Article
Radiology, Nuclear Medicine & Medical Imaging
Tuula Tolvanen, Kari Kalliokoski, Simona Malaspina, Anna Kuisma, Salla Lahdenpohja, Ernst J. Postema, Matthew P. Miller, Mika Scheinin
Summary: The study investigated the safety, biodistribution, and internal radiation dosimetry of a novel F-18-labeled radiohybrid PSA imaging agent in healthy volunteers, showing favorable results for PET imaging.
JOURNAL OF NUCLEAR MEDICINE
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Alexandra Gogola, Davneet S. Minhas, Victor L. Villemagne, Ann D. Cohen, James M. Mountz, Tharick A. Pascoal, Charles M. Laymon, N. Scott Mason, Milos D. Ikonomovic, Chester A. Mathis, Beth E. Snitz, Oscar L. Lopez, William E. Klunk, Brian J. Lopresti
Summary: This study compared the characteristics of two frequently used tau PET tracers, F-18-flortaucipir and F-18-MK-6240, in the same subjects. The results showed that both tracers performed equally well in visual interpretations and were capable of quantifying signal in a common set of brain regions that develop tau pathology in Alzheimer disease. However, they also showed distinct patterns of apparent off-target binding, and F-18-MK-6240 exhibited a greater dynamic range in SUVR estimates.
JOURNAL OF NUCLEAR MEDICINE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Aline Delva, Michel Koole, Kim Serdons, Guy Bormans, Longbin Liu, Jonathan Bard, Vinod Khetarpal, Celia Dominguez, Ignacio Munoz-Sanjuan, Andrew Wood, Mette Skinbjerg, Yuchuan Wang, Wim Vandenberghe, Koen Van Laere
Summary: In this study, the biodistribution and dosimetry of two tracers designed for PET imaging of aggregated mutant huntingtin (mHTT) in the brain were investigated in healthy volunteers. The results suggest that both tracers are safe for in vivo PET imaging in humans. One tracer showed promising kinetic properties in the brain, while the other may accumulate a brain-penetrant metabolite.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yali Long, Chang Yi, Renbo Wu, Yuying Zhang, Bing Zhang, Xinchong Shi, Xiangsong Zhang, Zhihao Zha
Summary: In this study, the distribution, tumor detecting ability, and radiation dosimetry of [F-18]DFA in humans were evaluated using PET imaging. [F-18]DFA showed high uptake and retention in tumors, and exhibited a similar distribution pattern as AA. This suggests that [F-18]DFA may be a promising radiopharmaceutical for identifying tumors with high affinity for SVCT2 and monitoring AA distribution in both normal tissues and tumors.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Qiao Yang, Wenjia Zhu, Chao Ren, Hongfeng Ji, Dongchun Wang, Yu Liu, Fang Li, Yanrong Du, Yuanhao Liu, Li Huo
Summary: D-[F-18]FBPA exhibited lower distribution and activity in normal brain, liver, spleen, pancreas, and skeleton compared to its L-isomer. The study confirmed the radiological safety of D-[F-18]FBPA, laying the foundation for further clinical trials in cancer patients.
NUCLEAR MEDICINE AND BIOLOGY
(2021)
Article
Chemistry, Medicinal
Xiaojun Zhang, Yitian Wu, Qi Zeng, Tianxin Xie, Shulin Yao, Jinming Zhang, Mengchao Cui
Summary: The study designed, synthesized, and evaluated three more lipophilic F-18-labeled PSMA tracers, investigating the effect of lipophilicity on their distribution and excretion in different species. Higher lipophilicity led to increased radioactivity accumulation in the liver of primates and humans, as well as reduced excretion to the bladder through urine. The screened tracer [F-18]8c showed low bladder retention and good imaging properties in patients with prostate cancer.
JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Akihito Ohnishi, Go Akamatsu, Yasuhiko Ikari, Hiroyuki Nishida, Keiji Shimizu, Keiichi Matsumoto, Kazuki Aita, Masahiro Sasaki, Yasuji Yamamoto, Tomohiko Yamane, Michio Senda
Summary: This study investigated the safety, radiation dosimetry, pharmacokinetics, and biodistribution of [F-18]MK-6240 in Japanese elderly subjects, as well as its accumulation patterns in healthy subjects and patients with Alzheimer's disease (AD). The results showed that [F-18]MK-6240 is safe and effective as a tau PET tracer in the Japanese population, with consistent dosimetry profiles, pharmacokinetics, and biodistribution compared to non-Japanese populations.
ANNALS OF NUCLEAR MEDICINE
(2023)
Article
Neurosciences
Yanxiao Li, Yee Ling Ng, Manish D. Paranjpe, Qi Ge, Fengyun Gu, Panlong Li, Shaozhen Yan, Jie Lu, Xiuying Wang, Yun Zhou
Summary: This study aimed to improve the statistical power in detecting changes in brain glucose metabolism, amyloid, and tau deposition in Alzheimer's disease studies by using a reference tissue-based quantification approach. The results showed that the tracer-specific reference tissue improved the detection of PET SUVR changes, which is beneficial for early diagnosis, disease progression monitoring, and therapeutic response in Alzheimer's disease.
HUMAN BRAIN MAPPING
(2022)
Article
Biotechnology & Applied Microbiology
Jiaying Zhang, Zefang Lin, Xiaojun Zhang, Rong Lin, Mengchao Cui, Weibing Miao, Shaobo Yao
Summary: The injection of Ga-68-DOTA-DiPSMA is safe and associated with low absorbed and effective doses. Ga-68-DOTA-DiPSMA demonstrates favorable kinetics and imaging characteristics, showing potential as an alternative for gallium-68-labeled PSMA clinical PET.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Lucas Rischka, Matej Murgas, Verena Pichler, Chrysoula Vraka, Ivo Rausch, Dietmar Winkler, Lukas Nics, Sazan Rasul, Leo Robert Silberbauer, Murray Bruce Reed, Godber Mathis Godbersen, Jakob Unterholzner, Patricia Handschuh, Gregor Gryglewski, Thomas Mindt, Markus Mitterhauser, Andreas Hahn, Simon Mensah Ametamey, Wolfgang Wadsak, Rupert Lanzenberger, Marcus Hacker
Summary: This study evaluated the safety, biodistribution, and dosimetry of the GluN2B-specific PET radioligand (R)-[C-11]Me-NB1. The radioligand was found to be safe and well-tolerated, with a low effective dose coefficient. This makes it suitable for longitudinal studies in drug development and treatment monitoring of neuropsychiatric disorders including neurodegenerative diseases.
Article
Orthopedics
L. Watkins, J. MacKay, B. Haddock, V Mazzoli, S. Uhlrich, G. Gold, F. Kogan
Summary: The study aimed to evaluate molecular information from PET imaging as a quantitative marker of bone metabolism, comparing healthy individuals and those with OA. Results indicate altered bone metabolism in OA subjects, including bone regions with or without structural findings. The kinetic parameters show potential to evaluate the role of bone physiology in OA initiation and progression.
OSTEOARTHRITIS AND CARTILAGE
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Sami Suilamo, Xiang-Guo Li, Petteri Lankinen, Vesa Oikonen, Tuula Tolvanen, Pauliina Luoto, Riikka Viitanen, Antti Saraste, Marko Seppanen, Laura Pirila, Ulla Hohenthal, Anne Roivainen
Summary: This study investigated the biodistribution and radiation exposure of 68Ga-citrate in healthy men. The results showed slow clearance of radioactivity from the blood, relatively slow excretion of radioactivity via urine, and high concentration of radioactivity in the urinary bladder at certain time points.
JOURNAL OF NUCLEAR MEDICINE
(2022)
Article
Computer Science, Artificial Intelligence
Jaewon Yang, Jae Ho Sohn, Spencer C. Behr, Grant T. Gullberg, Youngho Seo
Summary: This study demonstrates the feasibility of CT-less attenuation and scatter correction in whole-body PET using deep learning, highlighting the potential benefits and pitfalls. Results show that deep learning-corrected PET images exhibit high similarity with ASC-corrected PET, but also reveal potential issues such as radiation dose reduction and artifact removal, as well as possible false-negative and false-positive results.
RADIOLOGY-ARTIFICIAL INTELLIGENCE
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Leonie Beyer, Astrid Gosewisch, Simon Lindner, Friederike Voelter, Lena M. Mittlmeier, Reinhold Tiling, Matthias Brendel, Clemens C. Cyran, Marcus Unterrainer, Johannes Ruebenthaler, Christoph J. Auernhammer, Christine Spitzweg, Guido Boening, F. J. Gildehaus, Klaus Jurkschat, Carmen Wangler, Bjoern Wangler, Ralf Schirrmacher, Vera Wenter, Andrei Todica, Peter Bartenstein, Harun Ilhan
Summary: This study demonstrated the high tumor-to-background ratios and comparable effective dose of [F-18]SiTATE-PET/CT in NET patients from 60 to 180 minutes after injection, with the best compromise between image quality and tumor-to-background contrast reached at 120 minutes followed by 60 minutes.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Thomas Langbein, Alexander Wurzer, Andrei Gafita, Andrew Robertson, Hui Wang, Ayca Arcay, Michael Herz, Hans-Juergen Wester, Wolfgang A. Weber, Matthias Eiber
Summary: This study found that the time between synthesis and injection and the decrease in specific activity of F-18-rhPSMA-7.3 had only minor effects on its biodistribution in patients. This suggests that F-18-labeled PSMA ligands can be produced centrally and shipped to PET clinics similar to F-18-FDG.
JOURNAL OF NUCLEAR MEDICINE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Michel Koole, Talakad G. Lohith, John L. Valentine, Idriss Bennacef, Ruben Declercq, Tom Reynders, Kerry Riffel, Sofie Celen, Kim Serdons, Guy Bormans, Sandrine Ferry-Martin, Philippe Laroque, Abbas Walji, Eric D. Hostetler, Richard J. Briscoe, Jan de Hoon, Cyrille Sur, Koen Van Laere, Arie Struyk
MOLECULAR IMAGING AND BIOLOGY
(2020)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Elin Pauwels, Frederik Cleeren, Terence Tshibangu, Michel Koole, Kim Serdons, Jeroen Dekervel, Eric Van Cutsem, Chris Verslype, Koen Van Laere, Guy Bormans, Christophe M. Deroose
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2019)
Article
Radiology, Nuclear Medicine & Medical Imaging
Donatienne Van Weehaeghe, Michel Koole, Mark E. Schmidt, Stephanie Deman, Andreas H. Jacobs, Erika Souche, Kim Serdons, Stefan Sunaert, Guy Bormans, Wim Vandenberghe, Koen Van Laere
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2019)
Article
Radiology, Nuclear Medicine & Medical Imaging
Nathalie Mertens, Ralph Paul Maguire, Kim Serdons, Brigitte Lacroix, Joel Mercier, David Sciberras, Koen Van Laere, Michel Koole
MOLECULAR IMAGING AND BIOLOGY
(2020)
Article
Radiology, Nuclear Medicine & Medical Imaging
Donatienne Van Weehaeghe, Evelien Van Schoor, Joke De Vocht, Michel Koole, Bala Attili, Sofie Celen, Lieven Declereq, Dietmar R. Thal, Philip Van Damme, Guy Bormans, Koen Van Laere
JOURNAL OF NUCLEAR MEDICINE
(2020)
Article
Radiology, Nuclear Medicine & Medical Imaging
Michel Koole, Donatienne Van Weehaeghe, Kim Serdons, Marissa Herbots, Christopher Cawthorne, Sofie Celen, Frederick A. Schroeder, Jacob M. Hooker, Guy Bormans, Jan de Hoon, Janice E. Kranz, Koen Van Laere, Tonya M. Gilbert
Summary: HDAC6 is a cytoplasmic enzyme that modulates intracellular transport and protein quality control. Inhibiting HDAC6 deacetylase activity shows beneficial effects in disease models. This study evaluated the brain binding of [F-18]EKZ-001 in healthy adults, showing that it is safe for quantifying HDAC6 expression and that males have higher HDAC6 expression compared to females.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2021)
Article
Clinical Neurology
Heleen Vanhaute, Jenny Ceccarini, Laura Michiels, Michel Koole, Stefan Sunaert, Robin Lemmens, Eric Triau, Louise Emsell, Mathieu Vandenbulcke, Koen Van Laere
Article
Radiology, Nuclear Medicine & Medical Imaging
Christopher Cawthorne, Paul Maguire, Joel Mercier, David Sciberras, Kim Serdons, Guy Bormans, Jan de Hoon, Koen Van Laere, Michel Koole
Summary: The biodistribution and dosimetry estimates of [C-11]-UCB-J in humans, derived from whole-body PET scans, show that the method is safe and allows for multiple PET examinations in the same subject with low effective dose coefficients.
Article
Radiology, Nuclear Medicine & Medical Imaging
Guilherme D. Kolinger, David Vallez Garcia, Talakad G. Lohith, Eric D. Hostetler, Cyrille Sur, Arie Struyk, Ronald Boellaard, Michel Koole
Summary: A DTW protocol was simulated to reduce PET/CT acquisition time, considering perfusion changes and possible protocol deviations. Results showed that DTW protocol closely approximates uninterrupted TAC(120) for quantification, with less susceptibility to perfusion changes and protocol deviations compared to SUVR estimates.
Article
Biochemistry & Molecular Biology
Jenny Ceccarini, Michel Koole, Koen Van Laere
Summary: This study provides the first evidence that the availability of CB1R in the prefrontal cortex regulates dopamine release and drug-reinforcing effects. These preliminary findings support the existence of an interaction between CB1R and dopamine receptors at the molecular and behavioral level.
Article
Engineering, Biomedical
Masoomeh Rahimpour, Jeroen Bertels, Ahmed Radwan, Henri Vandermeulen, Stefan Sunaert, Dirk Vandermeulen, Frederik Maes, Karolien Goffin, Michel Koole
Summary: In this study, we proposed a cross-modal distillation approach to enhance the performance of single-sequence CNN models for brain tumor segmentation. By leveraging multi-sequence MRI data for training, the enriched CNN model achieved better segmentation results when only single-sequence MRI data were available for inference. This method shows potential in overcoming the limitations caused by missing or limited MRI sequences in clinical scenarios.
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING
(2022)
Review
Pharmacology & Pharmacy
Kaat Spoormans, Melissa Crabbe, Lara Struelens, Marijke De Saint-Hubert, Michel Koole
Summary: Targeted radionuclide therapy (TRT) has the potential for highly effective treatment, but its efficiency is dependent on the absorbed dose. Tumor control probability models can predict tumor response by considering characteristics like high LET radiation and heterogeneous radiopharmaceutical distribution.
Review
Medicine, General & Internal
Prodromos Gavriilidis, Michel Koole, Salvatore Annunziata, Felix M. Mottaghy, Roel Wierts
Summary: This literature review discusses the impact of positron range correction and denoising techniques on the image quality of Ga-68 PET. The results show that these techniques can improve image quality and achieve comparable results to F-18 PET in some cases. However, further validation in clinical studies is needed.
Article
Cell Biology
Joke De Vocht, Donatienne Van Weehaeghe, Fouke Ombelet, Pegah Masrori, Nikita Lamaire, Martijn Devrome, Hilde Van Esch, Mathieu Moisse, Michel Koole, Patrick Dupont, Koen Van Laere, Philip Van Damme
Summary: This study examined the impact of ALS-causing gene mutations on cerebral glucose metabolism using genetic testing and FDG PET imaging. The results showed distinctive differences in glucose metabolism patterns between C9orf72-ALS patients and sporadic ALS patients, particularly in specific regions of the brain.
Article
Radiology, Nuclear Medicine & Medical Imaging
Masoomeh Rahimpour, Marie-Judith Saint Martin, Frederique Frouin, Pia Akl, Fanny Orlhac, Michel Koole, Caroline Malhaire
Summary: This study developed a visual ensemble selection approach using deep convolutional neural networks (CNN) for 3D segmentation of breast tumors based on T1-weighted dynamic contrast-enhanced (T1-DCE) MRI, achieving good segmentation accuracy.
EUROPEAN RADIOLOGY
(2023)