Article
Engineering, Biomedical
Dalin Wang, Alon Lai, Jennifer Gansau, Philip Nasser, Yunsoo Lee, Damien M. Laudier, James C. Iatridis
Summary: This study established an ex-vivo rat lumbar endplate injury model and characterized the effects of endplate injury on motion segment biomechanical properties. Compared to annulus fibrosus injury, endplate injury had the greatest impact on axial biomechanical properties, while annulus fibrosus injury primarily affected torsional properties.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2022)
Article
Engineering, Biomedical
Patrice Sudres, Morgane Evin, Eric Wagnac, Nicolas Bailly, Lucien Diotalevi, Anthony Melot, Pierre-Jean Arnoux, Yvan Petit
Summary: This study aimed to quantify the elastic meningeal mechanical properties of porcine spinal cord, revealing the diverse mechanical properties of spinal meninges along the length of the spinal cord.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2021)
Article
Computer Science, Interdisciplinary Applications
Kai-Hua Li, Hui Yang, Zhi-Guo Li, Xin-Long Ma
Summary: This study analyzed the effects of annulus fibrosus incision and foraminoplasty on lumbar biomechanics during posterior lateral approach translaminar percutaneous endoscopic lumbar discectomy (PELD) using a lumbar 4/5 segment model and three-dimensional finite element analysis (FEA). The results showed that foraminoplasty can affect the stability and rotation axis of the segment during rotation, while annulus fibrosus incision significantly increases discal stress.
COMPUTER METHODS IN BIOMECHANICS AND BIOMEDICAL ENGINEERING
(2023)
Article
Biochemistry & Molecular Biology
Weidong Zhang, Huan Wang, Zhangqin Yuan, Genglei Chu, Heng Sun, Zilin Yu, Huan Liang, Tao Liu, Feng Zhou, Bin Li
Summary: The study showed that different levels of cyclic tensile strain have varying effects on annulus fibrosus cells, with moderate mechanical stimulation reducing inflammatory responses and exhibiting anti-inflammatory effects.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Sport Sciences
Molly Connolly, Kane Middleton, Graeme Spence, Olivia Cant, Machar Reid
Summary: This study compared the kinematics of the pelvis and ball toss in elite adolescent male and female tennis players with and without lumbar spine abnormalities during flat and kick serves. The results showed that gender and serve type can impact the pelvis and ball toss kinematics, while lumbar spine abnormalities did not necessarily affect the kinematics. Additionally, the order and timing of key serve events may help identify players at risk of lumbar spine abnormalities.
SPORTS MEDICINE-OPEN
(2021)
Review
Engineering, Biomedical
Simone Borrelli, Giovanni Putame, Giulia Pascoletti, Mara Terzini, Elisabetta M. Zanetti
Summary: This study performs a meta-analysis of the flexion/extension behavior of the lumbar spine under various boundary conditions. The results illustrate the impact of different boundary conditions reported in the literature, explaining the biomechanical behavior differences observed in different setups. The numerical approach used in this study effectively bypasses the natural variability among specimens and provides comprehensive information on the behavior of each functional spinal unit.
ANNALS OF BIOMEDICAL ENGINEERING
(2022)
Article
Engineering, Biomedical
Qiang Wei, Dachuan Liu, Genglei Chu, Qifan Yu, Zhao Liu, Jiaying Li, Qingchen Meng, Weishan Wang, Fengxuan Han, Bin Li
Summary: This study developed an injectable hydrogel for annulus fibrosus (AF) repair by combining polyethylene glycol diacrylate (PEGDA) and decellularized annulus fibrosus matrix (DAFM). Transforming growth factor-beta 1 (TGF-beta 1) was also incorporated into the hydrogel. The hydrogel showed improved mechanical strength, facilitated AF cell migration, adhesion, proliferation, and increased extracellular matrix (ECM) production. In vivo experiments showed that the hydrogel effectively repaired AF defects and restored biomechanical properties of the disc.
BIOACTIVE MATERIALS
(2023)
Article
Materials Science, Multidisciplinary
Weidong Zhang, Huan Wang, Genglei Chu, Li Yu, Feng Han, Qifan Yu, Youhua Wang, Bin Li
Summary: In this study, micropatterned collagen scaffolds were fabricated to mimic the microstructural features of annulus fibrosus (AF) and mechanically stimulate bone marrow mesenchymal stromal cells (BMSCs). The aligned cells showed enhanced expression of matrix anabolism-related genes and proteins under mechanical loading. Furthermore, Caveolin-1 (CAV1) was found to mediate the nuclear translocation of Yes-associated protein (YAP) in response to external mechanical cues. The biomimetic collagen membranes formed angle-ply and multilayered tissues that showed improved restoration of the disc in a rat model.
APPLIED MATERIALS TODAY
(2023)
Article
Cell Biology
Jackie D. Zehr, Fasih Ahmad Rahman, Jack P. Callaghan, Joe Quadrilatero
Summary: In this study, immunofluorescence analysis was used to characterize the histochemical and structural damage in collagenous spine tissues. The results showed that compression loading led to significant decreases in fluorescence area and intensity of COL II in the annulus fibrosus, while both COL I and COL II fluorescence area decreased in the endplate. These findings suggest that immunofluorescence analysis can effectively capture the histochemical and structural damage in collagenous spine tissues.
CELL AND TISSUE RESEARCH
(2022)
Article
Biotechnology & Applied Microbiology
Rongrong Deng, Ran Kang, Xiaoyu Jin, Zihan Wang, Xin Liu, Qing Wang, Lin Xie
Summary: In this study, it was found that the sticky Fib-T-G biological gel could effectively repair AF fissures in rats and increase the expression of AF-related proteins and mechanotransduction-related proteins. Furthermore, mechanical strain was shown to promote the differentiation of AF-hMSCs, and this effect could be regulated by inhibiting or overexpressing the RhoA/ROCK1 pathway.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Biology
Athanasios Triantafyllou, Georgios Papagiannis, Sophia Stasi, Daphne Bakalidou, Maria Kyriakidou, George Papathanasiou, Elias C. Papadopoulos, Panayiotis J. Papagelopoulos, Panayiotis Koulouvaris
Summary: The recurrence rate after lumbar spine disc surgeries is estimated to be 5-15%. Lumbar spine flexion of more than 10 degrees is mentioned as the most harmful load to the operated disc level that could lead to recurrence during the first six postoperative weeks. This study used wearable sensors technology to quantify flexions during daily living following such surgeries for six weeks postoperatively. The results showed that patients had a 30% normal lumbar motion after the first postoperative week, which increased to almost 75% at the end of the sixth week.
Article
Multidisciplinary Sciences
Tomasz Wiczenbach, Lukasz Pachocki, Karol Daszkiewicz, Piotr Luczkiewicz, Wojciech Witkowski
Summary: The purpose of this study is to develop and validate a lumbar spine section for biomechanical research. The modifications include applying orthotropic material properties, nonlinear stress-strain behavior for ligaments, and hyperelastic material properties for annulus fibrosus and nucleus pulposus. The obtained numerical results were validated with experimental data and showed good agreement.
Review
Biotechnology & Applied Microbiology
Ian J. Wellington, Cameron Kia, Ergin Coskun, Barrett B. Torre, Christopher L. Antonacci, Michael R. Mancini, John P. Connors, Sean M. Esmende, Heeren S. Makanji
Summary: While traditional fusion-based procedures have been commonly used to treat spinal disc pathology, there is growing interest in motion-preserving disc arthroplasties. These arthroplasties aim to avoid drawbacks associated with fusion, such as loss of motion and increased risks of adjacent segment disease. Recent advances in implant design and technology have shown promising outcomes, leading to increased utilization of disc arthroplasty. However, this procedure is not without risks, and efforts are being made to develop improved implant designs to minimize adverse outcomes.
BIOENGINEERING-BASEL
(2022)
Review
Engineering, Biomedical
Anran Zhang, Zhangrong Cheng, Yuhang Chen, Pengzhi Shi, Weikang Gan, Yukun Zhang
Summary: Low back pain is a common issue affecting 80% of the global population, often caused by intervertebral disc herniation. There is no consensus on the best approach for annulus fibrosus (AF) regeneration. This review summarizes strategies for AF repair, including ideal cell types and pro-differentiation targeting approaches, and discusses the prospects and challenges of implant systems combining cells and biomaterials for guiding future research directions.
ACTA BIOMATERIALIA
(2023)
Article
Clinical Neurology
Jui-Jung Yang, Yu-Yang Lin, Kuo-Hua Chao, Jaw-Lin Wang
Summary: The study evaluated a newly developed hydrogel for intervertebral disc repair, finding that the hydrogel with 20 mM EDC concentration exhibited good cytocompatibility and degradation rate, making it suitable as a sealant for small AF defects.
Article
Medicine, General & Internal
Hoon Choi, Jamie L. Baisden, Narayan Yoganandan
Article
Clinical Neurology
Hoon Choi, Yuvaraj Purushothaman, Jamie Baisden, Narayan Yoganandan
EUROPEAN SPINE JOURNAL
(2020)
Article
Engineering, Biomedical
Narayan Yoganandan, Jason Moore, Nicholas DeVogel, Frank Pintar, Anjishnu Banerjee, Jamie Baisden, Jiang Yue Zhang, Kathryn Loftis, David Barnes
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2020)
Review
Clinical Neurology
D. Scott Kreiner, Paul Matz, Christopher M. Bono, Charles H. Cho, John E. Easa, Gary Ghiselli, Zoher Ghogawala, Charles A. Reitman, Daniel K. Resnick, William C. Watters, Thiru M. Annaswamy, Jamie Baisden, Walter S. Bartynski, Shay Bess, Randall P. Brewer, R. Carter Cassidy, David S. Cheng, Sean D. Christie, Norman B. Chutkan, Bernard Allan Cohen, Simon Dagenais, Dennis E. Enix, Paul Dougherty, S. Raymond Golish, Padma Gulur, Steven W. Hwang, Cumhur Kilincer, Jeffrey A. King, Adam C. Lipson, Anthony J. Lisi, Richard J. Meagher, John E. O'Toole, Paul Park, Murat Pekmezci, Daniel R. Perry, Ravi Prasad, David A. Provenzano, Kris E. Radcliff, Gazanfar Rahmathulla, Tom E. Reinsel, Robert L. Rich, Daniel S. Robbins, Karie A. Rosolowski, Jonathan N. Sembrano, Anil K. Sharma, Alison A. Stout, Christopher K. Taleghani, Ryan A. Tauzell, Terry Trammell, Yakov Vorobeychik, Amy M. Yahiro
Article
Engineering, Biomedical
Yuvaraj Purushothaman, Narayan Yoganandan, Davidson Jebaseelan, Hoon Choi, Jamie Baisden
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2020)
Article
Medicine, General & Internal
Narayan Yoganandan, Jamie L. Baisden, Jobin John, Gurunathan Saravana Kumar, Anjishnu Banerjee, Hoon Choi
Summary: The study found that models with lesser vertebral depth, indicative of female-like spines, experience greater range of motions and pronounced nonphysiological curves during G(+x) loading, potentially leading to greater distraction/stretch of the posterior upper spine complex. The location of the head center of gravity (cg) has a significant influence on the motions of the upper and lower spines and the time of formation of the curve.
Article
Medicine, General & Internal
Alicia Abraczinskas, Ardyn Olszko, Christine Beltran, Jamie L. Baisden, Narayan Yoganandan, James McGhee, Shannon McGovern, Grace Lidl, Kimberly B. Vasquez, Valeta C. Chancey
Summary: The study exposed nonhuman primates (NHPs) to + Gz loading in supine or upright positions to assess the effect of orientation on injuries at accelerations unsafe for human participation. Results showed significant differences in peak sled acceleration (PSA) and injury occurrences between supine and upright orientations, with supine position leading to more central nervous system injuries and upright position leading to more musculoskeletal injuries. Both positions had equal thoracic injuries. The findings emphasize the importance of orientation during acceleration to reduce injury risks in next generation equipment design and testing.
Article
Medicine, General & Internal
Hoon Choi, Vicky Varghese, Jamie Baisden, Diane W. Braza, Anjishnu Banerjee, Narayan Yoganandan
Summary: This study analyzed muscle geometry parameters in 7 young healthy female volunteers using upright magnetic resonance imaging after continuous wear of a standard issued military helmet. The results showed that helmet wear can lead to morphometric alterations in cervical flexor/extensor musculature in females, with significant differences noted at different levels.
Article
Medicine, General & Internal
Hoon Choi, Yuvaraj Purushothaman, Jamie L. Baisden, Deepak Rajasekaran, Davidson Jebaseelan, Narayan Yoganandan
Summary: This study compared the biomechanics of ACDF and CDA surgeries under head supported mass loadings, showing that CDA demonstrates a more physiological response than ACDF, though the exact pattern depends on implant design. The study also found different load-sharing patterns between the two implants, which may impact implant selection based on anatomical and pathological factors at the index and adjacent levels.
Correction
Clinical Neurology
D. Scott Kreiner, Paul Matz, Christopher M. Bono, Charles H. Cho, John E. Easa, Gary Ghiselli, Zoher Ghogawala, Charles A. Reitman, Daniel K. Resnick, William C. Watters III, Thiru M. Annaswamy, Jamie Baisden, Walter S. Bartynski, Shay Bess, Randall P. Brewer, R. Carter Cassidy, David S. Cheng, Sean D. Christie, Norman B. Chutkan, Bernard Allan Cohen, Simon Dagenais, Dennis E. Enix, Paul Dougherty, S. Raymond Golish, Padma Gulur, Steven W. Hwang, Cumhur Kilincer, Jeffrey A. King, Adam C. Lipson, Anthony J. Lisi, Richard J. Meagher, John E. O'Toole, Paul Park, Murat Pekmezci, Daniel R. Perry, Ravi Prasad, David A. Provenzano, Kris E. Radcliff, Gazanfar Rahmathulla, Tom E. Reinsel, Robert L. Rich, Daniel S. Robbins, Karie A. Rosolowski, Jonathan N. Sembrano, Anil K. Sharma, Alison A. Stout, Christopher K. Taleghani, Ryan A. Tauzell, Terry Trammell, Yakov Vorobeychik, Amy M. Yahiro
Article
Clinical Neurology
Charles A. Reitman, Jeffrey M. Hills, Christopher J. Standaert, Christopher M. Bono, Charles A. Mick, Christopher G. Furey, Christopher P. Kauffman, Daniel K. Resnick, David A. Wong, Heidi Prather, James S. Harrop, Jamie Baisden, Jeffrey C. Wang, Jeffrey M. Spivak, Jerome Schofferman, K. Daniel Riew, Mark A. Lorenz, Michael H. Heggeness, Paul A. Anderson, Raj D. Rao, Ray M. Baker, Sanford E. Emery, William C. Watters, William J. Sullivan, William Mitchell, William Tontz Jr, Zoher Ghogawala
Summary: A study was conducted to develop appropriate use criteria for cervical fusion, revealing symptom type as the most strongly correlated modifier with final rating. Myelopathy or radiculopathy were most associated with an Appropriate rating, while axial pain without stenosis was most associated with Rarely Appropriate.
Article
Orthopedics
Yuvaraj Purushothaman, Hoon Choi, Narayan Yoganandan, Davidson Jebaseelan, Jamie Baisden, Shekar Kurpad
Summary: This study analyzed and compared the biomechanical behavior of four artificial cervical disks using validated finite element models, showing that the Secure-C and Mobi-C prostheses could reduce intradiscal pressures at adjacent levels. The findings provide guidance for clinical decision-making in choosing CDA procedures.
ASIAN SPINE JOURNAL
(2021)
Article
Engineering, Biomedical
Narayan Yoganandan, Yuvaraj Purushothaman, Hoon Choi, Davidson Jebaseelan, Jamie Baisden
Summary: The study found that removal of the uncinate process during cervical disc arthroplasty can increase motion at the index level while decreasing motion at adjacent levels. Additionally, removal of the uncinate process also reduces disc pressure and facet loads at adjacent segments.
CLINICAL BIOMECHANICS
(2021)
Article
Engineering, Biomedical
Sagar Umale, Narayan Yoganandan, Jamie L. Baisden, Hoon Choi, Shekar N. Kurpad
Summary: This study investigated the biomechanical effects of various lumbar interbody fusion techniques on the spine using a validated finite-element model. The results showed that bilateral posterior instrumentations (TLIF, PLIF, and CLIF/360) resulted in the greatest reduction in lumbar spine range of motion, with forces transmitted through the vertebrae and disc pressures increasing proportionally to the range of motion. The study provides valuable information for surgeons to make informed decisions when selecting fusion procedures based on biomechanical effects.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2022)
Article
Otorhinolaryngology
Narayan Yoganandan, Hoon Choi, Yuvaraj Purushothaman, Davidson Jebaseelan, Jamie Baisden, Shekar Kurpad
JOURNAL OF CRANIOVERTEBRAL JUNCTION AND SPINE
(2020)