Article
Clinical Neurology
Nickalus R. Khan, Turki Elarjani, Aria M. Jamshidi, Stephanie H. Chen, Clifford S. Brown, Josh Abecassis, Michael A. Silva, Victor M. Lu, Eva Wu, Monica Diaz-Kanelidis, Rita Bhatia, Michael E. Hoffer, Adrien A. Eshraghi, Christine T. Dinh, Simon I. Angeli, Fred F. Telischi, Jacques J. Morcos
Summary: This study retrospectively evaluated the clinical and surgical outcomes of a large surgical series of vestibular schwannoma in North America over 20 years. The study found that facial nerve outcomes were correlated with cerebellopontine angle extension, tumor volume, facial nerve stimulation threshold, facial nerve consistency, preoperative facial nerve function, and history of a prior resection. The data supports a continuation of a strategy of gross total resection, modifiable by intraoperative findings and judgment.
WORLD NEUROSURGERY
(2022)
Article
Oncology
Michel Heide Talebnasab, Dan Dupont Hougaard
Summary: Vestibular schwannoma is the most common type of intracranial schwannoma, accounting for about 8% of all intracranial tumors in adults with an estimated incidence rate of around 1.3/100,000. The incidence rates of facial nerve schwannomas and cochlear nerve schwannomas are not well-documented. These three types of nerve tumors often present with unilateral hearing loss, tinnitus, and disequilibrium. Facial nerve palsy is common in facial nerve schwannomas but rare in vestibular schwannomas. The symptoms are usually persistent and progressive, leading to interventions that may cause significant morbidity such as deafness and imbalance.
Article
Clinical Neurology
Zane Schnurman, Jason Gurewitz, Eric Smouha, Sean O. McMenomey, J. Thomas Roland, John G. Golfinos, Douglas Kondziolka
Summary: Through propensity score matching, this study found no significant difference in the loss of class A or serviceable hearing between patients managed with SRS or observation alone when controlling for potential confounders.
Article
Medicine, Research & Experimental
Candace E. Hobson, Joe Saliba, Nopawan Vorasubin, Robert H. Lyles, Bill Mastrodimos, Roberto A. Cueva
Summary: This study shows that the position of vestibular schwannoma relative to the IAC axis can be used along with tumor size to predict postoperative facial outcomes. A greater proportion of tumor posterior to the IAC axis was associated with significantly better facial outcomes.
Article
Otorhinolaryngology
Yin Ren, Bridget MacDonald, Kareem O. Tawfik, Marc S. Schwartz, Rick A. Friedman
Summary: Clinical predictors of facial nerve outcomes after microsurgical resection of vestibular schwannoma were identified, indicating excellent outcomes can be achieved with this procedure. Gross total resection and >= 100-mu V intraoperative FN electromyographic response were found to predict excellent FN outcomes.
OTOLARYNGOLOGY-HEAD AND NECK SURGERY
(2021)
Article
Oncology
Giuseppe Di Perna, Raffaele De Marco, Bianca Maria Baldassarre, Enrico Lo Bue, Fabio Cofano, Pietro Zeppa, Luca Ceroni, Federica Penner, Antonio Melcarne, Diego Garbossa, Michele Maria Lanotte, Francesco Zenga
Summary: This retrospective study aimed to investigate the impact of morphologic and neurophysiological factors on the short- and long-term facial nerve function after vestibular schwannoma resection. A multiparametric score, Facial Nerve Outcome Score (FNOS), was developed and shown to be a reliable predictor of facial nerve function.
FRONTIERS IN ONCOLOGY
(2023)
Article
Clinical Neurology
Michael A. Silva, Henry Chang, Ashish H. Shah, Nickalus R. Khan, Clifford S. Brown, Christine T. Dinh, Adrien A. Eshraghi, Fred F. Telischi, Simon Angeli, Jacques J. Morcos
Summary: Intracisternal papaverine irrigation during vestibular schwannoma resection can safely improve immediate postoperative facial nerve outcomes, maintain similar long-term facial nerve outcomes, and is not associated with a significant increase in complications.
WORLD NEUROSURGERY
(2022)
Article
Clinical Neurology
Kareem O. Tawfik, Marin McDonald, Yin Ren, Omid Moshtaghi, Marc S. Schwartz, Rick A. Friedman
Summary: The study found that preoperative cochlear FIESTA/CISS signal intensity may impact hearing outcomes after surgery for acoustic neuroma. Lower FIESTA/CISS signal ratios were associated with greater declines in hearing, suggesting a potential predictive value for postoperative hearing loss.
OTOLOGY & NEUROTOLOGY
(2021)
Article
Oncology
Sophie Shih-Yueng Wang, Kathrin Machetanz, Florian Ebner, Georgios Naros, Marcos Tatagiba
Summary: Surgical treatment of vestibular schwannoma in elderly patients is feasible and safe, with no significant functional deterioration. However, the extent of tumor resection determines the risk of recurrence, and further adjuvant therapy should be considered if only partial resection can be achieved.
FRONTIERS IN ONCOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Gang Xiao, Bin Huang, Ming Guo, Chaoxin Long, Pingan Li, Bin Zhong, Chuncheng Guan
Summary: BRCAT54 is an anti-tumor lncRNA that is downregulated in lung cancer and its role in vestibular schwannoma (VS) is unclear. This study found that BRCAT54 interacts with miR-21 and suppresses cell proliferation in VS.
Article
Clinical Neurology
Jason Gurewitz, Zane Schnurman, Aya Nakamura, Ralph E. Navarro, Dev N. Patel, Sean O. McMenomey, J. Thomas Roland, John G. Golfinos, Douglas Kondziolka
Summary: This study aimed to investigate the relationship between hearing loss and tumor volumetric growth rates in patients with untreated vestibular schwannoma (VS). The results showed that larger initial tumor size and faster tumor growth rates were associated with an elevated risk of loss of class A and serviceable hearing.
JOURNAL OF NEUROSURGERY
(2022)
Article
Otorhinolaryngology
Catherine Sobieski, Daniel E. Killeen, Samuel L. Barnett, Bruce E. Mickey, Jacob B. Hunter, Brandon Isaacson, Joe Walter Kutz
Summary: Facial nerve outcomes one year after microsurgical resection are poorer in patients with NF2 tumors compared to sporadic tumors, particularly for tumors with a volume greater than 3 cm³ and those classified as NF2 tumors.
OTOLARYNGOLOGY-HEAD AND NECK SURGERY
(2021)
Article
Clinical Neurology
Ricardo Ramina, Gustavo S. Jung, Felipe Constanzo, Erasmo Barros da Silva Jr
Summary: The study aimed to evaluate the effect of nerve position within the internal auditory canal on preoperative and postoperative cochlear and facial nerve function in patients with intracanalicular vestibular schwannoma. The study found that patients with tumors located between the vestibular and facial-cochlear nerves had worse outcomes in terms of facial nerve function and hearing preservation after surgery.
JOURNAL OF NEUROSURGERY
(2023)
Article
Clinical Neurology
Felix Arlt, Johannes Kasper, Dirk Winkler, Katja Jaehne, Michael Karl Fehrenbach, Juergen Meixensberger, Caroline Sander
Summary: Intraoperative neurophysiological monitoring is crucial in vestibular schwannoma surgery to prevent nerve injury. Repeated direct nerve stimulation and a detected decreased amplitude might show facial nerve function deterioration.
FRONTIERS IN NEUROLOGY
(2022)
Article
Otorhinolaryngology
Yin Ren, Kareem O. Tawfik, Bill J. Mastrodimos, Roberto A. Cueva
Summary: Radiographic predictors such as tumor size and extension relative to the internal auditory canal play a significant role in hearing preservation after retrosigmoid resection of vestibular schwannomas. Patients with small intracanalicular tumors and good preoperative hearing have the highest rates of hearing preservation, while tumors extending into the cerebellopontine angle may have worse outcomes if they have greater posterior and caudal extension relative to the internal auditory canal.
OTOLARYNGOLOGY-HEAD AND NECK SURGERY
(2021)
Article
Clinical Neurology
Maysam Alimohamadi, Mohamadreza Hajiabadi, Venelin Gerganov, Rudolf Fahlbusch, Madjid Samii
ACTA NEUROCHIRURGICA
(2015)
Correction
Clinical Neurology
Maysam Alimohamadi, Mohamadreza Hajiabadi, Venelin Gerganov, Rudolf Fahlbusch, Madjid Samii
ACTA NEUROCHIRURGICA
(2016)
Article
Clinical Neurology
Madjid Samii, Hussam Metwali, Venelin Gerganov
JOURNAL OF NEUROSURGERY
(2016)
Article
Clinical Neurology
Madjid Samii, Maysam Alimohamadi, Venelin Gerganov
JOURNAL OF NEUROSURGERY
(2016)
Article
Clinical Neurology
Hussam Metwali, Venelin Gerganov, Rudolf Fahlbusch
JOURNAL OF NEUROSURGERY
(2016)
Article
Clinical Neurology
Madjid Samii, Hussam Metwali, Venelin Gerganov
JOURNAL OF NEUROSURGERY
(2017)
Article
Clinical Neurology
M. Ebeling, W. Luedemann, J. Frisius, M. Karst, I. Schedel, V. Gerganov, A. Samii, R. Fahlbusch
Letter
Clinical Neurology
Hussam Metwali, Venelin Gerganov, Madjid Samii
WORLD NEUROSURGERY
(2018)
Article
Clinical Neurology
Mario Giordano, Venelin M. Gerganov, Massimo Gallieni, Amir Samii, Madjid Samii
WORLD NEUROSURGERY
(2018)
Article
Clinical Neurology
Hussam Metwali, Venelin Gerganov, Breno Nery, Ahmed Aly, Rodrigo Avila-Cervantes, Madjid Samii
WORLD NEUROSURGERY
(2018)
Article
Clinical Neurology
Hussam Metwali, Katja Kniese, Babak Kardavani, Venelin Gerganov, Madjid Samii
JOURNAL OF NEUROSURGERY
(2019)
Article
Clinical Neurology
Hussam Metwali, Amir Samii, Venelin Gerganov, Mario Giordano, Rudolf Fahlbusch, Madjid Samii
WORLD NEUROSURGERY
(2019)
Article
Clinical Neurology
Shunyu Guo, Venelin Gerganov, Mario Giordano, Amir Samii, Madjid Samii
WORLD NEUROSURGERY
(2020)
Review
Clinical Neurology
M. Petrov, V. Gerganov, N. Gabrovsky, M. Kamenova
INTERDISCIPLINARY NEUROSURGERY-ADVANCED TECHNIQUES AND CASE MANAGEMENT
(2020)
Article
Neuroimaging
Mario Giordano, Venelin Gerganov, Hussam Metwali, Massimo Gallieni, Madjid Samii, Amir Samii
NEURORADIOLOGY JOURNAL
(2020)