Article
Neurosciences
Mariko Nishibe, Hiroki Toyoda, Shin-ichiro Hiraga, Toshihide Yamashita, Yu Katsuyama
Summary: Patients with neurodevelopmental disorders exhibit impaired motor skill learning, which may be attributed to the effect of genetic variation on synaptic function and transcriptome profile, leading to inadequate experience-dependent cortical plasticity necessary for the development of fine motor skills.
Article
Cell Biology
Marco Bonizzato, Marina Martinez
Summary: Most rehabilitation interventions post-SCI target sublesional spinal networks, but mammalian locomotion involves more than just that. Recovery of cortical control is essential for voluntary movement and gait modulation. Neurostimulation delivered in phase coherence with ongoing locomotion immediately alleviated primary deficits in rats with incomplete SCI.
SCIENCE TRANSLATIONAL MEDICINE
(2021)
Article
Cell Biology
Qian Qiao, Chunling Wu, Lei Ma, Hua Zhang, Miao Li, Xujun Wu, Wen-Biao Gan
Summary: Learning induces the formation of new synapses, which are preferentially active and synchronized with dendritic/somatic activity during the execution of learned tasks. These new synapses increase the task specificity of neurons and are not affected by learning new tasks.
Article
Cell Biology
Ling Guo, Sravani Kondapavulur, Stefan M. Lemke, Seok Joon Won, Karunesh Ganguly
Summary: The study reveals the importance of consistent neural activity patterns across brain structures during recovery poststroke, and suggests that modulation of cross-area coordination can be a therapeutic target for enhancing motor function.
Article
Neurosciences
Marie-Noelle Calmels, Yohan Gallois, Mathieu Marx, Olivier Deguine, Soumia Taoui, Emma Arnaud, Kuzma Strelnikov, Pascal Barone
Summary: This research protocol utilizes fNIRS to analyze cortical changes in children with single-sided deafness and their relationship with auditory and language skills, providing important insights for developing individualized rehabilitation programs for untreated SSD children. By comparing cortical measures between SSD and normal hearing children and studying their association with binaural hearing, speech perception and production, and quality of life, the study aims to prevent long-term neurofunctional and clinical consequences.
Article
Multidisciplinary Sciences
Robert W. Nickl, Manuel A. Anaya, Tessy M. Thomas, Matthew S. Fifer, Daniel N. Candrea, David P. McMullen, Margaret C. Thompson, Luke E. Osborn, William S. Anderson, Brock A. Wester, Francesco Tenore, Nathan E. Crone, Gabriela L. Cantarero, Pablo A. Celnik
Summary: The study focused on characterizing the spatial organization and stability of sensorimotor maps in a participant with spinal cord injury using MEAs. Stability of firing strength within electrodes decreased over time, with differences observed between sensory and motor cortex, as well as contralateral and ipsilateral hemispheres. However, no differences were found at the network level, suggesting overall stability in decoding wrist motions.
SCIENTIFIC REPORTS
(2022)
Article
Chemistry, Multidisciplinary
Jingya Su, Yanran Li, Dingdong Xie, Jie Jiang
Summary: The development of a solid-state device for emulating pain recognition with ultralow voltage operation has been a great challenge. This study demonstrates a successful application of a vertical transistor with an ultrashort channel and ultralow voltage based on protonic silk fibroin/sodium alginate crosslinking hydrogel electrolyte. This device integrates pain perception, memory, and sensitization, and displays multi-state pain-sensitization enhancement abilities through Pavlovian training with the photogating effect of light stimulus. The cortical reorganization, which reveals the close relationship among pain stimulus, memory, and sensitization, is finally realized. This device provides great opportunities for multi-dimensional pain assessment and has significant implications for bio-inspired intelligent electronics.
MATERIALS HORIZONS
(2023)
Article
Multidisciplinary Sciences
Melissa Antons, Magdalena Lindner, Maximilian Grosch, Rosel Oos, Giovanna Palumbo, Matthias Brendel, Sibylle Ziegler, Peter Bartenstein, Marianne Dieterich, Andreas Zwergal
Summary: This study compared the serial whole-brain measurements of functional and structural synaptic plasticity before and after bilateral labyrinthectomy in rats. The results revealed complex spatial and temporal patterns of structure-function coupling in networks for vestibular, multisensory, and motor control. Locomotor training was found to improve neuroplasticity and reduce body rotations.
SCIENTIFIC REPORTS
(2022)
Article
Multidisciplinary Sciences
Elissa L. Newport, Anna Seydell-Greenwald, Barbara Landau, Peter E. Turkeltaub, Catherine E. Chambers, Kelly C. Martin, Rebecca Rennert, Margot Giannetti, Alexander W. Dromerick, Rebecca N. Ichord, Jessica L. Carpenter, Madison M. Berl, William D. Gaillard
Summary: The mature human brain is lateralized for language, with the left hemisphere primarily responsible for sentence processing and the right hemisphere primarily responsible for processing suprasegmental aspects of language. It has been hypothesized that there is plasticity for language in early life, allowing young children to acquire language in other cortical regions when LH areas are damaged. This reorganization is highly constrained, with sentence processing almost always occurring in the right hemisphere frontotemporal regions.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Neurosciences
Robert A. Morrison, Tanya T. Danaphongse, Stephanie T. Abe, Madison E. Stevens, Vikram Ezhil, Armin Seyedahmadi, Katherine S. Adcock, Robert L. Rennaker, Michael P. Kilgard, Seth A. Hays
Summary: The study found that moderate intensity VNS can enhance motor cortex plasticity in rats, while replacing half of moderate intensity stimulation with high intensity VNS can block this enhancement, and reinstating plasticity can be achieved by removing high intensity stimulation and using only 50 pairings of moderate intensity VNS.
Article
Multidisciplinary Sciences
Daan B. Wesselink, Zeena-Britt Sanders, Laura R. Edmondson, Harriet Dempsey-Jones, Paulina Kieliba, Sanne Kikkert, Andreas C. Themistocleous, Uzay Emir, Jorn Diedrichsen, Hannes P. Saal, Tamar R. Makin
Summary: This study investigates remapping in the brain map after finger amputation using pharmacological and neuroimaging methods. The findings reveal persistent representation of missing fingers in the brain map even decades after amputation. The study also shows that the blocked finger representation remains despite input loss.
Article
Neurosciences
Hunter R. Schone, Roni O. Maimon-Mor, Chris I. Baker, Tamar R. Makin
Summary: The study found that expert tool users do not incorporate their tools into their neural representation of the body as much as novices, preferring to differentiate between hands and tools. These findings suggest an alternative framework to the prominent tool embodiment theory.
JOURNAL OF NEUROSCIENCE
(2021)
Review
Psychology, Multidisciplinary
Isabella Lucia Chiara Mariani Wigley, Eleonora Mascheroni, Denis Peruzzo, Roberto Giorda, Sabrina Bonichini, Rosario Montirosso
Summary: This study systematically reviewed the role of DNA methylation in neural cell fate, focusing on the link between DNA methylation, neuroimaging data, early life stress, and behavioral outcomes. Results showed associations between DNA methylation and brain structure/functions in individuals with adverse early life experiences, with various genes and neuroimaging techniques being investigated. Statistical models used ranged from correlational to moderated mediation models, emphasizing the importance of understanding the interaction between DNA methylation, neural correlates, early life stress, and behavioral outcomes.
FRONTIERS IN PSYCHOLOGY
(2021)
Article
Geriatrics & Gerontology
Jingchun Liu, Caihong Wang, Jingliang Cheng, Peifang Miao, Zhen Li
Summary: In chronic subcortical stroke, there is increased interhemispheric resting-state functional connectivity (rsFC) between the bilateral primary motor cortex (M1) to compensate for corticospinal tract (CST) impairment, facilitating motor recovery. The FA of the affected M1 fiber in the acute stage showed the most significant correlation with long-term motor recovery, and the compensatory role of M1-M1 rsFC enhancement may start from the subacute stage in stroke patients with CST impairment.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Review
Clinical Neurology
Mouna Tahmi, Veronica A. Kane, Marykay A. Pavol, Imama A. Naqvi
Summary: Post-stroke cognitive impairment affects a significant number of patients, and neuroimaging techniques can be used as biomarkers to predict cognitive recovery, guiding treatment and rehabilitation methods.
FRONTIERS IN NEUROLOGY
(2022)
Article
Rehabilitation
Ada Tang, Amy Tao, Michelle Soh, Carolyn Tam, Hannah Tan, Jessica Thompson, Janice J. Eng
CLINICAL REHABILITATION
(2015)
Article
Rehabilitation
Nancy E. Mayo, Sharon Anderson, Ruth Barclay, Jill I. Cameron, Johanne Desrosiers, Janice J. Eng, Maria Huijbregts, Aura Kagan, Marilyn MacKay-Lyons, Carolina Moriello, Carol L. Richards, Nancy M. Salbach, Susan C. Scott, Robert Teasell, Mark Bayley
CLINICAL REHABILITATION
(2015)
Article
Health Care Sciences & Services
Louise A. Connell, Naoimh E. McMahon, Judith Redfern, Caroline L. Watkins, Janice J. Eng
IMPLEMENTATION SCIENCE
(2015)
Review
Engineering, Biomedical
Dennis R. Louie, Janice J. Eng, Tania Lam
JOURNAL OF NEUROENGINEERING AND REHABILITATION
(2015)
Article
Rehabilitation
Lisa A. Simpson, Janice J. Eng, Tara D. Klassen, Shannon B. Lim, Dennis R. Louie, Beena Parappilly, Brodie M. Sakakibara, Dominik Zbogar
JOURNAL OF REHABILITATION MEDICINE
(2015)
Article
Rehabilitation
Tania Lam, Katherine Pauhl, Amanda Ferguson, Raza N. Malik, Andrei Krassioukov, Janice J. Eng
JOURNAL OF REHABILITATION RESEARCH AND DEVELOPMENT
(2015)
Article
Orthopedics
Tara D. Klassen, Lisa A. Simpson, Shannon B. Lim, Dennis R. Louie, Beena Parappilly, Brodie M. Sakakibara, Dominik Zbogar, Janice J. Eng
Article
Rehabilitation
Krista L. Best, William C. Miller, Grant Huston, Francois Routhier, Janice J. Eng
ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION
(2016)
Article
Rehabilitation
Caryne Torkia, Krista L. Best, William C. Miller, Janice J. Eng
ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION
(2016)
Article
Rehabilitation
Bita Imam, William C. Miller, Heather Finlayson, Janice J. Eng, Tal Jarus
CLINICAL REHABILITATION
(2017)
Article
Rehabilitation
Lisa A. Simpson, Janice J. Eng, May Chan
DISABILITY AND REHABILITATION
(2017)
Review
Clinical Neurology
Christie W. L. Chan, Janice J. Eng, Charles H. Tator, Andrei Krassioukov
JOURNAL OF SPINAL CORD MEDICINE
(2016)
Article
Chemistry, Analytical
Xianta Jiang, Christopher Napier, Brett Hannigan, Janice J. Eng, Carlo Menon
Review
Psychology, Clinical
Krista L. Best, William C. Miller, Janice J. Eng, Francois Routhier
INTERNATIONAL JOURNAL OF BEHAVIORAL MEDICINE
(2016)
Review
Clinical Neurology
Adebimpe O. Obembe, Janice J. Eng
NEUROREHABILITATION AND NEURAL REPAIR
(2016)