Article
Clinical Neurology
Sam Ng, Guillaume Herbet, Anne-Laure Lemaitre, Jerome Cochereau, Sylvie Moritz-Gasser, Hugues Duffau
Summary: Early surgical treatment in presumed asymptomatic patients with ILGG was associated with stable or improved neuropsychological outcomes in 87.2% of patients at 3 months, with only mild cognitive decline observed in 6 patients.
JOURNAL OF NEUROSURGERY
(2021)
Article
Oncology
Anne E. Heffernan, Yilun Wu, Luke S. Benz, Roel G. W. Verhaak, Bethany M. Kwan, Elizabeth B. Claus
Summary: This study assessed the quality of life (QOL) for adults diagnosed with lower grade glioma (LGG). The results showed that these patients had reduced physical, emotional, and mental health functioning compared to individuals with nonmalignant brain tumors and the general population. This highlights the importance of acknowledging and managing these symptoms to improve the QOL of young patients diagnosed with LGG.
Article
Clinical Neurology
Sam Fairclough, John Goodden, Paul Chumas, Ryan Mathew, Melissa Maguire
Summary: This study aims to identify factors that influence the probability of seizure freedom and treatment failure in patients with WHO grade 2 glioma. The results show that using levetiracetam as a first-line antiseizure medication significantly increases the probability of seizure freedom at 2 years. Patients with mainly focal seizures without progression have a significantly lower chance of achieving seizure freedom within 10 years.
Review
Neurosciences
Melissa Silva, Catalina Vivancos, Hugues Duffau
Summary: This article reviews the cellular, metabolic, and radiological characteristics of the peritumoral zone (PTZ) in the specific context of diffuse low-grade gliomas (DLGG). A better delineation of PTZ may lead to improved therapeutic options and quality of life for DLGG patients. Surgical resection of PTZ can prolong survival and minimize the risk of malignant transformation. The timing and order of medical treatments can be adjusted based on the pattern of peritumoral infiltration. The development of new drugs targeting PTZ could be beneficial from both an oncological and epileptological perspective.
Article
Oncology
Sarah Christina Reitz, Marion Behrens, Irina Lortz, Nadine Conradi, Maximilian Rauch, Katharina Filipski, Martin Voss, Christian Kell, Marcus Czabanka, Marie-Therese Forster
Summary: This study evaluated the neurocognitive functioning and occurrence of epileptic seizures in patients with gliomas located in language-related areas before and after awake surgery. The results showed that there was a deterioration in word fluency and executive functions in the short-term after surgery, but the neurocognitive functioning improved to preoperative baseline levels in the long-term. The occurrence of mood disturbances significantly declined after surgery, and antiepileptic therapy effectively controlled seizures.
FRONTIERS IN ONCOLOGY
(2022)
Article
Clinical Neurology
Assaf Berger, Gali Tzarfati, Matias Costa, Marga Serafimova, Akiva Korn, Irina Vendrov, Tali Alfasi, Dana Krill, Daniel Aviram, Shlomit Ben Moshe, Alon Kashanian, Zvi Ram, Rachel Grossman
Summary: Ischemic complications are common in low-grade glioma surgeries, occurring in 23% of cases, particularly in recurrent and insular surgeries. While they do not affect survival, they result in significant activity and performance status decline in the first 3 postoperative months, gradually improving over 1 year. Various intraoperative parameters may indicate the development of an infarct.
JOURNAL OF NEUROSURGERY
(2021)
Article
Clinical Neurology
Lianwang Li, Shengyu Fang, Guanzhang Li, Kenan Zhang, Ruoyu Huang, Yinyan Wang, Chuanbao Zhang, Yiming Li, Wei Zhang, Zhong Zhang, Qiang Jin, Dabiao Zhou, Xing Fan, Tao Jiang
Summary: This study investigated the epidemiological characteristics, risk factors, and prognostic value of glioma-related epilepsy in patients with DHGGs. It found that the incidence of glioma-related epilepsy decreased with increasing tumor malignancy. Age, neurological function, and tumor grade were associated with preoperative glioma-related epilepsy, while preoperative glioma-related epilepsy, temporal lobe involvement, non-gross-total resection, and tumor grade were predictors of poor seizure outcome. Postoperative glioma-related epilepsy was also found to be a prognostic factor for overall survival.
JOURNAL OF NEUROSURGERY
(2022)
Article
Clinical Neurology
Marc Zanello, Alexandre Roux, Gilles Zah-Bi, Benedicte Trancart, Eduardo Parraga, Myriam Edjlali, Arnault Tauziede-Espariat, Xavier Sauvageon, Tarek Sharshar, Catherine Oppenheim, Pascale Varlet, Edouard Dezamis, Johan Pallud
Summary: Functional-based resection under awake conditions has a low rate of intraoperative and early postoperative seizures, with good seizure outcomes at 6 months and 2 years postoperatively. Factors like treatment time of at least 3 months postoperatively, frontal lobe involvement, intraoperative current intensity, and supratotal resection are independently associated with early postoperative seizures.
JOURNAL OF NEUROSURGERY
(2021)
Article
Multidisciplinary Sciences
Yasuo Nakai, Hiroki Nishibayashi, Tomohiro Donishi, Masaki Terada, Naoyuki Nakao, Yoshiki Kaneoke
Summary: In this study, regional functional connectivity alterations were observed in individuals with intractable focal epilepsy using resting-state functional MRI. The number of abnormal regions in each patient was associated with clinical parameters such as illness duration and seizure severity, and these abnormal regions were negatively related to quality of life. Additionally, abnormal regions in some patients were found to be distributed within the default mode network.
SCIENTIFIC REPORTS
(2021)
Review
Oncology
Sam Ng, Hugues Duffau
Summary: Diffuse low-grade gliomas promote cerebral plasticity mechanisms that have a critical impact on therapy success and risks. This review discusses clinical, radiological, and oncological markers that reflect plasticity potentials and limitations in low-grade glioma management, and highlights the interactions between plasticity and therapeutic factors. A multimodal oncological approach is proposed, integrating individual brain plasticity profiling for therapeutic decision-making. Postlesional plasticity, the compensation ability of neural circuits, is activated in diffuse low-grade gliomas, affecting tumor proliferation and migration as well as treatment outcomes. This review focuses on clinical markers, such as tumor location and white matter tract infiltration, and the interaction between plasticity and treatment options. A personalized longitudinal approach considering brain plasticity is proposed to optimize patient outcomes.
Article
Clinical Neurology
Sam Ng, Anne-Laure Lemaitre, Sylvie Moritz-Gasser, Guillaume Herbet, Hugues Duffau
Summary: The study showed that reoperation with awake monitoring in RLGG patients can lead to early recovery of neurocognitive abilities, with most patients experiencing no permanent neurological deficits postoperatively. However, 6.5% of patients developed new cognitive deficits at 3 months postoperatively. Most patients achieved total/subtotal resections, indicating favorable outcomes for reoperation in RLGG patients.
Article
Neurosciences
Xinghui He, Kai Zhang, Dingyang Liu, Zhuanyi Yang, Xuejun Li, Zhiquan Yang
Summary: This study aimed to identify predictors of postoperative seizures in patients with diffuse low-grade glioma (DLGG)-related epilepsy. The results showed that satisfactory seizure outcomes can be achieved in most patients after complete tumor resection, but patients with seizure duration of >6 years or first clinical symptoms other than seizures were more likely to experience postoperative seizure recurrence.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Clinical Neurology
Yuxin Wu, Zaiyu Zhang, Ping Liang, Bin Zou, Difei Wang, Xuan Zhai
Summary: ObjectiveEpilepsy after resection surgery significantly decreases the quality of life of children. This study aimed to investigate the quality of life of children with seizures after resection surgery and its influencing factors. It was found that surgery-related factors do not predict the quality of life, while preoperative language development retardation or language dysfunction and postoperative ILAE seizure outcome classification are independent predictors of the quality of life.
FRONTIERS IN NEUROLOGY
(2022)
Article
Oncology
Marie Blonski, Tiphaine Obara, Cyril Brzenczek, Celso Pouget, Celine Dillier, Mylene Meyer, Laura Lavigne, Natacha Forthoffer, Aurelie Broussois, Guillaume Gauchotte, Marie-Helene Baron, Fabien Rech, Sophie Mezieres, Yann Gaudeau, Antoine Verger, Guillaume Vogin, Rene Anxionnat, Jean-Marie Moureaux, Luc Taillandier
Summary: The study described a series of 20 patients treated with PCV followed by radiotherapy, showing significant neurotoxicity in long-term follow-up with memory and behavioral deterioration, leading to disability and inability to work in 65% of patients.
FRONTIERS IN ONCOLOGY
(2022)
Article
Clinical Neurology
Sofiane Mrah, Maxime Descoteaux, Michel Wager, Arnaud Bore, Francois Rheault, Bertrand Thirion, Emmanuel Mandonnet
Summary: This study aimed to predict set-shifting deterioration after resection of low-grade glioma by analyzing the relationship between surgical cavity topography and brain networks.
JOURNAL OF NEUROSURGERY
(2022)