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Molecular imaging of metastatic potential

期刊

JOURNAL OF NUCLEAR MEDICINE
卷 49, 期 -, 页码 96S-112S

出版社

SOC NUCLEAR MEDICINE INC
DOI: 10.2967/jnumed.107.045948

关键词

magnetic resonance imaging; radiopharmaceutical; PET; SPECT; optical imaging; bioluminescence; fluorescence; metastasis

资金

  1. NATIONAL CANCER INSTITUTE [R24CA092871, P50CA103175, U24CA092871] Funding Source: NIH RePORTER
  2. NCI NIH HHS [U24 CA92871, U24 CA092871, P50 CA103175, R24 CA092871] Funding Source: Medline

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If molecular imaging is to prove clinically useful it will have to surpass current, primarily anatomic techniques in terms of sensitivity and the ability to detect minimal changes in tissue. One of the most important tests for molecular imaging is to determine whether it can image the metastatic potential of tumors. Like all predictive endeavors, the imaging of such potential is a daunting task, but one that only molecular imaging-rather than standard, anatomic techniques-is likely to solve. Although difficult, imaging of metastatic potential is also arguably the most important task for molecular imaging of cancer because it is generally the dissemination of malignant tissue, not its prolonged residence in an inopportune site, which kills the patient. Below are examples of uses of molecular imaging of metastases as well as of metastatic potential, the former being a far more developed area of clinical inquiry.

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