期刊
JOURNAL OF NEUROTRAUMA
卷 26, 期 6, 页码 913-921出版社
MARY ANN LIEBERT, INC
DOI: 10.1089/neu.2008.0609
关键词
biomarkers; blast; brain injury; molecular pathways; traumatic brain injury
资金
- Department of Defense [N14-06-1-1029, W81XWH-8-1-0376, X81XWH-07-01-0701]
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [R01NS049175] Funding Source: NIH RePORTER
The nature of warfare in the 21st century has led to a significant increase in primary blast or over-pressurization injuries to the whole body and head, which manifest as a complex of neuro-somatic damage, including traumatic brain injury (TBI). Identifying relevant pathogenic pathways in reproducible experimental models of primary blast wave exposure is therefore vital to the development of biomarkers for diagnostics of blast brain injury. Comparative analysis of mechanisms and putative biomarkers of blast brain injury is complicated by a deficiency of experimental studies. In this article, we present an overview of current TBI biomarkers, as well as outline experimental strategies to investigate molecular signatures of blast neurotrauma and to develop a pathway network map for novel biomarker discovery. These biomarkers will be effective for triaging and managing both combat and civilian causalities.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据