Article
Clinical Neurology
Shengyu Guo, Taotao Lin, Gang Chen, Zhitao Shangguan, Linquan Zhou, Zhi Chen, Tengbin Shi, Dehui Chen, Zhenyu Wang, Wenge Liu
Summary: This study investigated the role of methyltransferase METTL3 in spinal cord injury (SCI). The expression of METTL3 and overall m6A modification level were significantly increased in neurons. Inhibition of METTL3 activity or expression can inhibit neuronal apoptosis after SCI through the m6A/Bcl-2 signaling pathway.
Review
Medicine, Research & Experimental
Chun-Lin Xiao, Wen-Chao Yin, Yan-Chun Zhong, Jia-Quan Luo, Lu-Lin Liu, Wu-Yang Liu, Kai Zhao
Summary: Spinal cord injury is a severe central nervous system injury that leads to sensory and motor dysfunction. The PI3K/Akt signaling pathway plays a key role in the pathological processes and neuronal recovery of spinal cord injury, and its activation can promote neurological function recovery by reducing cell apoptosis.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Oncology
Shun Xu, Jin Wang, Junjie Zhong, Minghao Shao, Jianyuan Jiang, Jian Song, Wei Zhu, Fan Zhang, Haocheng Xu, Guangyu Xu, Yuxuan Zhang, Xiaosheng Ma, Feizhou Lyu
Summary: The study demonstrates that CD73 inhibits microglial pyroptosis by suppressing the activation of NLRP3 inflammasome complexes and reducing GSDMD maturation. CD73 regulates GSDMD expression at the transcriptional level through Foxo1, and forms a positive feedback loop with HIF-1 alpha.
CLINICAL AND TRANSLATIONAL MEDICINE
(2021)
Article
Immunology
Zhenxin Hu, Lina Xuan, Tingting Wu, Nizhou Jiang, Xiangjun Liu, Jiazhen Chang, Te Wang, Nan Han, Xiliang Tian
Summary: Taxifolin reduces neuroinflammation and microglial pyroptosis after spinal cord injury by inhibiting oxidative stress and regulating the PI3K/AKT signaling pathway. It also promotes axonal regeneration and improves functional recovery. Taxifolin may be a potential therapeutic agent for spinal cord injury.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Cell Biology
Chongan Huang, Weiqi Zhang, Feifan Chu, Hao Qian, Yining Wang, Fangzhou Qi, Mengke Ye, Jiaying Zhou, Zhi Lin, Chenlin Dong, Xiangyang Wang, Qingqing Wang, Haiming Jin
Summary: The research demonstrates that patchouli alcohol (PA) has a protective effect against spinal cord injury (SCI) by maintaining the integrity of the blood-spinal cord barrier (BSCB). PA prevents hyperpermeability of the BSCB, reduces the loss of tight junctions and endothelial cells, and suppresses endoplasmic reticulum stress and apoptosis. In a rat model of SCI, PA effectively improves neurological deficits, making it a promising candidate for SCI treatment.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Neurosciences
Sajad Hassanzadeh, Mahsa Sabetvand, Reza Sardar, Roya Aryanpour, Zeinab Namjoo
Summary: The study investigates the impact of 17 beta-estradiol (E2) on mitochondrial alterations in motor neurons induced by spinal cord injury in rats. The results suggest that E2 treatment can improve mitochondria structural integrity and reduce irregular mitochondrial features in motor neurons.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Cell Biology
Rui Zhao, Xue Wu, Xue-Yuan Bi, Hao Yang, Qian Zhang
Summary: Baicalin is a natural active ingredient that can cross the blood-brain barrier and has neuroprotective effects on multiple central nervous system diseases. This study investigated the mechanism of action of Baicalin in treating spinal cord injury and found that it can inhibit blood-spinal cord barrier permeability and reduce neuronal apoptosis by activating the PI3K/Akt signaling pathway.
NEURAL REGENERATION RESEARCH
(2022)
Article
Plant Sciences
Lie Zang, Dewang Fu, Fan Zhang, Ning Li, Xue Ma
Summary: This study finds that Tenuigenin (TEN) can promote functional recovery in spinal cord injury rats by suppressing autophagy and blocking PTPN1 to rescue the IRS1/Akt/mTOR signaling pathway.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Medicine, Research & Experimental
Zhenfei Ding, Ce Dai, Lin Zhong, Rui Liu, Weilu Gao, Hui Zhang, Zongsheng Yin
Summary: The study demonstrated that Nrg1 could effectively convert reactive astrocytes to oligodendrocytes, inhibit astrogliosis, promote remyelination, protect axons, and improve SCI symptoms, suggesting a promising therapeutic strategy for spinal cord repair.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Biochemistry & Molecular Biology
Xinwang Ying, Qingfeng Xie, Xiaolan Yu, Shengcun Li, Qiaoyun Wu, Xiaolong Chen, Jingjing Yue, Kecheng Zhou, Wenzhan Tu, Songhe Jiang
Summary: The study demonstrated that water treadmill training (TT) protects the blood-spinal cord barrier (BSCB) after spinal cord injury (SCI) by upregulating the BDNF/TrkB-CREB signalling pathway, while application of the inhibitor blocks this protective effect.
NEUROCHEMISTRY INTERNATIONAL
(2021)
Review
Immunology
Jiansong Chen, Yiguo Shen, Xiaobo Shao, Weiliang Wu
Summary: Spinal cord injury (SCI) and spinal cord tumor cause significant damage to the spinal cord, leading to multiple impairments and high morbidity and mortality. The treatment options for these conditions are limited and the underlying molecular mechanisms remain unclear. In the review, the role of inflammasomes in SCI and spinal cord tumors is highlighted, and targeting inflammasomes is suggested as a potential therapeutic strategy.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Neurosciences
Xiaoping Ren, Weihua Zhang, Jie Qin, Jian Mo, Yi Chen, Jie Han, Xinjian Feng, Sitan Feng, Haibo Liang, Liangjue Cen, Xiaofei Wu, Linxuan Han, Rongyu Lan, Haixuan Deng, Huihui Yao, Zhongquan Qi, Hongjun Gao, Lishan Wei, Shuai Ren
Summary: This study tested spinal cord fusion (SCF) using the neuroprotective agent polyethylene glycol (PEG) in different animal models and developed a new clinical procedure called vascular pedicle hemisected spinal cord transplantation (vSCT) for the treatment of paraplegic patients. The results demonstrated the feasibility and efficacy of vSCT in re-establishing the continuity of spinal nerve fibers, potentially restoring motor, sensory, and autonomic nervous functions in paraplegic patients. Further clinical trials are needed to validate these findings.
CNS NEUROSCIENCE & THERAPEUTICS
(2022)
Article
Medicine, Research & Experimental
Zili He, Jiqing Du, Yu Zhang, Yitie Xu, Qian Huang, Qingwei Zhou, Min Wu, Yao Li, Xie Zhang, Hongyu Zhang, Yuepiao Cai, Keyong Ye, Xiangyang Wang, Yingze Zhang, Qi Han, Jian Xiao
Summary: Increasing evidence suggests that defects in autophagy and autophagy-lysosomal pathway (ALP) may contribute to endothelial barrier disruption following acute traumatic spinal cord injury (SCI). This study investigates whether Kruppel-like factor 2 (KLF2) coordinates ALP in endothelial cells in SCI. The results demonstrate that KLF2 is a key contributor to SCI-mediated ALP dysfunction and blood-spinal cord barrier (BSCB) disruption, and could be a promising pharmacological target for SCI management and treatment.
Article
Biochemistry & Molecular Biology
Tao Jiang, Tao Qin, Peng Gao, Zhiwen Tao, Xiaowei Wang, Mengyuan Wu, Jun Gu, Bo Chu, Ziyang Zheng, Jiang Yi, Tao Xu, Yifan Huang, Hao Liu, Shujie Zhao, Yongxin Ren, Jian Chen, Guoyong Yin
Summary: The expression of SIRT1 in spinal cord endothelial cells is decreased after spinal cord injury (SCI). SIRT1 has the ability to reduce endothelial reactive oxygen species production and protect endothelial barrier function, indicating its potential as a therapeutic target for promoting functional recovery against blood-spinal cord barrier (BSCB) disruption following SCI.
Article
Neurosciences
Shuai Ren, Weihua Zhang, HongMiao Liu, Xin Wang, Xiangchen Guan, Mingzhe Zhang, Jian Zhang, Qiong Wu, Yan Xue, Dan Wang, Yong Liu, Jianyu Liu, Xiaoping Ren
Summary: The study focused on investigating the restoration of motor function following spinal cord injury through transplanting a vascularized pedicle of hemisected spinal cord to bridge the transected spinal cord. Results showed that electrical continuity was restored, leading to motor function recovery, supporting the potential effectiveness of similar operative techniques in treating SCI patients previously considered to have irreversible damage or paralysis.
CNS NEUROSCIENCE & THERAPEUTICS
(2021)