Article
Engineering, Biomedical
Ciara M. Walsh, Jacek K. Wychowaniec, Louise Costello, Dermot F. Brougham, Dearbhaile Dooley
Summary: Spinal cord injury (SCI) is a devastating condition without effective treatment options. Immunomodulation, using locally injected hydrogels carrying immunotherapeutic cargo, shows promise as a potential therapeutic strategy for SCI. Gelatin methacrylate (GelMA) hydrogels are a promising candidate, but their immunogenicity in the SCI microenvironment has not been fully studied yet. This study analyzes the immunogenicity of GelMA hydrogels formulated with a relevant photoinitiator, both in vitro and ex vivo.
ADVANCED HEALTHCARE MATERIALS
(2023)
Review
Multidisciplinary Sciences
Xinli Hu, Yu Xu, Haojie Zhang, Yao Li, Xiangyang Wang, Cong Xu, Wenfei Ni, Kailiang Zhou
Summary: This review summarizes the role of necroptosis in central nervous system trauma and its therapeutic implications, providing important suggestions for researchers conducting in-depth research. The study focuses on the necroptosis signaling pathway, execution, temporal patterns of RIPKs in CNS trauma, association of miRNAs with necroptosis, and different types of CNS trauma cell death. It also highlights potential agents for curtailing necroptosis-related cell death in CNS trauma.
JOURNAL OF ADVANCED RESEARCH
(2022)
Article
Neurosciences
Carlos Gonzalez-Fernandez, Pau Gonzalez, Francisco Gonzalez-Perez, Francisco Javier Rodriguez
Summary: Inflammation plays a crucial role in neurodegenerative diseases and central nervous system injuries, with microglia and monocyte-derived macrophages being key players in neuroinflammation. The Wnt family of proteins is involved in neuropathologies characterized by dysregulated neuroinflammatory responses. This study explores the expression patterns of Wnt-related genes in microglia and macrophages after spinal cord injury (SCI) in a rat model, providing valuable insights for potential Wnt-driven immunomodulatory therapies.
Article
Rehabilitation
Cristina Shea, Chloe Slocum, Richard Goldstein, Mary Joan Roach, Russell Griffin, Yuying Chen, Ross Zafonte
Summary: This study aimed to investigate whether initial emergency department physiological measures and trauma severity predict functional outcomes and neurologic recovery in traumatic spinal cord injury. The results showed that emergency department physiological parameters did not predict functional outcomes in this cohort.
ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION
(2022)
Article
Clinical Neurology
Aladine A. Elsamadicy, Mani Ratnesh S. Sandhu, Isaac G. Freedman, Benjamin C. Reeves, Andrew B. Koo, Astrid Hengartner, John Havlik, Josiah Sherman, Richard Maduka, Isaac K. Agboola, Dirk C. Johnson, Luis Kolb, Maxwell Laurans
Summary: Frailty was found to be an independent predictor of adverse events and in-hospital mortality in patients with acute cervical spinal cord injury, with the risk increasing with higher frailty scores.
WORLD NEUROSURGERY
(2021)
Review
Medicine, General & Internal
Hideaki Nakajima, Kazuya Honjoh, Shuji Watanabe, Ai Takahashi, Arisa Kubota, Akihiko Matsumine
Summary: The incidence of cervical spinal cord injury (CSCI) without major bone injury is increasing, particularly among older individuals with pre-existing cervical spinal canal stenosis. The demographics, neurological injury, treatment, and prognosis of this type of CSCI differ from those with bone or central cord injury. The optimal management of CSCI without major bone injury is a subject of debate among spine surgeons worldwide. This narrative review aims to address unresolved clinical questions and discuss treatment strategies based on current findings.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Veterinary Sciences
Bianca Kuehl, Martin Beyerbach, Wolfgang Baumgaertner, Ingo Gerhauser
Summary: In this study, the phenotype of microglia/macrophages during acute and subacute spinal cord injury (SCI) in dogs was characterized. The expression of certain markers related to antigen recognition, processing, presentation, cell migration, and phagocytosis was found to increase in the gray matter of the spinal cord during subacute SCI. Interestingly, only CD204-positive cells were upregulated in the white matter. These findings contribute to our understanding of the immunological processes during SCI and could potentially serve as targets for future therapeutic strategies.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Engineering, Biomedical
A. Kinaci, S. van Thoor, S. Redegeld, M. Tooren, T. P. C. van Doormaal
Summary: This study demonstrates that Liqoseal is capable of achieving a strong watertight seal over a dural defect in ex vivo models.
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE
(2021)
Article
Pharmacology & Pharmacy
Sung Huang Laurent Tsai, Chun-Ru Lin, Shih-Chieh Shao, Chao-Hua Fang, Tsai-Sheng Fu, Tung-Yi Lin, Yu-Chiang Hung
Summary: This study evaluated the efficacy and safety of cannabinoids for pain reduction in spinal cord injury (SCI) patients through a systematic review and meta-analysis. The findings suggest that cannabinoids may not provide significant pain relief for SCI patients and may increase the likelihood of adverse events.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Cell Biology
Xinli Hu, Yu Xu, Hui Xu, Chenqiang Jin, Haojie Zhang, Haohan Su, Yao Li, Kailiang Zhou, Wenfei Ni
Summary: Ferroptosis, a novel type of programmed cell death, has been found to be associated with acute central nervous system (CNS) trauma. The processes that induce ferroptosis include iron overload, imbalanced glutathione metabolism, and lipid peroxidation. Understanding the mechanism of ferroptosis is important for studying the pathophysiological process of CNS trauma.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Clinical Neurology
P. Sreeharsha, Rishi Mugesh Kanna, Raunak Milton, Ajoy Prasad Shetty, S. Rajasekaran
Summary: The incidence and risk factors for complications, length of stay, and mortality after traumatic spinal injuries were analyzed in this study. Chest injuries, cervical spine injury, complete neurological deficit, and ankylosing spondylitis were key predictors of mortality, while age and thoracic injuries contributed to higher morbidity and prolonged hospitalization.
EUROPEAN SPINE JOURNAL
(2023)
Article
Clinical Neurology
Remi Pelletier-Roy, Antoine Dionne, Andreane Richard-Denis, Marie-Michele Briand, Etienne Bourassa-Moreau, Jean-Marc Mac-Thiong
Summary: This study aims to develop and validate a streamlined tool, MAC-SCI, for evaluating spinal cord injuries in trauma patients. The study found that MAC-SCI accurately detects and characterizes the severity grade and neurological level of tSCI.
GLOBAL SPINE JOURNAL
(2023)
Review
Clinical Neurology
Mathias Moller Thygesen, Tim Damgaard Nielsen, Mads Rasmussen, Dariusz Orlowski, Michael Pedersen, Mikkel Mylius Rasmussen
Summary: Interventions on spinal cord perfusion pressure may have a positive correlation with neurological outcome in traumatic spinal cord injuries, but causality cannot be confirmed due to limited literature. Further well-designed studies are needed to address this issue.
EUROPEAN SPINE JOURNAL
(2021)
Article
Clinical Neurology
Andrew M. Hersh, A. Daniel Davidar, Carly Weber-Levine, Divyaansh Raj, Safwan Alomari, Brendan F. Judy, Nicholas Theodore
Summary: Significant advancements in the treatment of spinal cord injury (SCI) were developed in military conflicts, improving outcomes for soldiers and civilians. Modern military SCIs resulting from blast mechanisms are different from traumatic SCIs sustained by civilians, and new forms of war and weapons have influenced the rise in SCIs among causes of casualties and wounds.
NEUROSURGICAL FOCUS
(2022)
Article
Engineering, Biomedical
Roman Frantsuzov, Subrata Mondal, Ciara M. Walsh, James P. Reynolds, Dearbhaile Dooley, David B. MacManus
Summary: Traumatic spinal cord injuries are caused by high impact forces on the spine, resulting in inflammation and dysfunction. The aim of this research is to analyze the biomechanics of spinal cord injury using a rat contusion model. The study found that increasing impactor depth leads to greater stresses and strains in the spinal cord tissue, and impactor geometry also plays a role. Finite element modeling can be used to predict stresses and strains during spinal cord trauma.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2023)
Article
Materials Science, Coatings & Films
Erfan Abedi Esfahani, Ogbemi Bukuaghangin, Sarah Banfield, Yenal Vangolu, Liuquan Yang, Anne Neville, Richard Hall, Michael Bryant
Summary: Surface engineering has a beneficial effect on the wear and corrosion performance of Ti-6Al-4V alloy for biomedical purposes. TiN ceramic coatings have been proven to be effective in improving the tribocorrosion properties of Ti-based alloys. A duplex TPON + TiN treatment process has been suggested for high contact load applications. The coated ALM materials show improved bio-tribology and corrosion resistance compared to conventional wrought manufactured alloy.
SURFACE & COATINGS TECHNOLOGY
(2022)
Article
Chemistry, Physical
Hanna Nilsson Ahman, Lena Thorsson, Pelle Mellin, Greta Lindwall, Cecilia Persson
Summary: This study aims to enhance the understanding of the effect of PBF-LB process parameters on the microstructure of Mg alloys by investigating the applicability of computational thermodynamic modelling and verifying the results experimentally. The findings demonstrate the feasibility of the PBF-LB process for Mg alloys and the correlation between process parameters and the formed microstructure.
Article
Critical Care Medicine
Alicja J. Bojan, Vincent A. Stadelmann, Dan Wu, Michael Pujari-Palmer, Gerard Insley, Daniel Sundh, Cecilia Persson, Hakan Engqvist, Philip Procter
Summary: This study evaluated the feasibility of bonding human trabecular bone with OsStic(R), a novel phosphoserine modified cement, and compared it with a commercial fibrin tissue adhesive. The results showed that OsStic(R) demonstrated good performance in bonding wet and fatty tissue, with high tensile strength.
INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
(2022)
Article
Engineering, Biomedical
Charlotte Skjoldebrand, Joanne L. Tipper, Peter Hatto, Michael Bryant, Richard M. Hall, Cecilia Persson
Summary: Hip and knee joint replacements are common and successful surgeries, but the release of metallic ions and particles from the implants can cause hypersensitivity and tissue necrosis. Coatings have the potential to improve implant properties and act as barriers to inhibit ion release. There are commercially available coatings for clinical use and ongoing research on new coatings. Adhesion of coatings remains a concern, but zirconium and TiNbN coatings have shown comparable results to traditional implants in terms of revision numbers and allergy symptom relief.
MATERIALS TODAY BIO
(2022)
Article
Materials Science, Ceramics
Mona Widhe, Anna Diez-Escudero, Yuling Liu, Nathalie Ringstrom, Maria-Pau Ginebra, Cecilia Persson, My Hedhammar, Gemma Mestres
Summary: Calcium phosphate cements (CPCs) are synthetic bone grafts with osteoconductive and osteoinductive properties. However, they lack macroporosity, which is essential for cell colonization. This study explores the use of recombinant silk to enhance CPCs by targeting both macroporosity and cell binding motifs.
CERAMICS INTERNATIONAL
(2022)
Article
Polymer Science
Elin Akerlund, Anna Diez-Escudero, Ana Grzeszczak, Cecilia Persson
Summary: The field of additive manufacturing, including 3D printing, has allowed for the production of patient-specific medical devices with high accuracy. This study focused on developing biocompatible and bioresorbable polymer-based composite filaments for 3D printing using a combination of polylactic acid, polycaprolactone, and hydroxyapatite. The materials were tested for their mechanical properties, thermal stability, chemical composition, and morphology. Results showed that the materials maintained their chemical composition and exhibited higher mechanical properties than human trabecular bone. The addition of hydroxyapatite significantly accelerated the degradation of the polymer, which can be beneficial for faster healing time.
Article
Nanoscience & Nanotechnology
Lisa Larsson, Jithin James Marattukalam, Eirini-Maria Paschalidou, Bjorgvin Hjorvarsson, Natalia Ferraz, Cecilia Persson
Summary: This study investigated the use of selective laser melting (SLM) technique to develop a Zr-based bulk metallic glass (BMG) with varying surface roughness. The potential of the additively manufactured BMG as an implant material was evaluated by studying osteoblastic cell response and stability under simulated biological conditions. The results showed that cell proliferation and differentiation were supported by the as-printed BMG, comparable to the reference material Ti-6Al-4V. The study also highlighted the effect of inflammatory conditions on the degradation of the alloy.
ACS APPLIED BIO MATERIALS
(2022)
Article
Biotechnology & Applied Microbiology
Sushil Kandel, Steven Su, Richard M. Hall, Joanne L. Tipper
Summary: Polymer wear debris is a major concern in total joint replacements due to potential biological reactions. This study proposes an automatic particle segmentation algorithm using adaptive thresholding and Convolution Neural Network (CNN) classification. The use of computer algorithms and CNN allows for more efficient analysis of wear debris with complex characteristics, resulting in robust size and volume distribution graphs for estimation.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Engineering, Biomedical
Robert J. Elkington, Richard M. Hall, Andrew R. Beadling, Hemant Pandit, Michael G. Bryant
Summary: To preserve the function of synovial joint counter-face during osteochondral defect repairs, it is important to develop surfaces optimized for healthy cartilage function. In this study, PEEK surfaces were modified with a hydrophilic coating (SPMK-g-PEEK) to provide a low friction and compliant sliding interface. The results showed that SPMK-g-PEEK maintained low friction and minimized forces on the cartilage interface, providing an enhanced cartilage counter-surface.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2023)
Article
Materials Science, Biomaterials
Estefania Echeverri, Charlotte Skjoldebrand, Paul O'Callaghan, Anders Palmquist, Johan Kreuger, Gry Hulsart-Billstrom, Cecilia Persson
Summary: Silicon nitride (SiN) coatings with added iron (Fe) and carbon (C) have the potential to reduce metal ion release from metallic implants. This study investigated the effect of Fe and C on the dissolution rate of SiN coatings and their impact on the viability of microglia cells expected at the implant site. The results showed that Fe and C additives reduced ion release and did not compromise cell viability, suggesting their potential for increasing the lifetime and functionality of SiN-coated metallic implants.
BIOMATERIALS SCIENCE
(2023)
Article
Engineering, Biomedical
Yijun Zhou, Lisa Ho, Ayan Samanta, Philip Procter, Cecilia Persson
Summary: In this study, soft, non-setting biomaterials based on Hyalectin gels and different morphological parameters of hydroxyapatite (HA) particles were evaluated as potential augmentation materials for orthopaedic implant fixation. The results showed that constructs reinforced with irregularly shaped nano-HA particles and spherically shaped micro-HA particles had significantly higher pull-out force compared to the control group.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2024)
Article
Engineering, Biomedical
Yijun Zhou, Per Isaksson, Cecilia Persson
Summary: An improved numerical model for mimicking trabecular bone structures was successfully developed using Voronoi tessellation and Boolean operations.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2023)
Article
Engineering, Biomedical
Ioannis Katsaros, Yijun Zhou, Ken Welch, Wei Xia, Cecilia Persson, Hakan Engqvist
Summary: This study successfully demonstrated a simple method to improve the in vitro bioactivity of Si3N4 implants while maintaining their bacteriostatic properties. The modified Si3N4 surface showed increased formation of apatite and a reduction in bacterial population.
JOURNAL OF FUNCTIONAL BIOMATERIALS
(2022)
Proceedings Paper
Computer Science, Artificial Intelligence
Kaushikk Iyer, David Keeling, Richard M. Hall
Summary: This paper presents the application of hardware-in-the-loop simulation technology in the development and testing of an artificial joint wear simulator. The simulation enables rapid testing of different control strategies and validates the accuracy and robustness of the prospective controller, supporting the reliability of the experimental results.
2022 8TH INTERNATIONAL CONFERENCE ON MECHATRONICS AND ROBOTICS ENGINEERING (ICMRE 2022)
(2022)
