期刊
JOURNAL OF NEUROSURGERY
卷 113, 期 1, 页码 133-140出版社
AMER ASSOC NEUROLOGICAL SURGEONS
DOI: 10.3171/2010.1.JNS09448
关键词
long-range plasticity; contralateral C-7 nerve transfer; brachial plexus avulsion injury
资金
- National Natural Science Foundation of China [30200288]
- Shanghai Municipal Science and Technology Committee [04DZ19901]
Object. Peripheral nerve injury in a limb usually causes intrahemispheric functional reorganization of the contralateral motor cortex. Recently, evidence has been emerging for significant interhemispheric cortical plasticity in humans, mostly from studies of direct cortical damage. However, in this study, a long-range interhemispheric plasticity was demonstrated in adults with brachial plexus avulsion injury (BPAI) who had received a contralateral cervical nerve transfer, and this plasticity reversed the BPAI-induced intrahemispheric cortical reorganization. Methods. In this study, 8 adult male patients with BPAI were studied using PET scanning. Results. The results indicated that the right somatomotor cortices, which may contribute to the control of the injured limb before brachial plexus deafferentation, still played an important role when patients with BPAI tried to move their affected limbs, despite the fact that the contralateral C-7 nerve transfer had been performed and the peripheral output had changed dramatically. Such findings are consistent with the results of the authors' previous animal study. Conclusions. The brain may try to restore the control of an injured limb to its original cortex area, and a complicated change of peripheral pathway also can induce long-range interhemispheric cortical reorganization in human motor cortex. (DOI: 10.3171/2010.1.JNS09448)
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据