Article
Clinical Neurology
Rebecca E. Woodrow, Stefan Winzeck, Andrea Luppi, Isaac R. Kelleher-Unger, Lennart R. B. Spindler, J. T. Lindsay Wilson, Virginia F. J. Newcombe, Jonathan P. Coles, David K. Menon, Emmanuel A. Stamatakis
Summary: Chronic post-concussive symptoms are common after mild traumatic brain injury (mTBI) and are difficult to predict or treat. The study found acute thalamic hyperconnectivity in mTBI, even without structural changes. These acute changes in thalamic connectivity can serve as early markers for persistent symptoms and have associations with specific emotional and cognitive symptoms.
Review
Clinical Neurology
Adriano Mollica, Rachel Greben, Chika Oriuwa, Shan H. Siddiqi, Matthew J. Burke
Summary: This article reviews recent research on neuromodulation for mild traumatic brain injury (mTBI). It suggests that transcranial magnetic stimulation (TMS) shows promise as a potential treatment strategy for post-concussive symptoms, such as depression and headaches, while transcranial direct current stimulation (tDCS) has more mixed results. Further studies are needed to explore new stimulation protocols, personalized approaches, and the role of placebo effects.
CURRENT NEUROLOGY AND NEUROSCIENCE REPORTS
(2022)
Article
Neurosciences
Eva Keatley, Kathleen Bechtold, Kevin Psoter, Matthew E. Peters, Allen Everett, Vani Rao, Timothy E. Van Meter, Hayley Falk, Frederick K. Korley, Durga Roy
Summary: This study utilized group-based trajectory modeling (GBTM) to identify distinct patterns of symptom recovery following mild traumatic brain injury (TBI) in the first 6 months after injury. The findings identified four distinct trajectories of recovery, which can be helpful for understanding the natural history of recovery and developing targeted interventions.
Article
Medicine, General & Internal
Harvey S. Levin, Nancy R. Temkin, Jason Barber, Lindsay D. Nelson, Claudia Robertson, Jeffrey Brennan, Murray B. Stein, John K. Yue, Joseph T. Giacino, Michael A. McCrea, Ramon Diaz-Arrastia, Pratik Mukherjee, David O. Okonkwo, Kim Boase, Amy J. Markowitz, Yelena Bodien, Sabrina Taylor, Mary J. Vassar, Geoffrey T. Manley
Summary: This study identified that women are more susceptible than men to persistent mTBI-related cognitive and somatic symptoms, with no sex differences observed after orthopedic injury. Post-concussion symptoms were also more severe in women aged 35 to 49 than in younger and older women.
Article
Clinical Neurology
Julian Takagi-Stewart, Ashleigh M. Johnson, Mallory B. Smith, Jin Wang, Lyscha A. Marcynyszyn, Douglas F. Zatzick, Carolyn A. McCarty, Frederick P. Rivara, Monica S. Vavilala
Summary: This study examined the association between physician recommended school accommodations and student outcomes among youth experiencing persistent post-concussive symptoms (PPCS). The results showed that physicians recommend more school accommodations for students experiencing more school problems post-concussion. However, there were no significant associations found between recommended school accommodations and GPA, health-related quality of life, anxiety symptoms, or depressive symptoms.
NEUROREHABILITATION
(2022)
Article
Critical Care Medicine
Ana Mikolic, Suzanne Polinder, Ewout W. Steyerberg, Isabel R. A. Retel Helmrich, Joseph T. Giacino, Andrew I. R. Maas, Joukje van der Naalt, Daphne C. Voormolen, Nicole von Steinbuechel, Lindsay Wilson, Hester F. Lingsma, David van Klaveren
Summary: Prognostic models for early prediction of outcomes after mild TBI lack both good calibration and discrimination, and future studies should focus on tailoring these models to the specific population with mild TBI.
JOURNAL OF NEUROTRAUMA
(2021)
Article
Clinical Neurology
Josh W. Faulkner, Alice Theadom, Deborah L. Snell, Matt N. Williams
Summary: This study applied network analysis to investigate post-concussion symptoms after mild traumatic brain injury (mTBI) and found that frustration, blurred vision, and concentration difficulties were central symptoms in two different mTBI samples. These symptoms may play an influential role in the experience and maintenance of post-concussion symptoms.
FRONTIERS IN NEUROLOGY
(2023)
Article
Neurosciences
Jackie L. Gottshall, Amma A. Agyemang, Maya O'Neil, Guo Wei, Angela Presson, Bryson Hewins, Daniel Fisher, Sara Mithani, Pashtun Shahim, Mary Jo Pugh, Elisabeth A. Wilde, Christina Devoto, Kristine Yaffe, Jessica Gill, Kimbra Kenney, J. Kent Werner
Summary: Following mild traumatic brain injury (mTBI), the severity of symptoms reported by individuals is positively correlated with biomarker levels of neurodegeneration. The associations between biomarkers and symptoms do not significantly change when sleep items are included or excluded. The Pittsburgh Sleep Quality Index demonstrates strong correlations with both sleep and non-sleep items of all symptom scales.
Article
Sport Sciences
Todd W. Lyons, Rebekah Mannix, Ken Tang, Keith Owen Yeates, Gurinder Sangha, Emma C. M. Burns, Darcy Beer, Alexander S. Dubrovsky, Isabelle Gagnon, Jocelyn Gravel, Stephen B. Freedman, William Craig, Kathy Boutis, Martin H. Osmond, Gerard Gioia, Roger Zemek
Summary: This study aimed to assess the occurrence and clustering of post-concussive symptoms in children and identify distinct patient phenotypes based on symptom type and severity. The results showed that post-concussive symptoms occur in distinct clusters and five patient groups were identified based on symptom type and severity.
BRITISH JOURNAL OF SPORTS MEDICINE
(2022)
Article
Multidisciplinary Sciences
Eli Fried, Uri Balla, Merav Catalogna, Eran Kozer, Adi Oren-Amit, Amir Hadanny, Shai Efrati
Summary: This study aimed to evaluate the prevalence of persistent post-concussion syndrome (PPCS) in children after mild traumatic brain injury (mTBI) and identify high-risk factors. The results showed that 25% of children may suffer from PPCS, but it is often underdiagnosed in the pediatric population. Screening guidelines should be implemented to identify and treat these children in a timely manner.
SCIENTIFIC REPORTS
(2022)
Article
Critical Care Medicine
Jonathan E. Elliott, Nadir M. Balba, Alisha A. McBride, Megan L. Callahan, Kendall T. Street, Matthew P. Butler, Mary M. Heinricher, Miranda M. Lim
Summary: This study examined the effectiveness of different methods for evaluating history of traumatic brain injury (TBI), finding that the Head Trauma Events Characteristics (HTEC) method had the highest sensitivity. It also noted that the results and conclusions may significantly differ depending on the diagnostic method used.
JOURNAL OF NEUROTRAUMA
(2021)
Article
Critical Care Medicine
Sara M. Lippa, Louis M. French, Tracey A. Brickell, Angela E. Driscoll, Megan E. Glazer, Corie E. Tippett, Jamie K. Sullivan, Rael T. Lange
Summary: This study found that PTSD symptoms were more strongly related to cognitive performance in individuals with a history of complicated mild/moderate TBI compared to those with severe/penetrating TBI. The impact of PTSD symptoms on cognition should be considered in individuals with complicated mild/moderate TBI.
JOURNAL OF NEUROTRAUMA
(2021)
Article
Neurosciences
Erica L. Underwood, John B. Redell, Mark E. Maynard, Nobuhide Kobori, Michael J. Hylin, Kimberly N. Hood, Rebecca K. West, Jing Zhao, Anthony N. Moore, Pramod K. Dash
Summary: The use of metformin as a treatment for repeat concussion can significantly reduce pathology, improve mitochondrial function, and enhance motor and cognitive functions.
Article
Neuroimaging
Julie M. Joyce, Leah J. Mercier, Mehak Stokoe, Parker L. La, Tiffany Bell, Julia M. Batycky, Chantel T. Debert, Ashley D. Harris
Summary: This study aimed to investigate the pathophysiology of persistent post-concussive symptoms (PPCS). The study found that anterior cingulate glutamate (Glu) was significantly reduced in PPCS patients compared to controls, while higher anterior cingulate gamma-aminobutyric acid (GABA) was significantly associated with a higher number of lifetime mild traumatic brain injuries (mTBIs). In addition, glutathione (GSH) in both regions of interest was positively associated with symptoms of sleepiness and headache burden.
NEUROIMAGE-CLINICAL
(2022)
Article
Critical Care Medicine
Rael T. Lange, Sara M. Lippa, Tracey A. Brickell, Ping-Hong Yeh, John Ollinger, Megan Wright, Angela Driscoll, Jamie Sullivan, Samantha Braatz, Rachel Gartner, Elizabeth Barnhart, Louis M. French
Summary: This study found a significant impact of PTSD on neuropsychological outcomes after MTBI, but no relationship between PTSD and white matter integrity. Concurrent PTSD and MTBI should be considered a risk factor for poor neuropsychological outcomes that requires early intervention.
JOURNAL OF NEUROTRAUMA
(2021)
Article
Oncology
Guilherme Dabus, Rupesh Kotecha, Italo Linfante, D. Jay Wieczorek, Alonso N. Gutierrez, John G. Candela, Michael W. McDermott
Summary: This study aimed to evaluate the utility of integrating a 3D vessel tree co-registration software platform into the treatment of brain arteriovenous malformation (bAVM) and its time-saving effect. The results showed that using this software platform can significantly save time in the treatment process, which is of great importance for the treatment of bAVMs.
Article
Mathematical & Computational Biology
Shiyang Ma, Michael P. McDermott
Summary: Adaptive designs in learning-phase clinical trials can be efficient and highly informative. This article extends the MCP-Mod procedure with GMCTs for two-stage adaptive designs for proof-of-concept. The results of an interim analysis guide adaptations to candidate dose-response models and dosages studied in the second stage, with GMCTs used in both stages to obtain and combine stage-wise p-values for an overall p-value. Simulation studies show advantages of adaptive designs over nonadaptive designs when candidate dose-response models are not well-informed by preclinical and early-phase evidence.
BIOMETRICAL JOURNAL
(2022)
Review
Clinical Neurology
Michael Benatar, Joanne Wuu, Caroline McHutchison, Ronald B. Postuma, Bradley F. Boeve, Ronald Petersen, Christopher A. Ross, Howard Rosen, Jalayne J. Arias, Stephanie Fradette, Michael P. McDermott, Jeremy Shefner, Christine Stanislaw, Sharon Abrahams, Stephanie Cosentino, Peter M. Andersen, Richard S. Finkel, Volkan Granit, Anne-Laure Grignon, Jonathan D. Rohrer, Corey T. McMillan, Murray Grossman, Ammar Al-Chalabi, Martin R. Turner
Summary: Significant progress has been made in understanding the pre-symptomatic phase of amyotrophic lateral sclerosis. Advances in other neurodegenerative diseases provide valuable insights and highlight opportunities for discovery in ALS. Biomarkers play a critical role in studying pre-symptomatic ALS and are essential for early therapeutic intervention and disease prevention.
Review
Cardiac & Cardiovascular Systems
Jennifer A. Rymer, Dennis Narcisse, Michael Cosiano, John Tanaka, Mary M. McDermott, Diane J. Treat-Jacobson, Michael S. Conte, Brandi Tuttle, Manesh R. Patel, Kim G. Smolderen
Summary: This review summarizes the validation of patient-reported outcome measures (PROMs) in people with symptomatic peripheral artery disease. The findings suggest that disease-specific PROMs have good reliability and sensitivity, while generic PROMs have more extensive validation evidence. These findings can guide the selection of PROMs aligned with scientific and clinical goals.
CIRCULATION-CARDIOVASCULAR INTERVENTIONS
(2022)
Meeting Abstract
Gastroenterology & Hepatology
Jamison Seabury, Jennifer Weinstein, Spencer Rosero, Anika Varma, Ellen Wagner, Christine Zizzi, Nuran Dilek, Michael McDermott, Aaron Kaat, Lawrence Saubermann, Larissa Temple, Scott Rogoff, Chad Heatwole, Zach Rose
INFLAMMATORY BOWEL DISEASES
(2022)
Correction
Gastroenterology & Hepatology
Jamison Seabury, Jennifer Weinstein, Spencer Rosero, Anika Varma, Ellen Wagner, Christine Zizzi, Nuran Dilek, Michael McDermott, Aaron Kaat, Lawrence Saubermann, Larissa Temple, Scott Rogoff, Chad Heatwole
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2022)
Editorial Material
Medicine, General & Internal
Mary M. McDermott
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2022)
Article
Medicine, General & Internal
Michela Guglieri, Kate Bushby, Michael P. McDermott, Kimberly A. Hart, Rabi Tawil, William B. Martens, Barbara E. Herr, Elaine McColl, Chris Speed, Jennifer Wilkinson, Janbernd Kirschner, Wendy M. King, Michelle Eagle, Mary W. Brown, Tracey Willis, Robert C. Griggs
Summary: A double-blind, parallel-group randomized clinical trial was conducted to compare the efficacy and adverse effects of different corticosteroid regimens in boys with Duchenne muscular dystrophy. The study found that daily prednisone and daily deflazacort were more effective than intermittent prednisone for improving motor function, pulmonary function, and satisfaction with treatment over a 3-year period. There was no significant difference between the two daily corticosteroid regimens.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2022)
Article
Genetics & Heredity
Abrar Choudhury, Stephen T. Magill, Charlotte D. Eaton, Briana C. Prager, William C. Chen, Martha A. Cady, Kyounghee Seo, Calixto-Hope G. Lucas, Tim J. Casey-Clyde, Harish N. Vasudevan, S. John Liu, Javier E. Villanueva-Meyer, Tai-Chung Lam, Jenny Kan-Suen Pu, Lai-Fung Li, Gilberto Ka-Kit Leung, Danielle L. Swaney, Michael Y. Zhang, Jason W. Chan, Zhixin Qiu, Michael V. Martin, Matthew S. Susko, Steve E. Braunstein, Nancy Ann Oberheim Bush, Jessica D. Schulte, Nicholas Butowski, Penny K. Sneed, Mitchel S. Berger, Nevan J. Krogan, Arie Perry, Joanna J. Phillips, David A. Solomon, Joseph F. Costello, Michael W. McDermott, Jeremy N. Rich, David R. Raleigh
Summary: DNA methylation profiling identified three groups of meningiomas with distinct clinical outcomes, biological drivers, and therapeutic vulnerabilities. Cytostatic cell cycle inhibitors showed efficacy in attenuating meningioma growth.
Article
Clinical Neurology
Rupesh Kotecha, Manmeet S. Ahluwalia, Vitaly Siomin, Michael W. McDermott
Summary: Brain metastases are the most common brain tumors in adults. Recent advances in understanding molecular biology have allowed for tailored systemic therapies and immunotherapies as treatment options. Improved surgical techniques and innovative radiotherapy approaches have also enhanced patient outcomes. Multidisciplinary care is crucial in managing operable patients with brain metastases in the modern era.
NEUROLOGIC CLINICS
(2022)
Article
Clinical Neurology
Anna G. Mayhew, Dionne Moat, Michael P. McDermott, Michelle Eagle, Robert C. Griggs, Wendy M. King, Meredith K. James, Robert Muni-Lofra, Alison Shillington, Sarah Gregson, Lindsey Pallant, Christy Skura, Loretta A. Staudt, Katy Eichinger, Heather McMurchie, Rosanna Rabb, Marina Di Marco, Sarah Brown, Riccardo Zanin, Maria Teresa Arnoldi, Melissa McIntyre, Amelia Wilson, Lindsay N. Alfano, Linda P. Lowes, Colleen Blomgren, Evelin Milev, Mario Iodice, Amy Pasternak, Angela Chiu, Ilka Lehnert, Nicole Claus, Kathy A. Dieruf, Enrica Rolle, Alina Nicorici, Barbara Andres, Elke Hobbiebrunken, Gerda Roetmann, Victoria Kern, Matthew Civitello, Sibylle Vogt, Melissa J. Hayes, Cheryl Scholtes, Catherine Lacroix, Tara Gunn, Sinead Warner, Jennifer Newman, Andrea Barp, Katherine Kundrat, Staci Kovelman, Penny J. Powers, Michela Guglieri
Summary: The purpose of this study was to quantify motor performance in genetically confirmed steroid-naive boys with Duchenne muscular dystrophy (DMD), evaluate the test-retest reliability of measures of motor performance in young DMD boys, and assess correlations among different functional outcomes. The study found that physiotherapy measures are reliable in a young, steroid-naive population and rise from floor velocity appears to be a sensitive measure of strength in this population.
NEUROMUSCULAR DISORDERS
(2022)
Article
Oncology
Sana Abbasi, Helia Rivand, Fatemeh Eshaghi, Mohammad Amin Moosavi, Saeid Amanpour, Michael F. Mcdermott, Marveh Rahmati
Summary: This study aimed to sensitize colorectal cancer cells to chemotherapy by targeting the IRE1a/XBP1 pathway. The results showed that the IRE1a inhibitor 4 mu 8C inhibited CRC cell growth and enhanced the cytotoxicity of 5-FU. In vivo experiments demonstrated that 4 mu 8C inhibited tumor growth and significantly enhanced drug responses when combined with 5-FU.
Letter
Hematology
Adam Al-Hakim, Alyssa Cull, Joanna Topping, Fatima Nadat, Joanna Milek, Razan F. Alhefzi, Michael F. McDermott, Roger Owen, Catherine Cargo, James G. Poulter, David G. Kent, Sinisa Savic, ImmunAID Consortium
Review
Clinical Neurology
Ramin A. Morshed, Nicole T. Jiam, Elaina J. Wang, Stephen T. Magill, Renata M. Knoll, Elliott D. Kozin, Philip Theodosopoulos, Steven W. Cheung, Jeffrey D. Sharon, Michael W. McDermott
Summary: This study found that posterior fossa meningiomas involving the endolymphatic sac can cause Meniere's syndrome. Early recognition and microsurgical excision of these tumors are crucial for relieving most symptoms and stabilizing hearing loss.
JOURNAL OF NEUROSURGERY
(2022)
Article
Clinical Neurology
Zachary A. Seymour, Jason W. Chan, Michael W. McDermott, Inga Grills, Hong Ye, Hideyuki Kano, Craig A. Lehocky, Rachel C. Jacobs, L. Dade Lunsford, Tomas Chytka, Roman Liscak, Cheng-Chia Lee, Huai-Che Yang, Dale Ding, Jason P. Sheehan, Caleb E. Feliciano, Rafael Rodriguez-Mercado, Veronica L. Chiang, Judith A. Hess, Samuel Sommaruga, Brendan McShane, John Y. K. Lee, Lucas T. Vasas, Anthony M. Kaufmann, Penny K. Sneed
Summary: The study is a multicentered retrospective review of 257 patients treated with volume-staged stereotactic radiosurgery (VS-SRS) for arteriovenous malformations (AVMs). The results showed that size remains the dominant predictor of toxicity following SRS, but overall rates of symptomatic adverse radiation effects (AREs) were lower than anticipated, suggesting dissociation of dose and size through volume staging. Further techniques need to be assessed to optimize outcomes.
JOURNAL OF NEUROSURGERY
(2022)