Which way does the citric acid cycle turn during hypoxia? The critical role of α-ketoglutarate dehydrogenase complex

An anticancer agent, pyrvinium pamoate inhibits the NADH–fumarate reductase system—a unique mitochondrial energy metabolism in tumour microenvironments

(2012) Eriko Tomitsuka et al.   JOURNAL OF BIOCHEMISTRY

Identification and Functional Expression of the Mitochondrial Pyruvate Carrier

(2012) S. Herzig et al.   SCIENCE

A Mitochondrial Pyruvate Carrier Required for Pyruvate Uptake in Yeast, Drosophila, and Humans

(2012) D. K. Bricker et al.   SCIENCE

Regulation of the structure and activity of pyruvate carboxylase by acetyl CoA

(2011) Abdussalam Adina-Zada et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Detailed kinetics and regulation of mammalian 2-oxoglutarate dehydrogenase

(2011) Feng Qi et al.   BMC BIOCHEMISTRY

Mitochondrial consumption of cytosolic ATP: Not so fast

(2011) Christos Chinopoulos   FEBS LETTERS

Direct measurement of backflux between oxaloacetate and fumarate following pyruvate carboxylation

(2011) Eva Brekke et al.   GLIA

Stimulation of reactive oxygen species generation by disease-causing mutations of lipoamide dehydrogenase

(2011) Attila Ambrus et al.   HUMAN MOLECULAR GENETICS

Up-regulation of the mitochondrial malate dehydrogenase by oxidative stress is mediated by miR-743a

(2011) Qingli Shi et al.   JOURNAL OF NEUROCHEMISTRY

The “B Space” of mitochondrial phosphorylation

(2011) Christos Chinopoulos   JOURNAL OF NEUROSCIENCE RESEARCH

Real-Time Molecular Imaging of Tricarboxylic Acid Cycle Metabolism in Vivo by Hyperpolarized 1-13C Diethyl Succinate

(2011) Niki M. Zacharias et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Succinate Receptors in the Kidney

(2011) P. M. T. Deen et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

A conditional knockout resource for the genome-wide study of mouse gene function

(2011) William C. Skarnes et al.   NATURE

Simultaneous investigation of cardiac pyruvate dehydrogenase flux, Krebs cycle metabolism and pH, using hyperpolarized [1,2-13C2]pyruvate in vivo

(2011) Albert P. Chen et al.   NMR IN BIOMEDICINE

Hypoxia promotes isocitrate dehydrogenase-dependent carboxylation of  -ketoglutarate to citrate to support cell growth and viability

(2011) D. R. Wise et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Revisiting the TCA cycle: signaling to tumor formation

(2011) Nuno Raimundo et al.   TRENDS IN MOLECULAR MEDICINE

A database of thermodynamic properties of the reactions of glycolysis, the tricarboxylic acid cycle, and the pentose phosphate pathway

(2011) X. Li et al.   Database-The Journal of Biological Databases and Curation

The Role of Mitochondria in Reactive Oxygen Species Metabolism and Signaling

(2010) Anatoly A. Starkov   Annals of the New York Academy of Sciences

The NADH-fumarate reductase system, a novel mitochondrial energy metabolism, is a new target for anticancer therapy in tumor microenvironments

(2010) Eriko Tomitsuka et al.   Annals of the New York Academy of Sciences

Inhibition of the malate–aspartate shuttle by pre-ischaemic aminooxyacetate loading of the heart induces cardioprotection

(2010) Nicolaj Brejnholt Støttrup et al.   CARDIOVASCULAR RESEARCH

Abnormalities in the tricarboxylic acid (TCA) cycle in the brains of schizophrenia patients

(2010) P. Bubber et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Forward operation of adenine nucleotide translocase during F0F1-ATPase reversal: critical role of matrix substrate-level phosphorylation

(2010) Christos Chinopoulos et al.   FASEB JOURNAL

The genetic basis of kidney cancer: a metabolic disease

(2010) W. Marston Linehan et al.   Nature Reviews Urology

Mitochondrial metabolism and ROS generation are essential for Kras-mediated tumorigenicity

(2010) F. Weinberg et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Quiescent Fibroblasts Exhibit High Metabolic Activity

(2010) Johanna M. S. Lemons et al.   PLOS BIOLOGY

Pyruvate kinase in pig liver mitochondria

(2009) Roberto Pizzuto et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Human NARP Mitochondrial Mutation Metabolism Corrected With α-Ketoglutarate/Aspartate

(2009) Gianluca Sgarbi et al.   ARCHIVES OF NEUROLOGY

Succinyl-CoA Synthetase Is a Phosphate Target for the Activation of Mitochondrial Metabolism

(2009) Darci Phillips et al.   BIOCHEMISTRY

Amino acid transamination is crucial for ischaemic cardioprotection in normal and preconditioned isolated rat hearts - focus onl-glutamate

(2009) Bo Løfgren et al.   EXPERIMENTAL PHYSIOLOGY

Real-time assessment of Krebs cycle metabolism using hyperpolarized 13C magnetic resonance spectroscopy

(2009) Marie A. Schroeder et al.   FASEB JOURNAL

Phosphoenolpyruvate Cycling via Mitochondrial Phosphoenolpyruvate Carboxykinase Links Anaplerosis and Mitochondrial GTP with Insulin Secretion

(2009) Romana Stark et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Evaluation of 13C isotopic tracers for metabolic flux analysis in mammalian cells

(2009) Christian M. Metallo et al.   JOURNAL OF BIOTECHNOLOGY

Regulation of succinate-ubiquinone reductase and fumarate reductase activities in human complex II by phosphorylation of its flavoprotein subunit

(2009) Eriko TOMITSUKA et al.   PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES

SDH5, a Gene Required for Flavination of Succinate Dehydrogenase, Is Mutated in Paraganglioma

(2009) H.-X. Hao et al.   SCIENCE

Novel functions of the α-ketoglutarate dehydrogenase complex may mediate diverse oxidant-induced changes in mitochondrial enzymes associated with Alzheimer's disease

(2008) Qingli Shi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

A Novel GDP-dependent Pyruvate Kinase Isozyme fromToxoplasma gondiiLocalizes to Both the Apicoplast and the Mitochondrion

(2008) Tomoya Saito et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Quantifying Reductive Carboxylation Flux of Glutamine to Lipid in a Brown Adipocyte Cell Line

(2008) Hyuntae Yoo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY