Article
Biology
Papangkorn Inkeaw, Salita Angkurawaranon, Piyapong Khumrin, Nakarin Inmutto, Patrinee Traisathit, Jeerayut Chaijaruwanich, Chaisiri Angkurawaranon, Imjai Chitapanarux
Summary: This paper introduces a new method for automatically segmenting hemorrhage subtypes in head CT scans based on a deep learning model. The experimental results show that the proposed method outperforms previous studies in terms of segmentation performance for each hemorrhage subtype.
COMPUTERS IN BIOLOGY AND MEDICINE
(2022)
Article
Materials Science, Multidisciplinary
Yang Wan, Wenqiang Fang, Rika Wright Carlsen, Haneesh Kesari
Summary: Rotational head motions play a crucial role in traumatic brain injury, and there is a need for methods to quickly predict brain tissue strains and strain rates to estimate injury risk and guide protective equipment design. Idealized continuum mechanics based head models provide a simpler and faster approach to estimate brain strains and strain rates. In this study, a new head model accounting for finite rotations is proposed, which shows comparable strain predictions to a more detailed finite element head model. This model can serve as a basis for introducing finite rotations into more sophisticated head models in the future.
JOURNAL OF THE MECHANICS AND PHYSICS OF SOLIDS
(2023)
Article
Clinical Neurology
Yegeta Wondafrash Habte, Hengameh B. Pajer, Temesgen Beyene Abicho, Yohannes Feleke, Yacob Alemu Bizuneh, Belinda Shao, Heather S. Spader
Summary: This study validated the applicability of the Canadian CT Head Rule and the New Orleans Criteria in an Ethiopian population, demonstrating their high sensitivity in ruling out clinically important brain injury and potentially reducing the need for CT scans in low-resource settings.
WORLD NEUROSURGERY
(2023)
Article
Neurosciences
Xiaoyan Jia, Xuan Li, Qiuyu Ji, Bo Yin, Yizhen Pan, Wenpu Zhao, Guanghui Bai, Jie Zhang, Lijun Bai
Summary: Blood proteins have the potential to be biomarkers for mild traumatic brain injury (mTBI). This study found that the angiogenic biomarker VEGF can identify patients with mTBI, while the inflammatory biomarker interleukin-1 beta and neuronal cell body injury biomarker ubiquitin carboxyl-terminal hydrolase L1 are elevated in acute-stage patients and associated with cognitive deterioration. The axonal injury biomarker neurofilament light is elevated in acute-stage patients and associated with impaired white matter integrity and progressive brain atrophy.
Article
Clinical Neurology
Ramona Guatta, Alberto Delaidelli, Adrien Thomas May, Gianpaolo Jannelli, Alessandro Moiraghi, Karl Schaller, Andrea Bartoli
Summary: The study found that for isolated subarachnoid hemorrhage (iSAH) in patients with mild traumatic brain injury (mTBI), the clinical utility of a repeat head CT scan within 72 hours is questionable, as there was minimal radiological progression or neurological deterioration observed. It suggests that neurologic observation and symptomatic treatment may be a reasonable alternative regardless of anticoagulation/antiplatelet therapy.
ACTA NEUROCHIRURGICA
(2021)
Article
Neurosciences
Colby Hansen, Laura C. Waller, Dalton Brady, Masaru Teramoto
Summary: This study found that, in pediatric patients with complicated mild traumatic brain injury (C-mTBI), other than the presence of multiple hemorrhagic contusions, no other imaging abnormality appears to be associated with the degree or length of recovery. Further studies with larger cohorts are encouraged.
Article
Radiology, Nuclear Medicine & Medical Imaging
Matthew Pease, Dooman Arefan, Jason Barber, Esther Yuh, Ava Puccio, Kerri Hochberger, Enyinna Nwachuku, Souvik Roy, Stephanie Casillo, Nancy Temkin, David O. Okonkwo, Shandong Wu
Summary: This study developed a deep learning model that combines head CT scans and clinical information to predict 6-month outcomes after severe traumatic brain injury.
Article
Medicine, General & Internal
Andreas Sakkas, Christel Weiss, Marcel Ebeling, Frank Wilde, Sebastian Pietzka, Qasim Mohammad, Oliver Christian Thiele, Robert Andreas Mischkowski
Summary: The aim of the study was to identify clinical indicators for primary cranial CT imaging in patients with mild traumatic brain injury (mTBI). The study also aimed to evaluate the need for short-term hospitalization based on clinical and CT findings. A retrospective study was conducted on mTBI patients over a five-year period, analyzing demographic data, clinical and radiological findings, and outcomes. The study found that a Glasgow Coma Scale (GCS) score of <15, loss of consciousness, amnesia, seizures, cephalgia, somnolence, dizziness, nausea, and clinical signs of fracture were significantly associated with acute intracranial hemorrhage (ICH).
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Critical Care Medicine
David Hacker, Christopher A. Jones, Eyrsa Yasin, Sophie Preece, Holly Davies, Andrew Hawkins, Antonio Belli, Emily Paton
Summary: Cognitive outcomes were compared between mild traumatic brain injury (mTBI) with positive brain imaging (complicated mTBI) and mTBI with normal imaging (uncomplicated mTBI) as well as moderate to severe TBI. The findings showed that complicated mTBI had poorer cognitive outcomes than uncomplicated mTBI, but the deficits were not as severe as in moderate-severe TBI. The deficits in complicated mTBI were present in processing speed, memory, executive function, and language beyond 3 months post-injury.
JOURNAL OF NEUROTRAUMA
(2023)
Review
Biochemistry & Molecular Biology
Charlotte Oris, Samy Kahouadji, Julie Durif, Damien Bouvier, Vincent Sapin
Summary: Mild traumatic brain injury (mTBI) is a growing burden worldwide, accounting for approximately 80% of all TBI cases. In recent years, candidate biomarkers have been investigated to improve the management of mTBI patients. Blood biomarker measurement in the acute phase after a traumatic event helps reduce unnecessary CT scans and hospitalizations. S100B protein has emerged as the most widely studied and used biomarker for clinical decision making in patients with mTBI. Besides its diagnostic use, S100B plays a role in the molecular pathogenic processes accompanying acute brain injury, making it a potential therapeutic target.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Critical Care Medicine
Timo Roine, Mehrbod Mohammadian, Jussi Hirvonen, Timo Kurki, Jussi P. Posti, Riikka S. K. Takala, Virginia F. Newcombe, Jussi Tallus, Ari J. Katila, Henna-Riikka Maanpaeae, Janek Frantzen, David Menon, Olli Tenovuo
Summary: We investigated the topology of structural brain connectivity networks and found that both global and local network properties are associated with outcome after mild traumatic brain injury. Higher normalized global efficiency, degree, and strength as well as lower small-worldness are correlated with better outcome. The local network properties of the left putamen and the left postcentral gyrus show the most prominent correlations with outcome.
JOURNAL OF NEUROTRAUMA
(2022)
Article
Clinical Neurology
Lucie Colas, Sahara Graf, Juliette Ding, Gregory Bertolotti, Nicolas Thellier, Jean-Francosis Budzik, Sebastien Verclytte
Summary: The purpose of this study was to assess the risk and impact of intracranial hemorrhages (IH) detected with CT in patients on antiplatelet (AP), anticoagulant (AC), or direct oral anticoagulant (DOAC) medication after mild traumatic brain injury (mTBI). The results showed a low frequency and severity of IH in mTBI patients treated with AP, AC, or DOAC, without surgical intervention, death, or neurological deterioration, suggesting limited benefit of systematic CT head scan in managing mTBI patients under antithrombotic therapy.
JOURNAL OF NEURORADIOLOGY
(2023)
Article
Pediatrics
Xenophon Sinopidis, Panagiotis Kallianezos, Constantinos Petropoulos, Despoina Gkentzi, Eirini Kostopoulou, Sotirios Fouzas, Theodore Dassios, Aggeliki Vervenioti, Ageliki Karatza, Stylianos Roupakias, Antonios Panagidis, Evangelos Blevrakis, Eleni Jelastopulu
Summary: This study aims to evaluate the stress of children with mild head injuries and their parents' relevant perception during the early post-traumatic period. Results showed that 33.7% of children and 19.0% of parents were diagnosed with stress after one week, and 9.9% of children and 3.9% of parents after one month. It indicates that mild head injuries can have an impact on the emotional well-being of children and should not be overlooked.
Article
Medicine, General & Internal
Torgeir Hellstrom, Nada Andelic, Ann-Marie G. de Lange, Eirik Helseth, Kristin Eiklid, Lars T. Westlye
Summary: The study found that compared to non-carriers, APOE e4 carriers showed lower fractional anisotropy (FA) in the hippocampal part of the cingulum bundle, but this difference did not remain significant after multiple comparison correction. No significant differences were found in brain age prediction, brain morphometry, and volumes between the two groups.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Clinical Neurology
Jung Ho Hong, Ikchan Jeon, Youngbeom Seo, Seong Ho Kim, Dongwoo Yu
Summary: This study found that postoperative CT findings of hemispheric hypodensity and effacement of cisterns are associated with poor outcomes in traumatic brain injury patients after primary decompressive craniectomy.
ACTA NEUROCHIRURGICA
(2021)