Article
Critical Care Medicine
Judith Bellapart, Fatima Nasrallah, James Winearls, Melissa Lassig-Smith, Janine Stuart, Rob Boots, Craig Winter, Dylan Flaws, Andrew Bulmer, Lee Jones, Kevin Bjorn Laupland
Summary: The study aimed to establish the diagnostic sensitivity of Endothelin-1 for clinical vasospasm after subarachnoid hemorrhage, concluding that its levels do not effectively predict symptomatic vasospasm. Variability in Endothelin-1 levels may limit its usefulness as a biomarker for predicting clinical events.
JOURNAL OF INTENSIVE CARE MEDICINE
(2022)
Review
Clinical Neurology
Mojtaba Dayyani, Behnam Sadeghirad, James C. Grotta, Samira Zabihyan, Saba Ahmadvand, Yuting Wang, Gordon H. Guyatt, Sepideh Amin-Hanjani
Summary: Network meta-analysis showed that nimodipine and cilostazol were likely the most effective treatments in preventing morbidity and mortality in patients with aneurysmal subarachnoid hemorrhage. Clazosentan, nicardipine, fasudil, and magnesium showed beneficial effects on delayed cerebral ischemia and vasospasm but they were not found to reduce mortality or disability.
Review
Clinical Neurology
Adam Beighley, Ryan Glynn, Tyler Scullen, Mansour Mathkour, Cassidy Werner, John F. Berry, Christopher Carr, Hussam Abou-Al-Shaar, Aimee Aysenne, John D. Nerva, Aaron S. Dumont
Summary: Aneurysmal subarachnoid hemorrhage (aSAH) during pregnancy requires early transfer to a specialized facility with neurocritical care, high-risk obstetric service, and neurosurgery team for management. Intensive monitoring and a multidisciplinary approach are essential to ensure maternal and fetal health.
NEUROSURGICAL REVIEW
(2021)
Article
Clinical Neurology
Julian Zimmermann, Johannes Weller, Sven Grub, Sied Kebir, Felix Lehmann, Hartmut Vatter, Patrick Schuss, Erdem Gueresir, Marcus Mueller
Summary: In aneurysmal subarachnoid hemorrhage (SAH), the enzyme arginase-1 is released into cerebrospinal fluid, leading to dysregulated metabolism of L-arginine. The levels of arginase-1 and the Arg/Orn ratio are associated with the occurrence of cerebral vasospasm syndrome (CVS), providing a novel prognostic biomarker for SAH.
TRANSLATIONAL STROKE RESEARCH
(2022)
Article
Clinical Neurology
S. Tsutsui, T. Matsuda, K. Takeda, M. Sasaki, Y. Kubo, K. Setta, S. Fujiwara, K. Chida, K. Ogasawara
Summary: This study aimed to quantitatively assess temperature increases on various types of titanium alloy aneurysm clips during 7T MR imaging. Results showed temperature increases varied among different types of clips, with some exceeding regulatory limits.
AMERICAN JOURNAL OF NEURORADIOLOGY
(2022)
Article
Medicine, General & Internal
Helena Merkel, Dirk Lindner, Khaled Gaber, Svitlana Ziganshyna, Jennifer Jentzsch, Simone Mucha, Thilo Gerhards, Sabine Sari, Annika Stock, Felicitas Vothel, Lea Falter, Ulf Quaeschling, Karl-Titus Hoffmann, Juergen Meixensberger, Dirk Halama, Cindy Richter
Summary: This study proposes a visual classification scheme for cerebral vasospasm that is suitable for endovascular treatment. The results show good agreement between mathematical clustering and physician scoring. Additionally, the study finds that a threshold-based criterion does not provide additional advantages, and automated vessel analysis is superior in research settings.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Clinical Neurology
Michael Ortiz, Ravi S. Nunna, Kaushik Ravipati, Angela Tran, Adnan Qureshi, Farhan Siddiq
Summary: Dantrolene shows promise as a therapeutic agent for cerebral vasospasm, with potential for both intra-arterial and intravenous administration, but uncertainties remain regarding dosage and safety. Limited clinical data suggest efficacy in treating cerebral vasospasm, but the level of evidence is low, requiring further high-quality studies.
WORLD NEUROSURGERY
(2022)
Review
Biochemistry & Molecular Biology
Matthias Simon, Alexander Grote
Summary: IL-6 is a proinflammatory cytokine that may serve as a potential biomarker in SAH patients, although discrepancies in research findings and lack of defined clinical endpoints hinder its routine clinical use. Further research is needed to better understand the role of IL-6 and neuroinflammation in the pathophysiology of SAH.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Michele Romoli, Fabrizio Giammello, Maria Giulia Mosconi, Antonio De Mase, Giovanna De Marco, Anna Digiovanni, Antonio Ciacciarelli, Raffaele Ornello, Benedetta Storti
Summary: Understanding the immunological mechanisms involved in SAH complications is crucial for predicting and treating vasospasm, which can improve prognosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Clinical Neurology
E. Francois Aldrich, Randall Higashida, Abdel Hmissi, Elizabeth J. Le, R. Loch Macdonald, Angelina Marr, Stephan A. Mayer, Sebastien Roux, Nicolas Bruder
Summary: Aneurysmal subarachnoid hemorrhage (aSAH) is associated with significant morbidity and mortality. The presence of thick, diffuse subarachnoid blood may indicate a worse clinical course and outcome, independently of other known prognostic factors. Patients with thick and diffuse SAH have higher rates of mortality, vasospasm-related morbidity, and poor clinical outcomes compared to those without thick and diffuse SAH.
JOURNAL OF NEUROSURGERY
(2021)
Article
Clinical Neurology
Christian Fung, Werner J. Z'Graggen, Stephan M. Jakob, Jan Gralla, Matthias Haenggi, Hans-Ulrich Rothen, Pasquale Mordasini, Michael Lensch, Nicole Soell, Nicole Terpolilli, Sergej Feiler, Markus F. Oertel, Andreas Raabe, Nikolaus Plesnila, Jukka Takala, Juergen Beck
Summary: The administration of iNO in patients with SAH is safe and improves tissue perfusion. Further large-scale prospective evaluation is needed.
FRONTIERS IN NEUROLOGY
(2022)
Review
Neurosciences
Marta Aleksandrowicz, Ewa Kozniewska
Summary: Hyponatremia, a water-electrolyte balance disorder, is associated with delayed cerebrovascular spasm and cerebral ischemia following subarachnoid hemorrhage. Reduced sodium ion concentration affects the regulation and tone of cerebral blood vessels, depending on their location and environmental conditions.
EXPERIMENTAL NEUROLOGY
(2022)
Article
Clinical Neurology
Chloe Louise Gelder, Melissa Bautista, Sidra Arif Awan, Ian A. Anderson
Summary: Patients with aSAH who develop diarrhea have a significantly higher risk of developing DIND. The use of osmotic laxatives can lead to enteral volume loss, which is a potential risk factor for DIND after aSAH.
NEUROSURGICAL FOCUS
(2022)
Article
Biology
Jong Kook Rhim, Dong Hyuk Youn, Bong Jun Kim, Youngmi Kim, Sungeun Kim, Heung Cheol Kim, Jin Pyeong Jeon
Summary: Continuous monitoring of plasma copeptin levels facilitates the screening of DCI in poor-grade SAH patients, while the relationship between CRP levels and DCI is not significant. Additionally, predicting DCI by combining TCD with copeptin changes has a better outcome than using TCD alone.
Article
Medicine, General & Internal
Ali Khanafer, Pervinder Bhogal, Victoria Hellstern, Christoph Harmening, Hansjoerg Baezner, Oliver Ganslandt, Hans Henkes
Summary: This study analyzed the diagnosis and management of patients with aneurysmal subarachnoid hemorrhage who died from ischemic brain damage caused by vasospasm. It was found that early recognition of severe vasospasm is crucial for treatment, but aggressive treatment may not prevent death.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Clinical Neurology
Robert J. Rothrock, Alexander G. Chartrain, Jacopo Scaggiante, Jonathan Pan, Rui Song, Danny Hom, Adam C. Lieber, Joshua B. Bederson, J. Mocco, Christopher P. Kellner
Summary: This study summarizes the operative nuances of endoscopic minimally invasive ICH evacuation developed at a single center over an experience of 80 procedures. The results show a significant reduction in preoperative and postoperative ICH volume, with an evacuation rate of 88.7% and a 30-day mortality rate of 8.9%. It emphasizes the importance of academic discussion of specific surgical techniques to enhance safety and efficacy as experience builds with this procedure.
OPERATIVE NEUROSURGERY
(2021)
Editorial Material
Neuroimaging
Zachary Troiani, Luis C. Ascanio, Kurt A. Yaeger, Muhammad Ali, Christopher Paul Kellner
JOURNAL OF NEUROINTERVENTIONAL SURGERY
(2021)
Review
Clinical Neurology
D. T. Goldman, D. Bageac, A. Mills, B. Yim, K. Yaeger, S. Majidi, C. P. Kellner, R. A. De Leacy
Summary: The study evaluated the safety and feasibility of transradial approach and distal transradial access for neuroendovascular procedures, showing that these methods are safe and effective for a wide range of neuroendovascular interventions with a high technical success rate. Despite some adverse events and complications, overall risks are relatively low.
AMERICAN JOURNAL OF NEURORADIOLOGY
(2021)
Article
Neurosciences
Amol Mehta, Johanna T. Fifi, Hazem Shoirah, I. Paul Singh, Tomoyoshi Shigematsu, Christopher P. Kellner, Reade De Leacy, J. Mocco, Shahram Majidi
Summary: From 2014 to 2016, there was a two-fold increase in the utilization of EVT in patients >= 80 years of age. The rate of good outcome in patients over 80 was significantly lower at 9% compared to younger patients at 26%. Additionally, the in-hospital mortality rate for patients >= 80 was higher at 19% compared to 13% in the younger cohort.
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2021)
Article
Clinical Neurology
Raul G. Nogueira, Jason M. Davies, Rishi Gupta, Ameer E. Hassan, Thomas Devlin, Diogo C. Haussen, Mahmoud H. Mohammaden, Christopher P. Kellner, Adam Arthur, Lucas Elijovich, Kumiko Owada, Dina Begun, Mukund Narayan, Nadia Mordenfeld, Wondwossen G. Tekle, Fadi Nahab, Tudor G. Jovin, Don Frei, Adnan H. Siddiqui, Michael R. Frankel, J. Mocco
Summary: This study evaluated the impact of COVID-19 on acute stroke screening using a commercial clinical artificial intelligence platform. Results showed a significant decline in stroke imaging screening during the pandemic, emphasizing the wider application of artificial intelligence neuroimaging platforms for real-time monitoring of stroke care systems.
Article
Clinical Neurology
A. M. Mehta, J. T. Fifi, H. Shoirah, T. Shigematsu, T. J. Oxley, C. P. Kellner, R. De Leacy, J. Mocco, S. Majidi
Summary: The study aimed to characterize disparities in the use of endovascular thrombectomy in acute ischemic stroke treatment based on race and income. Data from 2006 to 2016 showed an overall increase in endovascular thrombectomy use, with less significant growth observed in black patients and those in the lowest income quartile. The highest income quartile predicted higher rates of endovascular thrombectomy use and better outcomes, while black race predicted poorer outcomes.
AMERICAN JOURNAL OF NEURORADIOLOGY
(2021)
Article
Health Care Sciences & Services
Laura Tabacof, Jamie Wood, Nicki Mohammadi, Katherine E. Link, Jenna Tosto-Mancuso, Sophie Dewil, Erica Breyman, Leila Nasr, Christopher Kellner, David Putrino
Summary: Telehealth, particularly the Precision Recovery Program (PRP), was utilized during the COVID-19 pandemic to remotely monitor and support patients at home. A retrospective cohort study identified common factors (risk factors, vital signs, and symptoms) among patients requiring screening, triage, and hospitalization, providing valuable information for decision making. Implementing similar clinician-led remote patient monitoring programs may be beneficial for COVID-19 cohorts and other conditions at risk of rapid clinical deterioration in the home setting.
TELEMEDICINE AND E-HEALTH
(2022)
Article
Clinical Neurology
Emma Reford, Christopher P. Kellner
Summary: Stroke and COVID-19, both traumatic and life-changing experiences, present significant challenges during the pandemic. Investigating isolated stroke and the co-occurrence of stroke and COVID-19 is important on both medical and humanistic levels.
Review
Clinical Neurology
Dominic Nistal, Muhammad Ali, Daniel Wei, J. Mocco, Christopher Kellner
Summary: The study found that statins significantly improved behavioral outcomes in intracerebral hemorrhage (ICH), with variable results in histological outcomes. This suggests that statin therapy may be suitable for randomized clinical trials in humans, and that the STAIR criteria can be effectively modified to evaluate preclinical studies in ICH.
WORLD NEUROSURGERY
(2021)
Editorial Material
Neuroimaging
Christopher Paul Kellner, J. Mocco
JOURNAL OF NEUROINTERVENTIONAL SURGERY
(2023)
Article
Neuroimaging
Timothy J. Kleinig, Amal Abou-Hamden, John Laidlaw, Leonid Churilov, Christopher Paul Kellner, Teddy Wu, J. Mocco, Hui Lau, Alexios Adamides, Bhadrakant Kavar, James Dimou, Jennifer Cranefield, Amy McDonald, Stephanie Plummer, Stephen Davis, Bruce C. Campbell
Summary: This study aimed to demonstrate the safety, feasibility, and promise of efficacy of early minimally invasive surgery (MIS) for intracerebral hemorrhage (ICH) using the Aurora Surgiscope and Evacuator. The results showed that MIS was feasible and safe, with positive outcomes observed in the majority of patients. Further exploration of this method is warranted.
JOURNAL OF NEUROINTERVENTIONAL SURGERY
(2023)
Article
Cardiac & Cardiovascular Systems
Alexander J. Schupper, Mirhojjat Khorasanizadeh, Christina P. Rossitto, Lydia D. Foster, Christopher P. Kellner, Jose I. Suarez, Adnan I. Qureshi, Shahram Majidi
Summary: This study evaluated the impact of smoking on hematoma expansion and clinical outcome in patients with primary intracerebral hemorrhage. The results showed that smoking was associated with hematoma expansion, but had no significant effect on death and disability rates.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Health Care Sciences & Services
Tosto-Mancuso
Summary: This study demonstrated the feasibility of remote patient monitoring in patients poststroke or at immediate risk of stroke, and facilitates the triage of care when blood pressure exceeds recommended limits.
TELEMEDICINE REPORTS
(2022)
Article
Health Care Sciences & Services
Jenna M. Tosto-Mancuso, David Putrino, Jamie Wood, Laura Tabacof, Erica Breyman, Leila Nasr, Nicki Mohammadi, Neha S. Dangayach, Christopher P. Kellner
Summary: This study investigated the application of remote patient monitoring of blood pressure in patients poststroke or at immediate risk of stroke and its impact on triage and escalation of care. The study demonstrated the feasibility of using remote patient monitoring to triage care when blood pressure is elevated above recommended limits.
TELEMEDICINE REPORTS
(2022)
Article
Medicine, General & Internal
Katty Wu, Kurt A. Yaeger, Christopher Paul Kellner, Hazem Shoirah
Summary: This study presents a simultaneous bilateral thrombectomy method for acute bilateral middle cerebral artery occlusions, resulting in successful vessel recanalisation without hemorrhagic complications. However, the patient's unfavorable outcome was complicated by a history of heart failure and other cardiac-related problems, requiring maximal assistance at a skilled nursing facility.