Article
Rehabilitation
Laura A. Bonouvrie, Helga Haberfehlner, Jules G. Becher, Johan S. H. Vles, R. Jeroen Vermeulen, Annemieke Buizer
Summary: This study assessed the achievement of individual treatment goals one year after intrathecal baclofen pump implantation in patients with dyskinetic cerebral palsy. The study found that 71% of individuals fully achieved one or more treatment goals, while 97% partially achieved one or more treatment goals. The attainment of treatment goals was associated with baseline dyskinesia impairment score and improvement in pain during treatment.
DISABILITY AND REHABILITATION
(2023)
Article
Clinical Neurology
Laura A. Bonouvrie, Karen E. Lagendijk, Heleen Beckerman, K. Mariam Slot, Laura A. van de Pol, Annemieke Buizer
Summary: This study assessed the complications of intrathecal baclofen treatment (ITB) in children, with the most common being catheter-related complications. The introduction of a new coated catheter in 2012 has led to a decrease in the rate of catheter-related complications.
EUROPEAN JOURNAL OF PAEDIATRIC NEUROLOGY
(2022)
Article
Clinical Neurology
Adeel S. Zubair, Matthew Raymond, Huned S. Patwa
Summary: ITB is a safe and effective treatment for spasticity in PLS patients, with most patients experiencing significant improvement after treatment although a few may experience pump-related complications. The duration of treatment varies depending on individual cases, but the majority of patients benefit from it.
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Charalampos Konstantinidis, Eleni Moumtzi, Archodia Nicolia, Charalampos Thomas
Summary: Traumatic brain injury (TBI) often leads to spasticity, with neurogenic detrusor overactivity as a common complication. Our study investigated the effects of intrathecal baclofen (ITB) pump implantation on bladder function in TBI patients with spasticity. The results showed improved bladder function, with decreased incontinence and micturition episodes, and increased bladder capacity and reflex volume seen in urodynamic parameters. Further prospective studies are needed to fully understand the impact of ITB on bladder function.
Review
Clinical Neurology
Amogh Kudva, Mickey E. Abraham, Justin Gold, Neal A. Patel, Julian L. Gendreau, Yehuda Herschman, Antonios Mammis
Summary: Cerebral palsy is a chronic congenital disorder caused by abnormal brain development. Recent literature has focused on chronic spasticity in children with CP. Various neuromodulation procedures, such as selective dorsal rhizotomy, intrathecal baclofen pumps, and extracorporeal shockwave therapy, have been found to effectively improve spasticity, but further studies are needed to determine optimal frequencies and application sites for these treatments.
NEUROSURGICAL REVIEW
(2021)
Article
Clinical Neurology
Amparo Saenz, Miguel Grijalba, Juan Pablo Mengidel, Romina Arganaraz, Fernando Ford, Beatriz Mantese
Summary: This study introduced a novel technique for baclofen pump implantation with pre-brainstem catheter placement to effectively treat spasticity and dystonia. Physical examination and quality of life assessment showed significant improvement in patients with spasticity and dystonia who underwent this procedure.
CHILDS NERVOUS SYSTEM
(2021)
Article
Clinical Neurology
Bernardo Assumpcao de Monaco, Pablo Ramon Fruett da Costa, Paulo Roberto Franceschini
Summary: Limited therapies are available for severe cerebral palsy children (CP) with complex movement disorders. In this publication, we present the improvement of a child with severe CP after intracerebroventricular baclofen therapy. The treatment not only impacts the movement disorders but also improves the quality of life of the child and caregivers. Global functional improvements can be observed on the 6-month follow-up.
CHILDS NERVOUS SYSTEM
(2023)
Article
Clinical Neurology
Janina Gburek-Augustat, Matthias Krause, Matthias Bernhard, Ina Sorge, Daniel Grafe, Manuela Siekmeyer, Ulf Nestler, Andreas Merkenschlager
Summary: This study presents six pediatric patients who experienced unusual mechanical failures of intrathecal baclofen pump systems. Through these case-vignettes, a systematic approach on interpreting the symptoms of ITB complications and recommendations for further diagnostic and therapeutic steps are provided. The seriousness of baclofen overdose, underdosing, or withdrawal is emphasized.
CHILDS NERVOUS SYSTEM
(2021)
Article
Anesthesiology
Campbell Belisle Haley, Mrinal Agrawal, Keith Newton, Brent Yeung, Rakhi Dayal
Summary: This case report describes the successful treatment of a patient with spasticity related to ALS who developed an ITB pump infection. By using a combination of oral baclofen and oral diazepam, severe baclofen withdrawal was avoided.
Article
Pediatrics
Adrienne Harvey, Mary-Clare Waugh, James Rice, Giuliana Antolovich, Lisa Copeland, Francesca Orsini, Adam Scheinberg, Clare McKinnon, Megan Thorley, Felicity Baker, George Chalkiadis, Kirsty Stewart
Summary: Gabapentin is commonly used to manage pain in children with dystonic cerebral palsy, but limited evidence exists for its effectiveness in this population. This feasibility pilot study aimed to evaluate the impact of gabapentin on pain and comfort in children with dystonic CP. While improvements were seen in pain behavior and comfort, challenges in implementing a definitive randomized controlled trial were identified, suggesting the need for alternative trial designs to further examine the effectiveness of gabapentin in this heterogeneous population.
Article
Orthopedics
Anne Tabard-Fougere, Federico Canavese, Christina N. Steiger, Geraldo De Coulon
Summary: The purpose of this study was to investigate the incidence of complications in pediatric spastic cerebral palsy (CP) patients weighing less than 20 kg at the time of intrathecal baclofen (ITB) pump implantation and compare it with spastic CP patients weighing more than 20 kg. The study found that there was no significant difference in the rate of complications or reoperation between the two groups, but the mortality rate was higher in patients weighing less than 20 kg.
JOURNAL OF PEDIATRIC ORTHOPAEDICS-PART B
(2022)
Article
Clinical Neurology
Christopher Wilson, John Linczer, Sharle Newman, Johnathan Weyhenmeyer, Alexandra Roper, James Miller, Albert Lee
Summary: This study evaluated the impact of cerebrospinal fluid (CSF) leak and infection on the efficacy and complications of intrathecal drug therapy. Risk factors for CSF leak included smoking and younger age, while risk factors for infection included underweight body mass index, immunosuppression, smoking, and primary implantation. These complications led to increased perioperative adverse events and 90-day readmission rates.
WORLD NEUROSURGERY
(2023)
Article
Orthopedics
Aneesh Samineni, Susan E. Eklund, Patricia E. Miller, Kristin Buxton, Brian D. Snyder, Travis H. Matheney, Colyn J. Watkins, Scellig S. D. Stone, Walid Alrayashi, Roland Brusseau, Benjamin J. Shore
Summary: This retrospective study investigated the rate of serious complications and the efficacy of epidural analgesia compared to lumbar plexus blocks (LPBs) for pain management in children with cerebral palsy (CP) and intrathecal baclofen pump (ITB) undergoing hip reconstruction surgery. The results showed that epidural anesthesia provided improved analgesia compared to LPB analgesia, without increasing the risk of complications.
JOURNAL OF PEDIATRIC ORTHOPAEDICS
(2022)
Article
Orthopedics
Ali Asma, Armagan Can Ulusaloglu, Jason J. Howard, Kenneth J. Rogers, Freeman Miller, Michael Wade Shrader
Summary: Combining ITB with soft-tissue release for treating cerebral palsy spasticity does not reduce the need for subsequent hip surgery, but increases the risk of surgical site infection.
INDIAN JOURNAL OF ORTHOPAEDICS
(2022)
Article
Neurosciences
John Lopez, Gail F. Forrest, Einat Engel-Haber, Brittany Snider, Kam Momeni, Manikandan Ravi, Steven Kirshblum
Summary: This study investigates the effect of transcutaneous spinal stimulation on an implanted ITB pump and suggests that further studies can be considered, although communication with the programmer may be affected.
FRONTIERS IN NEUROSCIENCE
(2022)