期刊
JOURNAL OF NEUROVIROLOGY
卷 19, 期 2, 页码 123-130出版社
SPRINGER
DOI: 10.1007/s13365-013-0149-y
关键词
AIDS; HIV; Neurons; Astrocytes; Spatial pattern analysis
资金
- AVERT-The AIDS Education and Research Trust [NS26643, RR00722]
- [R01MH079881]
- [R41MH079728]
- [R25MH074508]
- [R25MH081482]
- [R21MH078728]
- NATIONAL CENTER FOR RESEARCH RESOURCES [M01RR000722] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF MENTAL HEALTH [R25MH074508, R41MH079728, R25MH081482, R01MH079881, R21MH078728] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [P01NS026643] Funding Source: NIH RePORTER
Specific neuronal spatial distributional patterns have previously been correlated with increasing severity of HIV-associated dementia (HAD). As astrocytes are also a putative site of neurotoxicity, we investigated the spatial relationships of astrocytes with pyramidal and interneurons in the superior frontal gyrus from 29 patients who died from acquired immunodeficiency syndrome. Frontal cortical brain tissue was taken from diseased HIV patients who had been assessed for the presence and severity of HAD using the Memorial Sloan-Kettering Scale. No correlation was found between neuronal density and severity of dementia. However, the pattern of astrocytes became more clustered as dementia progressed. Bivariate spatial pattern analysis of neuronal populations with astrocytes revealed that, with increasing dementia severity, astrocytes and large pyramidal neurons increasingly repelled each other, while astrocytes and interneurons evidenced increasing attraction. This implies that astrocytes may be more likely to be situated in the vicinity of surviving interneurons but less likely to be situated near surviving large pyramidal neurons in the setting of progressing HAD.
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