Article
Medicine, General & Internal
Inki Lee, Min Hwan Kim, Kyongkyu Lee, Keumrok Oh, Hyunwoo Lim, Jae Hun Ahn, Yong Jin Lee, Gi Jeong Cheon, Dae Yoon Chi, Sang Moo Lim
Summary: This study compared the effects of DOTA and NOTA as Cu-64-chelating agents on the pharmacokinetics of newly developed PSMA target compounds.
Retraction
Chemistry, Multidisciplinary
Laura Fisher
Summary: The retractions the article about the impact of Cetuximab on DNA-PK in cervical cancer cells.
Article
Medicine, General & Internal
Rona Yaeger, Jared Weiss, Meredith S. Pelster, Alexander Spira, Minal Barve, Sai-Hong Ou, Ticiana A. Leal, Tanios S. Bekaii-Saab, Cloud P. Paweletz, Grace A. Heavey, James G. Christensen, Karen Velastegui, Thian Kheoh, Hirak Der-Torossian, Samuel J. Klempner
Summary: In this study, the researchers investigated the clinical efficacy of adagrasib in combination with cetuximab for heavily pretreated patients with metastatic colorectal cancer harboring mutant KRAS G12C. The results showed that the overall response rate was 19% in the adagrasib monotherapy group, with a median progression-free survival of 5.6 months, and 46% in the combination therapy group, with a median progression-free survival of 6.9 months. Both groups experienced reversible adverse events.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Article
Chemistry, Inorganic & Nuclear
Ina Hierlmeier, Amaury Guillou, Daniel F. Earley, Anthony Linden, Jason P. Holland, Mark D. Bartholomae
Summary: In this study, we synthesized and investigated the coordination chemistry of novel copper(II) and zinc(II) complexes using two heterocyclic triazacyclononane(tacn)-based chelators (HNODThia and NODThia-AcNHEt). The modified chelator HNODThia was used to develop a PSMA-based bioconjugate (NODThia-PSMA) and a photoactivatable azamacrocyclic analogue (NODThia-PEG ( 3 ) -ArN ( 3 )) for copper-64 radiopharmaceuticals. The metal-binding chelates showed rapid radiolabeling, stability in human plasma, and successful photoconjugation to albumin and antibodies. These findings have significant implications for the development of stable Cu-64-based radiopharmaceuticals and the future application of Cu-67 in targeted radioimmunotherapy.
INORGANIC CHEMISTRY
(2023)
Review
Pharmacology & Pharmacy
Zaina T. Al-Salama
Summary: Encorafenib in combination with cetuximab has shown significantly longer overall survival, higher response rate, and better tolerability in patients with mCRC and a BRAF V600E mutation who have had prior therapy.
Article
Radiology, Nuclear Medicine & Medical Imaging
Cuicui Li, Jun Liu, Xu Yang, Qi Yang, Wenpeng Huang, Mingyu Zhang, Dandan Zhou, Rong Wang, Jianhua Gong, Qingfang Miao, Lei Kang, Jigang Yang
Summary: This study developed Cu-64/Lu-177-labeled anti-Trop2 monoclonal antibody for PET imaging and RIT application in pancreatic cancer tumor models. The results showed that Cu-64-labeled antibody had good accumulation ability in tumor models, and Lu-177-labeled antibody could inhibit the growth of Trop2-overexpressed tumors.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Chika Igarashi, Yukie Yoshii, Hideaki Tashima, Yuma Iwao, Kohei Sakurai, Fukiko Hihara, Tomoko Tachibana, Eiji Yoshida, Hidekatsu Wakizaka, Go Akamatsu, Taiga Yamaya, Mitsuyoshi Yoshimoto, Hiroki Matsumoto, Ming-Rong Zhang, Kotaro Nagatsu, Aya Sugyo, Atsushi B. Tsuji, Tatsuya Higashi
Summary: The study showed that OpenPET-guided surgery enabled the detection and resection of small residual tumors, resulting in significantly longer survival rates in mice compared to conventional surgery methods.
NUCLEAR MEDICINE COMMUNICATIONS
(2021)
Article
Multidisciplinary Sciences
Azmal Sarker, Minseok Suh, Yoori Choi, Ji Yong Park, Yun-Sang Lee, Dong Soo Lee
Summary: Age-related cognitive decline is associated with dysfunctional lymphatic drainage of cerebrospinal fluid (CSF) through meningeal lymphatic vessels. In this study, [Cu-64]Cu-albumin positron emission tomography (PET) was used to evaluate CSF lymphatic drainage in mice and found that it decreased with age. The PET scan revealed that the CSF clearance half-time was significantly longer in aged mice compared to adult mice, and the activity of paravertebral lymph nodes was also lower in aged mice.
SCIENTIFIC REPORTS
(2023)
Article
Health Care Sciences & Services
Sanja D. Tomic, Andrijana Coric, Slobodan Tomic, Ermina Mujicic, Jelena Malenkovic, Armin Sljivo, Goran Malenkovic
Summary: This questionnaire-based study aimed to evaluate the knowledge of cervical cancer prevention among female students at the University of Novi Sad during the COVID-19 pandemic. The study found that most students had good knowledge of primary prevention, but had low awareness of the vaccine against cervical cancer and its availability in Serbia. Older students had better knowledge of distressing symptoms and cytological examination, but a significant percentage of them had not received vaccinations. This study highlights the need for increased awareness and education about HPV vaccine and secondary prevention among young women in Serbia.
Article
Multidisciplinary Sciences
Tamon Kusumoto, Kentaro Baba, Sumitaka Hasegawa, Quentin Raffy, Satoshi Kodaira
Summary: The aim of this study was to evaluate the biological effect of targeted radionuclide therapy using Cu-64. The results showed a high relative biological effectiveness (RBE) on CHO wild-type cells and xrs5 cells, indicating that the radiosensitivity of xrs5 cells is independent of linear energy transfer (LET).
SCIENTIFIC REPORTS
(2022)
Article
Oncology
Itunu O. Sokale, Jane R. Montealegre, Abiodun O. Oluyomi, Aaron P. Thrift
Summary: This study examined recent trends and racial/ethnic differences in predictors of cervical cancer screening (CCS) uptake among US women. The findings showed little change in screening rates over the 5-year interval and disparities among racial minority women. Age and racial/ethnic disparities persist in CCS, but routine health examinations were positively associated with screening regardless of race/ethnicity.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2023)
Article
Multidisciplinary Sciences
Mpho Keetile, Kagiso Ndlovu, Gobopamang Letamo, Mpho Disang, Sanni Yaya, Kannan Navaneetham
Summary: This study assessed factors associated with breast and cervical cancer screening in Botswana, revealing lower likelihood of screening among women in poorer wealth quintiles. Wealth status was found to be the leading contributor to socioeconomic inequality in screening, highlighting the need for concerted efforts to address healthcare needs of the poor.
Article
Chemistry, Multidisciplinary
Stacey E. Rudd, Jessica K. Van Zuylekom, Anna Raicevic, Lesley A. Pearce, Carleen Cullinane, Charlotte C. Williams, Timothy E. Adams, Rodney J. Hicks, Paul S. Donnelly
Summary: Enzymatic bioconjugation was used to introduce positron-emitting radionuclides into an anti-EGFR antibody fragment for PET imaging, providing high-quality images of EGFR positive tumors within 3 hours post-injection. This method offers a significant advantage over radiolabeled full antibodies that require several days for imaging, potentially simplifying regulatory approval.
Article
Oncology
Jiawei Zhou, Quefeng Li, Yanguang Cao
Summary: The response of metastatic lesions varies across different anatomic sites and therapies. High interlesion heterogeneity is associated with shorter survival, highlighting the potential benefits of targeted therapies in reducing heterogeneity and improving efficacy. Favorable responses in liver metastases are linked to extended overall survival, while lesions in other organs show less favorable outcomes.
Article
Oncology
Susanne F. Jorgensen, Berit Andersen, Lone Kjeld Petersen, Matejka Rebolj, Sisse H. Njor
Summary: The study found that only 26% of women aged 60-64 with nonnegative primary HPV screening tests adhered to the national recommendations for follow-up, with the rest having insufficient or excessive follow-up. The average numbers of diagnostic tests and procedures used after positive HPV screening were higher than expected, highlighting inconsistencies in follow-up patterns.
Review
Oncology
Valerie S. LeBleu
Article
Radiology, Nuclear Medicine & Medical Imaging
Jessie R. Nedrow, Joseph D. Latoche, Kathryn E. Day, Jalpa Modi, Tanushree Ganguly, Dexing Zeng, Brenda F. Kurland, Clifford E. Berkman, Carolyn J. Anderson
MOLECULAR IMAGING AND BIOLOGY
(2016)
Article
Oncology
Su-Hyeong Kim, Eun-Ryeong Hahm, Julie A. Arlotti, Suman K. Samanta, Michelle B. Moura, Stephen H. Thorne, Yongli Shuai, Carolyn J. Anderson, Alexander G. White, Anna Lokshin, Joomin Lee, Shivendra V. Singh
BREAST CANCER RESEARCH AND TREATMENT
(2016)
Article
Chemistry, Inorganic & Nuclear
Yongkang Gai, Lingyi Sun, Wenqi Hui, Qin Ouyang, Carolyn J. Anderson, Guangya Xiang, Xiang Ma, Dexing Zeng
INORGANIC CHEMISTRY
(2016)
Article
Radiology, Nuclear Medicine & Medical Imaging
Deepti Soodgupta, Haiying Zhou, Wissam Beaino, Lan Lu, Michael Rettig, Mark Snee, James Skeath, John F. DiPersio, Walter J. Akers, Richard Laforest, Carolyn J. Anderson, Michael H. Tomasson, Monica Shokeen
JOURNAL OF NUCLEAR MEDICINE
(2016)
Article
Radiology, Nuclear Medicine & Medical Imaging
Zhengxin Cai, Neale Scott Mason, Carolyn J. Anderson, Wilson Barry Edwards
NUCLEAR MEDICINE AND BIOLOGY
(2016)
Review
Multidisciplinary Sciences
Carolyn J. Anderson, Jason S. Lewis
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES
(2017)
Article
Medicine, Research & Experimental
Cindy J. Choy, Xiaoxi Ling, Jonathan J. Geruntho, Sophia K. Beyer, Joseph D. Latoche, Beatrice Langton-Webster, Carolyn J. Anderson, Clifford E. Berkman
Article
Oncology
Masahiro Kikuchi, David A. Clump, Raghvendra M. Srivastava, Lingyi Sun, Dexing Zeng, Julio A. Diaz-Perez, Carolyn J. Anderson, W. Barry Edwards, Robert L. Ferris
Article
Biochemical Research Methods
Emre Demirci, Rafay Ahmed, Meltem Ocak, Joseph Latoche, April Radelet, Nicole DeBlasio, N. Scott Mason, Carolyn J. Anderson, James M. Mountz
Article
Multidisciplinary Sciences
Lixiong Dai, Chloe M. Jones, Wesley Ting Kwok Chan, Tiffany A. Pham, Xiaoxi Ling, Eric M. Gale, Nicholas J. Rotile, William Chi-Shing Tai, Carolyn J. Anderson, Peter Caravan, Ga-Lai Law
NATURE COMMUNICATIONS
(2018)
Article
Acoustics
Qiyang Chen, Jaesok Yu, Lyudmila Lukashova, Joseph D. Latoche, Jianhui Zhu, Linda Lavery, Konstantinos Verdelis, Carolyn J. Anderson, Kang Kim
IEEE TRANSACTIONS ON ULTRASONICS FERROELECTRICS AND FREQUENCY CONTROL
(2020)
Article
Hematology
Lydia A. Perkins, Lea Nyiranshuti, Lynda Little-Ihrig, Joseph D. Latoche, Kathryn E. Day, Qin Zhu, Sina Tavakoli, Prithu Sundd, Enrico M. Novelli, Carolyn J. Anderson
Article
Radiology, Nuclear Medicine & Medical Imaging
Michael C. Bellavia, Ravi B. Patel, Carolyn J. Anderson
Summary: Immune checkpoint inhibitors (ICIs) have revolutionized cancer care, but many patients with poorly immunogenic tumors fail to benefit. External beam radiotherapy (EBRT) has been shown to synergize with ICI to prompt remarkable tumor regression and even eradication, but is not suitable for widely disseminated disease. Targeted radiopharmaceutical therapy (TRT) selectively delivers radiation to both the primary tumor and the metastatic sites, and has shown promising results, leading to regulatory approval of certain agents.
JOURNAL OF NUCLEAR MEDICINE
(2022)
Article
Oncology
Feyisola P. Olatunji, Michael Pun, Jacob W. Herman, Oscar Romero, Mitchell Maniatopoulos, Joseph D. Latoche, Robert A. Parise, Jianxia Guo, Jan H. Beumer, Carolyn J. Anderson, Clifford E. Berkman
Summary: This study reports on the synthesis, pharmacokinetics, and efficacy of two small-molecule-drug conjugates targeting prostate-specific membrane antigen, showing potential for delivering chemotherapy drugs to prostate cancer tumors with minimal toxicity.
MOLECULAR CANCER THERAPEUTICS
(2022)