Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Jin Qi, Elizabeth Kurian, Orhan K. oez
Summary: Hibernomas are rare benign tumors originating from fetal brown adipose tissue. They can occur in various parts of the body, with thigh, shoulder, back, and neck being the most common locations, and are rarely found in the abdominal cavity, retroperitoneum, breast, bones, scrotum, and perirectum. We present a case of a 58-year-old woman with a mediastinal mass, who was incidentally found to have an FDG-avid fat-containing lesion in the omentum abutting the stomach.
CLINICAL NUCLEAR MEDICINE
(2023)
Article
Neurosciences
Yanxiao Li, Yee Ling Ng, Manish D. Paranjpe, Qi Ge, Fengyun Gu, Panlong Li, Shaozhen Yan, Jie Lu, Xiuying Wang, Yun Zhou
Summary: This study aimed to improve the statistical power in detecting changes in brain glucose metabolism, amyloid, and tau deposition in Alzheimer's disease studies by using a reference tissue-based quantification approach. The results showed that the tracer-specific reference tissue improved the detection of PET SUVR changes, which is beneficial for early diagnosis, disease progression monitoring, and therapeutic response in Alzheimer's disease.
HUMAN BRAIN MAPPING
(2022)
Article
Gastroenterology & Hepatology
Dae-Weung Kim, Soon-Ah Park, Myoung Hyoun Kim
Summary: A 77-year-old woman underwent F-18 FDG PET/CT for evaluation of fever focus. Diffuse and intense hepatosplenic uptake was noted, suggesting lymphoma or tuberculosis. Liver biopsy revealed chronic granulomatous inflammation with Langerhans-type giant cells and necrosis. A follow-up PET/CT after anti-tuberculosis treatment showed resolution of hepatosplenic uptake.
LIVER INTERNATIONAL
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Sung Ryul Shim, Seong-Jang Kim
Summary: This study evaluated the diagnostic accuracies of F-18-FDG PET or PET/CT for Merkel cell carcinoma (MCC) through a systematic review and meta-analysis. The results showed that F-18-FDG PET/CT had excellent performance in diagnosing MCC and could be useful for exclusion and confirmation of the disease. Further large multicenter studies are needed to validate its diagnostic accuracy.
CLINICAL NUCLEAR MEDICINE
(2022)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Yun Chen, Shan Zheng, Zenan Wu, Yanmin Lin, Weibing Miao
Summary: A 76-year-old man with yellowish discoloration of sclera and skin for 2 months was referred for F-18-FDG PET/CT to characterize a mass in the pancreas. PET/CT images showed intense FDG uptake in the head of the pancreas, with a lymph nodal mass in the hepatic hilar region, consistent with pancreatic malignancy. Histopathologic findings confirmed diffuse large B-cell lymphoma with no evidence of adenocarcinoma.
CLINICAL NUCLEAR MEDICINE
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Junhwan Kim, Joonhyung Gil, Se Ik Kim, Suhyun Hwangbo, Joseph J. J. Noh, Jeong-Won Lee, Gi Jeong Cheon, Jae-Weon Kim, Young Seok Cho, Maria Lee
Summary: The purpose of this study is to develop an F-18-FDG PET/CT-based model to predict complete cytoreduction during primary cytoreductive surgery (CRS) for ovarian cancer (OC). The model was constructed by combining clinicopathologic characteristics and PET/CT-derived parameters. It was validated using a test set and showed a good predictive performance.
CLINICAL NUCLEAR MEDICINE
(2023)
Article
Oncology
Mohammad Naghavi-Behzad, Marianne Vogsen, Rasmus Molgard Vester, Maiken Madsen Bjerregaard Olsen, Hjalte Oltmann, Poul-Erik Braad, Jon Thor Asmussen, Oke Gerke, Werner Vach, Kristian Kidholm, Annette Raskov Kodahl, Wolfgang Weber, Malene Grubbe Hildebrandt
Summary: This study compared the use of CE-CT, FDG-PET/CT, or a combination of both in monitoring metastatic breast cancer patients. The results showed that patients monitored with FDG-PET/CT alone or in combination with CE-CT had longer overall survival and earlier detection of disease progression.
BRITISH JOURNAL OF CANCER
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Abarnaa Sivapathasundaram, Nicolas Golse, Alina Pascale, Emmanuel Durand, Mylene Sebagh, Florent L. Besson
Summary: Contrary to common belief, F-18-FDG/F-18-choline dual-tracer PET behavior is not a relevant surrogate of tumor differentiation in hepatocellular carcinoma (HCC). Future multitracer PET studies are necessary to improve our understanding of their biological significance in this field.
CLINICAL NUCLEAR MEDICINE
(2023)
Review
Oncology
Domenico Albano, Giorgio Treglia, Francesco Dondi, Anna Calabro, Alessio Rizzo, Salvatore Annunziata, Luca Guerra, Silvia Morbelli, Alessandra Tucci, Francesco Bertagna
Summary: The new biomarker Dmax, which measures the maximal distance between the two farthest hypermetabolic PET lesions, has shown high accuracy as a prognostic factor in lymphoma patients. Most studies have demonstrated the significant predictive value of Dmax in predicting progression-free survival and overall survival.
Article
Oncology
Luca Filippi, Ilaria Proietti, Vincenzo Petrozza, Oreste Bagni, Orazio Schillaci
Summary: The effectiveness of F-18-FDG PET/CT for monitoring response to cemiplimab immunotherapy in patients with cutaneous squamocellular carcinoma was investigated. PET/CT was found to be capable of identifying responders and nonresponders.
CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS
(2022)
Article
Multidisciplinary Sciences
Ewa Burchardt, Agnieszka Bos-Liedke, Kamila Serkowska, Paulina Cegla, Adam Piotrowski, Julian Malicki
Summary: This study assessed the changes in metabolic, volumetric, statistical, and radiomic parameters of cervical cancer in response to chemotherapy, recurrence, and age using F-18 FDG PET/CT imaging and first-order statistical (FOS) and second-order texture analysis. The results showed significant differences in parameters such as SUVmax, SUVmean, TLG, MTV, ASP, E, COR, En, and H before and after chemotherapy, as well as in disease progression and treatment response. The study demonstrated the remarkable importance of pre- and post-treatment [F-18] FDG PET statistical and textural GLCM parameters in predicting recurrence and chemotherapy response in cervical cancer patients.
SCIENTIFIC REPORTS
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
David J. Liesker, Stijn Legtenberg, Paola A. Erba, Andor W. J. M. Glaudemans, Clark J. Zeebregts, Jean-Paul P. M. De Vries, Nabil Chakfe, Ben R. Saleem, Riemer H. J. A. Slart
Summary: This study aimed to assess the variability of [F-18]FDG-PET/LDCT reporting in suspected VGEI using a standardized reporting format. The results showed that less than half of the reports met all the pre-selected criteria, and the incompleteness of reports led to lower sensitivity and specificity.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Article
Nutrition & Dietetics
Paola Tiberio, Lidija Antunovic, Mariangela Gaudio, Alessandro Vigano, Manuela Pastore, Chiara Miggiano, Flavia Jacobs, Chiara Benvenuti, Elisabetta Farina, Arturo Chiti, Armando Santoro, Rita De Sanctis
Summary: The impact of patients' eating habits on breast cancer management and inflammation has been investigated. The study found positive correlations between bowel [18]F-FDG uptake and pro-inflammatory drinks and foods, as well as a negative correlation between rectum SUVmean and anti-inflammatory foods. In addition, colon SUVmean was significantly lower in patients with pCR. This suggests that PET scan could be used to identify patients with unhealthy behaviors.
Article
Oncology
Lidija Antunovic, Alessia Artesani, Alessandro Vigano, Arturo Chiti, Armando Santoro, Martina Sollini, Silvia D. Morbelli, Rita De Sanctis
Summary: This study aimed to examine brain metabolic patterns on [F-18]Fluorodeoxyglucose ([F-18]FDG) positron emission tomography (PET) in breast cancer (BC), comparing patients with tension-type headache (TTH), migraine (MiG), and those without headache. The results showed that headache patients exhibited hypometabolism in specific brain regions before neoadjuvant chemotherapy (NAC) and headache patients with a good response to NAC showed hypermetabolic brain regions in the anterior medial frontal cortex.
Article
Radiology, Nuclear Medicine & Medical Imaging
Sang Woo Lee, Seong-Jang Kim
Summary: The systematic review and meta-analysis showed that F-18-FDG PET/CT has good diagnostic performance in detecting lymph node metastasis in penile cancer patients, with similar accuracy in detecting inguinal and pelvic lymph node metastasis.
CLINICAL NUCLEAR MEDICINE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Xingfeng Li, Diana Marcus, James Russell, Eric O. Aboagye, Laura Burney Ellis, Alexander Sheeka, Won-Ho Edward Park, Nishat Bharwani, Sadaf Ghaem-Maghami, Andrea G. Rockall
Summary: A comprehensive model combining features from MRI and clinical variables can improve the estimation of survival time in women with endometrial cancer.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Article
Cardiac & Cardiovascular Systems
Andrej Corovic, Christopher Wall, Meritxell Nus, Deepa Gopalan, Yuan Huang, Maria Imaz, Michal Zulcinski, Marta Peverelli, Anna Uryga, Jordi Lambert, Dario Bressan, Robert T. Maughan, Charis Pericleous, Suraiya Dubash, Natasha Jordan, David R. Jayne, Stephen P. Hoole, Patrick A. Calvert, Andrew F. Dean, Doris Rassl, Tara Barwick, Mark Iles, Mattia Frontini, Greg Hannon, Roido Manavaki, Tim D. Fryer, Luigi Aloj, Martin J. Graves, Fiona J. Gilbert, Marc R. Dweck, David E. Newby, Zahi A. Fayad, Gary Reynolds, Ann W. Morgan, Eric O. Aboagye, Anthony P. Davenport, Helle F. Jorgensen, Ziad Mallat, Martin R. Bennett, James E. Peters, James H. F. Rudd, Justin C. Mason, Jason M. Tarkin
Summary: This study investigates the feasibility of using somatostatin receptor 2 (SST2) as a molecular imaging target for inflammation in large vessel vasculitis (LVV), and provides evidence for its potential in the diagnosis and therapeutic monitoring of LVV.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Review
Biotechnology & Applied Microbiology
Thomas Talbot, Haonan Lu, Eric O. Aboagye
Summary: High-grade serous ovarian carcinoma is characterized by universal TP53 mutations and widespread copy number alterations, including deletion of tumor suppressors and amplification of driver oncogenes. Amplified driver genes have been proposed as therapeutic targets. However, lack of validation and variable experimental procedures hinder clinical translation. This review collates candidate amplified therapeutic targets in high-grade serous ovarian carcinoma and quantitatively appraises the evidence for each gene.
CANCER GENE THERAPY
(2023)
Article
Oncology
Xingfeng Li, Michele Dessi, Diana Marcus, James Russell, Eric O. O. Aboagye, Laura Burney Ellis, Alexander Sheeka, Won-Ho Edward Park, Nishat Bharwani, Sadaf Ghaem-Maghami, Andrea G. G. Rockall
Summary: Machine learning classification methods can be used to predict deep myometrial infiltration, clinical risk category, histological type, and lymphovascular space invasion in endometrial cancer. Combining clinical and image signatures can improve the accuracy of these prediction models, which has important implications for patient management.
Article
Cell Biology
Haonan Lu, Hantao Lou, Georg Wengert, Reema Paudel, Naina Patel, Saral Desai, Bill Crum, Kristofer Linton-Reid, Mitchell Chen, Dongyang Li, Jacey Ip, Francesco Mauri, David J. Pinato, Andrea Rockall, Susan J. Copley, Sadaf Ghaem-Maghami, Eric O. Aboagye
Summary: This study confirms that the presence of tertiary lymphoid structure (TLS) in high-grade serous ovarian cancer (HGSOC) is associated with better progression-free survival (PFS). TLS is linked to B cell maturation and activation of cytotoxic tumor-specific T cells in HGSOC tumors. Copy-number loss of genes IL15 and CXCL10 may hinder TLS formation in HGSOC, and a list of dysregulated genes affecting TLS function is proposed. A radiomics-based signature is developed to predict TLS presence, which independently predicts PFS in HGSOC and non-small cell lung cancer (NSCLC) patients treated with immune checkpoint inhibitors (ICIs). Overall, this study reveals the role of TLS in coordinating immune responses in HGSOC and how the cancer genome evolves to counteract TLS formation.
CELL REPORTS MEDICINE
(2023)
Article
Oncology
Benjamin Hunter, Christos Argyros, Marianna Inglese, Kristofer Linton-Reid, Ilaria Pulzato, Andrew G. Nicholson, Samuel V. Kemp, Pallav L. Shah, Philip L. Molyneaux, Cillian Mcnamara, Toby Burn, Emily Guilhem, Marcos Mestas Nunez, Julia Hine, Anika Choraria, Prashanthi Ratnakumar, Susannah Bloch, Simon Jordan, Simon Padley, Carole A. Ridge, Graham Robinson, Hasti Robbie, Joseph Barnett, Mario Silva, Sujal Desai, Richard W. Lee, Eric O. Aboagye, Anand Devaraj
Summary: This study developed a radiomics model to assist in the diagnosis of lung cancer. By extracting radiomics features and using clustering methods, patients were stratified into different risk groups. The model showed high accuracy in predicting malignancy and has potential clinical applications.
BRITISH JOURNAL OF CANCER
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Shahriar Islam, Marianna Inglese, Matthew Grech-Sollars, Preetha Aravind, Suraiya Dubash, Tara D. Barwick, Kevin O'Neill, James Wang, Azeem Saleem, James O'Callaghan, Giulio Anchini, Matthew Williams, Adam Waldman, Eric O. Aboagye
Summary: MRI and PET are used in neuro-oncology to detect and characterize malignant lesions. In this study, the uptake of FPIA in brain tumors was investigated using PET/MRI.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Andrea G. Rockall, Xingfeng Li, Nicholas Johnson, Ioannis Lavdas, Shalini Santhakumaran, A. Toby Prevost, Shonit Punwani, Vicky Goh, Tara D. Barwick, Nishat Bharwani, Amandeep Sandhu, Harbir Sidhu, Andrew Plumb, James Burn, Aisling Fagan, Georg J. Wengert, Dow-Mu Koh, Krystyna Reczko, Qi Dou, Jane Warwick, Xinxue Liu, Christina Messiou, Nina Tunariu, Peter Boavida, Neil Soneji, Edward W. Johnston, Christian Kelly-Morland, Katja N. De Paepe, Heminder Sokhi, Kathryn Wallitt, Amish Lakhani, James Russell, Miriam Salib, Sarah Vinnicombe, Adam Haq, Eric O. Aboagye, Stuart Taylor, Ben Glocker
Summary: The study aimed to develop a machine learning algorithm to improve radiologists' sensitivity and specificity for metastasis detection in whole-body magnetic resonance imaging (WB-MRI). The results showed that using the algorithm can enhance the detection accuracy and reduce reading times for radiologists.
INVESTIGATIVE RADIOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Stanislav S. Piletsky, Ekaterina Baidyuk, Elena V. Piletska, Larissa Lezina, Konstantin Shevchenko, Donald J. L. Jones, Thong H. Cao, Rajinder Singh, Alan C. Spivey, Eric O. Aboagye, Sergey A. Piletsky, Nickolai A. Barlev
Summary: Molecularly imprinted polymer nanoparticles (nanoMIPs) have shown potential as an alternative to antibodies in diagnostic and therapeutic applications. Targeting intracellular epitopes can modulate protein function, making them a new tool for cancer therapy.
Article
Oncology
Mitchell Chen, Susan J. Copley, Patrizia Viola, Haonan Lu, Eric O. Aboagye
Summary: Lung cancer, the leading cause of cancer-related deaths worldwide, can be captured non-invasively on medical imaging as radiomic features, which can be used in an artificial intelligence paradigm to predict clinical outcomes and improve patient care. Compared to tissue sampling-driven approaches, radiomics-based methods are superior for being non-invasive, reproducible, cheaper, and less susceptible to intra-tumoral heterogeneity.
SEMINARS IN CANCER BIOLOGY
(2023)
Letter
Medicine, General & Internal
Benjamin Hunter, Catey Bunce, Matthew Blackledge, Eric Aboagye, Richard Lee, LIBRA study
Article
Oncology
Preetha Aravind, Sanjay Popat, Tara D. Barwick, Neil Soneji, Mark Lythgoe, Katherina B. Sreter, Jingky P. Lozano-Kuehne, Mattias Bergqvist, Neva Patel, Eric O. Aboagye, Laura M. Kenny
Summary: This study aimed to investigate the early drug action of the antifolate drug pemetrexed on thymidylate synthase (TS) inhibition using F-18-FLT PET/CT imaging. The results showed that patients who exhibited changes in the imaging biomarker had a better therapy response and longer overall survival. These findings suggest the potential use of F-18-FLT PET/CT in understanding the basis of drug action in studies involving TS inhibitors.
Article
Pharmacology & Pharmacy
Jin Hui Teh, Ala Amgheib, Ruisi Fu, Chris Barnes, Joel Abrahams, Ali Ashek, Ning Wang, Zixuan Yang, Muneera Mansoorudeen, Nicholas J. J. Long, Eric O. O. Aboagye
Summary: C-Met, a receptor tyrosine kinase overexpressed in various cancer types, has potential as a biomarker for cancer imaging and therapy. This study synthesized and evaluated an [F-18]AlF-labelled analogue, [F-18]AlF-EMP-105, for c-Met imaging using positron emission tomography. In vitro evaluation showed high specificity of [F-18]AlF-EMP-105 for c-Met-expressing cells. PET imaging in mice demonstrated renal clearance of the tracer predominantly as [F-18]fluoride. [F-18]AlF-EMP-105 shows promise as a diagnostic tool for imaging cancer due to its high specificity for c-Met expressing cells.
Article
Multidisciplinary Sciences
Reza Kalantar, Sumeet Hindocha, Benjamin Hunter, Bhupinder Sharma, Nasir Khan, Dow-Mu Koh, Merina Ahmed, Eric O. O. Aboagye, Richard W. W. Lee, Matthew D. D. Blackledge
Summary: Researchers developed a contrast-based CT image synthesis method to address the contrast heterogeneity issue in real-world datasets and evaluated its performance in COVID-19 research. The results showed that while the generated images demonstrated realism in human assessment, caution is advised when using GAN-synthesized images in medical imaging applications.
SCIENTIFIC REPORTS
(2023)
Article
Chemistry, Multidisciplinary
Zixuan Yang, Chris Barnes, Juozas Domarkas, Joanna Koch-Paszkowski, John Wright, Ala Amgheib, Isaline Renard, Ruisi Fu, Stephen Archibald, Eric O. Aboagye, Louis Allott
Summary: Sulfur-[F-18]fluoride exchange radiochemistry is a rapid and convenient method for incorporating fluorine-18 into biologically active molecules. We reported a fully automated radiolabelling procedure using the GE FASTLab(TM) cassette-based platform to synthesize a [F-18]SO3F-bearing prostate specific membrane antigen (PSMA) targeted ligand ([F-18](5)), which showed favorable biodistribution and pharmacokinetic profiles correlated with PSMA expression.
REACTION CHEMISTRY & ENGINEERING
(2023)
