Article
Neurosciences
Eileen Guelke, Martin A. Horn, Julian Caffier, Hans Pinnschmidt, Wolfgang Hamel, Christian K. E. Moll, Alessandro Gulberti, Monika Poetter-Nerger
Summary: This single-center study found that compared to unilateral TBS-DBS, bilateral TBS-DBS has minimal additional effects on the acute motor effects in Parkinson's disease patients.
FRONTIERS IN HUMAN NEUROSCIENCE
(2023)
Article
Clinical Neurology
Maidinamu Yakufujiang, Yoshinori Higuchi, Kyoko Aoyagi, Tatsuya Yamamoto, Toru Sakurai, Midori Abe, Yoji Okahara, Masaki Izumi, Osamu Nagano, Yoshitaka Yamanaka, Shigeki Hirano, Akihiro Shiina, Atsushi Murata, Yasuo Iwadate
Summary: This study found that preoperative evaluation using the Similarities and Object Assembly subtests in patients undergoing STN-DBS surgery may help predict cognitive declines postoperatively, especially in visuospatial functioning. A low score on the Similarities subtest may also predict future global cognitive deterioration.
WORLD NEUROSURGERY
(2021)
Article
Clinical Neurology
Jiping Li, Shanshan Mei, Xiaofei Jia, Yuqing Zhang
Summary: This study demonstrates that deep brain stimulation can effectively suppress levodopa-induced dyskinesia in Parkinson's disease patients without reducing levodopa dosage. The stimulation sites with good anti-dyskinesia effect are located above the subthalamic nucleus.
FRONTIERS IN NEUROLOGY
(2021)
Article
Clinical Neurology
Lais M. Oliveira, Marta Ruiz-Lopez, Alexandre Boutet, Gavin J. B. Elias, Suneil K. Kalia, Mojgan Hodaie, Andres M. Lozano, Renato P. Munhoz, Alfonso Fasano
Summary: The study found that using the advanced functions of the patient programmer delays programming optimization and is associated with a higher number of side effects. Therefore, there is a need for other faster and safer stimulation programming methods.
Review
Clinical Neurology
Hengameh Zahed, Jose Rafael Pantoja Zuzuarregui, Ro'ee Gilron, Timothy Denison, Philip A. Starr, Simon Little
Summary: Sleep disturbances are common nonmotor complications of Parkinson's disease, potentially contributing to disease progression. Limited options currently exist to modulate sleep disturbances, prompting the need for further research into neurophysiological changes affecting sleep in PD.
MOVEMENT DISORDERS
(2021)
Article
Clinical Neurology
Katharine A. Henry, Rohin Singh, Nan Zhang, Mark K. Lyons, Karen McNett, Matthew T. Neal, Shyamal H. Mehta
Summary: This study aimed to objectively assess changes in swallowing in Parkinson's disease (PD) patients following Deep Brain Stimulation (DBS) surgery using gold standard video fluoroscopy (VFS). The results showed that there was no clinically meaningful improvement or reduction in swallow function with DBS, regardless of the site of bilateral lead implantation.
PARKINSONISM & RELATED DISORDERS
(2022)
Article
Clinical Neurology
Shimiao Wang, Shun Gong, Yingqun Tao, Guobiao Liang, Rong Sha, Aotan Xie, Zirui Li, Lijia Yuan
Summary: The study demonstrated that utilizing a modified power-on programming method in DBS for PD can achieve similar clinical outcomes to the traditional method, while being more efficient.
WORLD NEUROSURGERY
(2022)
Article
Clinical Neurology
Xinxia Guo, Chen Feng, Jiali Pu, Hongjie Jiang, Zhoule Zhu, Zhe Zheng, Jianmin Zhang, Gao Chen, Junming Zhu, Hemmings Wu
Summary: The cost-effectiveness of deep brain stimulation (DBS) is more favorable than best medical treatment (BMT) for advanced Parkinson disease (PD) in developed countries. However, it remains unclear in developing countries. This study modeled and evaluated the long-term cost-effectiveness of DBS for advanced PD in China and found that DBS is cost-effective over a 15-year time horizon.
Article
Clinical Neurology
Henry M. Skelton, Dayton P. Grogan, Nealen G. Laxpati, Svjetlana Miocinovic, Robert E. Gross, Nicholas Au Yong
Summary: This study found that there is a significant underutilization of deep brain stimulation (DBS) in Black patients with Parkinson's disease (PD). The rate of evaluation for DBS in Black patients was lower than expected, and patients from regions with larger Black populations were underrepresented. Further research should focus on understanding the reasons behind the disparity in the transition from medical management to surgical evaluation and increase outreach efforts in underserved areas.
Article
Clinical Neurology
Yi Wang, Peng Gao, Xing Zhang, Bo Lv, Ziao Xu, Hongwei Cheng
Summary: The study showed that STN DBS not only improved motor function but also enhanced gastrointestinal motility in patients with PD, leading to shortened gastric emptying time.
WORLD NEUROSURGERY
(2021)
Article
Neurosciences
Amanda R. Merner, Thomas Frazier, Paul J. Ford, Scott E. Cooper, Andre Machado, Brittany Lapin, Jerrold Vitek, Cynthia S. Kubu
Summary: The study found that patients undergoing deep brain stimulation (DBS) treatment experience significant changes in their desired control and perception of global life control. Most participants reported increased perception of global life control post-treatment, while their desired control of stimulation decreased. Furthermore, the data show that patients have nuanced levels of desired control over stimulation.
FRONTIERS IN HUMAN NEUROSCIENCE
(2021)
Article
Clinical Neurology
Jed Noel A. Ong, Jung Hwan Shin, Seungho Jeon, Chan Young Lee, Han-Joon Kim, Sun Ha Paek, Beomseok Jeon
Summary: The study found that most patients develop clinical milestones after undergoing STN-DBS surgery, with the majority experiencing at least one milestone using moderately disabling criteria, particularly when using severely disabling criteria.
JOURNAL OF MOVEMENT DISORDERS
(2022)
Article
Clinical Neurology
Fang Wang, Lulin Dai, Yixin Pan, Peng Huang, Chencheng Zhang, Bomin Sun, Dianyou Li
Summary: This study evaluated the feasibility of unilateral anterior capsulotomy combined with subthalamic nucleus deep brain stimulation (STN-DBS) in managing advanced Parkinson's disease patients with psychosis. The results showed significant improvement in psychosis symptoms, motor symptoms, and quality of life after the combined treatment.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Neurosciences
Bernadette C. M. van Wijk, Wolf-Julian Neumann, Daniel Kroneberg, Andreas Horn, Friederike Irmen, Tilmann H. Sander, Qiang Wang, Vladimir Litvak, Andrea A. Kuehn
Summary: This study investigated the structural connectivity profile of the subthalamic nucleus (STN) using local field potential recordings and simultaneous magnetoencephalography. The results suggest the existence of a frequency-specific topography of cortico-STN coherence within the STN, with considerable spatial overlap between functional networks.
Article
Neurosciences
Chunguang Chu, Naying He, Kristina Zeljic, Zhen Zhang, Jiang Wang, Jun Li, Yu Liu, Youmin Zhang, Bomin Sun, Dianyou Li, Fuhua Yan, Chencheng Zhang, Chen Liu
Summary: The subthalamic nucleus (STN) and globus pallidus internus (GPi) are common targets for deep brain stimulation (DBS) treatment of Parkinson's disease. This study used resting-state fMRI data to investigate the changes in brain network topology associated with stimulation of these targets. The results showed that the stimulation had similar effects on motor brain regions for both targets, but target-specific effects were observed in non-motor brain regions.
Article
Psychology, Clinical
Adrianna M. Ratajska, Francesca Lopez, Lauren Kenney, Charles Jacobson, Kelly D. Foote, Michael S. Okun, Dawn Bowers
Summary: The study identified three cognitive subtypes of ET patients undergoing DBS, with 27.4% meeting criteria for MCI. The majority of MCI cases were in the Low Executive or Low Memory Multi-Domain groups, with the latter having a higher percentage of members classified as MCI. Future work should focus on examining these subgroups for progression to dementia.
CLINICAL NEUROPSYCHOLOGIST
(2022)
Article
Psychology, Multidisciplinary
Adrianna M. Ratajska, Anne N. Nisenzon, Francesca Lopez, Alexandra L. Clark, Didem Gokcay, Michael S. Okun, Dawn Bowers
Summary: The study found that patients with left-sided symptom onset in Parkinson's disease were slower to initiate anger and happiness facial expressions compared to patients with right-sided symptom onset and healthy controls.
Article
Clinical Neurology
Grace K. Kellaher, Sidney T. Baudendistel, Ryan T. Roemmich, Matthew J. Terza, Chris J. Hass
Summary: Individuals with Parkinson's disease demonstrated impaired interlimb coordination, particularly between the more affected arm and legs, during backward walking compared to healthy controls. This may contribute to difficulties in walking for those with Parkinson's disease, highlighting the importance of understanding and addressing coordination deficits in rehabilitation strategies.
PARKINSONISM & RELATED DISORDERS
(2022)
Article
Geriatrics & Gerontology
Ania L. Lipat, David J. Clark, Chris J. Hass, Yenisel Cruz-Almeida
Summary: This study identified and characterized three different gait clusters (Normal Gait, Shuffle Gait, and Unsteady Gait) within the older adult chronic pain population. The Shuffle Gait cluster exhibited reduced gray matter volume in certain brain regions and higher pain severity compared to other clusters, highlighting the importance of considering gait subgroups in future studies on pain, mobility, and aging.
EXPERIMENTAL GERONTOLOGY
(2022)
Article
Biophysics
Francesca E. Wade, Grace K. Kellaher, Sarah Pesquera, Sidney T. Baudendistel, Arkaprava Roy, David J. Clark, Rachael D. Seidler, Daniel P. Ferris, Todd M. Manini, Chris J. Hass
Summary: The ability to adapt walking speed is crucial for independent mobility, and this ability diminishes with age. This study examined the biomechanical parameters during transitions from preferred walking speed to slower or faster walking in older and younger adults. The findings showed distinct changes in step length, hip flexion, and dorsiflexion during the transition, as well as altered timing of peak joint angles in older adults. This study provides important insights into the kinematics of walking speed transitions in different age groups.
JOURNAL OF BIOMECHANICS
(2022)
Editorial Material
Biochemistry & Molecular Biology
Veerle Visser-Vandewalle, Pablo Andrade, Philip E. Mosley, Benjamin D. Greenberg, Rick Schuurman, Nicole C. McLaughlin, Valerie Voon, Paul Krack, Kelly D. Foote, Helen S. Mayberg, Martijn Figee, Brian H. Kopell, Mircea Polosan, Eileen M. Joyce, Stephan Chabardes, Keith Matthews, Juan C. Baldermann, Himanshu Tyagi, Paul E. Holtzheimer, Chris Bervoets, Clement Hamani, Carine Karachi, Damiaan Denys, Ludvic Zrinzo, Patric Blomstedt, Matilda Naesstrom, Aviva Abosch, Steven Rasmussen, Volker A. Coenen, Thomas E. Schlaepfer, Darin D. Dougherty, Philippe Domenech, Peter Silburn, James Giordano, Andres M. Lozano, Sameer A. Sheth, Terry Coyne, Jens Kuhn, Luc Mallet, Bart Nuttin, Marwan Hariz, Michael S. Okun
Summary: Deep brain stimulation is an effective but underutilized treatment for obsessive-compulsive disorder. Psychologists, psychiatrists, and insurers should take action to make this therapy accessible to patients with otherwise intractable cases, in order to improve their mental health.
Article
Psychology, Clinical
Adrianna M. Ratajska, Bonnie M. Scott, Francesca V. Lopez, Lauren E. Kenney, Kelly D. Foote, Michael S. Okun, Catherine Price, Dawn Bowers
Summary: This study compared the severity of mood symptoms in PD, ET, and HC groups and examined the relationship between mood and cognition. The results showed that both PD and ET groups reported more mood symptoms and lower cognitive scores compared to the HC group. The relationship between mood and cognition differed between PD and ET groups.
JOURNAL OF CLINICAL AND EXPERIMENTAL NEUROPSYCHOLOGY
(2022)
Article
Multidisciplinary Sciences
Ryan J. Downey, Natalie Richer, Rohan Gupta, Chang Liu, Erika M. Pliner, Arkaprava Roy, Jungyun Hwang, David J. Clark, Chris J. Hass, Todd M. Manini, Rachael D. Seidler, Daniel P. Ferris
Summary: This study investigated the effects of altering terrain unevenness on gait kinematics, and found that increasing terrain unevenness led to greater stride-to-stride variability and reduced perceived stability in participants.
Article
Clinical Neurology
Bonnie M. Scott, Robert S. Eisinger, Amtul-noor Rana, Jared F. Benge, Robin C. Hilsabeck, Michael S. Okun, Aysegul Gunduz, Dawn Bowers
Summary: Patients with both apathy and ICD exhibit significantly greater symptoms of positive and negative urgency, consummatory anhedonia, lack of premeditation and perseverance. Patients with apathy only showed significantly greater anticipatory anhedonia than those with ICD only or neither.
APPLIED NEUROPSYCHOLOGY-ADULT
(2022)
Article
Clinical Neurology
Frederick L. Hitti, Alik S. Widge, Patricio Riva-Posse, Donald A. Malone Jr, Michael S. Okun, Maryam M. Shanechi, Kelly D. Foote, Sarah H. Lisanby, Elizabeth Ankudowich, Srinivas Chivukula, Edward F. Chang, Aysegul Gunduz, Clement Hamani, Ashley Feinsinger, Cynthia S. Kubu, Winston Chiong, Jennifer A. Chandler, Rafael Carbunaru, Binith Cheeran, Robert S. Raike, Rachel A. Davis, Casey H. Halpern, Nora Vanegas-Arroyave, Dejan Markovic, Sarah K. Bick, Cameron C. McIntyre, R. Mark Richardson, Darin D. Dougherty, Brian H. Kopell, Jennifer A. Sweet, Wayne K. Goodman, Sameer A. Sheth, Nader Pouratian
Summary: Despite advances in treatment, neuromodulation, such as deep brain stimulation, has not gained widespread adoption as a potential therapy for psychiatric diseases. In 2016, the American Society for Stereotactic and Functional Neurosurgery organized a meeting to discuss the future path forward. A follow-up meeting in 2022 aimed to review the current state of the field and identify barriers and milestones for progress.
Article
Neurosciences
Bradley J. Wilkes, Emily R. Tobin, David J. Arpin, Wei-en Wang, Michael S. Okun, Michael S. Jaffee, Nikolaus R. McFarland, Daniel M. Corcos, David E. Vaillancourt
Summary: Objective measures of disease progression using the Purdue Pegboard Test (PPT) were conducted in patients with Parkinson's disease (PD), atypical Parkinsonism, and healthy controls. The decline in PPT performance in PD patients correlated with motor symptom progression, while no such decline was seen in controls. Neuroimaging measures from the basal ganglia were significant predictors of PPT performance in PD, and cortical, basal ganglia, and cerebellar regions were predictors for atypical Parkinsonism. Accelerometry in PD patients showed diminished acceleration range and irregular patterns, which correlated with PPT scores.
NPJ PARKINSONS DISEASE
(2023)
Article
Clinical Neurology
Robert S. Eisinger, Michael S. Okun, Stephanie Cernera, Jackson Cagle, Matthew Beke, Adolfo Ramirez-Zamora, B. Hope Kim, Daniel A. N. Barbosa, Liming Qiu, Pavan Vaswani, Whitley W. Aamodt, Casey H. Halpern, Kelly D. Foote, Aysegul Gunduz, Leonardo Almeida
Summary: Weight loss in Parkinson's disease patients accelerates before death. Patients who underwent deep brain stimulation surgery gained weight, and higher post-operative weight correlates with longer survival.
PARKINSONISM & RELATED DISORDERS
(2023)
Article
Clinical Neurology
Yoon Jin Choi, Basma Yacoubi, Agostina Casamento-Moran, Stefan Delmas, Bradley J. Wilkes, Christopher W. Hess, Aparna Wagle Shukla, Kelly D. Foote, David E. Vaillancourt, Michael S. Okun, Evangelos A. Christou
Summary: The study found that VIM DBS was effective in improving gait and balance in ET DBS patients. The improvements in gait and postural balance were associated with a reduction in axial tremor during the tasks.
TREMOR AND OTHER HYPERKINETIC MOVEMENTS
(2022)