期刊
JOURNAL OF NEUROSURGERY
卷 111, 期 4, 页码 825-831出版社
AMER ASSOC NEUROLOGICAL SURGEONS
DOI: 10.3171/2009.4.JNS09246
关键词
stereotactic radiosurgery; gamma knife; cancer; brain metastases; surgery
资金
- Osaka Medical Research Foundation for Incurable Diseases
Object. Radiosurgery for brain metastasis fails in some patients, who require further surgical care. In this paper the authors' goal was to evaluate prognostic factors that correlate with the survival of patients who require a resection of a brain metastasis after stereotactic radiosurgery (SRS). Methods. During the last 14 years when surgical navigation systems were routinely available, the authors identified 58 patients who required resection for various brain metastases after SRS. The median patient age was 54 years. Prior adjuvant treatment included whole-brain radiation therapy alone (17 patients), chemotherapy alone (9 patients), both radiotherapy and chemotherapy (10 patients), and prior resection before SRS (8 patients). The median target volumes at the time of SRS and resection were 7.7 cm(3) (range 0.5-24.9 cm(3)) and 15.5 cm(3) (range 1.3-81.2 cm(3)), respectively. Results. At a median follow-up of 7.6 months, 8 patients (14%) were living and 50 patients (86%) had died. The survival after surgical removal was 65, 30, and 16% at 6, 12, and 24 months, respectively (median survival after resection 7.7 months). The local tumor control rate after resection was 71, 62, and 43% at 6, 12, and 24 months, respectively. A univariate analysis revealed that patient preoperative recursive partitioning analysis classification, Karnofsky Performance Scale status, systemic disease status, and the interval between SRS and resection were factors associated with patient survival. The mortality and morbidity rates of resection were 1.7 and 6.9%, respectively. Conclusions. In patients with symptomatic mass effect after radiosurgery, resection may be warranted. Patients who had delayed local progression after SRS (>3 months) had the best outcomes after resection. (DOI: 10.3171/2009.4.JNS09246)
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