Dependency of cerebrospinal fluid outflow resistance on intracranial pressure

Object. The outflow resistance (R-out) of the cerebrospinal fluid (CSF) system has generally been accepted by most investigators as independent of intracranial pressure (ICP). but there are also those claiming that it is not. The general belief is that this question has been investigated numerous times in the past, but few studies have actually been specifically aimed at looking at this relationship. and no study has been able to provide scientific evidence to elucidate fully this fundamental and important issue. The objective of this study was to investigate the relationship between ICP and CSF Outflow in 30 patients investigated for idiopathic normal-pressure hydrocephalus. Methods. Lumbar infusion tests with constant pressure levels were performed. and ICP and corresponding flow were measured on 6 pressure levels for each patient. All data were standardized for comparison. Results. In the range of moderate increases from baseline pressure (similar to 5-12 min Hg, mean baseline pressure 11.7 mm Hg), the assumption of a pressure-independent R-out was confirmed (p = 0.5). However. when the pressure increment from baseline pressure was larger (similar to 15-22 mm Hg). the relationship had a nonlinear tendency (p < 0.05). Conclusions. The results of this study support the classic textbook theory of a pressure-independent R-out in the normal ICP range. where the CSF system is commonly operating. However, the theory might have to be questioned in regions where ICP exceeds baseline pressure by too much.