Article
Neurosciences
Yutaro Takayama, Naoki Ikegaya, Keiya Iijima, Yuiko Kimura, Suguru Yokosako, Norihiro Muraoka, Kenzo Kosugi, Yuu Kaneko, Tetsuya Yamamoto, Masaki Iwasaki
Summary: Combined implantation of subdural and depth electrodes is important for investigating brain activities in patients with refractory epilepsy, but there is no significant difference in detecting early ictal EEG changes. Total removal of MRI lesions is associated with seizure freedom, and depth electrodes should be carefully used to avoid injudicious usage after consideration of the suspected etiology.
Article
Clinical Neurology
Lara Jehi, Marcia Morita-Sherman, Thomas E. Love, Fabrice Bartolomei, William Bingaman, Kees Braun, Robyn M. Busch, John Duncan, Walter J. Hader, Guoming Luan, John D. Rolston, Stephan Schuele, Laura Tassi, Sumeet Vadera, Shehryar Sheikh, Imad Najm, Amir Arain, Justin Bingaman, Beate Diehl, Jane de Tisi, Matea Rados, Pieter Van Eijsden, Sandra Wahby, Xiongfei Wang, Samuel Wiebe
Summary: This study compared the outcomes of subdural electrode (SDE) implantations and stereotactic electroencephalography (SEEG) in drug-resistant focal epilepsy, finding that SDE is more likely to lead to resective surgery but with higher complications and lower seizure freedom rates compared to SEEG.
ANNALS OF NEUROLOGY
(2021)
Article
Biochemistry & Molecular Biology
Stefan Rampp, Martin Kaltenhaeuser, Nadia Mueller-Voggel, Arnd Doerfler, Burkhard S. Kasper, Hajo M. Hamer, Sebastian Brandner, Michael Buchfelder
Summary: Epilepsy surgery is an effective treatment option for patients with drug-resistant focal epilepsies, and accurate localization of the epileptogenic zone is essential. This study investigates the relationship between node degree (ND) and the seizure onset zone (SOZ) in resting state magnetoencephalography (MEG) data. The findings suggest that ND in certain frequency bands is significantly related to the SOZ, indicating its potential as a new tool for presurgical evaluation of epilepsy surgery.
Article
Clinical Neurology
Gadi Miron, Christoph Dehnicke, Heinz-Joachim Meencke, Julia Onken, Martin Holtkamp
Summary: This study evaluated the utility and safety of using FO and FOP VEM in epilepsy surgery cases. FOP VEM provided clinically significant electrophysiological information for treatment decisions in two-thirds of cases with a good benefit-risk profile. Predictors identified for electrophysiological and clinical outcomes can help in selecting patients optimally for this safe diagnostic approach.
JOURNAL OF NEUROLOGY
(2022)
Article
Clinical Neurology
Jurre Blaauw, Heleen M. den Hertog, Josje M. van Zundert, Niels A. van der Gaag, Korne Jellema, Ruben Dammers, Kuan H. Kho, Rob J. M. Groen, Hester F. Lingsma, Joukje van der Naalt, Bram Jacobs
Summary: Transient neurological deficits (TNDs) are not uncommon in patients with chronic subdural hematoma (CSDH). The characteristics of TNDs are strongly associated with the diagnosis of symptomatic seizures and functional outcome. Our findings suggest that the treatment of TNDs in CSDH patients should be carefully considered as it may have an impact on patient outcome.
JOURNAL OF NEUROLOGY
(2022)
Article
Clinical Neurology
Peter N. Taylor, Christoforos A. Papasavvas, Thomas W. Owen, Gabrielle M. Schroeder, Frances E. Hutchings, Fahmida A. Chowdhury, Beate Diehl, John S. Duncan, Andrew W. McEvoy, Anna Miserocchi, Jane de Tisi, Sjoerd B. Vos, Matthew C. Walker, Yujiang Wang
Summary: This study investigates the detection of interictal abnormalities in intracranial EEG by constructing a normative map of brain dynamics and quantitatively accounting for the range of healthy brain dynamics. The study finds that regions spared by surgery are more abnormal than resected regions, which can differentiate patient outcomes.
Article
Clinical Neurology
Joshua M. Diamond, Benjamin E. Diamond, Michael S. Trotta, Kate Dembny, Sara K. Inati, Kareem A. Zaghloul
Summary: Our study suggests that ictal activity observed by intracranial EEG may reflect propagated activity from a relatively focal seizure source, even during later time points when ictal activity is more widespread. By analyzing the time differences between ictal discharges in adjacent electrodes, we were able to estimate the location of the hypothesized focal source, which was found to closely match the clinically and neurophysiologically determined brain region giving rise to seizures. Furthermore, we found that this focal source is a dynamic entity that moves and evolves over the time course of a seizure, challenging the traditional conceptualization of the seizure source.
Article
Clinical Neurology
Hussam Hamou, Mohammed Alzaiyani, Tobias Rossmann, Rastislav Pjontek, Benedikt Kremer, Hasan Zaytoun, Hani Ridwan, Hans Clusmann, Anke Hoellig, Michael Veldeman
Summary: Chronic subdural hematoma (cSDH) is becoming more prevalent, and postoperative seizure in cSDH patients is associated with several factors, with depressed brain volume being independently associated with such seizures. While no formal recommendation can be made regarding prophylactic use of anti-epileptic drugs, the relative safety of new generation drugs and the negative impact of postoperative seizures on patient outcomes may justify their use in selected cases.
FRONTIERS IN NEUROLOGY
(2022)
Article
Neurosciences
Anna Witkowska-Wrobel, Kirill Aristovich, Abbe Crawford, Justin D. Perkins, David Holder
Summary: The study successfully reconstructed slow impedance changes evoked by cell swelling using Electrical Impedance Tomography (EIT) in a swine model of epilepsy, demonstrating the potential of combining EIT with intracranial EEG monitoring to improve diagnostic yield in epileptic patients.
Article
Clinical Neurology
Thomas Larrew, Jesse Skoch, S. Katie Z. Ihnen, Ravindra Arya, Katherine D. Holland, Jeffrey R. Tenney, Paul S. Horn, James L. Leach, Darcy A. Krueger, Hansel M. Greiner, Francesco T. Mangano
Summary: In comparison between SDG and SEEG cohorts, the SEEG group appeared to receive more aggressive management with higher multifocality, prior surgical interventions, baseline AEDs, and bilateral invasive monitoring. Despite this, the SEEG cohort showed similar seizure outcomes and a trend towards increased safety, making it a potential option for a wide range of TSC patients.
NEUROSURGICAL FOCUS
(2022)
Article
Clinical Neurology
Anthony T. Lee, Noah M. Nichols, Benjamin A. Speidel, Joline M. Fan, Iahn Cajigas, Robert C. Knowlton, Edward F. Chang
Summary: Recent trends in intracranial localization of seizures have favored stereo-electroencephalography (SEEG) depth electrodes over subdural grid electrocorticography (ECoG) recordings, mainly due to concerns about morbidity. This study reviews the outcomes of a hybrid approach involving the use of subdural grids, strips, and frameless stereotactic depth electrode implantations, finding low rates of hemorrhage and no permanent morbidity.
JOURNAL OF NEUROSURGERY
(2023)
Article
Clinical Neurology
David Satzer, Yasar T. Esengul, Peter C. Warnke, Naoum P. Issa, Douglas R. Nordli
Summary: This study aimed to assess the validity of ictal SEEG source localization, and the results showed that SEEG source localization accurately mapped the onset of seizures compared to conventional interpretation. Additionally, the proximity of dipoles to the surgical treatment volume predicted the outcome of seizures when near-field recordings were analyzed.
CLINICAL NEUROPHYSIOLOGY
(2022)
Article
Pediatrics
Rohini Coorg, Elaine S. Seto
Summary: Stereoelectroencephalography (SEEG) is increasingly used in epilepsy surgery due to evolving understanding of epileptic networks. It allows for sampling deep brain structures without a craniotomy or disrupting the dura, offering advantages over subdural electrode (SDE) monitoring. SEEG complements minimally invasive options, reducing the treatment gap for hesitant patients. Epileptologists can make informed decisions about invasive monitoring based on the strengths and limitations of SDE monitoring and SEEG.
JOURNAL OF PEDIATRIC EPILEPSY
(2023)
Article
Clinical Neurology
Tatiana Vander, Tatiana Stroganova, Diya Doufish, Dawn Eliashiv, Tal Gilboa, Mordekhay Medvedovsky, Dana Ekstein
Summary: Ambulatory at home video-EEG monitoring (HVEM) may offer a more cost-effective and accessible option for epilepsy patients. However, longer periods of monitoring may be necessary to capture a sufficient number of seizures. This study quantitatively estimated the necessary length of HVEM for different diagnostic scenarios.
FRONTIERS IN NEUROLOGY
(2022)
Article
Chemistry, Multidisciplinary
Marcin Kolodziej, Andrzej Majkowski, Andrzej Rysz
Summary: This article explores the possibilities, issues, and challenges associated with utilizing artificial intelligence for seizure detection using the publicly available iEEG database. It presents standard approaches for analyzing iEEG signals and discusses modern deep learning algorithms. The study shows that CNN and LSTM networks yield significantly better results, and the gradient-weighted class activation mapping algorithm can identify important iEEG signal fragments for seizure detection.
APPLIED SCIENCES-BASEL
(2023)