Article
Psychology, Multidisciplinary
Lilia Maria Morales Chacon, Judith Gonzalez Gonzalez, Martha Rios Castillo, Sheila Berrillo Batista, Karla Batista Garcia-Ramo, Aisel Santos Santos, Nelson Quintanal Cordero, Marilyn Zaldivar Bermudez, Randis Garbey Fernandez, Barbara Estupinan Diaz, Zenaida Hernandez Diaz, Juan E. Bender del Busto, Abel Sanchez Coroneux, Margarita M. Baez Martin, Lourdes Lorigados Pedre
Summary: This study presented the postsurgical outcome of ExTLE patients undergoing preoperative multimodal evaluation and intraoperative sequential ECoG. Results indicated that using SISCOM and ESI data alongside intraoperative ECoG allowed for seizure control in pharmacoresistant ExTLE epilepsy patients.
BEHAVIORAL SCIENCES
(2021)
Article
Clinical Neurology
Alessandra Maccabeo, Maryse A. Van't Klooster, Eline Schaft, Matteo Demuru, Willemiek Zweiphenning, Peter Gosselaar, Tineke Gebbink, Wim M. Otte, Maeike Zijlmans
Summary: In this study, the distribution of spikes and HFOs recorded during intraoperative electrocorticography (ioECoG) was investigated to predict the postsurgical outcomes of patients with lateral neocortical temporal lobe epilepsy (TLE) whose mesiotemporal structures are left in situ. The results showed that low rates of mesiotemporal post-ioECoG ripples and older age at epilepsy onset were predictors of good seizure outcomes. HFOs in ioECoG may be helpful in informing the success chance of hippocampus-sparing resection in patients with lateral neocortical TLE.
FRONTIERS IN NEUROLOGY
(2022)
Article
Clinical Neurology
Nebras M. Warsi, Karl Narvacan, Elizabeth Donner, Cristina Go, Samuel Strantzas, Ayako Ochi, Hiroshi Otsubo, Roy Sharma, O. Carter Snead, George M. Ibrahim
Summary: This study presents a simple technique to supplement extraoperative intracranial recordings with real-time iECoG using the same chronically implanted electrodes during two-stage resective epilepsy surgery, which may modify intraoperative decision-making.
OPERATIVE NEUROSURGERY
(2021)
Review
Clinical Neurology
Keshav Goel, Valerie Pek, Nathan A. Shlobin, Jia-Shu Chen, Andrew Wang, George M. Ibrahim, Aristides Hadjinicolaou, Karl Roessler, Roy W. Dudley, Dang K. Nguyen, Riem El-Tahry, Aria Fallah, Alexander G. Weil
Summary: Despite conflicting data on the efficacy of intraoperative electrocorticography (iECoG) in resective epilepsy surgery, this individual patient data (IPD) meta-analysis shows that iECoG use is associated with more favorable seizure outcomes, particularly for the focal cortical dysplasia (FCD) etiology. However, at the study level, iECoG was not associated with higher seizure freedom. The heterogeneity in iECoG use across centers highlights the need for further assessment and standardization.
Article
Neurosciences
R. P. Sangeetha, Suparna Bharadwaj
Summary: This study reports a novel anaesthetic technique for drug resistant epileptic patient undergoing craniotomy, combining ECoG and SCMEPM monitoring, with successful intraoperative monitoring and absence of intraoperative awareness. The balanced anaesthetic technique used in this case achieved a composite of patient safety, surgeon satisfaction, and adequate intraoperative monitoring.
Article
Clinical Neurology
Thomas W. Owen, Gabrielle M. Schroeder, Vytene Janiukstyte, Gerard R. Hall, Andrew McEvoy, Anna Miserocchi, Jane de Tisi, John S. Duncan, Fergus Rugg-Gunn, Yujiang Wang, Peter N. Taylor
Summary: By comparing the interictal magnetoencephalography (MEG) band power from patients with surgical failure to normative maps, we were able to identify patient-specific abnormalities and propose three mechanisms contributing to poor surgical outcome. We developed markers of these mechanisms and validated them against patient outcomes.
Article
Clinical Neurology
Oscar Woolnough, Kathryn M. Snyder, Cale W. Morse, Meredith J. McCarty, Samden D. Lhatoo, Nitin Tandon
Summary: The study evaluates the feasibility of using task-based electrocorticography (ECoG) recordings to guide stimulation mapping of reading in language-dominant ventral occipitotemporal cortex (vOTC). The results show that word-responsive cortex localized using ECoG has a high sensitivity to stimulation-induced reading deficits, and the confluence of ECoG and stimulation-positive sites appears to demarcate the visual word form area. Intraoperative task-based ECoG mapping can be performed quickly with high signal quality, allowing for rapid assessment of broad areas of cortex.
JOURNAL OF NEUROSURGERY
(2022)
Article
Clinical Neurology
Benjamin Edmonds, Makoto Miyakoshi, Luigi Gianmaria Remore, Samuel Ahn, H. Westley Phillips, Atsuro Daida, Noriko Salamon, Ausaf Bari, Raman Sankar, Joyce H. Matsumoto, Aria Fallah, Hiroki Nariai
Summary: This study aimed to characterize the ictal EEG changes in the CM and AN of the thalamus using SEEG recordings in pediatric-onset neocortical drug-resistant epilepsy patients. Visual and quantitative analysis showed consistent detection of ictal EEG changes in both CM and AN, with low-voltage fast activity being the most common pattern. The results suggest the feasibility of using a closed-loop system in the thalamus for detecting and modulating seizure activity in neocortical epilepsy.
CLINICAL NEUROPHYSIOLOGY
(2023)
Article
Clinical Neurology
Christopher W. Beatty, Stephanie M. Ahrens, Kristen H. Arredondo, Anto Bagic, Shasha Bai, Kevin E. Chapman, Michael A. Ciliberto, Dave F. Clarke, Mariah Eisner, Nathan B. Fountain, Jay R. Gavvala, M. S. Perry, Kyle C. Rossi, Lily C. Wong-Kisiel, Susan T. Herman, Adam P. Ostendorf
Summary: This study examines the variations in evaluation and treatment choices for epilepsy surgery, highlighting the need for comparative trials in the surgical management of drug-resistant epilepsy.
Article
Clinical Neurology
Thandar Aung, Olesya Grinenko, Jian Li, John C. Mosher, Patrick Chauvel, Jorge Gonzalez-Martinez
Summary: The correlation between seizure outcomes in patients with drug-resistant epilepsy (DRE) who underwent laser interstitial thermal therapy (LITT) and the extent of laser ablation was studied. The complete removal of seizure onset zone (SOZ) and epileptogenic zone (PEZ) was found to be associated with the duration of seizure freedom (SF).
Article
Oncology
Diana Cristina Ghinda, Ben Lambert, Junfeng Lu, Ning Jiang, Eve Tsai, Adam Sachs, Jin-Song Wu, Georg Northoff
Summary: The study demonstrated distinct power law exponent features in the tumoral tissue for the first time, potentially providing a novel electrophysiological marker in the future. The significant features observed in the peritumoral tissue of gliomas indicate the area where both the onset of epileptiform activity and the tumor infiltration occur.
FRONTIERS IN ONCOLOGY
(2021)
Article
Medicine, General & Internal
Syu-Jyun Peng, Tai-Tong Wong, Chao-Ching Huang, Hsi Chang, Kevin Li-Chun Hsieh, Min-Lan Tsai, Yi-Shang Yang, Chi-Long Chen
Summary: This study compared the ECoG characteristics of children with MCD and non-MCD undergoing epileptic surgery, revealing higher ED and HFO ripple frequencies in MCD patients on pre-resection ECoG. Higher frequencies of ED and ripples in pre-resection ECoG were also observed in patients with residual seizures, who were younger in age.
JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION
(2021)
Article
Clinical Neurology
Hsiang-Yu Yu, Chun-Fu Lin, Chien-Chen Chou, Yi-Jiun Lu, Sanford P. C. Hsu, Cheng-Chia Lee, Chien Chen
Summary: HSL in lesional TLE showed satisfactory seizure and cognitive outcomes, with complete resection associated with seizure-free outcomes without aura. Intraoperative hippocampography-guided resection of apparently normal hippocampi should be performed cautiously and might not be necessary.
CLINICAL NEUROPHYSIOLOGY
(2021)
Article
Neurosciences
Takumi Mitsuhashi, Masaki Sonoda, Ethan Firestone, Kazuki Sakakura, Jeong-Won Jeong, Aimee F. Luat, Sandeep Sood, Eishi Asano
Summary: This study investigated the spatiotemporal characteristics and functional significance of rapid, large-scale brain network dynamics during task switching in patients with drug-resistant focal epilepsy. The results demonstrated the presence of high-gamma augmentation during task switch trials, which was more intense than during repeat trials, and the high-gamma amplitude predicted the accuracy of upcoming responses among switch trials.
Review
Behavioral Sciences
Ayse Kacar Bayram, Qi Yan, Cigdem Isitan, Shilpa Rao, Dennis D. Spencer, Rafeed Alkawadri
Summary: This systematic literature review investigates the effect of anesthetic agents on intraoperative electrocorticography (ECoG) quality and reliability for localizing the epileptic focus. The review found favorable reports for dexmedetomidine and remifentanil during ECoG recording, but insufficient or conflicting evidence for other anesthetic agents. The study emphasizes the importance of optimizing ECoG recordings through proper use of anesthetic agents, careful dose titration, and effective communication between neurophysiologists and anesthesiologists.
EPILEPSY & BEHAVIOR
(2021)
Article
Clinical Neurology
Spencer Kellis, Larry Sorensen, Felix Darvas, Conor Sayres, Kevin O'Neill, Richard B. Brown, Paul House, Jeff Ojemann, Bradley Greger
CLINICAL NEUROPHYSIOLOGY
(2016)
Review
Behavioral Sciences
Daniel L. Drane, Jeffrey G. Ojemann, Michelle S. Kim, Robert E. Gross, John W. Miller, R. Edward Faught, David W. Loring
EPILEPSY & BEHAVIOR
(2016)
Article
Biochemical Research Methods
Bingni W. Brunton, Lise A. Johnson, Jeffrey G. Ojemann, J. Nathan Kutz
JOURNAL OF NEUROSCIENCE METHODS
(2016)
Article
Neurosciences
Kurt E. Weaver, Jeremiah D. Wander, Andrew L. Ko, Kaitlyn Casimo, Thomas J. Grabowski, Jeffrey G. Ojemann, Felix Darvas
Article
Clinical Neurology
Robert Buckley, Samuel Estronza-Ojeda, Jeffrey G. Ojemann
NEUROSURGERY CLINICS OF NORTH AMERICA
(2016)
Article
Biochemistry & Molecular Biology
Andrew S. Allen, Samuel F. Berkovic, Joshua Bridgers, Patrick Cossette, Dennis Dlugos, Michael P. Epstein, Tracy Glauser, David B. Goldstein, Erin L. Heinzen, Yu Jiang, Michael R. Johnson, Ruben Kuzniecky, Daniel H. Lowenstein, Anthony G. Marson, Heather C. Mefford, Terence J. O'Brien, Ruth Ottman, Steven Petrou, Slave Petrovski, Annapurna Poduri, Zhong Ren, Ingrid E. Scheffer, Elliott Sherr, Quanli Wang, Rudi Balling, Nina Barisic, Stephanie Baulac, Hande Caglayan, Dana Craiu, Peter De Jonghe, Christel Depienne, Renzo Guerrini, Ingo Helbig, Helle Hjalgrim, Dorota Hoffman-Zacharska, Johanna Jaehn, Karl Martin Klein, Bobby Koeleman, Vladimir Komarek, Roland Krause, Eric Leguern, Anna-Elina Lehesjoki, Johannes R. Lemke, Holger Lerche, Tarja Linnankivi, Carla Marini, Patrick May, Rikke S. Moller, Hiltrud Muhle, Deb Pal, Aarno Palotie, Felix Rosenow, Kaja Selmer, Jose M. Serratosa, Sanjay Sisodiya, Ulrich Stephani, Katalin Sterbova, Pasquale Striano, Arvid Suls, Tiina Talvik, Sarah von Spiczak, Yvonne Weber, Sarah Weckhuysen, Federico Zara, Bassel Abou-Khalil, Brian K. Alldredge, Dina Amrom, Eva Andermann, Frederick Andermann, Jocelyn F. Bautista, Samuel F. Berkovic, Judith Bluvstein, Gregory D. Cascino, Damian Consalvo, Patricia Crumrine, Orrin Devinsky, Dennis Dlugos, Michael P. Epstein, Miguel E. Fiol, Nathan B. Fountain, Jacqueline French, Daniel Friedman, Tracy Glauser, Kevin Haas, Sheryl R. Haut, Jean Hayward, Sucheta Joshi, Andres Kanner, Heidi E. Kirsch, Eric H. Kossoff, Rachel Kuperman, Ruben Kuzniecky, Daniel H. Lowenstein, Shannon M. McGuire, Paul V. Motika, Edward J. Novotny, Ruth Ottman, Juliann M. Paolicchi, Jack Parent, Kristen Park, Annapurna Poduri, Ingrid E. Scheffer, Renee A. Shellhaas, Elliott Sherr, Joseph Sirven, Michael C. Smith, Joseph Sullivan, Liu Lin Thio, Anu Venkat, Eileen P. G. Vining, Gretchen K. Von Allmen, Judith L. Weisenberg, Peter Widdess-Walsh, Melodie R. Winawer
EUROPEAN JOURNAL OF HUMAN GENETICS
(2017)
Article
Clinical Neurology
Andrew S. Allen, Susannah T. Bellows, Samuel F. Berkovic, Joshua Bridgers, Rosemary Burgess, Gianpiero Cavalleri, Seo-Kyung Chung, Patrick Cossette, Norman Delanty, Dennis Dlugos, Michael P. Epstein, Catharine Freyer, David B. Goldstein, Erin L. Heinzen, Michael S. Hildebrand, Michael R. Johnson, Ruben Kuzniecky, Daniel H. Lowenstein, Anthony G. Marson, Richard Mayeux, Caroline Mebane, Heather C. Mefford, Terence J. O'Brien, Ruth Ottman, Steven Petrou, Slave Petrovski, William O. Pickrell, Annapurna Poduri, Rodney A. Radtke, Mark I. Rees, Brigid M. Regan, Zhong Ren, Ingrid E. Scheffer, Graeme J. Sills, Rhys H. Thomas, Quanli Wang, Bassel Abou-Khalil, Brian K. Alldredge, Dina Amrom, Eva Andermann, Frederick Andermann, Jocelyn F. Bautista, Samuel F. Berkovic, Judith Bluvstein, Alex Boro, Gregory D. Cascino, Damian Consalvo, Patricia Crumrine, Orrin Devinsky, Dennis Dlugos, Michael P. Epstein, Miguel Fiol, Nathan B. Fountain, Jacqueline French, Catharine Freyer, Daniel Friedman, Eric B. Geller, Tracy Glauser, Simon Glynn, Kevin Haas, Sheryl R. Haut, Jean Hayward, Sandra L. Helmers, Sucheta Joshi, Andres Kanner, Heidi E. Kirsch, Robert C. Knowlton, Eric H. Kossoff, Rachel Kuperman, Ruben Kuzniecky, Daniel H. Lowenstein, Paul V. Motika, Edward J. Novotny, Ruth Ottman, Juliann M. Paolicchi, Jack M. Parent, Kristen Park, Annapurna Poduri, Lynette G. Sadleir, Ingrid E. Scheffer, Renee A. Shellhaas, Elliott H. Sherr, Jerry J. Shih, Shlomo Shinnar, Rani K. Singh, Joseph Sirven, Michael C. Smith, Joseph Sullivan, Liu Lin Thio, Anu Venkat, Eileen P. G. Vining, Gretchen K. Von Allmen, Judith L. Weisenberg, Peter Widdess-Walsh, Melodie R. Winawer
Editorial Material
Clinical Neurology
Edward J. Novotny
Article
Pediatrics
Anne T. Berg, Jason Coryell, Russell P. Saneto, Zachary M. Grinspan, John J. Alexander, Mariana Kekis, Joseph E. Sullivan, Elaine C. Wirrell, Renee A. Shellhaas, John R. Mytinger, William D. Gaillard, Eric H. Kossoff, Ignacio Valencia, Kelly G. Knupp, Courtney Wusthoff, Cynthia Keator, William B. Dobyns, Nicole Ryan, Tobias Loddenkemper, Catherine J. Chu, Edward J. Novotny, Sookyong Koh
Article
Clinical Neurology
Anthony C. Wang, George M. Ibrahim, Andrew V. Poliakov, Page I. Wang, Aria Fallah, Gary W. Mathern, Robert T. Buckley, Kelly Collins, Alexander G. Weil, Hillary A. Shurtleff, Molly H. Warner, Francisco A. Perez, Dennis W. Shaw, Jason N. Wright, Russell P. Saneto, Edward J. Novotny, Amy Lee, Samuel R. Browd, Jeffrey G. Ojemann
JOURNAL OF NEUROSURGERY-PEDIATRICS
(2018)
Article
Clinical Neurology
Kurt E. Weaver, Andrew Poliakov, Edward J. Novotny, Jared D. Olson, Thomas J. Grabowski, Jeffrey G. Ojemann
JOURNAL OF NEUROSURGERY-PEDIATRICS
(2018)
Article
Engineering, Biomedical
L. Bashford, J. Wu, D. Sarma, K. Collins, R. P. N. Rao, J. G. Ojemann, C. Mehring
JOURNAL OF NEURAL ENGINEERING
(2018)
Article
Behavioral Sciences
Sabra Zaraa, H. Steve White, Andy Stergachis, Edward Novotny Jr, Chris Protos, Grant Simic, Jennifer L. Bacci
Summary: This study used design thinking to develop a community pharmacist-led intervention for people living with epilepsy. Four features - pharmacist-patient consultations, care plan development, regular check-ins, and care coordination with other health care providers - were identified as desirable, feasible, and viable for the intervention. The study highlights the importance of involving pharmacists in epilepsy care and provides evidence-based features for such interventions.
EPILEPSY & BEHAVIOR
(2024)
Article
Clinical Neurology
Kelly L. Collins, Devapratim Sarma, Shahin Hakimian, Jeff J. Tsai, Jeffrey G. Ojemann
EPILEPSY & BEHAVIOR CASE REPORTS
(2019)
Article
Neurosciences
Kaitlyn Casimo, Felix Darvas, Jeremiah Wander, Andrew Ko, Thomas J. Grabowski, Edward Novotny, Andrew Poliakov, Jeffrey G. Ojemann, Kurt E. Weaver
BRAIN CONNECTIVITY
(2016)