Article
Biochemistry & Molecular Biology
Minghua Xian, Jiale Cai, Kening Zheng, Qu Liu, Yali Liu, Huiting Lin, Shengwang Liang, Shumei Wang
Summary: AE has a protective effect against cerebral ischemia-reperfusion injury, possibly through the PI3K/AKT/mTOR and NF-kappa B signaling pathways.
Article
Neurosciences
Haiying Li, Xiang Li, Zhongmou Xu, Jinxin Lu, Chang Cao, Wanchun You, Zhengquan Yu, Haitao Shen, Gang Chen
Summary: This study reveals the dual role of autophagy in cerebral ischemia-reperfusion injury and highlights the potential of targeting specific proteins associated with autophagy for improving the prognosis of ischemic stroke.
JOURNAL OF NEUROSCIENCE
(2022)
Review
Biochemistry & Molecular Biology
Huixia Geng, Luna Chen, Jing Tang, Yi'ang Chen, Lai Wang
Summary: CCL2/CCR2 signaling pathway plays an important role in the pathogenesis of stroke, both exacerbating brain injury and promoting neurological function recovery. Studies suggest that inhibiting CCL2/CCR2 in the acute phase can reduce neuroinflammation and brain injury, while promoting neurological function recovery in the chronic phase.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Ming-Shu Xu, Lei-Miao Yin, Ai-Fang Cheng, Ying-Jie Zhang, Di Zhang, Miao-Miao Tao, Yun-Yi Deng, Lin-Bao Ge, Chun-Lei Shan
Summary: The study found that high expression of Cofilin-1 after cerebral ischemia-reperfusion correlates with motor function deficits, suggesting that Cofilin-1 may partially affect motor cortex function.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Kemeng Zhao, Pengwei Wang, Xiaoguang Tang, Na Chang, Haonan Shi, Longfei Guo, Bingyi Wang, Pengfei Yang, Tiantian Zhu, Xinghua Zhao
Summary: Stroke is caused by ruptured or blocked cerebral blood vessels and subsequent disruption of brain blood circulation, resulting in rapid neurological deficits. The majority of stroke cases are ischemic strokes. Current treatments for ischemic stroke, such as t-PA thrombolytic therapy and surgical thrombectomy, can paradoxically lead to ischemia-reperfusion injury, exacerbating brain damage. Minocycline, a semi-synthetic tetracycline antibiotic, has demonstrated a wide range of neuroprotective effects independent of its antibacterial activity. In this article, we summarize the mechanisms underlying the protective effects of minocycline against cerebral ischemia-reperfusion injury, including modulation of oxidative stress, inflammatory response, excitotoxicity, programmed cell death, and blood-brain barrier injury. We also discuss the role of minocycline in alleviating stroke-related complications, providing a theoretical basis for its clinical application in cerebral ischemia-reperfusion injury.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Neurosciences
Yi Zhong, Bo Yin, Yingze Ye, Omar Y. A. T. Dekhel, Xiaoxing Xiong, Zhihong Jian, Lijuan Gu
Summary: The JAK2/STAT3 signaling pathway plays a crucial role in ischemic stroke by regulating inflammatory response, apoptosis, oxidative stress, and angiogenesis.
EXPERIMENTAL NEUROLOGY
(2021)
Article
Biochemistry & Molecular Biology
Dalia O. Saleh, Maha Nasr, Azza Hassan, Sally A. El-Awdan, Gehad A. Abdel Jaleel
Summary: The aim of this study was to investigate the therapeutic effects of curcumin nanoemulsion (NC) on cerebral damage in diabetic rats. The results showed that NC treatment reduced neurological deficit and redox imbalance, decreased inflammation and apoptosis, and restored glucose transporter 1 expression in the brain.
JOURNAL OF FOOD BIOCHEMISTRY
(2022)
Article
Multidisciplinary Sciences
Ye Tian, Lin Wang, Xiaojing Fan, Hui Zhang, Zhiwei Dong, Tianzhu Tao
Summary: This study found that beta-PAE can significantly alter sepsis-induced neuroinflammation and microglia activation, thereby reversing cognitive decline and improving peripheral immune function. The neuroprotective effects may be mediated through the activation of the Sirt1/Nrf2/HO-1 pathway. beta-PAE may serve as a promising therapeutic agent for the prevention and treatment of SAE.
Article
Behavioral Sciences
Ying Li, Min Gong
Summary: The treatment of cerebral ischemia-reperfusion injury remains a challenge, with GLP-1 receptor agonist Liraglutide showing promising effects in alleviating this type of injury. This study aimed to clarify the physiological protection role of Liraglutide in MCAO mice, revealing that it significantly reduced infarct volume and induced various effects on protein expression levels and phosphorylation. These findings contribute to identifying novel therapeutic targets for ischemia-reperfusion injury.
BRAIN AND BEHAVIOR
(2021)
Article
Medicine, Research & Experimental
Wenya Bai, Siying Huo, Guilin Zhou, Junjie Li, Yuan Yang, Jianlin Shao
Summary: This study investigated the potential of Biliverdin to alleviate cerebral ischemia reperfusion injury (CIRI) by inhibiting pyroptosis. Biliverdin was found to significantly alleviate CIRI both in vivo and in vitro by activating the Nrf2/A20/eEF1A2 axis, which in turn inhibited the NF-KB pathway. The findings of this study provide insights into novel therapeutic targets for the treatment of CIRI.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Medicine, Research & Experimental
Miaolin Zeng, Huifen Zhou, Yu He, Zhixiong Wang, Chongyu Shao, Junjun Yin, Haixia Du, Jiehong Yang, Haitong Wan
Summary: The study found that DHI can improve neurological function, reduce cerebral infarction, alleviate cerebral edema, improve microcirculatory perfusion, inhibit apoptosis, enhance neuronal survival, reduce oxidative stress, restore cytoplasmic glycolytic activity, increase PDH activity by inhibiting the HIF1 alpha/ PDK1 pathway, thereby eliminating the inhibitory effect of CI/R on mitochondrial metabolism.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Review
Medicine, Research & Experimental
Qianghua Yuan, Yan Yuan, Yan Zheng, Rong Sheng, Li Liu, Fan Xie, Jing Tan
Summary: Cerebral ischemia-reperfusion injury can lead to serious brain diseases and polysaccharides may be a potential treatment. Research shows that polysaccharides can improve neural damage through various mechanisms such as anti-oxidation and anti-inflammation.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Review
Medicine, Research & Experimental
Jie Huang, Lei Chen, Zi-meng Yao, Xiao-rong Sun, Xu-hui Tong, Shu-ying Dong
Summary: Stroke, particularly ischemic stroke, is a major cause of death and disability worldwide. Reperfusion, the restoration of blood supply, is crucial for treatment, but it can also worsen the injury through cerebral ischemia-reperfusion injury (CIRI). Mitochondrial dysfunction is a key characteristic of CIRI, and improving mitochondrial dynamics is considered a potential therapeutic approach to improve outcomes.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Chemistry, Physical
Wei Liu, Haowei Lu, Xiaoyong Rao, Xiang Li, Hongdan Lu, Feifei Li, Yan He, Riyue Yu, Rongsheng Zhong, Yao Zhang, Xiaojian Luo, Hongliang Xin
Summary: Inflammation is the main pathological mechanism of cerebral ischemia-reperfusion injury (CIRI), and neutrophils play a role in facilitating drug delivery to the ischemic penumbra through chemotaxis. Puerarin, a neuroprotective isoflavone derivative, is hindered by the blood-brain barrier in treating CIRI. Using neutrophils as carriers can enhance the BBB penetration of puerarin, improving its concentration in the brain parenchyma and enhancing neuroprotection at the ischemic penumbra in response to inflammatory conditions associated with brain injury.
Article
Biochemistry & Molecular Biology
Jiabei Ye, Yudong Shan, Xiaohong Zhou, Tian Tian, Weijuan Gao
Summary: This study detected the changes of circular RNAs (circRNAs) in the key penumbra area during cerebral ischemia-reperfusion (CI/R) injury in rats and established a circRNA-miRNA-mRNA network. It identified circRNAs associated with CI/R injury and suggested their potential as biomarkers for ischemic stroke treatment.
JOURNAL OF MOLECULAR NEUROSCIENCE
(2023)