Article
Cell Biology
Yun-Zhi Zhao, Jun Wei, Ke-Xin Song, Chen Zhou, Zhen Chai
Summary: The present study found that non-hibernating Daurian ground squirrel (GS) neurons were more resistant to oxygen-glucose deprivation (OGD) compared to rat neurons. Glutamate-aspartate transporter 1 (GLAST) was identified as a cytoprotective factor that contributed to the tolerance against OGD injury in GS neurons. Overexpression of GLAST rescued viability in rat neurons, while knockdown of GLAST led to decreased viability in GS neurons. This study revealed a molecular mechanism underlying the survival of hibernating mammals and suggested GLAST as a potential target for ischemic stroke therapy.
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
Review
Pharmacology & Pharmacy
Oykum Kaplan-Arabaci, Alperen Acari, Pinar Ciftci, Devrim Gozuacik
Summary: Stroke is the second leading cause of death and disability globally. Ischemic stroke, caused by blood vessel blockage, has limited treatment options. Previous studies aimed at reducing glutamate in ischemic stroke and other neurodegenerative diseases have failed due to delivery obstacles. Systemic glutamate scavenging, a new therapeutic approach, offers the advantage of working in the circulating blood without interfering with brain neurophysiology.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Neurosciences
Flavia A. Tejeda-Bayron, David E. Rivera-Aponte, Christian J. Malpica-Nieves, Geronimo Maldonado-Martinez, Hector M. Maldonado, Serguei N. Skatchkov, Misty J. Eaton
Summary: The GLT-1 translational activator LDN improved stroke outcomes in young adult male mice by reducing infarct size and enhancing sensorimotor performance, while no such improvement was observed in female mice.
Review
Pharmacology & Pharmacy
Yicheng Wei, Jialuo Cai, Ruiqiu Zhu, Ke Xu, Hongchang Li, Jianxin Li
Summary: This review focuses on the role of TRPA1 channel in fibroblasts, exploring its interactions with inflammatory factors and its different functions in the fibrosis process in different organs. The aim of this review is to describe the function of TRP channels in controlling fibrosis through fibroblasts in various inflammatory and immune-mediated diseases.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Medicine, Research & Experimental
Diogo Neves, Ivan L. Salazar, Ramiro D. Almeida, Raquel M. Silva
Summary: Excitotoxicity is the neuronal damage caused by excessive release of glutamate and subsequent activation of excitatory plasma membrane receptors. This phenomenon is mainly driven by excessive activation of glutamate receptors. Excitotoxicity is common in chronic disorders of the CNS and is considered the primary mechanism of neuronal loss of function and cell death in acute CNS diseases.
Article
Biotechnology & Applied Microbiology
Weiwei Yan, Hongfei Zhu, Bianbian Yu, Xin Ma, Hang Liang, Shuyan Zhao, Kebin Deng
Summary: The study suggests that tinnitus leads to an upregulation of Homer1 expression in the auditory cortex, which can be significantly reduced by the noncompetitive mGluR5 inhibitor MPEP.
Article
Critical Care Medicine
Matt Thomas, Kati Hayes, Paul White, Aravind Ramesh, Lucy Culliford, Gareth Ackland, Anthony Pickering
Summary: Traumatic brain injury is a major global cause of death and disability. Beta-blockade with esmolol has shown potential as a neuroprotective agent in severe traumatic brain injury. This study aims to determine a dose schedule for esmolol that reduces heart rate and maintains cerebral perfusion pressure, with the goal of testing its patient benefits in future trials.
NEUROCRITICAL CARE
(2023)
Article
Immunology
Yi Guo, Xia-Nan Zhang, Shan Su, Zi-Lun Ruan, Ming-Ming Hu, Hong-Bing Shu
Summary: Upon viral infection, the levels of beta-adrenergic hormones and their receptors decrease, inhibiting the innate antiviral response. Increased levels of beta-adrenergic hormones activate PKA kinase, which phosphorylates MITA and VISA, suppressing the innate immune response to DNA and RNA viruses. These findings provide insights into the regulatory mechanisms of innate antiviral responses and the increased susceptibility to viral infection in stressful situations.
CELLULAR & MOLECULAR IMMUNOLOGY
(2023)
Article
Emergency Medicine
J. R. Krenz, M. E. O'Brien, J. Lee, B. D. Hayes
Summary: This study evaluated the efficacy and safety of esmolol for heart rate control in patients with acute aortic dissection, showing that lenient heart rate control was achieved in most patients within the first hour of treatment. However, a small percentage of patients experienced hypotension during the initial treatment period, highlighting the need for further investigation.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2021)
Article
Neurosciences
Bartosz Pomierny, Weronika Krzyzanowska, Alicja Skorkowska, Jakub Jurczyk, Beata Bystrowska, Boguslawa Budziszewska, Joanna Pera
Summary: Brain ischemia is a major cause of death and disability worldwide, and the release of glutamate after ischemia induces neuronal excitotoxicity. VGLUT1 and VGLUT2 are involved in filling presynaptic vesicles with glutamate. This study explores the effect of cerebral ischemia on the expression of VGLUT1 and VGLUT2, and the impact of VGLUT inhibition on glutamate release and stroke outcome.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Neurosciences
Angelina Lacroix, Melodie Proteau-Lemieux, Samantha Cote, Jamie Near, Steve C. N. Hui, Richard A. E. Edden, Sarah Lippe, Artuela Caku, Francois Corbin, Jean-Francois Lepage
Summary: Patients with FXS and NF1 exhibit lower GABA concentration levels compared to healthy controls, with FXS patients showing increased GABAB-mediated inhibition. Results of MRS and TMS assessments suggest a partial overlap in neurophysiological alterations involving the GABA system in NF1 and FXS patients, supporting the hypothesis that MRS and TMS assess different aspects of the neurotransmitter systems.
NEUROBIOLOGY OF DISEASE
(2022)
Article
Biochemistry & Molecular Biology
Qiaojuan Liu, Yonglun Kong, Xiangdong Guo, Baien Liang, Haixia Xie, Shan Hu, Mengke Han, Xiaoduo Zhao, Pinning Feng, Qianqian Lyu, Wei Dong, Xinling Liang, Weidong Wang, Chunling Li
Summary: Renal ischemia/reperfusion injury leads to downregulation of Aquaporin channels and sodium transporters, as well as suppression of autophagy and increased inflammation. Treatment that activates autophagy can prevent these changes and improve kidney function.
Article
Neurosciences
Xin Sui, Hideyuki Yoshioka, Yuichiro Fukumoto, Kazuya Kanemaru, Hiroyuki Kinouchi
Summary: HAX-1 is a mitochondrial protein that plays a neuroprotective role against ischemic neuronal injury, and the downregulation of HAX-1 by NOX2-produced ROS can induce apoptosis after cerebral ischemia.
EXPERIMENTAL NEUROLOGY
(2021)
Article
Medicine, General & Internal
Tony Whitehouse, Anower Hossain, Gavin D. Perkins, Anthony C. Gordon, Julian Bion, Duncan Young, Danny Mcauley, Mervyn Singer, Janet Lord, Simon Gates, Tonny Veenith, Niall S. Maccallum, Joyce Yeung, Richard Innes, Ingeborg Welters, Nafisa Boota, Emma Skilton, Belinder Ghuman, Maddy Hill, Scott E. Regan, Dipesh Mistry, Ranjit Lall
Summary: This study aimed to assess the efficacy and safety of landiolol in patients with septic shock. The results showed that landiolol did not reduce organ failure and may increase mortality in this patient population.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2023)
Article
Critical Care Medicine
Bruno Levy, Caroline Fritz, Caroline Piona, Kevin Duarte, Andrea Morelli, Philippe Guerci, Antoine Kimmoun, Nicolas Girerd
Summary: The Esmosepsis study aimed to investigate the effects of Esmolol on heart rate control in septic shock patients. The results showed that in the early phase of septic shock, reducing heart rate using Esmolol was associated with an increased risk of hypotension and decreased cardiac index, despite adequate tissue perfusion.
Article
Anesthesiology
Yuta Horikoshi, Toru Goyagi, Ryohei Kudo, Sahoko Kodama, Takashi Horiguchi, Toshiaki Nishikawa
JOURNAL OF CLINICAL ANESTHESIA
(2017)
Article
Neurosciences
Toru Goyagi
Article
Neurosciences
Toru Goyagi, Takashi Horiguchi, Toshiaki Nishikawa, Yoshitsugu Tobe, Yoko Masaki
Article
Neurosciences
Toru Goyagi, Yoshitsugu Tobe
Article
Anesthesiology
T. Goyagi, Y. Tobe, T. Nishikawa
BRITISH JOURNAL OF ANAESTHESIA
(2012)
Article
Neurosciences
Toru Goyagi
NEUROTOXICITY RESEARCH
(2019)
Article
Developmental Biology
Toru Goyagi
INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE
(2019)
Article
Anesthesiology
Akira Nemoto, Toru Goyagi, Wataru Nemoto, Osamu Nakagawasai, Koichi Tan-No, Yukitoshi Niiyama
Summary: This study found that preoperative muscle atrophy induced by tail suspension (TS) was associated with a decrease in brain-derived neurotrophic factor (BDNF) and neurogenesis, resulting in an increased occurrence of perioperative neurocognitive disorder (PND). Therefore, it was concluded that preoperative low skeletal muscle mass can induce PND due to impaired postoperative neurogenesis. Our findings suggest that low-cost perioperative interventions, such as preoperative exercise, may be beneficial in preventing PND.
ANESTHESIA AND ANALGESIA
(2022)
Article
Anesthesiology
Hiroki Iida, Shigeki Yamaguchi, Toru Goyagi, Yoko Sugiyama, Chie Taniguchi, Takako Matsubara, Naoto Yamada, Hiroshi Yonekura, Mami Iida
Summary: Smoking is closely associated with the development of various cancers and tobacco-related illnesses. It plays a critical role in pain-related pathophysiology. Smoking cessation interventions aim to reduce pain, improve daily activities, and reduce the risks of tobacco-related disorders.
JOURNAL OF ANESTHESIA
(2022)
Meeting Abstract
Anesthesiology
Toru Goyagi
ANESTHESIA AND ANALGESIA
(2021)
Article
Medicine, Research & Experimental
Akira Nemoto, Toru Goyagi
Summary: This study investigated a simple method for studying sarcopenia in rats. Results showed that muscle mass, muscle contraction, and cross-sectional area were significantly lower in the tail-suspended and spontaneously hypertensive rat groups compared to the control group, indicating sarcopenic phenotypes.
LABORATORY ANIMAL RESEARCH
(2021)
Article
Anesthesiology
Akira Nemoto, Kana Mizuno, Toru Goyagi
TURKISH JOURNAL OF ANAESTHESIOLOGY AND REANIMATION
(2020)
Meeting Abstract
Endocrinology & Metabolism
T. Goyagi
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2017)
Meeting Abstract
Endocrinology & Metabolism
T. Goyagi, T. Horiguchi, T. Nishikawa
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2016)
Article
Cardiac & Cardiovascular Systems
Yukako Imai, Kazuhiro Imai, Tetsu Kimura, Takashi Horiguchi, Toru Goyagi, Hajime Saito, Yusuke Sato, Satoru Motoyama, Toshiaki Nishikawa, Yoshihiro Minamiya
GENERAL THORACIC AND CARDIOVASCULAR SURGERY
(2015)