Review
Clinical Neurology
Roberta Bonomo, Antonio E. Elia, Giulio Bonomo, Luigi M. Romito, Caterina Mariotti, Grazia Devigili, Roberto Cilia, Riccardo Giossi, Roberto Eleopra
Summary: In patients with Huntington's disease, deep brain stimulation in the globus pallidus internus can lead to significant improvements in disease rating and motor symptoms, while effectively reducing chorea scores. Further studies are needed to identify reliable criteria to guide patient selection for DBS therapy.
NEUROLOGICAL SCIENCES
(2021)
Article
Clinical Neurology
Yijie Lai, Naying He, Hongjiang Wei, Lifu Deng, Haiyan Zhou, Jun Li, Marcus Kaiser, Chencheng Zhang, Dianyou Li, Bomin Sun
Summary: This study investigated patient-specific functional connectivity related to globus pallidus internus (GPi) deep brain stimulation (DBS) outcome in Parkinson disease (PD) and established connectivity models for outcome prediction. The results showed that patient-specific functional connectivity seeding from the VTA-GPi intersection could help in GPi DBS outcome prediction.
JOURNAL OF NEUROSURGERY
(2023)
Article
Clinical Neurology
Takashi Tsuboi, Janine Lemos Melo Lobo Jofili Lopes, Kathryn Moore, Bhavana Patel, Joseph Legacy, Adrianna M. Ratajska, Dawn Bowers, Robert S. Eisinger, Leonardo Almeida, Kelly D. Foote, Michael S. Okun, Adolfo Ramirez-Zamora
Summary: Globus pallidus internus deep brain stimulation in Parkinson's disease patients showed sustained long-term benefits in tremor scores, motor complications, but gradual worsening in HRQoL and cardinal motor symptoms other than tremor in the long term. Benefits in tremor and dyskinesia are expected to be most persistent following bilateral GPi DBS implantation.
JOURNAL OF NEUROSURGERY
(2021)
Article
Clinical Neurology
Suzhen Lin, Yimei Shu, Chencheng Zhang, Lingbing Wang, Peng Huang, Yixin Pan, Jianqing Ding, Bomin Sun, Dianyou Li, Yiwen Wu
Summary: This study compared the effectiveness of targeting the globus pallidus internus (GPi) and the subthalamic nucleus (STN) in patients with isolated dystonia. The results showed that STN-DBS had superior effects at 1 month, 1 year, and 3 years, while GPi-DBS was better for axis symptoms, particularly for trunk involvement. STN-DBS was also more effective for symptoms involving the eyes and generalized dystonia, and required less electrical energy.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
Takashi Tsuboi, Marc Charbel, David T. Peterside, Mohit Rana, Ahmad Elkouzi, Wissam Deeb, Adolfo Ramirez-Zamora, Janine Lemos Melo Lobo Jofili Lopes, Leonardo Almeida, Pamela R. Zeilman, Robert S. Eisinger, Kelly D. Foote, Lela Okromelidze, Sanjeet S. Grewal, Michael S. Okun, Erik H. Middlebrooks
Summary: This study aimed to identify anatomical regions related to stimulation-induced dyskinesia (SID) in PD patients after pallidal DBS and analyze the connectivity associated with SID. The results showed that SID VTAs were primarily located in the dorsal GPi/GPe and had higher structural connectivity to certain cortical regions compared to non-SID VTAs. Differences in connectivity between motor-related cortices and subcortical regions may explain the presence or absence of SID.
MOVEMENT DISORDERS
(2021)
Article
Clinical Neurology
Nicholas Dietz, Ahmad Alhourani, Scott A. Wylie, Jessica L. McDonnell, Fenna T. Phibbs, Benoit M. Dawant, William J. Rodriguez, Elise B. Bradley, Joseph S. Neimat, Nelleke C. van Wouwe
Summary: Deep brain stimulation (DBS) of the Subthalamic Nucleus (STN) and Globus Pallidus (GPi) in Parkinson's disease (PD) patients have similar effects on inhibitory control processes.
CLINICAL NEUROPHYSIOLOGY
(2022)
Review
Clinical Neurology
Stephen Tisch, Kishore Raj Kumar
Summary: GPi DBS is an effective intervention for refractory dystonia, with factors such as disease duration and subtype influencing outcomes. Other factors affecting variability in results include body distribution, pattern of dystonia, and DBS-related factors. Different monogenic forms of dystonia may respond differently to DBS.
FRONTIERS IN NEUROLOGY
(2021)
Article
Surgery
Marek Balaz, Jiri Buril, Tereza Jurkova, Eva Koritakova, Dusan Hrabovsky, Jonas Kunst, Petra Bartova, Jan Chrastina
Summary: This study aims to compare the preplanned trajectories for deep brain stimulation (DBS) with the final trajectories selected after electrophysiological monitoring, and to discuss the factors responsible for the differences. The results showed significant differences between the preplanned and final trajectories, but no predictors for these differences were identified. There was also no association between the anatomical-electrophysiological differences and clinical outcome.
FRONTIERS IN SURGERY
(2023)
Article
Clinical Neurology
Wentao Zheng, Gaoquan Lv, Yunwei Lu, Jiayu Liu, Qingpei Hao, Hu Ding, Yezu Liu, Ruen Liu
Summary: Bilateral globus pallidus internus deep brain stimulation (GPi-DBS) is a safe and effective treatment approach for Meige syndrome, improving motor function and quality of life without cognitive and mood side effects.
Article
Neurosciences
Shiro Horisawa, Kotaro Kohara, Masato Murakami, Atsushi Fukui, Takakazu Kawamata, Takaomi Taira
Summary: The Forel field has potential for the treatment of cervical dystonia, Parkinson's disease, and dystonia. Recent studies have shown promising results for the efficacy of FF-DBS in treating dystonia.
FRONTIERS IN HUMAN NEUROSCIENCE
(2021)
Article
Clinical Neurology
Hong Tian, Bo Zhang, Yanbing Yu, Xueke Zhen, Li Zhang, Yue Yuan, Liang Wang
Summary: DBS of the posterior GPi may lead to better clinical outcomes in treating primary Meige syndrome, and higher GPi neuronal activity, particularly in the ventral part, can be utilized as a biomarker to guide DBS electrode implantation during surgery.
Review
Clinical Neurology
Weibin He, Chenhui Li, Hongjuan Dong, Lingmin Shao, Bo Yin, Dianyou Li, Liguo Ye, Ping Hu, Chencheng Zhang, Wei Yi
Summary: Globus pallidus internus deep brain stimulation (GPi-DBS) is an effective and safe treatment option for chorea-acanthocytosis (ChAc) patients, especially for those with oromandibular dystonia. However, there are no reliable predictors of efficacy at the moment.
JOURNAL OF MOVEMENT DISORDERS
(2022)
Article
Neurosciences
Suzhen Lin, Lingbing Wang, Yimei Shu, Shunyu Guo, Tao Wang, Hongxia Li, Chencheng Zhang, Bomin Sun, Dianyou Li, Yiwen Wu
Summary: Bilateral STN-DBS plus unilateral PVP may be an effective rescue procedure for patients with isolated dystonia who experienced suboptimal movement improvement following GPi-DBS.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Clinical Neurology
Tariq Parker, Ashley L. B. Raghu, James J. FitzGerald, Alexander L. Green, Tipu Z. Aziz
Summary: Dual thalamo-pallidal stimulation demonstrates great flexibility and efficacy in managing complex movement disorders, but also has limitations.
JOURNAL OF NEUROSURGERY
(2021)
Article
Clinical Neurology
Chun-Hwei Tai, Sheng-Che Chou, Chin-Hsien Lin, Wang-Tso Lee, Ruey-Meei Wu, Sheng-Hong Tseng
Summary: Patients with isolated dystonia, either monogenic or idiopathic, tend to respond better to GPi DBS compared to those with acquired dystonia. Selection of patients based on dystonia etiology, accurate placement of DBS leads in GPi targets, and proper stimulation programming are crucial for achieving better long-term outcomes.
WORLD NEUROSURGERY
(2022)
Article
Medicine, General & Internal
I. Kalar, H. Xu, J. Secnik, E. Schwertner, M. G. Kramberger, B. Winblad, M. von Euler, M. Eriksdotter, S. Garcia-Ptacek
Summary: This study investigated the impact of calcium channel blockers on mortality and ischaemic stroke risk in dementia patients. It found that nifedipine was associated with increased mortality risk, while amlodipine was linked to reduced mortality risk in dementia patients with Alzheimer's disease and Lewy body/Parkinson's disease dementia. Amlodipine was also found to lower the risk of ischaemic stroke in Alzheimer's disease patients compared to other calcium channel blockers.
JOURNAL OF INTERNAL MEDICINE
(2021)
Article
Neurosciences
Minh Tuan Hoang, Ingemar Kareholt, Mia von Euler, Lena von Koch, Maria Eriksdotter, Sara Garcia-Ptacek
Summary: The study compared satisfaction with stroke care between dementia patients and non-dementia stroke patients, finding that dementia patients reported lower satisfaction with acute stroke care, healthcare staff's attitude, communication with doctors, and stroke information. Patients with dementia had higher satisfaction in inpatient rehabilitation compared to other aspects of care.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Article
Geriatrics & Gerontology
Hong Xu, Sara Garcia-Ptacek, Juraj Secnik, Ann-Katrin Edlund, Karin Westling, Minh Tuan Hoang, Kristina Johnell, Edwin C. K. Tan, Dorota Religa, Maria Eriksdotter
Summary: A study in Sweden found that changes in the management of comorbidities in patients with dementia were associated with improved survival rates. The risk of fracture, MACE, and mortality in dementia patients decreased significantly over a 10-year period.
JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION
(2021)
Article
Neurosciences
Dannys Rivero Rodriguez, Claudio Scherle Matamoros, Daniela Dicapua Sacoto, Sara Garcia-Ptacek, Yanelis Pernas Sanchez, Graham Pluck
Summary: Few studies have evaluated the incidence, predisposing factors, and impact of healthcare-associated infections (HCAIs) among patients with status epilepticus (SE). This retrospective analysis found that HCAIs were common among Ecuadorian patients with SE and were associated with a lower survival rate at three months. Prolonged hospital length of stay, refractory SE, and CCI >= 2 were associated with the risk of developing HCAIs.
ARQUIVOS DE NEURO-PSIQUIATRIA
(2021)
Article
Urology & Nephrology
Hong Xu, Sara Garcia-Ptacek, Martin Annetorp, Annette Bruchfeld, Tommy Cederholm, Peter Johnson, Miia Kivipelto, Carina Metzner, Dorota Religa, Maria Eriksdotter
Summary: Older patients hospitalized with COVID-19 had a higher incidence of AKI compared to patients hospitalized for other diagnoses. COVID-19 and reduced baseline kidney function were risk factors for developing AKI. AKI and COVID-19 were associated with in-hospital death.
JOURNAL OF NEPHROLOGY
(2021)
Article
Neurosciences
Juraj Secnik, Hong Xu, Emilia Schwertner, Niklas Hammar, Michael Alvarsson, Bengt Winblad, Maria Eriksdotter, Sara Garcia-Ptacek, Dorota Religa
Summary: This study analyzed the all-cause mortality among users of six glucose-lowering drugs in patients with and without dementia. The results showed that insulin and sulfonylurea were associated with higher mortality risk among dementia patients, while GLP-1a and SGLT-2i were associated with lower risk.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Article
Geriatrics & Gerontology
Mandy Roheger, Hong Xu, Minh Tuan Hoang, Maria Eriksdotter, Sara Garcia-Ptacek
Summary: This study presents a reliable and simple method for converting MMSE scores to MoCA scores (and vice versa) in patients with different types of dementia. By establishing a conversion table, the scores of the two assessment tools can be easily compared, facilitating research and clinical practice.
JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION
(2022)
Article
Clinical Neurology
Marta Correa-Vela, Joao Carvalho, Julia Ferrero-Turrion, Ana Cazurro-Gutierrez, Maria Vanegas, Victoria Gonzalez, Ramiro Alvarez, Anna Marce-Grau, Antonio Moreno, Alfons Macaya-Ruiz, Belen Perez-Duenas
Summary: This study aims to evaluate early dystonic features in children and adolescents with SGCE-myoclonus-dystonia. The study found that these patients show recognizable dystonic patterns and sensory tricks, which can lead to early diagnosis and timely treatment.
DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY
(2023)
Article
Clinical Neurology
Marc Rodrigo-Gisbert, Arnau Llaurado, Andres Baucells, Cristina Auger, Victoria Gonzalez
Summary: We report a case of an 82-year-old woman with subacute altered mental status, oculomotor disturbances, and ataxia. The examination revealed bilateral ptosis, complete horizontal ophthalmoplegia, limited vertical eye movements during upgaze, and prominent truncal ataxia. MRI showed mild hyperintensity in the posterior brainstem extending to the upper cervical cord without gadolinium enhancement. This case highlights the importance of comprehensive differential diagnosis and screening for malignancy in patients with subacute brainstem encephalitis, in case of negative initial workup.
Article
Geriatrics & Gerontology
Minjia Mo, Hong Xu, Minh Tuan Hoang, Pol Grau Jurado, Shayan Mostafaei, Ingemar Kareholt, Kristina Johnell, Maria Eriksdotter, Sara Garcia-Ptacek
Summary: This study analyzed the risk of death from specific external causes, including falls, complications of medical and surgical care, unintentional injuries, and suicide, in dementia patients. The study found that dementia patients had an increased risk of unintentional injuries, falls, and suicide compared to control participants. Frontotemporal dementia had the highest risks of unintentional injuries and falls, while mixed dementia patients were less likely to die from suicide and complications of medical and surgical care.
JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION
(2023)
Editorial Material
Clinical Neurology
Andreu Vilaseca, Elena Martinez-Saez, Victoria Gonzalez, Cristina Auger, Laura Naranjo, Raquel Ruiz-Garcia
Summary: Paraneoplastic cerebellar degeneration (PCD) has been observed in a small number of patients with melanoma and specific neuronal antibodies (Yo and CARPVIII).
Article
Medicine, General & Internal
Minjia Mo, Lluis Zacarias-Pons, Minh Tuan Hoang, Shayan Mostafaei, Pol Grau Jurado, Isidora Stark, Kristina Johnell, Maria Eriksdotter, Hong Xu, Sara Garcia-Ptacek
Summary: This study examines the temporal risk patterns of psychiatric disorders among patients with dementia before, at the time of, and after diagnosis. The findings highlight the significant increase in psychiatric disorders both before and after dementia diagnosis, emphasizing the importance of incorporating psychiatric preventative and management interventions for individuals with dementia across various diagnostic stages.
Article
Multidisciplinary Sciences
Sara Garcia-Ptacek, Hong Xu, Martin Annetorp, Viktoria Back Jerlardtz, Tommy Cederholm, Malin Engstrom, Miia Kivipelto, Lars Goeran Lundberg, Carina Metzner, Maria Olsson, Josefina Skogo Nyvang, Carina Suhl Oberg, Elisabet Akesson, Dorota Religa, Maria Eriksdotter
Summary: This study examines changes in hospitalizations and mortality rates for COVID-19 and non-COVID cases among elderly patients in geriatric hospitals. The findings suggest that hospital admissions and mortality rates for COVID-19 patients increased during periods of high community transmission, but declined over time, possibly due to the effects of vaccination. The study also highlights the challenges faced by the healthcare system in providing care for both COVID-19 and non-COVID geriatric patients during peak pandemic periods.
Meeting Abstract
Transplantation
Hong Xu, Sara Garcia-Ptacek, Annette Bruchfeld, Edouard Fu, Taher Darreh Shori, Bengt Lindholm, Maria Eriksdotter, Juan Jesus Carrero
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2022)
Meeting Abstract
Clinical Neurology
M. Correa-Vela, J. Carvalho, M. Vanegas, A. Cazurro-Gutierrez, V. Gonzalez, R. Alvarez, A. Marce-Grau, A. Moreno, A. Macaya, B. Perez-Duenas
MOVEMENT DISORDERS
(2021)