koen Van de Vijver, Joost Bart, Hugo Horlings, Trudy Jonges, Nicole Visser, Loes Kooreman, Patricia C. Ewing-Graham, Johan Bulten
LABORATORY INVESTIGATION
(2023)
Article
Oncology
Laure Nicolai, Refika Yigit, Maaike C. G. Bleeker, Joost Bart, Jacobus van der Velden, Constantijne H. Mom
Summary: For patients with stage IA cervical cancer with a diameter >7 mm, we recommend considering a pelvic lymph node assessment in case of DOI >3 mm and/or presence of LVSI.
JOURNAL OF GYNECOLOGIC ONCOLOGY
(2023)