Article
Neurosciences
Ashley L. Ware, Keith Owen Yeates, Bryce Geeraert, Xiangyu Long, Miriam H. Beauchamp, William Craig, Quynh Doan, Stephen B. Freedman, Bradley G. Goodyear, Roger Zemek, Catherine Lebel
Summary: Sophisticated network-based approaches such as structural connectomics may help detect a biomarker of mild traumatic brain injury (mTBI) in children. This study compared the structural connectome of children with mTBI or mild orthopedic injury (OI) to that of typically developing (TD) children, finding that both mTBI and OI groups demonstrated reduced global and regional network efficiency and segregation compared to TD children. This suggests a general effect of childhood injury on brain structure that could reflect pre- and postinjury factors.
HUMAN BRAIN MAPPING
(2022)
Article
Nanoscience & Nanotechnology
Xuyang Huang, Yongqing Ye, Jianyong Zhang, Xuefeng Zhang, Hongwei Ma, Yongkang Zhang, Xianhua Fu, JiaJia Tang, Ning Jiang, Yuhan Han, Hongmei Liu, Honglin Chen
Summary: This study presents a ROS-scavenging functional hydrogel that can deliver drugs by responding to the traumatic microenvironment. By avoiding the blood-brain barrier and directly targeting the traumatic area on the brain tissue surface, the hydrogel can release encapsulated drugs to regulate the cellular oxidative stress response.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Biochemistry & Molecular Biology
Luke Berger, Barbara Holshouser, Joy G. Nichols, Jamie Pivonka-Jones, Stephen Ashwal, Brenda Bartnik-Olson
Summary: This study examines the predictive ability of global white matter and gray matter metabolite ratios following pediatric traumatic brain injury (TBI), and their relationship to neuropsychological assessments at 12 months. The results show that the metabolite ratios were significantly lower in the TBI groups compared to controls during the acute phase, but normalized at 12 months. Acute gray matter and white matter metabolite ratios were significantly correlated to 12-month assessments of IQ, attention, and memory.
Article
Cell Biology
Hongzhi Wang, Emily W. Baker, Abhyuday Mandal, Ramana M. Pidaparti, Franklin D. West, Holly A. Kinder
Summary: This study used a translational large animal piglet TBI model to identify clinically relevant MRI biomarkers and predict functional outcomes. Results showed that lesion size and midline shift acquired using T2-weighted imaging were predictive of functional impairments, while gait parameters like velocity, cadence, and stride length explained changes in gait data variability post-TBI.
NEURAL REGENERATION RESEARCH
(2021)
Review
Clinical Neurology
Alex S. Aguirre, Kenny Rojas, Alcy R. Torres
Summary: Our study reveals that head injuries are the most common casualties in war zones, affecting both male and female children with an average age of 8-10 years. Most children are from Afghanistan, and blasts are the most common mechanism of injury, with a mortality rate ranging from 3% to 47%.
FRONTIERS IN NEUROLOGY
(2023)
Article
Behavioral Sciences
Yuyang Wang, Yuwei Zhou, Xinyu Zhang, Kai Wang, Xingui Chen, Hongwei Cheng
Summary: Patients with mild traumatic brain injury (MTBI) exhibit deficits in the orienting network of attention and extensive cognitive impairments, including those related to general attention, memory, and information processing speed.
BEHAVIOURAL BRAIN RESEARCH
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Ling Wang, Shengqiang Wang, Weimin Zheng, Beining Yang, Yanhui Yang, Xin Chen, Qian Chen, Xuejing Li, Yongsheng Hu, Jubao Du, Wen Qin, Jie Lu, Nan Chen
Summary: This study reveals the specific functional changes in the brain of children after complete spinal cord injury, providing potential neural mechanisms for the sensory motor and cognitive-emotional deficits they face during rehabilitation.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Article
Chemistry, Physical
Weikang Luo, Lianglin Zhang, Xuexuan Li, Jun Zheng, Quan Chen, Zhaoyu Yang, Menghan Cheng, Yao Chen, Yao Wu, Wei Zhang, Tao Tang, Yang Wang
Summary: This study reports a novel carbon dot (CD) synthesized from green plants for repairing the blood-brain barrier (BBB) after traumatic brain injury (TBI). The results show that the carbon dot has neuroprotective effects and improves BBB permeability in animal models.
Review
Clinical Neurology
Rebecka O. Serpa, Lindsay Ferguson, Cooper Larson, Julie Bailard, Samantha Cooke, Tiffany Greco, Mayumi L. Prins
Summary: Traumatic brain injury (TBI) incidence is highest in the pediatric population, with peaks in toddlers and adolescents. Acute pathophysiology and outcomes differ between age groups, highlighting the importance of age-associated mechanisms in pediatric TBI research. Timecourse of pathophysiological processes and developmental windows of susceptibility are crucial for understanding the long-term effects of TBI in children.
FRONTIERS IN NEUROLOGY
(2021)
Article
Biochemistry & Molecular Biology
Qi Lu, Jun Xiong, Yuan Yuan, Zhanwei Ruan, Yu Zhang, Bo Chai, Lei Li, Shufang Cai, Jian Xiao, Yanqing Wu, Peng Huang, Hongyu Zhang
Summary: This study demonstrates that minocycline can improve the functional recovery of traumatic brain injury (TBI) by reducing the levels of aquaporin-4 (AQP4). Minocycline treatment effectively reduces neuronal apoptosis, ameliorates brain edema and blood-brain barrier disruption in TBI. The expression of tight junction proteins and the morphology of astrocytes are also optimized by minocycline administration. AQP4 may be an important therapeutic target for minocycline treatment of TBI.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Rehabilitation
Pierre Simeone, Guillaume Auzias, Julien Lefevre, Sylvain Takerkart, Olivier Coulon, Blandine Lesimple, Gregory Torkomian, Valentine Battisti, Alice Jacquens, David Couret, Lionel Naccache, Eleonore Bayen, Nicolas Bruder, Vincent Perlbarg, Louis Puybasset, Lionel Velly
Summary: This study found a significant decrease in volumes of white matter and deep grey nuclear structures in severe TBI patients. These lesions were associated with lower baseline scores and higher diffusion tensor imaging values, which can be used to predict long-term neurological outcomes.
ANNALS OF PHYSICAL AND REHABILITATION MEDICINE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Teresa Gerhalter, Martijn Cloos, Anna M. Chen, Seena Dehkharghani, Rosemary Peralta, James S. Babb, Alejandro Zarate, Tamara Bushnik, Jonathan M. Silver, Brian S. Im, Stephen Wall, Steven Baete, Guillaume Madelin, Ivan I. Kirov
Summary: The relaxation properties derived from MRF, particularly T-1, showed higher utility for predicting outcomes 3 months after mild traumatic brain injury (mTBI) compared to T-2, fractional anisotropy (FA), and apparent diffusion coefficient (ADC). High T-1 at baseline and serially increasing T-1 were strong indicators of non-recovery at 3 months post-injury.
EUROPEAN RADIOLOGY
(2022)
Article
Neurosciences
Madison M. Fagan, Christina B. Welch, Kelly M. Scheulin, Sydney E. Sneed, Julie H. Jeon, Morgane E. Golan, Savannah R. Cheek, Deborah A. Barany, Georg Oeltzschner, Todd R. Callaway, Qun Zhao, Hea Jin Park, Jeferson M. Lourenco, Kylee J. Duberstein, Franklin D. West
Summary: This study investigates the efficacy of daily fecal microbial transplant (FMT) in alleviating neural injury severity, preventing gut dysbiosis, and improving functional recovery post pediatric traumatic brain injury (TBI). The research was conducted using a pediatric piglet model and found that FMT treatment resulted in decreased lesion volume, improved neuron and oligodendrocyte survival, and restored ileum tissue morphology at 7 days post TBI. Moreover, FMT treatment led to decreased dysbiosis and an increase in probiotic Lactobacilli species in the cecum, while non-treated TBI animals showed an increase in pathogenic bacteria in feces.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Neurosciences
Reut Raizman, Nofar Itzhaki, Johanna Sirkin, Inbar Meningher, Galia Tsarfaty, Ofer Keren, Zion Zibli, Tamar Silberg, Chagi G. Pick, Abigail Livny
Summary: This study investigated the differences in homotopic functional connectivity (HoFC) between traumatic brain injury (TBI) patients and healthy controls, and found decreased HoFC in multiple brain regions in TBI patients. Furthermore, a logistic regression model incorporating regional HoFC and fractional anisotropy (FA) of the corpus callosum (CC) demonstrated a high accuracy in distinguishing msTBI patients.
Article
Pharmacology & Pharmacy
Chen-Mei Chen, Pei-Yu Gung, Yen-Chun Ho, Candra D. D. Hamdin, Shaw-Fang Yet
Summary: This study found that probucol can improve functional recovery and cognitive impairment after traumatic brain injury (TBI) by promoting neuroregeneration and neuronal remodeling. In addition, probucol exerts its neuroregenerative effects by increasing the expression of BDNF and activation of TrkB. Therefore, probucol may be a promising new drug for the treatment of TBI.
BRITISH JOURNAL OF PHARMACOLOGY
(2023)