Review
Clinical Neurology
Peter Weir, Ashwin Kumaria, Alhassan Mohmed, Shazia Javed, Simon Paine, Paul Byrne
Summary: Beckwith-Wiedemann syndrome (BWS) is a rare congenital overgrowth syndrome that may be associated with certain childhood tumors. This case report presents the first documented case of glioblastoma associated with BWS, and explores similarities in the molecular pathomechanisms of BWS and glioblastoma.
ACTA NEUROCHIRURGICA
(2022)
Article
Biochemistry & Molecular Biology
Jonas Feldheim, David Wend, Mara J. Lauer, Camelia M. Monoranu, Martin Glas, Christoph Kleinschnitz, Ralf-Ingo Ernestus, Barbara M. Braunger, Patrick Meybohm, Carsten Hagemann, Malgorzata Burek
Summary: This study found that high expression of PCDHGC3 is associated with longer progression-free survival (PFS) in glioma patients. Knockout of PCDHGC3 decreased the growth rate but increased the migration rate of glioma cells, and also affected the expression of genes involved in the WNT signaling pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Yuanning Zheng, Francisco Carrillo-Perez, Marija Pizurica, Dieter Henrik Heiland, Olivier Gevaert
Summary: In this study, two deep learning models were used to predict the transcriptional subtypes and prognosis of glioblastoma (GBM) cells from histology images. The results showed consistent associations between spatial cellular organization and patient prognosis. The study also confirmed that transcriptional heterogeneity and cell-state plasticity are key factors in the development of therapeutic resistance in GBM.
NATURE COMMUNICATIONS
(2023)
Article
Clinical Neurology
Anya A. Kim, Antonio Dono, Adham M. Khalafallah, Barbara Nettel-Rueda, George Samandouras, Constantinos G. Hadjipanayis, Debraj Mukherjee, Yoshua Esquenazi
Summary: This study surveyed current practices regarding early repeat resection (ERR) and analyzed the impact of geographic location and practice setting. The results showed that neurosurgeons rarely performed ERR in their practices, with an extent of resection threshold of 80.2% and significant variability in ERR likelihood based on tumor location.
JOURNAL OF NEUROSURGERY
(2022)
Review
Clinical Neurology
Peer Asad Aziz, Salma Farrukh Memon, Mubarak Hussain, A. Rauf Memon, Kiran Abbas, Shurjeel Uddin Qazi, Riaz A. R. Memon, Kanwal Ali Qambrani, Osama Taj, Shamas Ghazanfar, Aayat Ellahi, Moiz Ahmed
Summary: The study found that Supratotal resection (SpTR) is associated with increased overall survival and progression-free survival compared to other glioblastoma surgeries like GTR or SubTR.
WORLD NEUROSURGERY
(2023)
Review
Biochemistry & Molecular Biology
Marianna Makowska, Beata Smolarz, Hanna Romanowicz
Summary: Glioblastoma multiforme (GBM) is a common, malignant brain tumor with a poor prognosis. Traditional treatments have limited success due to the tumor's infiltrating growth and resistance. The search for new therapies is crucial.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Medicine, General & Internal
Francisco Revilla-Pacheco, Pamela Rodriguez-Salgado, Monica Barrera-Ramirez, Maria Paula Morales-Ruiz, Mauro Loyo-Varela, Johnatan Rubalcava-Ortega, Tenoch Herrada-Pineda
Summary: The study revealed a weak but statistically significant association between the extent of surgical resection and overall survival in patients with glioblastoma multiforme. However, the evidence level for this association is low and cannot establish a cause-and-effect relationship between these variables.
Article
Mathematical & Computational Biology
Duane C. Harris, Giancarlo Mignucci-Jimenez, Yuan Xu, Steffen E. Eikenberry, C. Chad Quarles, Mark C. Preul, Yang Kuang, Eric J. Kostelich
Summary: This study describes a preliminary effort to model the growth and progression of glioblastoma multiforme in patients undergoing treatment for tumor recurrence. Two reaction-diffusion models are used, and the simulations are based on 3D brain geometries derived from MRI scans. The study shows the feasibility of model parameters and discusses potential improvements in parameterization and initialization.
MATHEMATICAL BIOSCIENCES AND ENGINEERING
(2022)
Review
Immunology
Boyuan Huang, Xuesong Li, Yuntao Li, Jin Zhang, Zhitao Zong, Hongbo Zhang
Summary: Glioblastoma multiforme (GBM) is the most common and aggressive malignant tumor in the central nervous system. Immunotherapy has shown promising results in the treatment of GBM, but future developments will require an integrated approach with various treatment modalities and specific targeted therapies for the tumor microenvironment.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Yung-Lung Chang, Yao-Feng Li, Chung-Hsing Chou, Li-Chun Huang, Yi-Ping Wu, Ying Kao, Chia-Kuang Tsai
Summary: Diosmin, a natural flavone glycoside, demonstrated inhibitory effects on GBM cell growth, migration, and invasion, as well as modulation of autophagy and cell cycle progression. It showed limited cytotoxicity towards astrocytes and holds potential for new GBM treatment therapies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Clinical Neurology
Asgeir S. Jakola, Lars Kjelsberg Pedersen, Anne J. Skjulsvik, Kristin Myrmel, Kristin Sjavik, Ole Solheim
Summary: This study aimed to provide extended follow-up data on IDH-mutant dLGGs and compare the outcomes of early resection and biopsy wait-and-scan approaches. The results showed that early resection was associated with longer survival and did not appear to reduce health-related quality of life.
JOURNAL OF NEUROSURGERY
(2022)
Article
Biochemistry & Molecular Biology
Mark Marsland, Amiee Dowdell, Sam Faulkner, Phillip Jobling, Robert A. Rush, Craig Gedye, James Lynam, Cassandra P. Griffin, Mark Baker, Joanne Marsland, Chen Chen Jiang, Hubert Hondermarck
Summary: In this study, we investigated the expression and biological activity of proNGF in glioblastoma multiforme (GBM). The results showed that proNGF was significantly overexpressed in GBM and could stimulate cancer cell growth. Therefore, further investigations are needed to confirm the potential of proNGF as a clinical biomarker and therapeutic target.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Maya A. Dymova, Elena Kuligina, Vladimir A. Richter
Summary: This review summarizes recent advances in understanding the molecular mechanisms of therapeutic resistance of GBM, molecular characteristics of glioblastoma cells, and barriers in the brain that contribute to drug resistance. The progress in developing new targeted drugs for glioblastoma and drug delivery across the blood-brain barrier (BBB) and blood-brain tumor barrier (BBTB) is also discussed.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Clinical Neurology
Filippo Friso, Paola Rucci, Vittoria Rosetti, Alessandro Carretta, Carlo Bortolotti, Vania Ramponi, Matteo Martinoni, Giorgio Palandri, Matteo Zoli, Filippo Badaloni, Enrico Franceschi, Sofia Asioli, Viscardo Paolo Fabbri, Arianna Rustici, Maria P. Foschini, Alba A. Brandes, Diego Mazzatenta, Carmelo Sturiale, Alfredo Conti
Summary: The extent of surgical resection influences survival in patients with mGBMs, with gross total resection and subtotal resection associated with longer progression free survival. Gross total resection remains associated with overall survival in multivariable analysis.
Article
Oncology
Robyn A. Umans, Joelle Martin, Megan E. Harrigan, Dipan C. Patel, Lata Chaunsali, Aarash Roshandel, Kavya Iyer, Michael D. Powell, Ken Oestreich, Harald Sontheimer
Summary: Glioblastoma multiforme (GBM) is a deadly brain tumor with limited treatment options. Recent research suggests that tumor protein 53 (TP53) is a molecular regulator of System xc- (SXC) in GBM, with its expression negatively correlated with xCT expression. This finding indicates that p53 may serve as a potential therapeutic target for GBM by regulating glutamate biology.
Article
Radiology, Nuclear Medicine & Medical Imaging
Zachary M. Wilseck, Leanne Y. Lin, Neeraj Chaudhary, Francisco Rivas -Rodriguez
Summary: Pediatric neurovascular pathology refers to vascular disorders directly involving or near the central nervous system (CNS) in children. These pathologies can occur independently or in connection with broader syndromes. Imaging techniques such as ultrasound, CT, and MRI play a critical role in the diagnosis, treatment planning, and follow-up of these vascular lesions. Digital subtraction angiography (DSA) may be used as a diagnostic and therapeutic imaging method. Close collaboration between various pediatric specialists is necessary for the diagnosis and management of pediatric cerebrovascular diseases. This review provides an overview of pediatric neurovascular pathologies, presents pathognomonic imaging findings, and briefly discusses endovascular treatment options.
SEMINARS IN ROENTGENOLOGY
(2023)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Jayapalli R. Bapuraj, Neeraj Chaudhary
Review
Clinical Neurology
Varun Padmanaban, Patricia P. Yee, Sravanthi Koduri, Bashar Zaidat, Badih J. Daou, Neeraj Chaudhary, Joseph J. Gemmete, B. Gregory Thompson, Chris D. Kazmierczak, Kevin M. Cockroft, Aditya S. Pandey, D. Andrew Wilkinson
Summary: This study investigates the safety and efficacy of modern neuroendovascular techniques in treating cerebrovascular diseases in patients with vEDS. The evaluation of 59 patients who underwent 66 neuroendovascular procedures shows a success rate of 94%, a complication rate of 30%, and a mortality rate of 7.5%.
WORLD NEUROSURGERY
(2023)
Article
Ophthalmology
Emily Chang, Yunshu Zhou, David Musch, Amy Edmonds, Laura Sedig, Raymond Hutchinson, Neeraj Chaudhary, Hakan Demirci
Summary: The purpose of this study was to compare the efficacy of intraarterial chemotherapy (IAC) for retinoblastoma delivered via the ophthalmic artery (OA) division of the internal carotid artery (ICA) versus alternative branches of the external carotid artery (ECA). The results showed that when delivery of chemotherapeutic agents via the OA is no longer feasible, the utilization of alternative routes for IAC safely allows for continuation of therapy and results in similar rates of globe salvage, reduction in tumor thickness, and reduction in basal diameter.
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2023)
Article
Endocrinology & Metabolism
Miles P. P. Mannas, Derek Jones, Fang-Ming Deng, Deepthi Hoskoppal, Jonathan Melamed, Daniel A. Orringer, Samir S. S. Taneja
Summary: Stimulated Raman histology (SRH) is a novel microscopic technique that provides real-time, label-free, high-resolution microscopic images of unprocessed tissue. This technology has the potential to significantly reduce the time for prostate biopsy diagnosis. The study assessed the concordance between pathologist interpretation of SRH and traditional hematoxylin and eosin (H&E) stained slides.
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Neeraj Chaudhary, Joseph John Gemmete
Article
Clinical Neurology
S. Dogra, D. Zagzag, M. Young, J. Golfinos, D. Orringer, R. Jain
Summary: This study evaluated the volume changes of MVNTs during long-term follow-up using segmentation tools and found that these tumors did not show significant changes in volume over time, suggesting that frequent surveillance imaging may not be necessary for newly diagnosed MVNTs.
AMERICAN JOURNAL OF NEURORADIOLOGY
(2023)
Article
Education, Scientific Disciplines
Benjamin M. Pinsky, Sreehari Panicker, Neeraj Chaudhary, Joseph J. Gemmete, Zachary M. Wilseck, Leanne Lin
Summary: The complexity and variability of cross-sectional imaging make it a challenge to teach radiologic anatomy to medical students. Recent advancements in 3D segmentation and augmented reality technology provide a promising solution by creating interactive, patient-specific 3D/AR models incorporating multiple imaging modalities.
Editorial Material
Medicine, Research & Experimental
Daniel A. Orringer, Todd C. Hollon
Summary: The AI algorithm CHARM mentioned in this issue has the potential to simplify molecular classification, intraoperative diagnosis, surgical decision making, and trial enrollment for glioma patients, thus bringing new opportunities for improving the diagnosis and treatment of human disease in the AI era.
Meeting Abstract
Clinical Neurology
Todd Charles Hollon, John G. Golfinos, Daniel A. Orringer, Mitchel Berger, Shawn L. Hervey-Jumper, Karin M. Muraszko, Christian Freudiger, Jason Heth, Oren Sagher, Cheng Jiang, Asadur Chowdury, Mustafa Nasir Moin, Akhil Kondepudi, Alexander Arash Aabedi, Arjun R. Adapa, Wajd Al-Holou, Lisa Wadiura, Georg Widhalm, Volker Neuschmelting, David Reinecke, Sandra Camelo-Piragua
Article
Oncology
Kristyn Galbraith, Varshini Vasudevaraja, Jonathan Serrano, Guomiao Shen, Ivy Tran, Nancy Abdallat, Mandisa Wen, Seema Patel, Misha Movahed-Ezazi, Arline Faustin, Marissa Spino-Keeton, Leah Geiser Roberts, Ekrem Maloku, Steven A. Drexler, Benjamin L. Liechty, David Pisapia, Olga Krasnozhen-Ratush, Marc Rosenblum, Seema Shroff, Daniel R. Boue, Christian Davidson, Qinwen Mao, Mariko Suchi, Paula North, Amanda Hopp, Annette Segura, Jason A. Jarzembowski, Lauren Parsons, Mahlon D. Johnson, Bret Mobley, Wesley Samore, Declan McGuone, Pallavi P. Gopal, Peter D. Canoll, Craig Horbinski, Joseph M. Fullmer, Midhat S. Farooqui, Murat Gokden, Nitin R. Wadhwani, Timothy E. Richardson, Melissa Umphlett, Nadejda M. Tsankova, John C. DeWitt, Chandra Sen, Dimitris G. Placantonakis, Donato Pacione, Jeffrey H. Wisoff, Eveline Teresa Hidalgo, David Harter, Christopher M. William, Christine Cordova, Sylvia C. Kurz, Marissa Barbaro, Daniel A. Orringer, Matthias A. Karajannis, Erik P. Sulman, Sharon L. Gardner, David Zagzag, Aristotelis Tsirigos, Jeffrey C. Allen, John G. Golfinos, Matija Snuderl
Summary: This study used DNA methylation analysis as a primary diagnostic method for 1921 brain tumors. The results showed that DNA methylation can provide tumor type-specific signature for diagnosis and prognostic information. This study provides a framework for inclusion of DNA methylation profiling as a primary molecular diagnostic test into professional guidelines for CNS tumors.
NEURO-ONCOLOGY ADVANCES
(2023)
Meeting Abstract
Oncology
D. M. Edwards, A. Hopkins, A. Scott, R. Mannan, X. Cao, L. Zhang, A. Andren, J. A. Heth, K. Muraszko, O. Sagher, D. Orringer, T. Hollon, S. Hervey-Jumper, S. Venneti, S. Camelo-Piragua, W. Al-Holou, A. Chinnaiyan, C. A. Lyssiotis, D. R. Wahl
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2023)
Proceedings Paper
Computer Science, Artificial Intelligence
Cheng Jiang, Xinhai Hou, Akhil Kondepudi, Asadur Chowdury, Christian W. Freudiger, Daniel A. Orringer, Honglak Lee, Todd C. Hollon
Summary: Learning high-quality, self-supervised, visual representations is crucial for the advancement of computer vision in biomedical microscopy and clinical medicine. HiDisc is a data-driven method that leverages the patient-slide-patch hierarchy in clinical biomedical microscopy to learn features of the underlying diagnosis. Experimental results demonstrate that HiDisc outperforms other self-supervised methods for cancer diagnosis and genetic mutation prediction, without the need for strong data augmentations.
2023 IEEE/CVF CONFERENCE ON COMPUTER VISION AND PATTERN RECOGNITION (CVPR)
(2023)
Article
Clinical Neurology
Matthew D. Lee, Sohil H. Patel, Suyash Mohan, Hamed Akbari, Spyridon Bakas, MacLean P. Nasrallah, Evan Calabrese, Jeffrey Rudie, Javier Villanueva-Meyer, Pamela LaMontagne, Daniel S. Marcus, Rivka R. Colen, Carmen Balana, Yoon Seong Choi, Chaitra Badve, Jill S. Barnholtz-Sloan, Andrew E. Sloan, Thomas C. Booth, Joshua D. Palmer, Adam P. Dicker, Adam E. Flanders, Wenyin Shi, Brent Griffith, Laila M. Poisson, Arnab Chakravarti, Abhishek Mahajan, Susan Chang, Daniel Orringer, Christos Davatzikos, Rajan Jain
Summary: The partial T2-FLAIR mismatch sign is a highly specific imaging biomarker for IDH mutation in WHO grade 4 gliomas.
Article
Oncology
Yoshie Umemura, Daniel Orringer, Larry Junck, Maria L. Varela, Molly E. J. West, Syed M. Faisal, Andrea Comba, Jason Heth, Oren Sagher, Denise Leung, Aaron Mammoser, Shawn Hervey-Jumper, Daniel Zamler, Viveka N. Yadav, Patrick Dunn, Wajd Al-Holou, Todd Hollon, Michelle M. Kim, Daniel R. Wahl, Sandra Camelo-Piragua, Andrew P. Lieberman, Sriram Venneti, Paul Mckeever, Theodore Lawrence, Ryo Kurokawa, Karen Sagher, David Altshuler, Lili Zhao, Karin Muraszko, Maria G. Castro, Pedro Lowenstein
Summary: This study evaluated the safety and activity of two adenoviral vectors in patients with high-grade glioma. The treatment was well-tolerated and showed feasibility in patients, suggesting that further clinical trials are warranted to investigate its potential.