期刊
JOURNAL OF NEUROTRAUMA
卷 29, 期 16, 页码 2548-2554出版社
MARY ANN LIEBERT, INC
DOI: 10.1089/neu.2012.2483
关键词
Egr3 pathway; GABA(A) receptor; JaK/STAT pathway; traumatic brain injury
资金
- Department of Defense (DoD) [W81XWH-11-1-0501]
- NIH/NCRR Colorado CTSI [TL1 RR025778]
The gamma-aminobutyric acid (GABA) type A receptor (GABA(A)R) is responsible for most fast synaptic inhibition in the adult brain. The GABA(A)R protein is composed of multiple subunits that determine the distribution, properties, and dynamics of the receptor. Several studies have shown that the Janus kinase/signal transducer and activator of transcription (JaK/STAT) and early growth response 3 (Egr3) signaling pathways can alter GABA(A)R subunit expression after status epilepticus (SE). In this study we investigated changes in these pathways after experimental TBI in the rat using a lateral fluid percussion injury (FPI) model. Our results demonstrated changes in the expression of several GABA(A)R subunit levels after injury, including GABA(A)R alpha 1 and alpha 4 subunits. This change appears to be transcriptional, and there is an associated increase in the phosphorylation of STAT3, and an increase in the expression of Egr3 and inducible cAMP element repressor (ICER) after FPI. These findings suggest that the activation of the JaK/STAT and Egr3 pathways after TBI may regulate injury-related changes in GABA(A)R subunit expression.
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