Article
Chemistry, Multidisciplinary
Yihui Bi, Wenxiu Duan, Jing Chen, Tao You, Shuya Li, Wei Jiang, Min Li, Gang Wang, Xueyin Pan, Jiang Wu, Dan Liu, Jun Li, Yucai Wang
Summary: Post spinal cord injury, using neutrophil membrane-coated nanoparticles as decoys can reduce local neutrophil infiltration and alleviate oxidative stress, leading to improved neural regeneration and functional recovery in injured spinal cords.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Article
Immunology
Yue Guo, Peng Zhang, Haosen Zhao, Chang Xu, Sen Lin, Xifan Mei, He Tian
Summary: In this study, melatonin was found to promote the beneficial polarization of microglia from pro-inflammatory to anti-inflammation, decrease ROS activity, and restore mitochondrial metabolism. Melatonin may have therapeutic potential for neuroinflammation-related neurological disorders, such as spinal cord injury.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Engineering, Biomedical
Xiang Gao, Zhihui Han, Cheng Huang, Huali Lei, Guangqiang Li, Lin Chen, Dandan Feng, Zijie Zhou, Qin Shi, Liang Cheng, Xiaozhong Zhou
Summary: The RA@BSA@Cur nanoparticles constructed in this study have multiple effects on SCI treatment, including suppressing inflammation, increasing neurite length and neural differentiation, and promoting neuron regeneration, which indicates their potential value in treating SCI.
BIOACTIVE MATERIALS
(2022)
Article
Engineering, Environmental
Wenxin Chen, Sen Lin, Yanfeng Xu, Qiang Guo, Yuanhong Xu, Yusheng Niu
Summary: PA-Zn, a nanozyme with SOD and CAT-like activities, can effectively reduce oxidative stress caused by spinal cord injury, promote neuron survival and functional recovery, and has a good therapeutic effect on SCI.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Chemistry, Multidisciplinary
Kui Shen, Guodong Sun, Leung Chan, Lizhen He, Xiaowei Li, Shuxian Yang, Baocheng Wang, Hua Zhang, Jiarun Huang, Minmin Chang, Zhizhong Li, Tianfeng Chen
Summary: In this study, a polymer-based nanodrug delivery system was constructed to target spinal cord injury (SCI) sites. By inhibiting inflammation and promoting macrophage polarization, the system effectively treated SCI.
Article
Immunology
Zhou Feng, Lingxia Min, Liang Liang, Beike Chen, Hui Chen, Yi Zhou, Weiwei Deng, Hongliang Liu, Jingming Hou
Summary: It has been discovered that infiltrated neutrophils in spinal cord injury produce NETs, promoting neuroinflammation and blood-spinal cord barrier disruption, exacerbating SCI. Inhibition or disruption of NETs formation can alleviate damage and promote functional recovery after SCI.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Nanoscience & Nanotechnology
Feng Lin, Yixuan Liu, Wenqi Luo, Shuhan Liu, Yiming Wang, Rui Gu, Wanguo Liu, Chunsheng Xiao
Summary: This study describes the design, synthesis, release kinetics, biosafety, and preclinical efficacy of MC-PαLA-MP NPs for the combined anti-inflammatory treatment of TSCI. The NPs showed the ability to mitigate secondary inflammation and preserve motor function following TSCI, suggesting their potential for clinical application.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2022)
Article
Neurosciences
Alireza Masoudi, Masoumeh Jorjani, Morteza Alizadeh, Solmaz Mirzamohammadi, Mola Mohammadi
Summary: The study demonstrates that astaxanthin offers significant protective effects on SCI rat models by reducing tissue damage and mechanical pain through its anti-inflammatory and antioxidant properties.
BRAIN RESEARCH BULLETIN
(2021)
Review
Neurosciences
Sandra Zivkovic, Maryam Ayazi, Grace Hammel, Yi Ren
Summary: Neutrophils are crucial components of the innate immune system, playing a key role in defense against infections and tissue injuries by recognizing and neutralizing pathogens. They are proficient in various immune response mechanisms, such as phagocytosis, granule release, and formation of NETs. In the pathologic changes in injured spinal cord, neutrophils play a significant role.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Yona Goldshmit, Moshe Shalom, Angela Ruban
Summary: This study tested the efficacy of the PELF-EMF SEQEX device in a compression spinal cord injury mouse model and found that it significantly reduced inflammation and provided neuroprotective effects.
Article
Biotechnology & Applied Microbiology
Chuanjie Zhang, Daoyong Li, Hengshuo Hu, Zhe Wang, Jinyu An, Zhanshan Gao, Kaihua Zhang, Xifan Mei, Chao Wu, He Tian
Summary: Engineered extracellular vesicles with anti-inflammatory and neuroprotective properties were prepared by combining nerve growth factor (NGF) and curcumin (Cur). These vesicles effectively accumulated at the injured site, inhibiting inflammation and releasing NGF for neuroprotection. The vesicles significantly improved the microenvironment after injury and promoted the recovery of motor function after SCI.
JOURNAL OF NANOBIOTECHNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Baokun Zhang, Fangqi Lin, Jiqing Dong, Jingwen Liu, Zhenyu Ding, Jianguang Xu
Summary: This study demonstrates that PM-Exos can promote recovery in spinal cord injury patients by activating microglial autophagy and enhancing the polarization of anti-inflammatory type microglia, potentially through inhibition of the PI3K/AKT/mTOR signaling pathway.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Clinical Neurology
Wu Zhou, Zelu Mao, Zhihua Wang, Huaxin Zhu, Yeyu Zhao, Zhixiong Zhang, Yanyang Zeng, Meihua Li
Summary: This study aimed to assess the relationships between neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), lymphocyte-to-monocyte ratio, and systemic immune inflammatory index (SII) and the American Spinal Injury Association Impairment Scale (AIS) grade in patients with acute traumatic spinal cord injury (TSCI). The results showed that NLR, PLR, and SII were elevated in TSCI patients and exceeded the reference values. AIS grades were inversely correlated with NLR, PLR, and SII. NLR showed higher diagnostic performance than PLR and SII.
WORLD NEUROSURGERY
(2023)
Article
Medicine, Research & Experimental
Feng Sun, Haiwei Zhang, Tianwen Huang, Jianhui Shi, Tianli Wei, Yansong Wang
Summary: This study found that S100A9 is highly expressed in the injured spinal cord and serum in the early stages of spinal cord injury. Treatment with an S100A9-specific blocker significantly improved motor function, reduced cavity formation and neutrophil infiltration, and improved the survival and viability of neurons.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2022)
Article
Neurosciences
Qiang Shi, Yinghao Wu, Baokun Zhang, Shengting Wu, Xin Wang, Fangqi Lin, Guowang Zhang, Xiaofeng Lian, Jianguang Xu
Summary: Progranulin can reduce proinflammatory cytokine production at the lesion site and promote locomotor functional recovery after acute spinal cord injury. In vitro experiments showed that progranulin can activate microglia to acquire an anti-inflammatory phenotype. Progranulin enhances anti-inflammatory microglial polarization through the protection of lysosomal function and the enhancement of autophagic flux.
MOLECULAR NEUROBIOLOGY
(2022)
Article
Clinical Neurology
Natalie Kozyrev, Shawn Albers, Jennifer Yang, Vania F. Prado, Marco A. M. Prado, Gregory J. Fonseca, R. Jane Rylett, Gregory A. Dekaban
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
(2020)
Article
Cell & Tissue Engineering
Kevin P. Robb, Laura Juignet, Pascal Morissette Martin, John T. Walker, Courtney R. Brooks, Christy Barreira, Gregory A. Dekaban, Lauren E. Flynn
Summary: The study investigated the role of donor adipose-derived stromal cells (ASCs) and host macrophages in tissue remodeling of decellularized adipose tissue (DAT) scaffolds. Results showed that exogenous ASCs indirectly enhanced tissue regeneration through multiple mechanisms including cell recruitment and immunomodulation, providing important data for soft tissue engineering.
TISSUE ENGINEERING PART A
(2021)
Article
Critical Care Medicine
Michael R. Miller, Michael Robinson, Robert Bartha, Tanya Charyk Stewart, Lisa Fischer, Gregory A. Dekaban, Ravi S. Menon, J. Kevin Shoemaker, Douglas D. Fraser
Summary: Concussions in sports can lead to significant neurological disability, with adolescents being particularly susceptible. This study found that after sports-related concussions, specific plasma glycerophospholipids (PCs) decreased significantly, with no increase observed. Combining four specific PCs could provide excellent diagnostic potential for adolescent concussions, but external validation in larger cohorts is needed.
JOURNAL OF NEUROTRAUMA
(2021)
Article
Cell Biology
Romain Gasser, Marc Cloutier, Jeremie Prevost, Corby Fink, Eric Ducas, Shilei Ding, Nathalie Dussault, Patricia Landry, Tony Tremblay, Audrey Laforce-Lavoie, Antoine Lewin, Guillaume Beaudoin-Bussieres, Annemarie Laumaea, Halima Medjahed, Catherine Larochelle, Jonathan Richard, Gregory A. Dekaban, Jimmy D. Dikeakos, Renee Bazin, Andres Finzi
Summary: Depletion of immunoglobulin M is associated with the most substantial loss of virus neutralization, followed by immunoglobulin G. This finding may have implications for designing more effective antibody-based COVID-19 therapies and explaining the increased susceptibility of autoimmune patients receiving therapies that inhibit the production of immunoglobulin M (IgM).
Article
Neurosciences
Xiaoyun Xu, Matthew Cowan, Flavio Beraldo, Amy Schranz, Patrick McCunn, Nicole Geremia, Zalman Brown, Maitray Patel, Karen L. Nygard, Reza Khazaee, Lihong Lu, Xingyu Liu, Michael J. Strong, Gregory A. Dekaban, Ravi Menon, Robert Bartha, Mark Daley, Haojie Mao, Vania Prado, Marco A. M. Prado, Lisa Saksida, Tim Bussey, Arthur Brown
Summary: Research has shown that even repetitive mild traumatic brain injuries (rmTBI) that do not reach the diagnostic threshold for concussion can have long-term effects on athletes, including brain damage, behavioral deficits, metabolic changes, etc., which may only become apparent months after the initial injury.
ACTA NEUROPATHOLOGICA COMMUNICATIONS
(2021)
Article
Biotechnology & Applied Microbiology
Tim Tian Y. Han, John T. Walker, Aaron Grant, Gregory A. Dekaban, Lauren E. Flynn
Summary: The study shows that bioreactor preconditioning enhances the regenerative potential of human ASCs by altering the expression characteristics of ASCs on DAT scaffolds through in vitro culture, and also promotes the infiltration of host cells.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Immunology
Irfan Ullah, Jeremie Prevost, Mark S. Ladinsky, Helen Stone, Maolin Lu, Sai Priya Anand, Guillaume Beaudoin-Bussieres, Kelly Symmes, Mehdi Benlarbi, Shilei Ding, Romain Gasser, Corby Fink, Yaozong Chen, Alexandra Tauzin, Guillaume Goyette, Catherine Bourassa, Halima Medjahed, Matthias Mack, Kunho Chung, Craig B. Wilen, Gregory A. Dekaban, Jimmy D. Dikeakos, Emily A. Bruce, Daniel E. Kaufmann, Leonidas Stamatatos, Andrew T. McGuire, Jonathan Richard, Marzena Pazgier, Pamela J. Bjorkman, Walther Mothes, Andres Finzi, Priti Kumar, Pradeep D. Uchil
Summary: Neutralizing antibodies are effective in treating COVID-19, but the mechanism of immune protection is not fully understood. Real-time imaging revealed that highly potent NAbs can prevent and resolve established infections when administered within three days. Both Fab and Fc effector functions of NAbs are essential for optimal efficacy against SARS-CoV-2.
Article
Clinical Neurology
Patrick McCunn, Xiaoyun Xu, Alexander Moszczynski, Alex Li, Arthur Brown, Robert Bartha
Summary: This study utilized NODDI to detect microstructural changes in a rodent model of mTBI, showing significant increases in NDI and ODI in the hippocampus and corpus callosum following injury, with no changes in FA, MD, AD, or RD. Histological analysis revealed increased GFAP staining and evidence of activated astrocytes in these regions.
JOURNAL OF NEUROIMAGING
(2021)
Article
Biophysics
Lihong Lu, Xingyu Liu, Kewei Bian, John G. Sled, Kenneth Monson, Arthur Brown, Haojie Mao
Summary: Blood vessels have a significant impact on the mechanical behavior of brain tissue, with the major branches of the vasculature playing a crucial role in reducing brain strains. The effect of the vasculature varies under different injury loads.
JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME
(2022)
Article
Microbiology
Gyoung Nyoun Kim, Jung-ah Choi, Kunyu Wu, Nasrin Saeedian, Eunji Yang, Hayan Park, Sun-Je Woo, Gippeum Lim, Seong-Gyu Kim, Su-Kyeong Eo, Hoe Won Jeong, Taewoo Kim, Jae-Hyung Chang, Sang Hwan Seo, Na Hyung Kim, Eunsil Choi, Seungho Choo, Sangkyun Lee, Andrew Winterborn, Yue Li, Kate Parham, Justin M. Donovan, Brock Fenton, Jimmy D. Dikeakos, Gregory A. Dekaban, S. M. Mansour Haeryfar, Ryan M. Troyer, Eric J. Arts, Stephen D. Barr, Manki Song, C. Yong Kang
Summary: The COVID-19 pandemic has had unprecedented global impact. Vaccinating the majority of the world's population is crucial in preventing new infections. Developing new derivatives of current vaccines and utilizing safe vesicular stomatitis virus-based delivery vehicles have shown promise in protecting against SARS-CoV-2 infection and reducing lung damage.
Review
Immunology
Eoin N. Blythe, Lynne C. Weaver, Arthur Brown, Gregory A. Dekaban
Summary: CD11d/CD18 is a recently discovered and poorly understood β2 integrin, playing a crucial role in localizing white blood cells to inflammation sites. Although its adhesive mechanisms and signaling pathways have been investigated, further research is needed to fully understand its functions.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Clinical Neurology
Michael R. Miller, Michael Robinson, Lisa Fischer, Alicia DiBattista, Maitray A. Patel, Mark Daley, Robert Bartha, Gregory A. Dekaban, Ravi S. Menon, J. Kevin Shoemaker, Eleftherios P. Diamandis, Ioannis Prassas, Douglas D. Fraser
Summary: This study identified three protein biomarkers (ATOX1, SPARC, and NT5C3A) in plasma that, when combined, showed high accuracy in diagnosing sport concussions. These proteins may play a role in tissue inflammation modulation and regulation of the cerebral microvasculature, making them potential candidates for future screening of adolescent sport concussions. Further validation in larger cohorts is needed to confirm their utility.
FRONTIERS IN NEUROLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Julia J. Gevaert, Corby Fink, Jimmy D. Dikeakos, Gregory A. Dekaban, Paula J. Foster
Summary: This study evaluates magnetic particle imaging (MPI) as a method for in vivo tracking of dendritic cells (DC) and demonstrates its potential applications in migration models.
MOLECULAR IMAGING AND BIOLOGY
(2022)
Article
Virology
Antony Lurie, Corby Fink, Genevieve Gosselin, Gregory A. Dekaban, Jimmy D. Dikeakos
Summary: The article explores the rationale for pharmacologically targeting the HIV-1 accessory protein Nef and reviews the progress in the identification and development of Nef inhibitors.
